SIMILAR PATTERNS OF AMINO ACIDS FOR 4JLT_A_8PRA505_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ILE A  30
VAL A  25
PRO A  26
VAL A 129
 None
 0.73A 4jltA-1anuA:
undetectable		 4jltA-1anuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		4 ILE A  47
ALA A 245
PRO A 225
VAL A 269
 None
 0.80A 4jltA-1fiuA:
undetectable		 4jltA-1fiuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 243
ILE A 323
VAL A 308
VAL A 257
 None
 0.76A 4jltA-1kt8A:
undetectable		 4jltA-1kt8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 675
ALA A 681
VAL A 667
PRO A 668
 None
 0.76A 4jltA-1qf7A:
0.0		 4jltA-1qf7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ALA A 210
VAL A 219
PRO A 220
VAL A 187
 None
None
DTB  A 502 ( 4.7A)
None
 0.53A 4jltA-1r30A:
0.0		 4jltA-1r30A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		4 ILE A  42
ILE A 112
ALA A 144
VAL A  51
 None
 0.67A 4jltA-1tzbA:
0.0		 4jltA-1tzbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 293
ILE A 367
ALA A  10
VAL A 303
 None
 0.70A 4jltA-1vftA:
undetectable		 4jltA-1vftA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		4 ALA A  77
VAL A  68
PRO A  69
VAL A  53
 None
 0.81A 4jltA-1wloA:
undetectable		 4jltA-1wloA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 ILE A 142
ALA A  74
VAL A 188
VAL A  53
 None
 0.62A 4jltA-1wy0A:
1.5		 4jltA-1wy0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 203
ILE A 185
ALA A 150
GLU A 152
 None
 0.77A 4jltA-1wy2A:
undetectable		 4jltA-1wy2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 ILE A 194
ILE A 270
ALA A  20
VAL A 425
 None
 0.70A 4jltA-1x3lA:
undetectable		 4jltA-1x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep) 		4 ILE A  59
ILE A 119
ALA A  69
VAL A  18
 None
 0.70A 4jltA-1xatA:
undetectable		 4jltA-1xatA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		4 ILE A  91
ILE A 145
ALA A  77
VAL A 221
 None
None
MTM  A 301 (-4.9A)
None
 0.81A 4jltA-1zosA:
undetectable		 4jltA-1zosA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 ILE A  56
ILE A 200
ALA A 223
VAL A  58
 None
 0.72A 4jltA-2aamA:
undetectable		 4jltA-2aamA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		4 ILE A 113
ILE A 175
ALA A 311
VAL A 301
 None
 0.82A 4jltA-2bbvA:
undetectable		 4jltA-2bbvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A  10
ILE A  24
ALA A 298
PRO A 135
 None
 0.78A 4jltA-2be7A:
undetectable		 4jltA-2be7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 ILE A 143
ILE A 104
ALA A 117
VAL A 177
PRO A 176
 None
 1.23A 4jltA-2bi7A:
undetectable		 4jltA-2bi7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ALA A  24
GLU A  26
VAL A  63
PRO A  64
 None
 0.80A 4jltA-2c4nA:
undetectable		 4jltA-2c4nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ILE A  35
ILE A  59
PRO A  31
VAL A 134
 None
None
PO4  A1155 (-4.5A)
None
 0.81A 4jltA-2cclA:
undetectable		 4jltA-2cclA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyj HYPOTHETICAL PROTEIN
PH1505

(Pyrococcus
horikoshii) 		PF04430
(DUF498) 		5 ILE A  13
ILE A 114
GLU A   4
ALA A  97
VAL A   6
 None
 1.31A 4jltA-2cyjA:
undetectable		 4jltA-2cyjA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 110
ILE A  29
ALA A  68
VAL A  90
 None
 0.73A 4jltA-2eggA:
undetectable		 4jltA-2eggA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  36
ALA A 226
VAL A 181
PRO A 182
 None
 0.82A 4jltA-2fqdA:
undetectable		 4jltA-2fqdA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		4 ILE A 234
ILE A 190
ALA A 204
VAL A 244
 None
 0.76A 4jltA-2gupA:
undetectable		 4jltA-2gupA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		4 ILE A 102
ILE A 108
GLU A 184
PRO A 148
 None
 0.84A 4jltA-2hlsA:
undetectable		 4jltA-2hlsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  35
ILE A  52
VAL A  44
PRO A  45
 None
 0.63A 4jltA-2jgzA:
undetectable		 4jltA-2jgzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msw RESPONSE
REGULATOR/SENSOR
HISTIDINE KINASE

(Erythrobacter
litoralis) 		PF00072
(Response_reg) 		5 ALA A  35
GLU A  12
VAL A  68
PRO A  67
VAL A  57
 None
 1.30A 4jltA-2mswA:
undetectable		 4jltA-2mswA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3l SERINE/ARGININE-RICH
PROTEIN 1,
PFSR1-RRM1

(Plasmodium
falciparum) 		PF00076
(RRM_1) 		4 ALA A  60
VAL A  80
PRO A  81
VAL A  12
 None
 0.72A 4jltA-2n3lA:
undetectable		 4jltA-2n3lA:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 113
ALA A 297
VAL A 366
PRO A 367
 225  A 501 ( 4.3A)
HEM  A 500 (-3.5A)
225  A 501 ( 3.7A)
225  A 501 ( 4.7A)
 0.25A 4jltA-2nnjA:
54.2		 4jltA-2nnjA:
55.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 ILE A  11
GLU A  70
ALA A  13
PRO A 121
 None
 0.82A 4jltA-2p25A:
undetectable		 4jltA-2p25A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 ALA A 295
GLU A 302
VAL A  65
PRO A  66
VAL A 311
 None
 1.32A 4jltA-2pbzA:
undetectable		 4jltA-2pbzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 ILE A 272
ALA A  19
VAL A  98
VAL A  34
 None
 0.82A 4jltA-2pfkA:
undetectable		 4jltA-2pfkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		4 ILE A 219
ILE A 195
ALA A 176
VAL A 207
 None
 0.84A 4jltA-2ranA:
undetectable		 4jltA-2ranA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 ILE A 101
ALA A 322
GLU A  53
VAL A  50
 None
FAD  A1395 ( 3.9A)
None
None
 0.81A 4jltA-2vouA:
undetectable		 4jltA-2vouA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 ILE A 146
ILE A   9
ALA A  70
VAL A  98
 None
 0.65A 4jltA-2vtcA:
undetectable		 4jltA-2vtcA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 ILE A 408
ALA A 509
VAL A 402
PRO A 403
 None
 0.71A 4jltA-2wsuA:
undetectable		 4jltA-2wsuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		4 ILE A 487
ALA A 477
GLU A 475
VAL A 497
 None
 0.83A 4jltA-2z4tA:
undetectable		 4jltA-2z4tA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		4 ILE A  86
ALA A 295
GLU A 331
VAL A 328
 None
 0.78A 4jltA-3cg3A:
undetectable		 4jltA-3cg3A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A 141
VAL A 171
PRO A 172
VAL A 166
 None
 0.79A 4jltA-3cvwA:
undetectable		 4jltA-3cvwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 126
GLU A 137
PRO A 194
VAL A 188
 None
 0.69A 4jltA-3eb7A:
undetectable		 4jltA-3eb7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eev CHLORAMPHENICOL
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep) 		4 ILE A  58
ILE A 117
ALA A  68
VAL A  17
 None
 0.69A 4jltA-3eevA:
undetectable		 4jltA-3eevA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		4 ILE A 147
ILE A  15
ALA A  99
VAL A  52
 None
 0.75A 4jltA-3fkjA:
1.8		 4jltA-3fkjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		4 ILE A 172
ALA A 108
VAL A  12
VAL A  41
 None
 0.83A 4jltA-3fseA:
undetectable		 4jltA-3fseA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		4 ILE A 313
ALA A 263
VAL A 242
VAL A 322
 None
None
GOL  A   6 ( 4.9A)
None
 0.78A 4jltA-3g3lA:
undetectable		 4jltA-3g3lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 ILE A  48
ILE A  40
ALA A 297
PRO A  61
 None
 0.64A 4jltA-3gohA:
undetectable		 4jltA-3gohA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N

(Homo sapiens) 		PF00179
(UQ_con) 		4 ILE B 101
ILE B   8
ALA B  32
PRO B  67
 None
 0.75A 4jltA-3hcuB:
undetectable		 4jltA-3hcuB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkl MUSCLE, SKELETAL
RECEPTOR TYROSINE
PROTEIN KINASE

(Rattus
norvegicus) 		PF01392
(Fz) 		4 ILE A 393
ALA A 370
VAL A 431
PRO A 432
 None
 0.71A 4jltA-3hklA:
undetectable		 4jltA-3hklA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		4 ILE X 147
ILE X 108
ALA X 140
PRO X 133
 None
 0.79A 4jltA-3ighX:
undetectable		 4jltA-3ighX:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ILE A  43
GLU A  70
VAL A  13
VAL A 105
 None
 0.81A 4jltA-3k55A:
undetectable		 4jltA-3k55A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5r NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 ILE A 198
GLU A 186
ALA A 132
VAL A 178
 None
 0.75A 4jltA-3m5rA:
undetectable		 4jltA-3m5rA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		4 ILE A 375
ALA A 384
VAL A 242
PRO A 243
 None
 0.82A 4jltA-3nd0A:
undetectable		 4jltA-3nd0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		4 ILE A 382
ALA A 374
VAL A 165
PRO A 166
 None
 0.66A 4jltA-3nxlA:
undetectable		 4jltA-3nxlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		4 ILE A 261
ILE A  57
ALA A 289
VAL A 225
 None
 0.75A 4jltA-3qhyA:
undetectable		 4jltA-3qhyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 218
ALA A 407
VAL A 214
PRO A 215
VAL A 180
 None
 1.04A 4jltA-3rv6A:
undetectable		 4jltA-3rv6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 186
GLU A 116
VAL A 178
PRO A 179
 None
CA  A 901 (-2.6A)
None
None
 0.61A 4jltA-3sunA:
undetectable		 4jltA-3sunA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		4 ILE A  64
GLU A 179
VAL A  36
PRO A  37
 None
 0.70A 4jltA-3t12A:
undetectable		 4jltA-3t12A:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 ILE A 114
GLU A 218
ALA A 298
VAL A 367
PRO A 368
 HEM  A 500 (-4.0A)
None
CPZ  A 501 (-3.5A)
HEM  A 500 ( 4.3A)
None
 0.64A 4jltA-3tk3A:
60.7		 4jltA-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 355
ALA A 326
PRO A 323
VAL A 386
 None
 0.82A 4jltA-3u0fA:
undetectable		 4jltA-3u0fA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ALA A 277
VAL A 267
PRO A 268
VAL A 425
 None
 0.84A 4jltA-3v7nA:
undetectable		 4jltA-3v7nA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		5 ILE A 197
ALA A 327
VAL A 192
PRO A 193
VAL A 322
 None
 1.24A 4jltA-3vxiA:
undetectable		 4jltA-3vxiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5x 4-HYDROXY-2-OXO-HEPT
ANE-1,7-DIOATE
ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 ALA A 107
VAL A  92
PRO A  93
VAL A  69
 None
 0.68A 4jltA-4b5xA:
undetectable		 4jltA-4b5xA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsj CAPSID PROTEIN BETA

(Flock House
virus) 		PF01829
(Peptidase_A6) 		4 ILE A 113
ILE A 175
ALA A 311
VAL A 301
 None
 0.69A 4jltA-4fsjA:
undetectable		 4jltA-4fsjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fte CAPSID PROTEIN ALPHA

(Flock House
virus) 		PF01829
(Peptidase_A6) 		4 ILE A 113
ILE A 175
ALA A 311
VAL A 301
 None
 0.72A 4jltA-4fteA:
undetectable		 4jltA-4fteA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9q 4-CARBOXYMUCONOLACTO
NE DECARBOXYLASE

(Sinorhizobium
meliloti) 		PF02627
(CMD) 		4 ILE A 120
ILE A  88
ALA A  78
GLU A  80
 None
 0.81A 4jltA-4g9qA:
undetectable		 4jltA-4g9qA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 ILE A  80
GLU A  59
ALA A 108
VAL A  95
 None
 0.76A 4jltA-4gt6A:
undetectable		 4jltA-4gt6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 ILE A 379
ALA A 371
VAL A 162
PRO A 163
 None
 0.69A 4jltA-4hn8A:
undetectable		 4jltA-4hn8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		4 ILE A 249
ALA A  87
VAL A 246
VAL A 197
 None
 0.84A 4jltA-4jcnA:
undetectable		 4jltA-4jcnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		PF04446
(Thg1) 		4 ILE A  64
ALA A 105
VAL A  27
VAL A  70
 None
 0.80A 4jltA-4kgkA:
undetectable		 4jltA-4kgkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 195
ILE A 131
ALA A 112
VAL A 148
 None
 0.79A 4jltA-4lcbA:
undetectable		 4jltA-4lcbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 201
ILE A 137
ALA A 118
VAL A 154
 None
 0.73A 4jltA-4lgmA:
undetectable		 4jltA-4lgmA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz9 SINGLE-STRANDED
DNA-BINDING PROTEIN

(Escherichia
coli) 		PF00436
(SSB) 		4 ILE A  79
ILE A  32
ALA A  67
VAL A  77
 None
 0.81A 4jltA-4mz9A:
undetectable		 4jltA-4mz9A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 ILE A 144
ALA A 198
GLU A 201
VAL A 238
 None
 0.80A 4jltA-4nq3A:
undetectable		 4jltA-4nq3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 ILE A 131
ILE A 140
ALA A 300
VAL A 322
 None
 0.65A 4jltA-4nzmA:
undetectable		 4jltA-4nzmA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 ILE A 490
ILE A 481
ALA A 474
VAL A 194
 None
 0.80A 4jltA-4oerA:
undetectable		 4jltA-4oerA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		4 ILE A 161
ALA A 126
VAL A 155
PRO A 156
 None
 0.80A 4jltA-4ohqA:
undetectable		 4jltA-4ohqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 ILE A 101
ILE A 136
ALA A   9
GLU A   7
 None
 0.84A 4jltA-4qxdA:
undetectable		 4jltA-4qxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyp CELLULOSOMAL
SCAFFOLDIN ANCHORING
PROTEIN C

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ILE A  31
VAL A  26
PRO A  27
VAL A 132
 None
 0.72A 4jltA-4uypA:
undetectable		 4jltA-4uypA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ALA A 225
GLU A 221
VAL A 245
VAL A 189
 None
None
None
NAD  A 301 (-4.1A)
 0.83A 4jltA-4wecA:
undetectable		 4jltA-4wecA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ILE A  89
GLU A 233
ALA A  93
VAL A 230
 None
MN  A 502 ( 2.3A)
None
None
 0.80A 4jltA-4y67A:
undetectable		 4jltA-4y67A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 ILE A 123
ALA A 110
VAL A 117
PRO A 118
 None
None
None
PEG  A 402 ( 4.6A)
 0.77A 4jltA-4yt2A:
undetectable		 4jltA-4yt2A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 4 ILE A 112
ALA A  99
VAL A 106
PRO A 107
 None
 0.80A 4jltA-4yteA:
undetectable		 4jltA-4yteA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b82 TLL0287 PROTEIN

(Thermosynechococcus
elongatus) 		PF11845
(DUF3365) 		4 ILE A  78
ALA A  37
GLU A  39
VAL A 178
 None
 0.59A 4jltA-5b82A:
undetectable		 4jltA-5b82A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c14 PLATELET ENDOTHELIAL
CELL ADHESION
MOLECULE

(Homo sapiens) 		PF13895
(Ig_2) 		4 ILE B 134
VAL B 103
PRO B 104
VAL B 100
 None
None
GOL  B 301 ( 4.3A)
None
 0.77A 4jltA-5c14B:
undetectable		 4jltA-5c14B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A1308
GLU A1475
ALA A1349
VAL A1477
 None
 0.84A 4jltA-5dotA:
undetectable		 4jltA-5dotA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 ILE A 101
GLU A 218
ALA A 298
VAL A 367
PRO A 368
 CPZ  A 502 (-4.7A)
None
HEM  A 501 ( 3.1A)
HEM  A 501 ( 4.4A)
None
 1.09A 4jltA-5e0eA:
54.7		 4jltA-5e0eA:
79.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 ILE A  83
ILE A 131
VAL A  66
PRO A  67
 None
 0.73A 4jltA-5f4zA:
undetectable		 4jltA-5f4zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 306
ILE A 380
ALA A  18
VAL A 316
 None
 0.78A 4jltA-5facA:
undetectable		 4jltA-5facA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 ILE A 297
ILE A 117
VAL A 293
PRO A 294
 None
 0.79A 4jltA-5hsgA:
undetectable		 4jltA-5hsgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 568
ALA A 670
PRO A 710
VAL A 465
 None
 0.79A 4jltA-5i2gA:
undetectable		 4jltA-5i2gA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE EPSILON
CHAIN

(Caldalkalibacillus
thermarum) 		PF02823
(ATP-synt_DE_N) 		5 ILE H  77
GLU H  87
ALA H  25
VAL H  63
VAL H 130
 None
 0.97A 4jltA-5ik2H:
undetectable		 4jltA-5ik2H:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 150
ILE A  78
ALA A  95
VAL A 168
 None
 0.77A 4jltA-5kyvA:
undetectable		 4jltA-5kyvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1

(Arabidopsis
thaliana) 		PF00719
(Pyrophosphatase) 		5 ILE A  41
ILE A 195
ALA A 122
VAL A  91
PRO A  92
 None
 1.32A 4jltA-5ls0A:
undetectable		 4jltA-5ls0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 475
ILE A 491
VAL A 428
VAL A 469
 None
 0.81A 4jltA-5lu4A:
undetectable		 4jltA-5lu4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ILE A1183
ILE A1211
VAL A1260
VAL A1197
 None
 0.80A 4jltA-5mznA:
undetectable		 4jltA-5mznA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		4 ILE A 151
ALA A 205
GLU A 208
VAL A 245
 None
 0.72A 4jltA-5t13A:
undetectable		 4jltA-5t13A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE B 152
ILE B 189
ALA B 181
VAL B 158
 None
 0.77A 4jltA-5vljB:
undetectable		 4jltA-5vljB:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 6 ILE A 101
ILE A 114
GLU A 218
ALA A 298
VAL A 367
PRO A 368
 9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
None
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 4.2A)
None
 0.70A 4jltA-5wbgA:
57.9		 4jltA-5wbgA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 4 ILE G 309
ALA G 319
PRO G 124
VAL G 120
 None
 0.83A 4jltA-5wduG:
undetectable		 4jltA-5wduG:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		4 ILE A 228
ILE A 169
ALA A 148
VAL A 186
 None
 0.81A 4jltA-5xmiA:
undetectable		 4jltA-5xmiA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		4 ILE A 322
ILE A 311
ALA A  66
VAL A  58
 None
 0.77A 4jltA-5y1iA:
31.9		 4jltA-5y1iA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 4 ILE A 316
GLU A 230
ALA A 323
GLU A 326
 None
 0.73A 4jltA-6g3dA:
undetectable		 4jltA-6g3dA:
11.23