SIMILAR PATTERNS OF AMINO ACIDS FOR 4JJK_A_FOLA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		5 ALA A 147
PRO A 403
LEU A 161
LEU A 193
TRP A 405
 None
 1.23A 4jjkA-1crzA:
undetectable		 4jjkA-1crzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 ALA A 194
PRO A 184
LEU A 205
LEU A 237
 None
 0.93A 4jjkA-1crzA:
undetectable		 4jjkA-1crzA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		7 ASN A1382
ALA A1383
PRO A1385
GLU A1389
LEU A1392
TYR A1396
TRP A1412
 SO4  A   7 (-3.0A)
None
None
None
None
None
SO4  A   7 (-3.2A)
 0.43A 4jjkA-1eg7A:
62.5		 4jjkA-1eg7A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN
TRANSLOCATED INTIMIN
RECEPTOR

(Escherichia
coli;
Escherichia
coli) 		PF02368
(Big_2)
PF02369
(Big_1)
PF07979
(Intimin_C)
PF03549
(Tir_receptor_M) 		4 ASN T 306
ALA T 307
PRO T 309
LEU I 923
 None
 0.91A 4jjkA-1f02T:
undetectable		 4jjkA-1f02T:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3o HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
MJ0796

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 ASN A 103
ALA A 100
LEU A 134
LEU A 146
 None
 0.94A 4jjkA-1f3oA:
undetectable		 4jjkA-1f3oA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ASN A 360
ALA A 361
PRO A 363
TYR A 307
LEU A 358
 None
 1.40A 4jjkA-1flgA:
undetectable		 4jjkA-1flgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 ASN A 268
ALA A 265
PRO A 263
LEU A 310
 None
 0.92A 4jjkA-1g59A:
undetectable		 4jjkA-1g59A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 268
ALA A 796
TYR A 262
LEU A 391
 None
 0.95A 4jjkA-1h0hA:
undetectable		 4jjkA-1h0hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ALA A 175
GLU A 191
LEU A 194
LEU A 198
 None
 0.81A 4jjkA-1iqpA:
2.4		 4jjkA-1iqpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 ALA A 310
PRO A 309
GLU A 276
LEU A 279
LEU A 283
 None
 1.28A 4jjkA-1iy1A:
2.3		 4jjkA-1iy1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Magnaporthe
grisea) 		PF00926
(DHBP_synthase) 		4 ALA A 126
PRO A 124
GLU A  72
LEU A  77
 None
 0.81A 4jjkA-1k4lA:
undetectable		 4jjkA-1k4lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ASN A 896
ALA A 869
LEU A 871
TYR A 821
LEU A 828
 None
 1.37A 4jjkA-1kz7A:
undetectable		 4jjkA-1kz7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldd ANAPHASE PROMOTING
COMPLEX

(Saccharomyces
cerevisiae) 		PF08672
(ANAPC2) 		4 GLU A 832
LEU A 829
TYR A 825
LEU A 782
 None
 0.91A 4jjkA-1lddA:
undetectable		 4jjkA-1lddA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 ASN A 396
LEU A 538
TYR A 536
LEU A 353
TRP A 398
 None
 1.38A 4jjkA-1mpxA:
2.1		 4jjkA-1mpxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ALA A 344
PRO A 346
LEU A 335
LEU A 339
 None
 0.73A 4jjkA-1nneA:
undetectable		 4jjkA-1nneA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		4 ASN A 113
ALA A 112
LEU A  46
LEU A  67
 None
 0.80A 4jjkA-1npmA:
undetectable		 4jjkA-1npmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 GLU A  76
LEU A  73
TYR A  69
LEU A  39
 None
 0.97A 4jjkA-1o1yA:
undetectable		 4jjkA-1o1yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		4 ASN A 326
PRO A 313
TYR A 340
LEU A 324
 None
 0.97A 4jjkA-1opeA:
undetectable		 4jjkA-1opeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 332
ALA A 329
LEU A 191
LEU A 195
 None
 0.95A 4jjkA-1q8iA:
undetectable		 4jjkA-1q8iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ASN A 149
ALA A 148
PRO A 146
LEU A 142
TYR A 259
 None
 1.32A 4jjkA-1qgzA:
undetectable		 4jjkA-1qgzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 ASN A 408
ALA A 409
PRO A 411
LEU A 449
 None
 0.96A 4jjkA-1r6vA:
2.3		 4jjkA-1r6vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ALA A 151
PRO A 149
GLU A 474
LEU A 472
 None
 0.93A 4jjkA-1s5jA:
undetectable		 4jjkA-1s5jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 ALA A 523
PRO A 530
LEU A  67
LEU A  71
 None
 0.85A 4jjkA-1t1uA:
undetectable		 4jjkA-1t1uA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASN A 164
PRO A 292
LEU A 300
LEU A 295
 None
 0.91A 4jjkA-1t2fA:
undetectable		 4jjkA-1t2fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 ALA A 214
PRO A 212
LEU A 209
TYR A 218
LEU A 173
 None
 1.38A 4jjkA-1txkA:
undetectable		 4jjkA-1txkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 ASN A 182
ALA A 179
LEU A 211
LEU A 203
 None
 0.92A 4jjkA-1uc4A:
1.4		 4jjkA-1uc4A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		4 ASN A  14
ALA A  11
LEU A  73
LEU A  85
 None
 0.81A 4jjkA-1ucpA:
undetectable		 4jjkA-1ucpA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASN A 400
ALA A 401
TYR A  38
LEU A  33
 None
 0.80A 4jjkA-1uliA:
undetectable		 4jjkA-1uliA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 ASN A 203
ALA A 179
PRO A 181
TRP A 202
 None
 0.94A 4jjkA-1wnoA:
undetectable		 4jjkA-1wnoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr2 HYPOTHETICAL PROTEIN
PH1789

(Pyrococcus
horikoshii) 		PF13549
(ATP-grasp_5) 		4 ASN A  97
ALA A  98
PRO A 103
LEU A  63
 None
 0.91A 4jjkA-1wr2A:
undetectable		 4jjkA-1wr2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 ALA A 172
GLU A 236
LEU A 230
LEU A 227
 None
CA  A1004 (-3.6A)
None
None
 0.92A 4jjkA-1y4jA:
undetectable		 4jjkA-1y4jA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ALA A 423
LEU A 117
TYR A 119
TRP A 421
 None
 0.88A 4jjkA-1z8lA:
undetectable		 4jjkA-1z8lA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 ASN A 254
ALA A 252
LEU A  30
LEU A   6
 None
 0.98A 4jjkA-1ztvA:
undetectable		 4jjkA-1ztvA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ALA B  90
PRO B  92
LEU B  96
LEU B 118
 None
 0.92A 4jjkA-2amcB:
undetectable		 4jjkA-2amcB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		4 ASN A 322
ALA A 319
PRO A 315
LEU A 446
 None
 0.87A 4jjkA-2b5uA:
undetectable		 4jjkA-2b5uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 ALA A 186
PRO A 188
LEU A 106
TYR A 102
 None
None
None
ACT  A1501 (-4.5A)
 0.92A 4jjkA-2bb0A:
1.8		 4jjkA-2bb0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 263
PRO A 266
GLU A  62
LEU A 257
 None
 0.98A 4jjkA-2cb1A:
undetectable		 4jjkA-2cb1A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 ASN A  68
ALA A  70
GLU A 252
LEU A 223
 None
 0.96A 4jjkA-2ch1A:
2.5		 4jjkA-2ch1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cz4 HYPOTHETICAL PROTEIN
TTHA0516

(Thermus
thermophilus) 		no annotation 4 ASN A  55
ALA A  13
LEU A  21
LEU A  17
 None
 0.96A 4jjkA-2cz4A:
undetectable		 4jjkA-2cz4A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esb DUAL SPECIFICITY
PROTEIN PHOSPHATASE
18

(Homo sapiens) 		PF00782
(DSPc) 		4 ASN A  37
ALA A  34
LEU A 101
LEU A  20
 None
 0.98A 4jjkA-2esbA:
2.4		 4jjkA-2esbA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		4 ALA A 416
GLU A 466
LEU A 405
LEU A 399
 None
 0.97A 4jjkA-2exaA:
2.0		 4jjkA-2exaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		4 ALA A 149
PRO A 147
LEU A 181
LEU A 173
 None
 0.98A 4jjkA-2fefA:
undetectable		 4jjkA-2fefA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		4 ALA A   7
PRO A  37
LEU A  59
LEU A  67
 None
 0.84A 4jjkA-2fexA:
undetectable		 4jjkA-2fexA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ASN A 422
GLU A 378
LEU A 375
LEU A 424
 None
 0.74A 4jjkA-2fknA:
undetectable		 4jjkA-2fknA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 ASN A  73
ALA A  74
PRO A  92
LEU A 106
 None
 0.98A 4jjkA-2gahA:
undetectable		 4jjkA-2gahA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 ALA A 147
PRO A 135
LEU A 275
LEU A 271
 None
 0.90A 4jjkA-2go4A:
undetectable		 4jjkA-2go4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		4 ASN A  87
PRO A  80
LEU A  96
LEU A 102
 None
 0.97A 4jjkA-2h12A:
undetectable		 4jjkA-2h12A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE

(Streptomyces
diastaticus) 		PF06616
(BsuBI_PstI_RE) 		4 ALA A 273
PRO A 271
LEU A 275
LEU A 244
 None
 0.95A 4jjkA-2ixsA:
undetectable		 4jjkA-2ixsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 ALA A 114
LEU A 120
TYR A  70
LEU A  59
 None
 0.96A 4jjkA-2n7gA:
undetectable		 4jjkA-2n7gA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd9 MID-CELL-ANCHORED
PROTEIN Z

(Streptococcus
pneumoniae) 		no annotation 5 ASN A 105
ALA A 106
PRO A  95
LEU A 102
LEU A 134
 None
 1.40A 4jjkA-2nd9A:
undetectable		 4jjkA-2nd9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 ASN A  42
ALA A  43
LEU A 112
LEU A  94
 FMN  A 401 (-2.8A)
None
None
None
 0.98A 4jjkA-2nr4A:
undetectable		 4jjkA-2nr4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 289
PRO A 297
LEU A 324
LEU A 320
 None
 0.91A 4jjkA-2og9A:
undetectable		 4jjkA-2og9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 ASN A 309
ALA A 356
LEU A 268
LEU A 314
 None
 0.91A 4jjkA-2ptsA:
undetectable		 4jjkA-2ptsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ASN A 271
LEU A 264
TYR A 313
LEU A 275
 None
 0.97A 4jjkA-2q3oA:
2.2		 4jjkA-2q3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ALA A 310
LEU A 248
LEU A 244
TRP A 202
 None
 0.98A 4jjkA-2uuuA:
undetectable		 4jjkA-2uuuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 ASN A  16
ALA A  13
PRO A  11
LEU A 427
 None
 0.91A 4jjkA-2vn7A:
undetectable		 4jjkA-2vn7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 ALA A 103
PRO A 281
LEU A 149
LEU A 264
 None
 0.87A 4jjkA-2vy0A:
undetectable		 4jjkA-2vy0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  97
GLU A  17
LEU A  19
LEU A  95
 None
None
ADP  A1303 ( 3.9A)
None
 0.86A 4jjkA-2w4kA:
undetectable		 4jjkA-2w4kA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 ASN A 455
ALA A 452
PRO A 450
LEU A 316
 None
None
BGC  A1526 (-4.5A)
None
 0.77A 4jjkA-2wzfA:
2.4		 4jjkA-2wzfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 ASN A 455
ALA A 452
PRO A 450
LEU A 316
 None
None
UPG  A1525 (-4.9A)
None
 0.84A 4jjkA-2wzgA:
4.0		 4jjkA-2wzgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ASN A 334
LEU A 237
TYR A 239
LEU A 338
 None
 0.82A 4jjkA-2x5fA:
undetectable		 4jjkA-2x5fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		4 ALA A 780
PRO A 751
LEU A 793
LEU A 758
 None
 0.90A 4jjkA-2x8aA:
2.4		 4jjkA-2x8aA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 ALA A 320
PRO A  34
LEU A  68
LEU A 324
 None
 0.95A 4jjkA-2z1bA:
1.9		 4jjkA-2z1bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 231
ALA A 229
LEU A 166
LEU A 299
 None
 0.98A 4jjkA-2zauA:
3.1		 4jjkA-2zauA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		4 ALA A 211
PRO A 213
LEU A 191
LEU A 221
 None
 0.82A 4jjkA-2ze3A:
2.1		 4jjkA-2ze3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		4 PRO A   5
GLU A  13
LEU A   8
LEU A  36
 None
 0.90A 4jjkA-2zwrA:
undetectable		 4jjkA-2zwrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 ALA A 637
LEU A 323
TYR A 720
LEU A 331
 None
 0.91A 4jjkA-3abzA:
undetectable		 4jjkA-3abzA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ALA A  52
PRO A  50
LEU A 120
LEU A 124
 None
 0.97A 4jjkA-3bjxA:
undetectable		 4jjkA-3bjxA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 ALA A 239
GLU A 343
LEU A 340
LEU A 336
 None
 0.86A 4jjkA-3bw2A:
undetectable		 4jjkA-3bw2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		4 ASN A  42
ALA A  44
PRO A  49
GLU A 129
 None
SO4  A 206 (-3.1A)
None
None
 0.98A 4jjkA-3bw8A:
undetectable		 4jjkA-3bw8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 ALA A 148
PRO A 146
LEU A 152
LEU A 271
 None
 0.96A 4jjkA-3c4nA:
2.2		 4jjkA-3c4nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 ASN B  68
PRO B  55
TYR B  82
LEU B  66
 None
 0.97A 4jjkA-3cdkB:
undetectable		 4jjkA-3cdkB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		4 ALA A 133
LEU A 144
TYR A 143
LEU A 185
 None
 0.89A 4jjkA-3cgxA:
undetectable		 4jjkA-3cgxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm0 ADENYLATE KINASE

(Thermus
thermophilus) 		PF00406
(ADK) 		4 PRO A 153
GLU A 159
LEU A 164
LEU A 111
 None
 0.97A 4jjkA-3cm0A:
4.8		 4jjkA-3cm0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1d RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Schizosaccharomyces
pombe) 		no annotation 4 ALA A 512
PRO A 510
LEU A 505
LEU A 537
 None
 0.97A 4jjkA-3d1dA:
undetectable		 4jjkA-3d1dA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		4 ASN A  38
LEU A  99
LEU A  44
TRP A 238
 None
 0.90A 4jjkA-3d43A:
1.9		 4jjkA-3d43A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		5 ASN A  85
ALA A 170
PRO A  82
LEU A  21
LEU A 119
 None
 1.32A 4jjkA-3dkqA:
undetectable		 4jjkA-3dkqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmn PUTATIVE DNA
HELICASE

(Lactobacillus
plantarum) 		PF13538
(UvrD_C_2) 		5 ASN A 720
ALA A 716
LEU A 753
LEU A 730
TRP A 714
 ACT  A   4 ( 4.1A)
None
None
None
ACT  A  10 (-4.1A)
 1.22A 4jjkA-3dmnA:
3.3		 4jjkA-3dmnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		4 ALA A  91
PRO A  93
LEU A  96
LEU A  58
 None
 0.98A 4jjkA-3e29A:
undetectable		 4jjkA-3e29A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 ASN A 178
ALA A 175
LEU A 450
LEU A 154
 None
 0.93A 4jjkA-3e4eA:
undetectable		 4jjkA-3e4eA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PRO A 521
LEU A 538
TYR A 543
LEU A 534
TRP A 530
 None
 1.46A 4jjkA-3fawA:
undetectable		 4jjkA-3fawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ALA A 413
LEU A 107
TYR A 109
TRP A 411
 None
 0.93A 4jjkA-3fedA:
undetectable		 4jjkA-3fedA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASN A 173
ALA A 191
PRO A 197
LEU A 160
 None
 0.89A 4jjkA-3fi9A:
2.5		 4jjkA-3fi9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		4 ASN A 208
ALA A 207
LEU A 236
TYR A 240
 None
 0.90A 4jjkA-3fluA:
2.2		 4jjkA-3fluA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h15 PROTEIN MCM10
HOMOLOG

(Xenopus laevis) 		PF09329
(zf-primase) 		4 ASN A 346
ALA A 347
PRO A 349
LEU A 344
 None
 0.89A 4jjkA-3h15A:
undetectable		 4jjkA-3h15A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		4 ALA A 246
PRO A 220
LEU A 277
LEU A 210
 None
 0.93A 4jjkA-3hlkA:
undetectable		 4jjkA-3hlkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i38 PUTATIVE CHAPERONE
DNAJ

(Klebsiella
pneumoniae) 		PF01556
(DnaJ_C) 		4 PRO A 241
GLU A 220
LEU A 216
LEU A 214
 None
 0.97A 4jjkA-3i38A:
undetectable		 4jjkA-3i38A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihw CENTG3

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 187
ALA A 188
PRO A 192
LEU A 182
 None
None
UNX  A   3 ( 4.1A)
None
 0.96A 4jjkA-3ihwA:
6.5		 4jjkA-3ihwA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ASN B 821
ALA B 818
PRO B 816
LEU B1047
 None
 0.81A 4jjkA-3iz3B:
undetectable		 4jjkA-3iz3B:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 ALA A 151
PRO A 153
LEU A  14
LEU A 121
 None
 0.89A 4jjkA-3kb1A:
10.4		 4jjkA-3kb1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr0 SENSOR PROTEIN

(Burkholderia
pseudomallei) 		PF16524
(RisS_PPD) 		4 ALA A  57
GLU A  77
LEU A  73
LEU A  69
 None
 0.92A 4jjkA-3lr0A:
undetectable		 4jjkA-3lr0A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr4 SENSOR PROTEIN

(Burkholderia
pseudomallei) 		PF16524
(RisS_PPD) 		4 ALA A  57
GLU A  77
LEU A  73
LEU A  69
 None
 0.92A 4jjkA-3lr4A:
undetectable		 4jjkA-3lr4A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 ALA A 426
PRO A 424
LEU A 449
LEU A 398
 None
 0.96A 4jjkA-3m6xA:
undetectable		 4jjkA-3m6xA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 ASN A 186
ALA A 187
PRO A 189
TRP A 165
 None
 0.80A 4jjkA-3n05A:
4.5		 4jjkA-3n05A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A 179
GLU A 228
LEU A 225
LEU A 221
 None
 0.91A 4jjkA-3n2bA:
3.1		 4jjkA-3n2bA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		4 ASN B 140
ALA B 141
PRO B 143
LEU B 232
 None
 0.96A 4jjkA-3napB:
undetectable		 4jjkA-3napB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ASN A 452
ALA A 449
PRO A 445
LEU A 429
LEU A 455
 None
 1.07A 4jjkA-3oeeA:
undetectable		 4jjkA-3oeeA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		4 ASN A 170
ALA A 167
LEU A  99
LEU A  97
 None
 0.92A 4jjkA-3os6A:
undetectable		 4jjkA-3os6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 250
ALA A 247
PRO A 243
LEU A 224
 None
 0.91A 4jjkA-3pi7A:
undetectable		 4jjkA-3pi7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 ALA A 864
PRO A 894
LEU A 809
TYR A 816
LEU A 782
 None
 1.50A 4jjkA-3pieA:
4.2		 4jjkA-3pieA:
18.43