SIMILAR PATTERNS OF AMINO ACIDS FOR 4JI8_A_SRYA1601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		3 LYS A  13
LYS A   9
TRP A 235
 None
 1.37A 4ji8L-1i4wA:
0.0		 4ji8L-1i4wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		3 LYS A 140
LYS A   8
TRP A 109
 None
 1.18A 4ji8L-2ddtA:
0.0		 4ji8L-2ddtA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LYS A  22
LYS A  16
TRP A  21
 None
 1.10A 4ji8L-3gbdA:
0.0		 4ji8L-3gbdA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		3 LYS A 126
LYS A  35
TRP A 128
 None
 1.49A 4ji8L-3gz8A:
0.0		 4ji8L-3gz8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfn UNCHARACTERIZED
PROTEIN

(Dyadobacter
fermentans) 		no annotation 3 LYS A  71
LYS A  65
TRP A  75
 None
 1.38A 4ji8L-3mfnA:
undetectable		 4ji8L-3mfnA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		3 LYS A 181
LYS A 211
TRP A 242
 None
 1.45A 4ji8L-4ctaA:
0.0		 4ji8L-4ctaA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		3 LYS A  57
LYS A 157
TRP A  55
 None
 1.10A 4ji8L-4ig7A:
0.0		 4ji8L-4ig7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 LYS A  91
LYS A  85
TRP A  80
 None
 1.26A 4ji8L-4kmzA:
0.0		 4ji8L-4kmzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roj GUANINE NUCLEOTIDE
EXCHANGE FACTOR VAV2

(Homo sapiens) 		PF00017
(SH2) 		3 LYS A 736
LYS A 725
TRP A 728
 None
 1.41A 4ji8L-4rojA:
0.0		 4ji8L-4rojA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		3 LYS B 653
LYS B 997
TRP B 992
 None
 1.29A 4ji8L-4wwxB:
0.0		 4ji8L-4wwxB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		3 LYS A 205
LYS A 199
TRP A 202
 None
 1.31A 4ji8L-4y4nA:
undetectable		 4ji8L-4y4nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 3 LYS A  88
LYS A 360
TRP A  92
 None
 1.31A 4ji8L-5y9dA:
undetectable		 4ji8L-5y9dA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 3 LYS A 653
LYS A 997
TRP A 992
 None
 1.40A 4ji8L-6cg0A:
undetectable		 4ji8L-6cg0A:
16.41