SIMILAR PATTERNS OF AMINO ACIDS FOR 4JEC_B_478B401_3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		3 ASP A 188
LEU A 229
VAL A 279
 None
 0.71A 4jecB-1bf6A:
undetectable		 4jecB-1bf6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 ASP A  59
LEU A 340
VAL A  15
 None
 0.59A 4jecB-1cptA:
0.0		 4jecB-1cptA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 ASP A 460
LEU A 475
VAL A 498
 None
 0.67A 4jecB-1d9zA:
undetectable		 4jecB-1d9zA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 ASP P 207
LEU P 117
VAL P  24
 None
NDG  P 602 (-4.9A)
None
 0.64A 4jecB-1e33P:
0.0		 4jecB-1e33P:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		3 ASP A 260
LEU A  39
VAL A  43
 None
 0.72A 4jecB-1f1uA:
0.0		 4jecB-1f1uA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 ASP A 260
LEU A  39
VAL A  43
 None
 0.71A 4jecB-1f1xA:
0.0		 4jecB-1f1xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 ASP A1204
LEU A1190
VAL A1216
 None
 0.72A 4jecB-1fnfA:
0.0		 4jecB-1fnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 ASP A1039
LEU A1206
VAL A1124
 None
 0.68A 4jecB-1foeA:
0.0		 4jecB-1foeA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		3 ASP A 288
LEU A 291
VAL A 257
 None
 0.71A 4jecB-1gfnA:
undetectable		 4jecB-1gfnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A 111
LEU A 143
VAL A 135
 None
 0.63A 4jecB-1gnwA:
undetectable		 4jecB-1gnwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6f T-BOX TRANSCRIPTION
FACTOR TBX3

(Homo sapiens) 		PF00907
(T-box) 		3 ASP A 154
LEU A 207
VAL A 202
 None
 0.64A 4jecB-1h6fA:
undetectable		 4jecB-1h6fA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ASP A  29
LEU A  76
VAL A  82
 A79  A 800 (-2.8A)
None
A79  A 800 (-4.5A)
 0.39A 4jecB-1hvcA:
14.2		 4jecB-1hvcA:
46.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 472
LEU A 467
VAL A 178
 SWA  A1103 (-2.9A)
None
None
 0.63A 4jecB-1hwwA:
undetectable		 4jecB-1hwwA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A 513
LEU A 506
VAL A 502
 None
 0.70A 4jecB-1i2dA:
undetectable		 4jecB-1i2dA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 ASP A 127
LEU A 130
VAL A  79
 None
 0.72A 4jecB-1i2oA:
undetectable		 4jecB-1i2oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 ASP A1765
LEU A1773
VAL A1703
 None
 0.70A 4jecB-1iahA:
undetectable		 4jecB-1iahA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 ASP A 242
LEU A 312
VAL A 277
 None
 0.70A 4jecB-1ii2A:
undetectable		 4jecB-1ii2A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		3 ASP A 232
LEU A 228
VAL A 264
 None
 0.59A 4jecB-1kt8A:
undetectable		 4jecB-1kt8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		3 ASP A 232
LEU A 235
VAL A 264
 None
 0.70A 4jecB-1kt8A:
undetectable		 4jecB-1kt8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		3 ASP A  86
LEU A  89
VAL A  32
 None
 0.68A 4jecB-1l5xA:
undetectable		 4jecB-1l5xA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 ASP A  51
LEU A 366
VAL A  47
 None
 0.70A 4jecB-1ms8A:
undetectable		 4jecB-1ms8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 ASP A 443
LEU A 572
VAL A 543
 None
 0.67A 4jecB-1qjmA:
undetectable		 4jecB-1qjmA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 ASP A 235
LEU A 177
VAL A 182
 None
 0.70A 4jecB-1qvbA:
undetectable		 4jecB-1qvbA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		3 ASP A 326
LEU A 345
VAL A 350
 None
 0.65A 4jecB-1uf2A:
undetectable		 4jecB-1uf2A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		3 ASP A 131
LEU A 168
VAL A 178
 None
 0.69A 4jecB-1uioA:
undetectable		 4jecB-1uioA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		3 ASP A 211
LEU A 169
VAL A  71
 None
 0.71A 4jecB-1vblA:
undetectable		 4jecB-1vblA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjw FERREDOXIN(A)

(Thermotoga
maritima) 		PF13370
(Fer4_13) 		3 ASP A  49
LEU A  19
VAL A  34
 None
 0.64A 4jecB-1vjwA:
undetectable		 4jecB-1vjwA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		no annotation 3 ASP A  61
LEU A  65
VAL A  71
 None
 0.68A 4jecB-1whmA:
undetectable		 4jecB-1whmA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ASP A 326
LEU A 315
VAL A 276
 None
 0.67A 4jecB-1x9nA:
undetectable		 4jecB-1x9nA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 ASP A 576
LEU A 549
VAL A 587
 None
 0.62A 4jecB-1xf1A:
undetectable		 4jecB-1xf1A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES

(Homo sapiens) 		PF13883
(Pyrid_oxidase_2) 		3 ASP A  57
LEU A  89
VAL A 163
 None
 0.70A 4jecB-1xhnA:
undetectable		 4jecB-1xhnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 ASP A  69
LEU A 105
VAL A 169
 None
 0.69A 4jecB-1yggA:
undetectable		 4jecB-1yggA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 ASP A 500
LEU A 275
VAL A 280
 None
 0.41A 4jecB-1yksA:
undetectable		 4jecB-1yksA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylm HYPOTHETICAL PROTEIN
BSU32300

(Bacillus
subtilis) 		PF01934
(DUF86) 		3 ASP A  55
LEU A 133
VAL A  81
 None
 0.71A 4jecB-1ylmA:
undetectable		 4jecB-1ylmA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		3 ASP A  24
LEU A 148
VAL A 140
 None
 0.52A 4jecB-1z72A:
undetectable		 4jecB-1z72A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ASP A 279
LEU A 294
VAL A 225
 None
 0.67A 4jecB-1zj9A:
undetectable		 4jecB-1zj9A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		3 ASP A 404
LEU A 371
VAL A 464
 None
 0.70A 4jecB-2ahwA:
undetectable		 4jecB-2ahwA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 ASP A 496
LEU A 452
VAL A 469
 None
 0.69A 4jecB-2b8eA:
undetectable		 4jecB-2b8eA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c21 TRYPANOTHIONE-DEPEND
ENT GLYOXALASE I

(Leishmania
major) 		PF00903
(Glyoxalase) 		3 ASP A 113
LEU A  27
VAL A  31
 None
 0.68A 4jecB-2c21A:
undetectable		 4jecB-2c21A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0w CYTOCHROME CL

(Hyphomicrobium
denitrificans) 		PF13442
(Cytochrome_CBB3) 		3 ASP A 109
LEU A 118
VAL A  30
 ZN  A1206 (-3.2A)
HEM  A 200 ( 4.9A)
None
 0.66A 4jecB-2d0wA:
undetectable		 4jecB-2d0wA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 ASP A 199
LEU A 178
VAL A 218
 None
 0.71A 4jecB-2d4yA:
undetectable		 4jecB-2d4yA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		3 ASP A 281
LEU A 277
VAL A 218
 None
 0.70A 4jecB-2e0pA:
undetectable		 4jecB-2e0pA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 ASP A 301
LEU A  69
VAL A  84
 None
 0.52A 4jecB-2ejwA:
undetectable		 4jecB-2ejwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		3 ASP A  29
LEU A  49
VAL A 164
 None
 0.66A 4jecB-2fcrA:
undetectable		 4jecB-2fcrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		3 ASP A  29
LEU A  49
VAL A 168
 None
 0.50A 4jecB-2fcrA:
undetectable		 4jecB-2fcrA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		3 ASP A  29
LEU A  81
VAL A  87
 LP1  A 201 (-3.6A)
None
LP1  A 201 ( 4.9A)
 0.41A 4jecB-2fmbA:
14.9		 4jecB-2fmbA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		3 ASP A 430
LEU A 350
VAL A 383
 MG  A 701 ( 4.0A)
None
None
 0.70A 4jecB-2gryA:
undetectable		 4jecB-2gryA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 ASP A 145
LEU A   3
VAL A 169
 None
 0.48A 4jecB-2gv8A:
undetectable		 4jecB-2gv8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		3 ASP A 227
LEU A  57
VAL A  48
 None
 0.65A 4jecB-2ivdA:
undetectable		 4jecB-2ivdA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 ASP A 272
LEU A 275
VAL A 234
 None
None
U2F  A 900 (-4.6A)
 0.55A 4jecB-2iw1A:
undetectable		 4jecB-2iw1A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 ASP A  97
LEU A 118
VAL A 109
 None
 0.71A 4jecB-2j04A:
undetectable		 4jecB-2j04A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9m BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD) 		3 ASP A 494
LEU A 483
VAL A 475
 None
 0.63A 4jecB-2l9mA:
undetectable		 4jecB-2l9mA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxf UNCHARACTERIZED
PROTEIN

(Giardia
intestinalis) 		PF00708
(Acylphosphatase) 		3 ASP A  86
LEU A  36
VAL A  40
 None
 0.48A 4jecB-2lxfA:
undetectable		 4jecB-2lxfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF12804
(NTP_transf_3) 		3 ASP A 183
LEU A  24
VAL A  33
 None
 0.71A 4jecB-2mzbA:
undetectable		 4jecB-2mzbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASP A 316
LEU A 207
VAL A 241
 None
 0.55A 4jecB-2olsA:
undetectable		 4jecB-2olsA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox6 HYPOTHETICAL PROTEIN
SO3848

(Shewanella
oneidensis) 		PF14590
(DUF4447) 		3 ASP A  59
LEU A   7
VAL A  37
 None
 0.68A 4jecB-2ox6A:
undetectable		 4jecB-2ox6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjs UNCHARACTERIZED
PROTEIN ATU1953

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		3 ASP A 104
LEU A  26
VAL A  30
 None
 0.49A 4jecB-2pjsA:
undetectable		 4jecB-2pjsA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 3 ASP A 164
LEU A 227
VAL A  82
 None
 0.65A 4jecB-2q9uA:
undetectable		 4jecB-2q9uA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpv UNCHARACTERIZED
PROTEIN ATU1531

(Agrobacterium
fabrum) 		no annotation 3 ASP A 123
LEU A  87
VAL A  83
 None
 0.55A 4jecB-2qpvA:
undetectable		 4jecB-2qpvA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		3 ASP A 100
LEU A  53
VAL A  36
 None
 0.63A 4jecB-2qsjA:
undetectable		 4jecB-2qsjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		3 ASP A 256
LEU A 179
VAL A 171
 None
 0.50A 4jecB-2r0sA:
undetectable		 4jecB-2r0sA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		3 ASP A 256
LEU A 179
VAL A 171
 None
 0.44A 4jecB-2r0vA:
undetectable		 4jecB-2r0vA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ASP A  84
LEU A  22
VAL A  15
 None
 0.68A 4jecB-2v6oA:
undetectable		 4jecB-2v6oA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		3 ASP A  91
LEU A 108
VAL A 124
 None
 0.66A 4jecB-2vefA:
undetectable		 4jecB-2vefA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 ASP J 496
LEU J 452
VAL J 469
 None
 0.69A 4jecB-2voyJ:
undetectable		 4jecB-2voyJ:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w35 ENDONUCLEASE V

(Thermotoga
maritima) 		PF04493
(Endonuclease_5) 		3 ASP A 188
LEU A 114
VAL A 137
 None
 0.69A 4jecB-2w35A:
undetectable		 4jecB-2w35A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqk 5'-NUCLEOTIDASE SURE

(Aquifex
aeolicus) 		PF01975
(SurE) 		3 ASP A  87
LEU A  90
VAL A  33
 None
 0.70A 4jecB-2wqkA:
undetectable		 4jecB-2wqkA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		3 ASP A 122
LEU A 115
VAL A 183
 None
 0.69A 4jecB-2y4tA:
undetectable		 4jecB-2y4tA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 ASP A  20
LEU A  39
VAL A  53
 None
 0.71A 4jecB-2ynpA:
undetectable		 4jecB-2ynpA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		3 ASP A 147
LEU A 143
VAL A 253
 ZN  A1006 ( 2.5A)
None
None
 0.69A 4jecB-2z00A:
undetectable		 4jecB-2z00A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		3 ASP A 360
LEU A 363
VAL A 335
 None
 0.61A 4jecB-3a9gA:
undetectable		 4jecB-3a9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		3 ASP A  45
LEU A  74
VAL A  78
 None
 0.62A 4jecB-3cjyA:
undetectable		 4jecB-3cjyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		3 ASP A 261
LEU A 317
VAL A 321
 None
 0.56A 4jecB-3clhA:
undetectable		 4jecB-3clhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		3 ASP A  92
LEU A   6
VAL A 118
 None
 0.66A 4jecB-3ddjA:
undetectable		 4jecB-3ddjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 ASP X 182
LEU X 207
VAL X 288
 None
 0.62A 4jecB-3e13X:
undetectable		 4jecB-3e13X:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 ASP X 182
LEU X 222
VAL X 288
 None
 0.69A 4jecB-3e13X:
undetectable		 4jecB-3e13X:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 ASP D 306
LEU D 226
VAL D 259
 MG  D 501 ( 4.0A)
None
None
 0.67A 4jecB-3edlD:
undetectable		 4jecB-3edlD:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eop THYMOCYTE NUCLEAR
PROTEIN 1

(Homo sapiens) 		PF01878
(EVE) 		3 ASP A  91
LEU A 102
VAL A 130
 None
 0.69A 4jecB-3eopA:
undetectable		 4jecB-3eopA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		3 ASP A 200
LEU A  93
VAL A 246
 LLP  A 226 ( 2.8A)
None
None
 0.68A 4jecB-3fd0A:
undetectable		 4jecB-3fd0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		3 ASP A 390
LEU A 329
VAL A 200
 None
 0.58A 4jecB-3h2iA:
undetectable		 4jecB-3h2iA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		3 ASP A1176
LEU A1182
VAL A1166
 None
 0.58A 4jecB-3h4zA:
undetectable		 4jecB-3h4zA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		3 ASP A 198
LEU A 103
VAL A 251
 LLP  A 227 ( 2.9A)
None
None
 0.57A 4jecB-3h7fA:
undetectable		 4jecB-3h7fA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 ASP A 132
LEU A 121
VAL A 219
 None
 0.69A 4jecB-3hbjA:
undetectable		 4jecB-3hbjA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		3 ASP A 205
LEU A 202
VAL A 145
 None
 0.62A 4jecB-3hv1A:
undetectable		 4jecB-3hv1A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		3 ASP A 217
LEU A 108
VAL A 270
 LLP  A 243 ( 2.9A)
None
None
 0.71A 4jecB-3hvyA:
undetectable		 4jecB-3hvyA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASP A 174
LEU A 445
VAL A 251
 None
 0.69A 4jecB-3hz6A:
undetectable		 4jecB-3hz6A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica) 		PF02267
(Rib_hydrolayse) 		3 ASP A  82
LEU A 195
VAL A 166
 None
 0.60A 4jecB-3i9kA:
undetectable		 4jecB-3i9kA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 ASP K 514
LEU K 432
VAL K 465
 None
 0.63A 4jecB-3j2uK:
undetectable		 4jecB-3j2uK:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		3 ASP A 200
LEU A  93
VAL A 246
 LLP  A 226 ( 2.8A)
None
None
 0.71A 4jecB-3jzlA:
undetectable		 4jecB-3jzlA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		3 ASP A 150
LEU A  38
VAL A 198
 GOL  A   7 (-4.8A)
None
None
 0.58A 4jecB-3kd4A:
undetectable		 4jecB-3kd4A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		3 ASP A  48
LEU A  51
VAL A 218
 None
 0.62A 4jecB-3kmhA:
undetectable		 4jecB-3kmhA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		3 ASP A  60
LEU A  84
VAL A  88
 None
 0.58A 4jecB-3lzdA:
undetectable		 4jecB-3lzdA:
13.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ASP A  29
LEU A  76
VAL A  82
 None
 0.52A 4jecB-3mwsA:
19.9		 4jecB-3mwsA:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 ASP B 364
LEU B 271
VAL B 351
 None
 0.62A 4jecB-3ozvB:
undetectable		 4jecB-3ozvB:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 123
LEU A  81
VAL A  74
 None
 0.70A 4jecB-3pfrA:
undetectable		 4jecB-3pfrA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 524
LEU A 457
VAL A 464
 None
 0.71A 4jecB-3qdeA:
undetectable		 4jecB-3qdeA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 3 ASP A 480
LEU A 510
VAL A 370
 None
 0.56A 4jecB-3r6nA:
undetectable		 4jecB-3r6nA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sng NUCLEASE

(Solanum
lycopersicum) 		PF02265
(S1-P1_nuclease) 		3 ASP A 110
LEU A  84
VAL A 158
 None
NAG  A 501 (-4.3A)
None
 0.69A 4jecB-3sngA:
undetectable		 4jecB-3sngA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 ASP A 102
LEU A  59
VAL A  22
 None
NAD  A2402 ( 4.4A)
NAD  A2402 (-3.8A)
 0.66A 4jecB-3sxpA:
undetectable		 4jecB-3sxpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus) 		no annotation 3 ASP A 240
LEU A 259
VAL A 297
 None
 0.70A 4jecB-3vu4A:
undetectable		 4jecB-3vu4A:
15.82