SIMILAR PATTERNS OF AMINO ACIDS FOR 4JD6_A_TOYA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASP A 605
ILE A 609
TRP A 142
SER A 125
VAL A 126
 2MD  A1001 (-2.8A)
None
None
None
None
 1.50A 4jd6A-1h0hA:
0.0		 4jd6A-1h0hA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		5 PHE A 180
SER A 168
VAL A 171
TYR A 149
GLU A  37
 None
 1.04A 4jd6A-1kqjA:
0.0		 4jd6A-1kqjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A  70
ASP A  67
ILE A  68
TRP A 319
TYR A 656
 None
 1.13A 4jd6A-5na7A:
0.0		 4jd6A-5na7A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		7 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
TYR A 126
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
 0.93A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		7 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
VAL A  85
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
 0.62A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		7 PHE A  24
ASP A  26
TRP A  36
SER A  83
VAL A  85
GLU A 203
GLU A 401
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
7LF  A 502 (-3.3A)
 0.75A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ASP A 728
ILE A 733
VAL A 685
GLU A 737
GLU A 449
 None
 1.18A 4jd6A-5wugA:
0.0		 4jd6A-5wugA:
15.72