SIMILAR PATTERNS OF AMINO ACIDS FOR 4JBT_B_ASDB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		5 ALA A 165
ALA A 166
ALA A 163
VAL A  66
LEU A  56
 None
 1.15A 4jbtB-1abrA:
0.2		 4jbtB-1abrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.07A 4jbtB-1c8uA:
undetectable		 4jbtB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.07A 4jbtB-1ewkA:
0.0		 4jbtB-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 TRANSLOCATED INTIMIN
RECEPTOR

(Escherichia
coli) 		PF03549
(Tir_receptor_M) 		5 GLN T 273
ALA T 274
ALA T 277
ALA T 278
THR T 282
 None
 0.87A 4jbtB-1f02T:
undetectable		 4jbtB-1f02T:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLN A  87
ALA A  88
ALA A 114
VAL A 122
LEU A 138
 None
 1.10A 4jbtB-1f0kA:
0.0		 4jbtB-1f0kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 ALA A 459
ALA A 266
ALA A 267
VAL A 363
LEU A 365
 None
 1.00A 4jbtB-1fc9A:
0.0		 4jbtB-1fc9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 252
ALA A 254
ALA A 255
VAL A 208
GLN A 206
 None
 1.12A 4jbtB-1mroA:
0.0		 4jbtB-1mroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 MET A 235
ALA A 252
ALA A 254
ALA A 255
GLN A 206
 None
 1.11A 4jbtB-1mroA:
0.0		 4jbtB-1mroA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.82A 4jbtB-1odoA:
54.2		 4jbtB-1odoA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4jbtB-1smkA:
0.0		 4jbtB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 MET A  19
ALA A  48
ALA A  51
ALA A  52
THR A  56
 None
 1.15A 4jbtB-1svdA:
undetectable		 4jbtB-1svdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.07A 4jbtB-1ulqA:
undetectable		 4jbtB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 ALA A 540
ALA A 480
ALA A 506
THR A 509
LEU A 379
 None
 1.10A 4jbtB-1un9A:
undetectable		 4jbtB-1un9A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb7 PDZ AND LIM DOMAIN 2

(Mus musculus) 		PF00595
(PDZ) 		5 GLN A  60
ALA A  56
ALA A  62
VAL A  34
LEU A  48
 None
 1.13A 4jbtB-1vb7A:
undetectable		 4jbtB-1vb7A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.07A 4jbtB-1vtkA:
undetectable		 4jbtB-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ALA A  59
ALA A  60
ALA A  61
THR A 331
LEU A 344
 None
 1.09A 4jbtB-1w5dA:
undetectable		 4jbtB-1w5dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 PHE A 431
ALA A 361
ALA A 359
VAL A 349
LEU A 446
 None
 1.16A 4jbtB-1x9nA:
undetectable		 4jbtB-1x9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 ALA A 121
ALA A 124
ALA A 125
VAL A  22
GLN A  26
 None
 1.12A 4jbtB-1zchA:
undetectable		 4jbtB-1zchA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.13A 4jbtB-2a0uA:
undetectable		 4jbtB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		5 GLN A 141
ALA A 142
ALA A 145
ALA A 146
LEU A 101
 None
 1.11A 4jbtB-2c94A:
undetectable		 4jbtB-2c94A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN C 382
ALA C 277
ALA C 275
VAL C 387
LEU C 373
 None
 1.08A 4jbtB-2d3tC:
undetectable		 4jbtB-2d3tC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.88A 4jbtB-2gcaA:
undetectable		 4jbtB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		5 GLN A 327
ALA A 326
ALA A 324
THR A 322
VAL A 276
 None
 1.11A 4jbtB-2grvA:
undetectable		 4jbtB-2grvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.03A 4jbtB-2hg4A:
undetectable		 4jbtB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 GLN A 117
ALA A 292
ALA A 291
ALA A 262
VAL A 234
 None
 1.14A 4jbtB-2hgsA:
undetectable		 4jbtB-2hgsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
 None
 0.90A 4jbtB-2nlxA:
undetectable		 4jbtB-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.13A 4jbtB-2nztA:
undetectable		 4jbtB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA X 259
ALA X 261
ALA X 262
VAL X 240
LEU X 248
 None
 1.05A 4jbtB-2qvxX:
undetectable		 4jbtB-2qvxX:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 338
ALA A 404
ALA A 405
THR A 384
VAL A 380
 None
 1.15A 4jbtB-2qykA:
undetectable		 4jbtB-2qykA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 248
ALA A 314
ALA A 315
THR A 294
VAL A 290
 None
 1.11A 4jbtB-2qymA:
undetectable		 4jbtB-2qymA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA

(Bacillus
subtilis) 		PF00403
(HMA) 		5 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.14A 4jbtB-2rmlA:
undetectable		 4jbtB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.11A 4jbtB-2vrcA:
undetectable		 4jbtB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjk AFP

(Microbacterium
arborescens) 		PF00210
(Ferritin) 		5 ALA A  15
ALA A  18
ALA A  19
THR A  23
VAL A  26
 None
 1.11A 4jbtB-2yjkA:
undetectable		 4jbtB-2yjkA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.96A 4jbtB-2zbzA:
46.2		 4jbtB-2zbzA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		5 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.12A 4jbtB-3bkxA:
undetectable		 4jbtB-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c18 NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF14540
(NTF-like) 		5 ALA A  14
ALA A  13
THR A  18
VAL A  43
LEU A  41
 None
 1.15A 4jbtB-3c18A:
undetectable		 4jbtB-3c18A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 PHE A 527
PHE A 459
GLN A 489
ALA A 493
LEU A 501
 None
 1.15A 4jbtB-3c2gA:
undetectable		 4jbtB-3c2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.02A 4jbtB-3d8kA:
undetectable		 4jbtB-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 ALA A  83
ALA A  87
ALA A  86
VAL A  93
LEU A  18
 None
 1.02A 4jbtB-3da8A:
undetectable		 4jbtB-3da8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 GLN A 481
ALA A 480
ALA A 482
ALA A 483
LEU A 449
 None
 1.01A 4jbtB-3e1sA:
undetectable		 4jbtB-3e1sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 292
ALA A 358
ALA A 359
THR A 338
VAL A 334
 None
 1.11A 4jbtB-3g4gA:
undetectable		 4jbtB-3g4gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 ALA A  34
ALA A  37
ALA A  36
VAL A  71
LEU A  76
 None
 1.07A 4jbtB-3h7uA:
undetectable		 4jbtB-3h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.12A 4jbtB-3hm8A:
undetectable		 4jbtB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 461
ALA A 464
ALA A 465
VAL A  64
LEU A  61
 None
 0.94A 4jbtB-3i8bA:
undetectable		 4jbtB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A  33
ALA A  54
ALA A  58
VAL A  64
LEU A  67
 None
 1.09A 4jbtB-3i8bA:
undetectable		 4jbtB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		5 ALA A  55
ALA A  56
ALA A  57
THR A 251
LEU A   8
 None
 1.12A 4jbtB-3k4wA:
undetectable		 4jbtB-3k4wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 ALA A 324
ALA A 327
ALA A 326
VAL A 287
LEU A 305
 None
 1.14A 4jbtB-3nf2A:
undetectable		 4jbtB-3nf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.00A 4jbtB-3nraA:
undetectable		 4jbtB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		5 ALA A 216
ALA A 219
ALA A 220
VAL A 327
LEU A 285
 None
 1.02A 4jbtB-3ox4A:
undetectable		 4jbtB-3ox4A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.90A 4jbtB-3r9uA:
undetectable		 4jbtB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.09A 4jbtB-3rd7A:
undetectable		 4jbtB-3rd7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		5 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.13A 4jbtB-3ro8A:
undetectable		 4jbtB-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 ALA A 431
ALA A 434
ALA A 435
VAL A  91
LEU A  92
 None
 1.00A 4jbtB-3rx8A:
undetectable		 4jbtB-3rx8A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 247
ALA A 249
ALA A 250
LEU A 200
GLN A 204
 None
 0.97A 4jbtB-3snxA:
undetectable		 4jbtB-3snxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t69 PUTATIVE
2-DEHYDRO-3-DEOXYGAL
ACTONOKINASE

(Sinorhizobium
meliloti) 		PF05035
(DGOK) 		5 PHE A 194
ALA A 204
ALA A 200
THR A 231
LEU A 184
 None
 1.10A 4jbtB-3t69A:
undetectable		 4jbtB-3t69A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 GLN B 311
ALA B 312
ALA B 315
ALA B 316
VAL B  30
 None
 1.06A 4jbtB-3vrdB:
undetectable		 4jbtB-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.34A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.03A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.41A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 ALA A 108
ALA A 112
ALA A 111
VAL A  85
LEU A  88
 None
 1.08A 4jbtB-3zvtA:
undetectable		 4jbtB-3zvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		5 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4jbtB-4a6uA:
undetectable		 4jbtB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 PHE A 241
ALA A 196
ALA A 135
ALA A 195
LEU A  39
 None
 1.15A 4jbtB-4bpsA:
undetectable		 4jbtB-4bpsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.08A 4jbtB-4dokA:
undetectable		 4jbtB-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A  35
ALA A  39
ALA A  37
THR A  66
VAL A  68
 None
 1.09A 4jbtB-4egfA:
undetectable		 4jbtB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A  35
ALA A  39
ALA A  37
VAL A  68
LEU A  45
 None
 1.06A 4jbtB-4egfA:
undetectable		 4jbtB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE

(Burkholderia
thailandensis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ALA A 173
ALA A 177
ALA A 174
THR A 212
LEU A 205
 None
 1.14A 4jbtB-4f4hA:
undetectable		 4jbtB-4f4hA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.07A 4jbtB-4f9oA:
undetectable		 4jbtB-4f9oA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		11 MET A  84
PHE A  92
PHE A 179
GLN A 239
ALA A 240
ALA A 243
ALA A 244
THR A 248
VAL A 291
LEU A 294
GLN A 398
 STR  A 501 (-4.3A)
STR  A 501 (-4.0A)
STR  A 501 (-4.0A)
STR  A 501 ( 4.5A)
STR  A 501 (-3.6A)
STR  A 501 ( 3.7A)
HEM  A 502 (-3.2A)
HEM  A 502 ( 3.4A)
STR  A 501 (-4.5A)
HEM  A 502 ( 4.0A)
STR  A 501 (-3.1A)
 0.26A 4jbtB-4j6cA:
70.3		 4jbtB-4j6cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		6 MET A  84
PHE A  92
PHE A 180
ALA A 240
ALA A 243
LEU A 294
 STR  A 501 (-4.3A)
STR  A 501 (-4.0A)
None
STR  A 501 (-3.6A)
STR  A 501 ( 3.7A)
HEM  A 502 ( 4.0A)
 1.47A 4jbtB-4j6cA:
70.3		 4jbtB-4j6cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		5 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.15A 4jbtB-4k1oA:
undetectable		 4jbtB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		6 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.47A 4jbtB-4lomA:
undetectable		 4jbtB-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ALA A  85
ALA A  87
THR A  94
VAL A  41
LEU A  63
 None
None
None
None
NAP  A 201 (-4.0A)
 1.07A 4jbtB-4m7vA:
undetectable		 4jbtB-4m7vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.01A 4jbtB-4qfwA:
undetectable		 4jbtB-4qfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.04A 4jbtB-4qs9A:
undetectable		 4jbtB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.09A 4jbtB-4u4eA:
undetectable		 4jbtB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.03A 4jbtB-4wkyA:
undetectable		 4jbtB-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.01A 4jbtB-4xgtA:
undetectable		 4jbtB-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 163
ALA A 166
ALA A 165
VAL A  69
LEU A 194
 None
 1.10A 4jbtB-4yweA:
undetectable		 4jbtB-4yweA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		5 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.10A 4jbtB-5ahoA:
undetectable		 4jbtB-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.09A 4jbtB-5cjuA:
undetectable		 4jbtB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLN A 288
ALA A 289
ALA A 292
ALA A 293
VAL A 567
 None
 1.05A 4jbtB-5cxwA:
undetectable		 4jbtB-5cxwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.93A 4jbtB-5dj4A:
undetectable		 4jbtB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 PHE A 504
ALA A 507
ALA A 470
VAL A 458
LEU A 435
 None
 1.15A 4jbtB-5dseA:
undetectable		 4jbtB-5dseA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		5 GLN A 319
ALA A 323
ALA A 326
VAL A 344
LEU A 121
 None
 1.01A 4jbtB-5dvjA:
undetectable		 4jbtB-5dvjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.89A 4jbtB-5ek8A:
undetectable		 4jbtB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		5 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.08A 4jbtB-5ey5A:
undetectable		 4jbtB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
 MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
 1.14A 4jbtB-5ez3A:
undetectable		 4jbtB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 PHE A  77
ALA A 121
ALA A 124
ALA A 125
GLN A  26
 None
 0.92A 4jbtB-5hdjA:
undetectable		 4jbtB-5hdjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.05A 4jbtB-5heiA:
undetectable		 4jbtB-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.08A 4jbtB-5jjpA:
undetectable		 4jbtB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 ALA B  85
ALA B  88
ALA B  89
THR B  93
LEU B  74
 None
 0.82A 4jbtB-5khnB:
undetectable		 4jbtB-5khnB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 5 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.03A 4jbtB-5lfdA:
undetectable		 4jbtB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.88A 4jbtB-5lx8A:
undetectable		 4jbtB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.12A 4jbtB-5muxA:
undetectable		 4jbtB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 PHE A 372
ALA A 438
ALA A 439
THR A 418
VAL A 414
 None
 1.15A 4jbtB-5ohjA:
undetectable		 4jbtB-5ohjA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 PHE A 163
ALA A 139
ALA A 141
ALA A 138
VAL A 174
 None
 1.14A 4jbtB-5xnzA:
undetectable		 4jbtB-5xnzA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 GLN A 345
ALA A 346
ALA A 350
VAL A 295
LEU A 292
 None
 1.13A 4jbtB-6bfiA:
undetectable		 4jbtB-6bfiA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 MET A  31
ALA A 139
ALA A 138
VAL A  16
LEU A  38
 None
 1.11A 4jbtB-6bk1A:
undetectable		 4jbtB-6bk1A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.11A 4jbtB-6chjA:
undetectable		 4jbtB-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana) 		no annotation 5 ALA A 411
ALA A 409
ALA A 375
LEU A 415
GLN A 398
 None
 1.15A 4jbtB-6gbcA:
undetectable		 4jbtB-6gbcA:
undetectable