SIMILAR PATTERNS OF AMINO ACIDS FOR 4JBT_A_ASDA501_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1abr | ABRIN-A (Abrusprecatorius) |
PF00161(RIP) | 5 | PHE A 86GLN A 83ALA A 80VAL A 75LEU A 155 | None | 1.12A | 4jbtA-1abrA:0.6 | 4jbtA-1abrA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7j | PROTEIN(PARA-NITROBENZYLESTERASE) (Bacillussubtilis) |
PF00135(COesterase) | 5 | PHE A 274PHE A 275ALA A 258ALA A 259LEU A 146 | None | 1.09A | 4jbtA-1c7jA:0.0 | 4jbtA-1c7jA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8u | ACYL-COATHIOESTERASE II (Escherichiacoli) |
PF13622(4HBT_3) | 5 | GLN A 42ALA A 43ALA A 46ALA A 47THR A 50 | None | 1.08A | 4jbtA-1c8uA:undetectable | 4jbtA-1c8uA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ewk | METABOTROPICGLUTAMATE RECEPTORSUBTYPE 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | PHE A 244GLN A 211ALA A 212ALA A 214LEU A 253 | None | 1.08A | 4jbtA-1ewkA:0.0 | 4jbtA-1ewkA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f02 | TRANSLOCATED INTIMINRECEPTOR (Escherichiacoli) |
PF03549(Tir_receptor_M) | 5 | GLN T 273ALA T 274ALA T 277ALA T 278THR T 282 | None | 0.85A | 4jbtA-1f02T:undetectable | 4jbtA-1f02T:10.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0k | UDP-N-ACETYLGLUCOSAMINE-N-ACETYLMURAMYL-(PENTAPEPTIDE)PYROPHOSPHORYL-UNDECAPRENOLN-ACETYLGLUCOSAMINETRANSFERASE (Escherichiacoli) |
PF03033(Glyco_transf_28)PF04101(Glyco_tran_28_C) | 5 | GLN A 87ALA A 88ALA A 114VAL A 122LEU A 138 | None | 1.10A | 4jbtA-1f0kA:0.0 | 4jbtA-1f0kA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc9 | PHOTOSYSTEM II D1PROTEASE (Tetradesmusobliquus) |
PF03572(Peptidase_S41)PF13180(PDZ_2) | 5 | ALA A 459ALA A 266ALA A 267VAL A 363LEU A 365 | None | 1.00A | 4jbtA-1fc9A:0.0 | 4jbtA-1fc9A:22.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gwi | CYTOCHROME P450154C1 (Streptomycescoelicolor) |
PF00067(p450) | 6 | PHE A 177PHE A 178GLN A 237ALA A 241ALA A 242THR A 246 | NoneNoneNoneNoneHEM A1414 ( 3.7A)HEM A1414 (-3.7A) | 1.28A | 4jbtA-1gwiA:52.7 | 4jbtA-1gwiA:51.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 425ALA A 239VAL A 312LEU A 337GLN A 310 | None | 1.05A | 4jbtA-1iyxA:undetectable | 4jbtA-1iyxA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqs | SLY1 PROTEIN (Saccharomycescerevisiae) |
PF00995(Sec1) | 5 | PHE A 336GLN A 410ALA A 406ALA A 405VAL A 343 | None | 1.12A | 4jbtA-1mqsA:undetectable | 4jbtA-1mqsA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | ALA A 252ALA A 254ALA A 255VAL A 208GLN A 206 | None | 1.11A | 4jbtA-1mroA:undetectable | 4jbtA-1mroA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | MET A 235ALA A 252ALA A 254ALA A 255GLN A 206 | None | 1.11A | 4jbtA-1mroA:undetectable | 4jbtA-1mroA:20.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1odo | PUTATIVE CYTOCHROMEP450 154A1 (Streptomycescoelicolor) |
PF00067(p450) | 5 | PHE A 88ALA A 242THR A 246VAL A 289LEU A 292 | PIM A1408 (-3.6A)HEM A1407 ( 3.4A)HEM A1407 ( 3.1A)NoneHEM A1407 ( 4.2A) | 0.81A | 4jbtA-1odoA:54.1 | 4jbtA-1odoA:40.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smk | MALATEDEHYDROGENASE,GLYOXYSOMAL (Citrulluslanatus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 81ALA A 53ALA A 52VAL A 118LEU A 144 | None | 0.94A | 4jbtA-1smkA:undetectable | 4jbtA-1smkA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLN A 391ALA A 287ALA A 285VAL A 396LEU A 382 | None | 1.08A | 4jbtA-1ulqA:undetectable | 4jbtA-1ulqA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un9 | DIHYDROXYACETONEKINASE (Citrobacterfreundii) |
PF02733(Dak1)PF02734(Dak2) | 5 | ALA A 540ALA A 480ALA A 506THR A 509LEU A 379 | None | 1.11A | 4jbtA-1un9A:undetectable | 4jbtA-1un9A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb7 | PDZ AND LIM DOMAIN 2 (Mus musculus) |
PF00595(PDZ) | 5 | GLN A 60ALA A 56ALA A 62VAL A 34LEU A 48 | None | 1.13A | 4jbtA-1vb7A:undetectable | 4jbtA-1vb7A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vtk | THYMIDINE KINASE (Humanalphaherpesvirus1) |
PF00693(Herpes_TK) | 5 | ALA A 114ALA A 117ALA A 118THR A 122VAL A 187 | None | 1.07A | 4jbtA-1vtkA:undetectable | 4jbtA-1vtkA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5d | PENICILLIN-BINDINGPROTEIN (Bacillussubtilis) |
PF02113(Peptidase_S13) | 5 | ALA A 59ALA A 60ALA A 61THR A 331LEU A 344 | None | 1.10A | 4jbtA-1w5dA:undetectable | 4jbtA-1w5dA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zch | HYPOTHETICALOXIDOREDUCTASE YCND (Bacillussubtilis) |
PF00881(Nitroreductase) | 5 | ALA A 121ALA A 124ALA A 125VAL A 22GLN A 26 | None | 1.12A | 4jbtA-1zchA:undetectable | 4jbtA-1zchA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0u | INITIATION FACTOR 2B (Leishmaniamajor) |
PF01008(IF-2B) | 5 | ALA A 67ALA A 71ALA A 70VAL A 45LEU A 30 | None | 1.13A | 4jbtA-2a0uA:undetectable | 4jbtA-2a0uA:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | PHE A 326PHE A 337ALA A 329ALA A 331VAL A 257 | None | 1.04A | 4jbtA-2bvgA:undetectable | 4jbtA-2bvgA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c94 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Mycobacteriumtuberculosis) |
PF00885(DMRL_synthase) | 5 | GLN A 141ALA A 142ALA A 145ALA A 146LEU A 101 | None | 1.11A | 4jbtA-2c94A:undetectable | 4jbtA-2c94A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | 3-KETOACYL-COATHIOLASE (Pseudomonasfragi) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLN C 382ALA C 277ALA C 275VAL C 387LEU C 373 | None | 1.08A | 4jbtA-2d3tC:undetectable | 4jbtA-2d3tC:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4v | ISOCITRATEDEHYDROGENASE (Acidithiobacillusthiooxidans) |
PF00180(Iso_dh) | 5 | GLN A 387ALA A 388ALA A 391ALA A 392THR A 396 | None | 0.94A | 4jbtA-2d4vA:undetectable | 4jbtA-2d4vA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gca | FOLYLPOLYGLUTAMATESYNTHASE (Lactobacilluscasei) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 206ALA A 210ALA A 209VAL A 195LEU A 163 | None | 0.87A | 4jbtA-2gcaA:undetectable | 4jbtA-2gcaA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grv | LPQW (Mycolicibacteriumsmegmatis) |
PF00496(SBP_bac_5) | 5 | GLN A 327ALA A 326ALA A 324THR A 322VAL A 276 | None | 1.12A | 4jbtA-2grvA:undetectable | 4jbtA-2grvA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 5 | ALA A 382ALA A 379ALA A 378VAL A 228LEU A 92 | None | 1.04A | 4jbtA-2hg4A:undetectable | 4jbtA-2hg4A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzt | HEXOKINASE-2 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | ALA A 836ALA A 840ALA A 839VAL A 858LEU A 676 | None | 1.12A | 4jbtA-2nztA:undetectable | 4jbtA-2nztA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvx | 4-CHLOROBENZOATE COALIGASE (Alcaligenes sp.AL3007) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA X 259ALA X 261ALA X 262VAL X 240LEU X 248 | None | 1.02A | 4jbtA-2qvxX:undetectable | 4jbtA-2qvxX:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qym | PHOSPHODIESTERASE 4C (Homo sapiens) |
PF00233(PDEase_I) | 5 | PHE A 248ALA A 314ALA A 315THR A 294VAL A 290 | None | 1.11A | 4jbtA-2qymA:undetectable | 4jbtA-2qymA:25.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrc | TRIPHENYLMETHANEREDUCTASE (Citrobacter sp.MY-5) |
PF05368(NmrA) | 5 | ALA A 179ALA A 182ALA A 183THR A 187VAL A 24 | None | 1.12A | 4jbtA-2vrcA:undetectable | 4jbtA-2vrcA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjk | AFP (Microbacteriumarborescens) |
PF00210(Ferritin) | 5 | ALA A 15ALA A 18ALA A 19THR A 23VAL A 26 | None | 1.10A | 4jbtA-2yjkA:undetectable | 4jbtA-2yjkA:16.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | GLN A 397ALA A 291ALA A 289ALA A 347LEU A 64 | NoneHEM A 413 ( 3.7A)NoneHEM A 413 (-4.5A)None | 0.96A | 4jbtA-2zbzA:46.3 | 4jbtA-2zbzA:34.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq1 | THERMOSOME SUBUNIT (Methanococcoidesburtonii) |
PF00118(Cpn60_TCP1) | 5 | GLN B 492ALA B 493ALA B 496ALA B 497THR B 501 | None | 0.87A | 4jbtA-3aq1B:undetectable | 4jbtA-3aq1B:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkx | SAM-DEPENDENTMETHYLTRANSFERASE (Lactobacillusparacasei) |
PF13649(Methyltransf_25) | 5 | PHE A 134ALA A 139ALA A 141VAL A 154LEU A 127 | None | 1.12A | 4jbtA-3bkxA:undetectable | 4jbtA-3bkxA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cio | TYROSINE-PROTEINKINASE ETK (Escherichiacoli) |
PF13614(AAA_31) | 5 | PHE A 501GLN A 558ALA A 557ALA A 554ALA A 553 | None | 1.05A | 4jbtA-3cioA:undetectable | 4jbtA-3cioA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8k | PROTEIN PHOSPHATASE2C (Toxoplasmagondii) |
PF00481(PP2C) | 5 | PHE A 351ALA A 356ALA A 359ALA A 358VAL A 341 | None | 1.02A | 4jbtA-3d8kA:undetectable | 4jbtA-3d8kA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da8 | PROBABLE5'-PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASEPURN (Mycobacteriumtuberculosis) |
PF00551(Formyl_trans_N) | 5 | ALA A 83ALA A 87ALA A 86VAL A 93LEU A 18 | None | 1.01A | 4jbtA-3da8A:undetectable | 4jbtA-3da8A:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1s | EXODEOXYRIBONUCLEASEV, SUBUNIT RECD (Deinococcusradiodurans) |
PF13538(UvrD_C_2)PF13604(AAA_30)PF14490(HHH_4) | 5 | GLN A 481ALA A 480ALA A 482ALA A 483LEU A 449 | None | 1.03A | 4jbtA-3e1sA:undetectable | 4jbtA-3e1sA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4g | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D (Homo sapiens) |
PF00233(PDEase_I) | 5 | PHE A 292ALA A 358ALA A 359THR A 338VAL A 334 | None | 1.12A | 4jbtA-3g4gA:undetectable | 4jbtA-3g4gA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7u | ALDO-KETO REDUCTASE (Arabidopsisthaliana) |
PF00248(Aldo_ket_red) | 5 | ALA A 34ALA A 37ALA A 36VAL A 71LEU A 76 | None | 1.08A | 4jbtA-3h7uA:undetectable | 4jbtA-3h7uA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hm8 | HEXOKINASE-3 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | ALA A 842ALA A 846ALA A 845VAL A 864LEU A 682 | None | 1.11A | 4jbtA-3hm8A:1.1 | 4jbtA-3hm8A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 461ALA A 464ALA A 465VAL A 64LEU A 61 | None | 0.95A | 4jbtA-3i8bA:undetectable | 4jbtA-3i8bA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | GLN A 33ALA A 54ALA A 58VAL A 64LEU A 67 | None | 1.09A | 4jbtA-3i8bA:undetectable | 4jbtA-3i8bA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4w | UNCHARACTERIZEDPROTEIN BB4693 (Bordetellabronchiseptica) |
PF04909(Amidohydro_2) | 5 | ALA A 55ALA A 56ALA A 57THR A 251LEU A 8 | None | 1.12A | 4jbtA-3k4wA:undetectable | 4jbtA-3k4wA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nra | ASPARTATEAMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00155(Aminotran_1_2) | 5 | GLN A 385ALA A 393ALA A 394VAL A 401LEU A 343 | None | 1.00A | 4jbtA-3nraA:undetectable | 4jbtA-3nraA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ox4 | ALCOHOLDEHYDROGENASE 2 (Zymomonasmobilis) |
PF00465(Fe-ADH) | 5 | ALA A 216ALA A 219ALA A 220VAL A 327LEU A 285 | None | 1.03A | 4jbtA-3ox4A:undetectable | 4jbtA-3ox4A:25.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9u | THIOREDOXINREDUCTASE (Campylobacterjejuni) |
PF07992(Pyr_redox_2) | 5 | ALA A 298ALA A 300ALA A 301VAL A 28LEU A 74 | None | 0.90A | 4jbtA-3r9uA:undetectable | 4jbtA-3r9uA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro8 | ENDO-1,4-BETA-XYLANASE (Paenibacillussp. JDR-2) |
PF00331(Glyco_hydro_10) | 5 | GLN A 170ALA A 171ALA A 174ALA A 175VAL A 122 | None | 1.12A | 4jbtA-3ro8A:undetectable | 4jbtA-3ro8A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3snx | PUTATIVE SUSD-LIKECARBOHYDRATE BINDINGPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | ALA A 247ALA A 249ALA A 250LEU A 200GLN A 204 | None | 0.97A | 4jbtA-3snxA:undetectable | 4jbtA-3snxA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t69 | PUTATIVE2-DEHYDRO-3-DEOXYGALACTONOKINASE (Sinorhizobiummeliloti) |
PF05035(DGOK) | 5 | PHE A 194ALA A 204ALA A 200THR A 231LEU A 184 | None | 1.11A | 4jbtA-3t69A:undetectable | 4jbtA-3t69A:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrd | FLAVOCYTOCHROME CFLAVIN SUBUNIT (Thermochromatiumtepidum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | GLN B 311ALA B 312ALA B 315ALA B 316VAL B 30 | None | 1.06A | 4jbtA-3vrdB:undetectable | 4jbtA-3vrdB:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwo | PEPTIDOGLYCANHYDROLASE FLGJ (Sphingomonassp. A1) |
PF01832(Glucosaminidase) | 6 | ALA A 168ALA A 165ALA A 164THR A 160VAL A 157LEU A 300 | None | 1.33A | 4jbtA-3vwoA:undetectable | 4jbtA-3vwoA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwo | PEPTIDOGLYCANHYDROLASE FLGJ (Sphingomonassp. A1) |
PF01832(Glucosaminidase) | 6 | GLN A 169ALA A 168ALA A 164THR A 160VAL A 157LEU A 304 | None | 1.02A | 4jbtA-3vwoA:undetectable | 4jbtA-3vwoA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwo | PEPTIDOGLYCANHYDROLASE FLGJ (Sphingomonassp. A1) |
PF01832(Glucosaminidase) | 6 | GLN A 169ALA A 168ALA A 165ALA A 164THR A 160VAL A 157 | None | 1.39A | 4jbtA-3vwoA:undetectable | 4jbtA-3vwoA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zvt | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Actinomadurasp. R39) |
PF02113(Peptidase_S13) | 5 | ALA A 108ALA A 112ALA A 111VAL A 85LEU A 88 | None | 1.09A | 4jbtA-3zvtA:undetectable | 4jbtA-3zvtA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3r | ENOLASE (Bacillussubtilis) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 425ALA A 240VAL A 312LEU A 337GLN A 310 | None | 1.08A | 4jbtA-4a3rA:undetectable | 4jbtA-4a3rA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6u | OMEGA TRANSAMINASE (Chromobacteriumviolaceum) |
PF00202(Aminotran_3) | 5 | ALA A 334ALA A 338ALA A 337VAL A 106LEU A 103 | None | 1.06A | 4jbtA-4a6uA:undetectable | 4jbtA-4a6uA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dok | SIMILARITY TOCHALCONE-FLAVONONEISOMERASE (Arabidopsisthaliana) |
PF02431(Chalcone) | 5 | PHE A 75ALA A 78ALA A 82ALA A 80VAL A 47 | None | 1.07A | 4jbtA-4dokA:undetectable | 4jbtA-4dokA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egf | L-XYLULOSE REDUCTASE (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | ALA A 35ALA A 39ALA A 37THR A 66VAL A 68 | None | 1.09A | 4jbtA-4egfA:undetectable | 4jbtA-4egfA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egf | L-XYLULOSE REDUCTASE (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | ALA A 35ALA A 39ALA A 37VAL A 68LEU A 45 | None | 1.06A | 4jbtA-4egfA:undetectable | 4jbtA-4egfA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9o | HEXOKINASE-1 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | ALA A 836ALA A 840ALA A 839VAL A 858LEU A 676 | None | 1.06A | 4jbtA-4f9oA:undetectable | 4jbtA-4f9oA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hg2 | METHYLTRANSFERASETYPE 11 (Anaeromyxobacterdehalogenans) |
PF08241(Methyltransf_11) | 5 | PHE A 109PHE A 114ALA A 100VAL A 121LEU A 92 | None | 1.10A | 4jbtA-4hg2A:undetectable | 4jbtA-4hg2A:23.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j6c | CYTOCHROME P450MONOOXYGENASE (Nocardiafarcinica) |
PF00067(p450) | 12 | MET A 84PHE A 92PHE A 179PHE A 180GLN A 239ALA A 240ALA A 243ALA A 244THR A 248VAL A 291LEU A 294GLN A 398 | STR A 501 (-4.3A)STR A 501 (-4.0A)STR A 501 (-4.0A)NoneSTR A 501 ( 4.5A)STR A 501 (-3.6A)STR A 501 ( 3.7A)HEM A 502 (-3.2A)HEM A 502 ( 3.4A)STR A 501 (-4.5A)HEM A 502 ( 4.0A)STR A 501 (-3.1A) | 0.26A | 4jbtA-4j6cA:70.5 | 4jbtA-4j6cA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lom | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Mycobacteriumtuberculosis) |
PF00475(IGPD) | 6 | PHE A 104GLN A 192ALA A 103ALA A 115ALA A 114LEU A 170 | None | 1.47A | 4jbtA-4lomA:undetectable | 4jbtA-4lomA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 5 | ALA A 85ALA A 87THR A 94VAL A 41LEU A 63 | NoneNoneNoneNoneNAP A 201 (-4.0A) | 1.07A | 4jbtA-4m7vA:undetectable | 4jbtA-4m7vA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 5 | PHE A 116ALA A 310ALA A 313ALA A 314THR A 318 | None | 1.07A | 4jbtA-4m88A:1.4 | 4jbtA-4m88A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mks | ENOLASE 2 (Lactobacillusgasseri) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 425ALA A 240VAL A 312LEU A 337GLN A 310 | None | 1.05A | 4jbtA-4mksA:undetectable | 4jbtA-4mksA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdi | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE (Acinetobacterbaumannii) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLN A 295ALA A 297ALA A 299ALA A 300VAL A 170 | None | 1.01A | 4jbtA-4qdiA:undetectable | 4jbtA-4qdiA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfw | ACYL-COATHIOESTERASE II (Yersinia pestis) |
PF13622(4HBT_3) | 5 | GLN A 42ALA A 43ALA A 46ALA A 47THR A 50 | None | 1.02A | 4jbtA-4qfwA:undetectable | 4jbtA-4qfwA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qs9 | HEXOKINASE-1 (Arabidopsisthaliana) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | ALA A 257ALA A 248ALA A 247VAL A 469LEU A 457 | None | 1.04A | 4jbtA-4qs9A:undetectable | 4jbtA-4qs9A:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4e | THIOLASE (Sphaerobacterthermophilus) |
PF02803(Thiolase_C) | 5 | ALA A 88ALA A 90ALA A 91THR A 8LEU A 380 | None | 1.08A | 4jbtA-4u4eA:undetectable | 4jbtA-4u4eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ALA A 374ALA A 371ALA A 370VAL A 219LEU A 79 | None | 1.03A | 4jbtA-4wkyA:undetectable | 4jbtA-4wkyA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xf7 | CARBOHYDRATE/PYRIMIDINE KINASE, PFKBFAMILY (Thermococcuskodakarensis) |
no annotation | 5 | GLN A 236ALA A 237ALA A 241THR A 245LEU A 35 | IOD A 307 ( 4.7A)NoneNoneACP A 302 (-3.8A)None | 0.86A | 4jbtA-4xf7A:undetectable | 4jbtA-4xf7A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgt | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 5 | PHE A1087GLN A1070ALA A1072ALA A1074ALA A1075 | None | 1.00A | 4jbtA-4xgtA:undetectable | 4jbtA-4xgtA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywe | PUTATIVE ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | ALA A 163ALA A 166ALA A 165VAL A 69LEU A 194 | None | 1.10A | 4jbtA-4yweA:undetectable | 4jbtA-4yweA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z17 | ENOLASE (Chloroflexusaurantiacus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 424ALA A 241VAL A 311LEU A 336GLN A 309 | None | 1.08A | 4jbtA-4z17A:undetectable | 4jbtA-4z17A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aho | 5' EXONUCLEASEAPOLLO (Homo sapiens) |
PF07522(DRMBL) | 5 | ALA A 284ALA A 288ALA A 287VAL A 294LEU A 144 | None | 1.09A | 4jbtA-5ahoA:undetectable | 4jbtA-5ahoA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 5 | GLN A 75ALA A 181ALA A 179THR A 171LEU A 200 | None | 1.08A | 4jbtA-5cjuA:undetectable | 4jbtA-5cjuA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxw | PENICILLIN-BINDINGPROTEIN 1A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | GLN A 288ALA A 289ALA A 292ALA A 293VAL A 567 | None | 1.06A | 4jbtA-5cxwA:undetectable | 4jbtA-5cxwA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dj4 | SESTRIN-2 (Homo sapiens) |
PF04636(PA26) | 5 | ALA A 116ALA A 119ALA A 120VAL A 211LEU A 79 | None | 0.94A | 4jbtA-5dj4A:undetectable | 4jbtA-5dj4A:25.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dvj | BINDING PROTEINCOMPONENT OF ABCSUGAR TRANSPORTER (Pseudomonasputida) |
PF01547(SBP_bac_1) | 5 | GLN A 319ALA A 323ALA A 326VAL A 344LEU A 121 | None | 1.02A | 4jbtA-5dvjA:undetectable | 4jbtA-5dvjA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ek8 | LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 5 | GLN A 193ALA A 194ALA A 198THR A 202LEU A 404 | None | 0.88A | 4jbtA-5ek8A:0.5 | 4jbtA-5ek8A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey5 | LBCATS-A (syntheticconstruct) |
PF00290(Trp_syntA) | 5 | ALA A 67ALA A 71THR A 76VAL A 81LEU A 50 | None | 1.09A | 4jbtA-5ey5A:undetectable | 4jbtA-5ey5A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqr | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE TDR (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | PHE B 514ALA B 464ALA B 488ALA B 462LEU B 472 | None | 1.07A | 4jbtA-5gqrB:undetectable | 4jbtA-5gqrB:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdj | NFRA1 (Bacillusmegaterium) |
PF00881(Nitroreductase) | 5 | PHE A 77ALA A 121ALA A 124ALA A 125GLN A 26 | None | 0.93A | 4jbtA-5hdjA:undetectable | 4jbtA-5hdjA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hei | NFRA2 (Bacillusmegaterium) |
PF00881(Nitroreductase) | 5 | ALA A 120ALA A 123ALA A 124VAL A 22LEU A 75 | None | 1.05A | 4jbtA-5heiA:undetectable | 4jbtA-5heiA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjp | NONRIBOSOMAL PEPTIDESYNTHASE (Streptomycessp. MJ635-86F5) |
PF00501(AMP-binding) | 5 | PHE A 95ALA A 81ALA A 84ALA A 83LEU A 226 | None | 1.09A | 4jbtA-5jjpA:undetectable | 4jbtA-5jjpA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khn | RND TRANSPORTER (Burkholderiamultivorans) |
no annotation | 5 | ALA B 85ALA B 88ALA B 89THR B 93LEU B 74 | None | 0.83A | 4jbtA-5khnB:3.4 | 4jbtA-5khnB:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfd | ALLANTOIN RACEMASE (Pseudomonasfluorescens) |
no annotation | 5 | ALA A 99ALA A 98ALA A 204THR A 207VAL A 25 | None | 1.04A | 4jbtA-5lfdA:undetectable | 4jbtA-5lfdA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | PHE A 250GLN A 200ALA A 279ALA A 198ALA A 281 | NoneNoneOGA A 402 (-3.6A)OGA A 402 ( 4.2A)OGA A 402 ( 3.7A) | 1.10A | 4jbtA-5lunA:undetectable | 4jbtA-5lunA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lx8 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | GLN A 215ALA A 216ALA A 219ALA A 220LEU A 429 | None | 0.89A | 4jbtA-5lx8A:undetectable | 4jbtA-5lx8A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mux | 2-METHYLCITRATEDEHYDRATASE (Bacillussubtilis) |
no annotation | 5 | ALA A 81ALA A 80ALA A 114VAL A 119LEU A 179 | None | 1.11A | 4jbtA-5muxA:undetectable | 4jbtA-5muxA:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj6 | HIGH CONDUCTANCECALCIUM-ACTIVATEDPOTASSIUM CHANNEL (Aplysiacalifornica) |
PF00520(Ion_trans)PF03493(BK_channel_a) | 6 | PHE A 492PHE A 768ALA A 489ALA A 988THR A1063LEU A 950 | None | 1.46A | 4jbtA-5tj6A:1.0 | 4jbtA-5tj6A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vaz | DNA PRIMASE (Pseudomonasaeruginosa) |
PF08275(Toprim_N)PF10410(DnaB_bind)PF13662(Toprim_4) | 5 | MET A 415PHE A 377PHE A 376ALA A 399ALA A 400 | None | 1.11A | 4jbtA-5vazA:undetectable | 4jbtA-5vazA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF00374(NiFeSe_Hases) | 5 | PHE D 128PHE D 129ALA D 220ALA D 218ALA D 217 | None | 1.09A | 4jbtA-5xfaD:undetectable | 4jbtA-5xfaD:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xw5 | TYROSINE-PROTEINPHOSPHATASE CDC14 (Saccharomycescerevisiae) |
PF00782(DSPc)PF14671(DSPn) | 6 | PHE A 127GLN A 90ALA A 94ALA A 92ALA A 95VAL A 145 | None | 1.37A | 4jbtA-5xw5A:undetectable | 4jbtA-5xw5A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 5 | MET A 31ALA A 139ALA A 138VAL A 16LEU A 38 | None | 1.12A | 4jbtA-6bk1A:undetectable | 4jbtA-6bk1A:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chj | DIACYLGLYCEROLO-ACYLTRANSFERASE (Marinobacterhydrocarbonoclasticus) |
no annotation | 5 | PHE A 292ALA A 357ALA A 359ALA A 360LEU A 10 | None | 1.12A | 4jbtA-6chjA:undetectable | 4jbtA-6chjA:12.41 |