SIMILAR PATTERNS OF AMINO ACIDS FOR 4J7X_J_SASJ804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		5 LEU A  74
LEU A  44
CYH A 149
PHE A 150
ASP A 200
 None
 1.23A 4j7xJ-1dqpA:
undetectable		 4j7xJ-1dqpA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 332
LEU A 400
PRO A 398
GLN A 328
ASP A 320
 None
 1.31A 4j7xJ-1fcpA:
undetectable		 4j7xJ-1fcpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 LEU A 439
LEU A 423
TYR A 437
ASP A 389
ASP A 451
 None
 1.42A 4j7xJ-1gxnA:
undetectable		 4j7xJ-1gxnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU E  96
PHE F 100
TRP F 103
ASP F 101
ASP F  99
 None
 1.16A 4j7xJ-1nfdE:
undetectable		 4j7xJ-1nfdE:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		9 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ASP A 216
 OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
None
 0.36A 4j7xJ-1oaaA:
42.3		 4j7xJ-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU B 185
LEU B 195
PHE A 113
GLN B 201
ASP A 105
 None
 1.44A 4j7xJ-1qhhB:
undetectable		 4j7xJ-1qhhB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  23
LEU A 190
PRO A 221
ASP A 166
ASP A 167
 None
 1.37A 4j7xJ-1tkkA:
undetectable		 4j7xJ-1tkkA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A 479
TYR A 532
PRO A 223
GLN A 218
ASP A 591
 None
 1.11A 4j7xJ-1xkhA:
undetectable		 4j7xJ-1xkhA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4j7xJ-2ad1A:
undetectable		 4j7xJ-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A  85
LEU A  96
PHE A   9
ASP A  10
ASP A 166
 None
 1.49A 4j7xJ-2ah5A:
4.9		 4j7xJ-2ah5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		5 LEU A 221
LEU A 170
TYR A 140
PRO A 174
ASP A 128
 None
 1.20A 4j7xJ-2exhA:
undetectable		 4j7xJ-2exhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 LEU A 246
SER A 155
LEU A 158
PHE A 237
ASP A 238
 None
 1.49A 4j7xJ-2f6dA:
undetectable		 4j7xJ-2f6dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 281
LEU A 441
TRP A 289
ASP A 503
MET A 504
 None
 1.22A 4j7xJ-2h2qA:
undetectable		 4j7xJ-2h2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 222
LEU A 259
PHE A 163
ASP A 243
ASP A 292
 None
None
None
ZN  A 500 ( 2.4A)
ZN  A 500 ( 4.9A)
 1.33A 4j7xJ-2ptzA:
undetectable		 4j7xJ-2ptzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		5 LEU A 209
SER A 260
LEU A 261
TYR A 256
ASP A 191
 None
 1.46A 4j7xJ-2q3rA:
3.6		 4j7xJ-2q3rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 LEU A  34
LEU A  17
PHE A 249
PRO A  19
ASP A 248
 None
 1.42A 4j7xJ-2yb4A:
undetectable		 4j7xJ-2yb4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 LEU X 296
SER X 254
TRP X 233
PRO X  58
ASP X 232
 None
 1.49A 4j7xJ-2z22X:
undetectable		 4j7xJ-2z22X:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		5 SER A 187
LEU A 185
CYH A 184
PHE A 106
ASP A 104
 None
 1.08A 4j7xJ-3cueA:
undetectable		 4j7xJ-3cueA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
 None
 1.35A 4j7xJ-3fhcB:
0.7		 4j7xJ-3fhcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4j7xJ-3jckA:
2.1		 4j7xJ-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 LEU A 121
LEU A  90
PHE A   9
TYR A 124
ASP A  10
 None
 1.47A 4j7xJ-3kzxA:
4.1		 4j7xJ-3kzxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		5 LEU A  31
PHE A  12
TYR A  28
GLN A  46
ASP A 102
 None
 1.48A 4j7xJ-3qr3A:
undetectable		 4j7xJ-3qr3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 SER A 332
LEU A 329
TYR A 238
GLN A 201
ASP A 235
 None
None
None
NAD  A 343 ( 4.8A)
None
 1.48A 4j7xJ-3rucA:
16.7		 4j7xJ-3rucA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 351
SER A 313
LEU A 312
ASP A 404
ASP A 448
 None
 1.36A 4j7xJ-3s9vA:
undetectable		 4j7xJ-3s9vA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 SER A 154
LEU A 157
PHE A 186
TYR A  77
ASP A 187
 None
 1.37A 4j7xJ-3ty7A:
3.1		 4j7xJ-3ty7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 LEU A 543
LEU A 599
CYH A 598
PHE A 546
ASP A 615
 None
None
SAM  A 802 (-3.3A)
SAM  A 802 (-4.5A)
None
 1.31A 4j7xJ-3v8vA:
6.7		 4j7xJ-3v8vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 276
TYR A 280
PRO A 549
ASP A  74
ASP A 321
 None
 1.42A 4j7xJ-3vskA:
undetectable		 4j7xJ-3vskA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		5 LEU A  94
LEU A  98
PHE A 107
PRO A  86
GLN A  72
 None
 1.47A 4j7xJ-4a39A:
undetectable		 4j7xJ-4a39A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		5 LEU A 209
LEU A 218
PHE A 233
PRO A 213
ASP A 230
 None
None
None
None
MAL  A 500 (-2.7A)
 1.47A 4j7xJ-4bzgA:
undetectable		 4j7xJ-4bzgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		5 LEU A 346
PHE A 318
TYR A 319
PRO A 328
ASP A 383
 None
 1.32A 4j7xJ-4fo0A:
2.4		 4j7xJ-4fo0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		5 LEU A 141
PHE A 218
TYR A 131
PRO A 137
ASP A 220
 None
 1.08A 4j7xJ-4j5iA:
undetectable		 4j7xJ-4j5iA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jsb ENOYL-COA HYDRATASE

(Thermobifida
fusca) 		PF00378
(ECH_1) 		5 LEU A 168
SER A 110
ASP A  75
ASP A  77
MET A  78
 None
 1.02A 4j7xJ-4jsbA:
undetectable		 4j7xJ-4jsbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		5 LEU A  38
CYH A  91
TRP A  37
TYR A  34
ASP A 134
 None
 1.37A 4j7xJ-4k00A:
undetectable		 4j7xJ-4k00A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 380
LEU A 303
CYH A 304
TYR A 386
ASP A 335
 None
 1.28A 4j7xJ-4m0mA:
5.3		 4j7xJ-4m0mA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 LEU A 323
TYR A 329
PRO A 241
ASP A 274
ASP A 255
 None
 1.42A 4j7xJ-4m7fA:
undetectable		 4j7xJ-4m7fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		5 LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
 None
None
None
CA  B 706 ( 3.4A)
None
 1.19A 4j7xJ-4nenB:
4.3		 4j7xJ-4nenB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LEU A 614
LEU A 560
PHE A 558
ASP A 556
ASP A 511
 None
 1.37A 4j7xJ-4nsxA:
undetectable		 4j7xJ-4nsxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 323
PHE D 224
TYR D 232
PRO D 325
ASP D 222
 None
None
None
None
MG  D 401 ( 4.4A)
 1.30A 4j7xJ-4qqfD:
undetectable		 4j7xJ-4qqfD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyb UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF10765
(DUF2591) 		5 LEU A 118
PHE A 111
TRP A  14
TYR A  13
ASP A 113
 None
 1.28A 4j7xJ-4qybA:
undetectable		 4j7xJ-4qybA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 263
LEU A 343
PHE A 327
PRO A 277
ASP A 326
 None
 1.46A 4j7xJ-4u33A:
undetectable		 4j7xJ-4u33A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		5 LEU A 160
LEU A 481
CYH A 478
PHE A 136
ASP A 134
 None
 1.49A 4j7xJ-4x9eA:
undetectable		 4j7xJ-4x9eA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		6 LEU A 101
CYH A 168
PHE A 161
TRP A 164
ASP A 212
MET A 215
 None
 1.44A 4j7xJ-4z3kA:
45.3		 4j7xJ-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		12 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ASP A 212
ASP A 214
MET A 215
 None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
None
None
 0.60A 4j7xJ-4z3kA:
45.3		 4j7xJ-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		6 SER A 154
LEU A 155
PHE A 161
PRO A 197
GLN A 203
ASP A 212
 4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
 1.05A 4j7xJ-4z3kA:
45.3		 4j7xJ-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
 None
 1.18A 4j7xJ-5e6sB:
3.6		 4j7xJ-5e6sB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 580
PHE A 555
ASP A 558
ASP A 560
MET A 561
 None
 1.29A 4j7xJ-5erbA:
undetectable		 4j7xJ-5erbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 LEU A 272
LEU A 259
CYH A 242
TRP A 280
ASP A 233
 None
 1.38A 4j7xJ-5hgcA:
undetectable		 4j7xJ-5hgcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 203
PRO A 526
GLN A 525
ASP A 593
ASP A 595
 None
 1.40A 4j7xJ-5ipwA:
undetectable		 4j7xJ-5ipwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a TRNA NUCLEASE CDIA

(Burkholderia
pseudomallei) 		no annotation 5 LEU A 284
PHE A 268
PRO A 248
GLN A 253
ASP A 262
 None
 1.44A 4j7xJ-5j4aA:
undetectable		 4j7xJ-5j4aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 LEU A 610
LEU A 711
PHE A 725
PRO A 715
ASP A 726
 None
 1.33A 4j7xJ-5nfhA:
3.2		 4j7xJ-5nfhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 LEU A1211
PHE A1112
PRO A1232
ASP A1113
ASP A1129
 None
 1.37A 4j7xJ-5ng6A:
undetectable		 4j7xJ-5ng6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 LEU A 583
SER A 552
LEU A 553
PRO A 555
ASP A 604
 None
 1.48A 4j7xJ-5o1pA:
undetectable		 4j7xJ-5o1pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 239
LEU A 319
PHE A 303
PRO A 253
ASP A 302
 None
 1.44A 4j7xJ-5vsjA:
undetectable		 4j7xJ-5vsjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxv PEROXISOMAL MEMBRANE
PROTEIN PEX15

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 242
SER A 223
CYH A 216
TRP A 213
TYR A 212
 None
 1.31A 4j7xJ-5vxvA:
undetectable		 4j7xJ-5vxvA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Zea mays) 		no annotation 5 LEU L 163
SER L  65
TRP H  68
PRO L  56
ASP H  57
 None
 1.36A 4j7xJ-5zjiL:
undetectable		 4j7xJ-5zjiL:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 LEU A 179
SER C1038
LEU C1037
TYR A 182
GLN A 202
 None
None
None
None
GOL  A 401 ( 3.3A)
 1.43A 4j7xJ-6au8A:
undetectable		 4j7xJ-6au8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 SER C1038
LEU C1037
TYR A 182
GLN A 202
ASP A 193
 None
None
None
GOL  A 401 ( 3.3A)
None
 1.25A 4j7xJ-6au8C:
undetectable		 4j7xJ-6au8C:
8.03