SIMILAR PATTERNS OF AMINO ACIDS FOR 4J7X_B_SASB804_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL

(Escherichia
coli) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 LEU A 116
MET A 111
ASP A  14
 None
 0.71A 4j7xB-1a04A:
2.7		 4j7xB-1a04A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7e PHOTOACTIVE YELLOW
PROTEIN

(Halorhodospira
halophila) 		PF00989
(PAS) 		3 LEU A  23
MET A  18
ASP A  34
 None
 0.78A 4j7xB-1d7eA:
undetectable		 4j7xB-1d7eA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA

(Homo sapiens) 		PF00714
(IFN-gamma) 		3 LEU A  95
MET A 245
ASP A 111
 None
 0.74A 4j7xB-1fyhA:
undetectable		 4j7xB-1fyhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 LEU A 259
MET A 290
ASP A 410
 None
 0.77A 4j7xB-1g01A:
2.9		 4j7xB-1g01A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		3 LEU A 433
MET A 454
ASP A 480
 None
 0.70A 4j7xB-1gxnA:
undetectable		 4j7xB-1gxnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		3 LEU A 112
MET A 104
ASP A 139
 None
 0.80A 4j7xB-1mumA:
2.7		 4j7xB-1mumA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 LEU A 450
MET A 375
ASP A  25
 None
 0.67A 4j7xB-1nfgA:
2.4		 4j7xB-1nfgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nks ADENYLATE KINASE

(Sulfolobus
acidocaldarius) 		PF13207
(AAA_17) 		3 LEU A  88
MET A   1
ASP A  71
 None
 0.75A 4j7xB-1nksA:
4.1		 4j7xB-1nksA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		3 LEU A 229
MET A 267
ASP A  12
 None
 0.74A 4j7xB-1o60A:
undetectable		 4j7xB-1o60A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Neisseria
meningitidis) 		PF02548
(Pantoate_transf) 		3 LEU A 217
MET A 232
ASP A  32
 None
 0.81A 4j7xB-1o66A:
undetectable		 4j7xB-1o66A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		3 LEU A 841
MET A 840
ASP A 793
 None
 0.71A 4j7xB-1q1oA:
undetectable		 4j7xB-1q1oA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus) 		PF00054
(Laminin_G_1) 		3 LEU A 116
MET A  80
ASP A 169
 None
 0.72A 4j7xB-1q56A:
undetectable		 4j7xB-1q56A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7r PREDICTED
AMIDOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF01174
(SNO) 		3 LEU A  84
MET A  99
ASP A  39
 None
 0.81A 4j7xB-1q7rA:
2.8		 4j7xB-1q7rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1

(Homo sapiens) 		PF07686
(V-set) 		3 LEU A  37
MET A 100
ASP A  42
 None
 0.75A 4j7xB-1q8mA:
undetectable		 4j7xB-1q8mA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00270
(DEAD) 		3 LEU A 187
MET A 217
ASP A 196
 None
 0.82A 4j7xB-1t6nA:
undetectable		 4j7xB-1t6nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		3 LEU A  94
MET A  23
ASP A 145
 None
 0.75A 4j7xB-1t8bA:
undetectable		 4j7xB-1t8bA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		3 LEU A 334
MET A 116
ASP A 132
 None
 0.80A 4j7xB-1wytA:
undetectable		 4j7xB-1wytA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		3 LEU A 112
MET A  31
ASP A  57
 None
 0.76A 4j7xB-1xdzA:
4.7		 4j7xB-1xdzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
YSCB
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF05932
(CesT)
PF07201
(HrpJ) 		3 LEU C  33
MET C  35
ASP A  82
 None
 0.77A 4j7xB-1xkpC:
undetectable		 4j7xB-1xkpC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 LEU A 222
MET A 226
ASP A 170
 None
 0.72A 4j7xB-1yzyA:
undetectable		 4j7xB-1yzyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5e PROTEIN
DISULFIDE-ISOMERASE

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 LEU A 313
MET A 307
ASP A 245
 None
 0.79A 4j7xB-2b5eA:
undetectable		 4j7xB-2b5eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		3 LEU A 890
MET A 948
ASP A 905
 None
 0.79A 4j7xB-2c3oA:
undetectable		 4j7xB-2c3oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LEU A 224
MET A 250
ASP A 366
 None
 0.67A 4j7xB-2cxeA:
undetectable		 4j7xB-2cxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		3 LEU A  54
MET A  49
ASP A  75
 None
 0.76A 4j7xB-2fbiA:
undetectable		 4j7xB-2fbiA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		3 LEU A 188
MET A 192
ASP A 117
 None
 0.74A 4j7xB-2grvA:
undetectable		 4j7xB-2grvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		3 LEU A 190
MET A 122
ASP A  38
 None
 0.52A 4j7xB-2i0mA:
undetectable		 4j7xB-2i0mA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		3 LEU A 144
MET A 166
ASP A  88
 None
 0.76A 4j7xB-2imhA:
undetectable		 4j7xB-2imhA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Homo sapiens) 		PF14580
(LRR_9) 		3 LEU A  24
MET A   3
ASP A  18
 None
 0.57A 4j7xB-2je1A:
undetectable		 4j7xB-2je1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		3 LEU A  24
MET A   3
ASP A  18
 None
 0.62A 4j7xB-2jqdA:
undetectable		 4j7xB-2jqdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgs C-X-C MOTIF
CHEMOKINE 5

(Homo sapiens) 		PF00048
(IL8) 		3 LEU A  48
MET A  26
ASP A  57
 None
 0.63A 4j7xB-2mgsA:
undetectable		 4j7xB-2mgsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7j PUTATIVE SENSORY
BOX/GGDEF FAMILY
PROTEIN

(Vibrio
parahaemolyticus) 		PF02743
(dCache_1) 		3 LEU A 167
MET A 155
ASP A 172
 None
 0.74A 4j7xB-2p7jA:
undetectable		 4j7xB-2p7jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE

(uncultured
Thermotogales
bacterium) 		PF01966
(HD) 		3 LEU A   6
MET A   1
ASP A 131
 None
None
FE  A 221 (-2.6A)
 0.58A 4j7xB-2pq7A:
undetectable		 4j7xB-2pq7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rqa ATP-DEPENDENT RNA
HELICASE DHX58

(Homo sapiens) 		PF11648
(RIG-I_C-RD) 		3 LEU A 554
MET A 638
ASP A 661
 None
 0.80A 4j7xB-2rqaA:
undetectable		 4j7xB-2rqaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7c ORPHAN NUCLEAR
RECEPTOR NR1D2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 482
MET A 486
ASP A 515
 None
 0.81A 4j7xB-2v7cA:
undetectable		 4j7xB-2v7cA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 LEU A  66
MET A  70
ASP A 468
 None
 0.67A 4j7xB-2v8jA:
undetectable		 4j7xB-2v8jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		3 LEU A  37
MET A 276
ASP A 358
 None
 0.76A 4j7xB-2v95A:
undetectable		 4j7xB-2v95A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 LEU A 293
MET A 198
ASP A 184
 None
 0.79A 4j7xB-2vw8A:
undetectable		 4j7xB-2vw8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 LEU A 341
MET A 357
ASP A 325
 None
 0.71A 4j7xB-2wanA:
undetectable		 4j7xB-2wanA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT

(Sulfolobus
shibatae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 LEU D 145
MET D  39
ASP D 113
 None
 0.79A 4j7xB-2wb1D:
undetectable		 4j7xB-2wb1D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		3 LEU A  57
MET A  59
ASP A  36
 None
 0.80A 4j7xB-2wyrA:
undetectable		 4j7xB-2wyrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		3 LEU A 152
MET A 255
ASP A 112
 None
 0.79A 4j7xB-2x24A:
4.0		 4j7xB-2x24A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		3 LEU A 164
MET A 197
ASP A 130
 None
 0.81A 4j7xB-2x8uA:
undetectable		 4j7xB-2x8uA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 LEU A  51
MET A  55
ASP A 148
 None
 0.73A 4j7xB-2xdqA:
2.6		 4j7xB-2xdqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywj GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Methanocaldococcus
jannaschii) 		PF01174
(SNO) 		3 LEU A  81
MET A  95
ASP A  39
 None
 0.73A 4j7xB-2ywjA:
2.4		 4j7xB-2ywjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		3 LEU A  47
MET A 120
ASP A  94
 None
 0.50A 4j7xB-3alxA:
undetectable		 4j7xB-3alxA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alz CDW150

(Saguinus
oedipus) 		PF06214
(SLAM) 		3 LEU B  47
MET B 120
ASP B  94
 None
 0.54A 4j7xB-3alzB:
undetectable		 4j7xB-3alzB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdh TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Ruegeria
pomeroyi) 		PF01047
(MarR) 		3 LEU A  60
MET A  55
ASP A 103
 None
SO4  A 206 ( 4.7A)
None
 0.81A 4j7xB-3cdhA:
undetectable		 4j7xB-3cdhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdn PHEROMONE-BINDING
PROTEIN ASP1

(Apis mellifera) 		PF01395
(PBP_GOBP) 		3 LEU A  58
MET A  70
ASP A  11
 None
 0.76A 4j7xB-3cdnA:
undetectable		 4j7xB-3cdnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cex UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF04978
(DUF664) 		3 LEU A 104
MET A  45
ASP A  78
 None
 0.82A 4j7xB-3cexA:
undetectable		 4j7xB-3cexA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 LEU A  45
MET A  49
ASP A 119
 None
 0.76A 4j7xB-3cr8A:
undetectable		 4j7xB-3cr8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 165
MET A 173
ASP A 127
 None
 0.77A 4j7xB-3dipA:
2.1		 4j7xB-3dipA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 LEU A1021
MET A1025
ASP A 947
 None
 0.80A 4j7xB-3eh1A:
undetectable		 4j7xB-3eh1A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo2 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00621
(RhoGEF) 		3 LEU A 321
MET A 182
ASP A 309
 None
 0.81A 4j7xB-3eo2A:
undetectable		 4j7xB-3eo2A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		3 LEU A 412
MET A 479
ASP A 513
 None
 0.79A 4j7xB-3h9cA:
undetectable		 4j7xB-3h9cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LEU A 367
MET A 355
ASP A 304
 None
None
EDO  A   4 (-3.3A)
 0.58A 4j7xB-3i4gA:
undetectable		 4j7xB-3i4gA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9s INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		PF00583
(Acetyltransf_1) 		3 LEU A 107
MET A  85
ASP A   9
 None
None
SO4  A 163 (-4.8A)
 0.78A 4j7xB-3i9sA:
undetectable		 4j7xB-3i9sA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		3 LEU A 135
MET A 110
ASP A  94
 None
 0.79A 4j7xB-3js8A:
undetectable		 4j7xB-3js8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 LEU A 132
MET A 517
ASP A  35
 None
 0.80A 4j7xB-3ljpA:
3.1		 4j7xB-3ljpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nff RNA POLYMERASE I
SUBUNIT A34.5
RNA POLYMERASE I
SUBUNIT A49

([Candida]
glabrata) 		PF06870
(RNA_pol_I_A49)
PF08208
(RNA_polI_A34) 		3 LEU A  85
MET A  72
ASP B  72
 None
 0.63A 4j7xB-3nffA:
undetectable		 4j7xB-3nffA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 LEU A 189
MET A 193
ASP A 163
 None
None
EPE  A 338 ( 4.6A)
 0.81A 4j7xB-3qz4A:
undetectable		 4j7xB-3qz4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 LEU A 229
MET A 251
ASP A 286
 None
None
ACT  A1359 (-3.2A)
 0.82A 4j7xB-3zpcA:
undetectable		 4j7xB-3zpcA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 LEU A 303
MET A 183
ASP A 103
 None
 0.80A 4j7xB-3zukA:
undetectable		 4j7xB-3zukA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5d CAPITELLA TELETA
ACHBP

(Capitella
teleta) 		PF02931
(Neur_chan_LBD) 		3 LEU A 101
MET A 109
ASP A 144
 None
 0.70A 4j7xB-4b5dA:
undetectable		 4j7xB-4b5dA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LEU A 290
MET A 285
ASP A 214
 None
 0.76A 4j7xB-4bedA:
undetectable		 4j7xB-4bedA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		3 LEU A 447
MET A 479
ASP A 424
 None
None
NA  A1855 ( 4.5A)
 0.82A 4j7xB-4c90A:
undetectable		 4j7xB-4c90A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		3 LEU A 200
MET A  22
ASP A 182
 None
 0.51A 4j7xB-4dbeA:
undetectable		 4j7xB-4dbeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		3 LEU A 246
MET A 286
ASP A  48
 None
 0.67A 4j7xB-4fguA:
4.8		 4j7xB-4fguA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 LEU A 150
MET A 252
ASP A 211
 None
 0.55A 4j7xB-4fr2A:
3.1		 4j7xB-4fr2A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A 227
MET A 226
ASP A 275
 None
 0.79A 4j7xB-4hozA:
undetectable		 4j7xB-4hozA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 LEU A 755
MET A 716
ASP A 683
 None
 0.82A 4j7xB-4j5tA:
undetectable		 4j7xB-4j5tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		3 LEU A 209
MET A 331
ASP A 258
 None
 0.79A 4j7xB-4js1A:
undetectable		 4j7xB-4js1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 LEU A 266
MET A 280
ASP A 255
 None
 0.70A 4j7xB-4ljsA:
2.8		 4j7xB-4ljsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 LEU A 243
MET A 257
ASP A 278
 None
None
29X  A 702 ( 4.8A)
 0.74A 4j7xB-4mk0A:
undetectable		 4j7xB-4mk0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		3 LEU A 206
MET A 328
ASP A 255
 None
 0.78A 4j7xB-4mpsA:
undetectable		 4j7xB-4mpsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 LEU A  52
MET A  21
ASP A  84
 None
 0.75A 4j7xB-4nmnA:
2.4		 4j7xB-4nmnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		3 LEU A 113
MET A 110
ASP A 127
 None
 0.77A 4j7xB-4nx1A:
undetectable		 4j7xB-4nx1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 324
MET A 319
ASP A 445
 None
 0.68A 4j7xB-4pwnA:
undetectable		 4j7xB-4pwnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG

(Pseudomonas
aeruginosa) 		PF01895
(PhoU) 		3 LEU A 100
MET A  29
ASP A 152
 None
 0.55A 4j7xB-4q25A:
undetectable		 4j7xB-4q25A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		3 LEU A 389
MET A 397
ASP A 357
 None
 0.79A 4j7xB-4qjiA:
8.0		 4j7xB-4qjiA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 LEU A 365
MET A 115
ASP A  47
 None
 0.71A 4j7xB-4utfA:
undetectable		 4j7xB-4utfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m HI113 PROTEIN

(Lama glama) 		PF07686
(V-set) 		3 LEU A  81
MET A  83
ASP A 108
 None
 0.63A 4j7xB-4y7mA:
undetectable		 4j7xB-4y7mA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		3 LEU A 101
MET A 202
ASP A 214
 None
NAP  A 801 (-3.5A)
None
 0.20A 4j7xB-4z3kA:
45.2		 4j7xB-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		3 LEU A1025
MET A1027
ASP A1068
 None
 0.72A 4j7xB-4ziuA:
undetectable		 4j7xB-4ziuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 LEU C 726
MET A 243
ASP A 255
 None
 0.77A 4j7xB-5a5tC:
undetectable		 4j7xB-5a5tC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bov PUTATIVE EPOXIDE
HYDROLASE PROTEIN

(Klebsiella
pneumoniae) 		PF00561
(Abhydrolase_1) 		3 LEU A 100
MET A 122
ASP A 139
 None
 0.82A 4j7xB-5bovA:
undetectable		 4j7xB-5bovA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		3 LEU A 349
MET A  45
ASP A 116
 None
 0.68A 4j7xB-5eqvA:
undetectable		 4j7xB-5eqvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f29 NA+/H+
ANTIPORTER-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02080
(TrkA_C) 		3 LEU A 189
MET A 150
ASP A 168
 None
 0.80A 4j7xB-5f29A:
undetectable		 4j7xB-5f29A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 LEU A 250
MET A 254
ASP A 223
 None
None
MN  A 805 (-2.6A)
 0.79A 4j7xB-5f56A:
3.2		 4j7xB-5f56A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		3 LEU A 233
MET A 229
ASP A 204
 HEM  A 501 (-4.4A)
None
None
 0.80A 4j7xB-5gnmA:
undetectable		 4j7xB-5gnmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		3 LEU A 406
MET A 427
ASP A 374
 None
 0.77A 4j7xB-5haxA:
undetectable		 4j7xB-5haxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 3 LEU A 159
MET A 189
ASP A 207
 None
 0.81A 4j7xB-5o34A:
undetectable		 4j7xB-5o34A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU W 489
MET W 437
ASP W 450
 None
 0.79A 4j7xB-5o9gW:
undetectable		 4j7xB-5o9gW:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 243
MET A 257
ASP A 278
 None
 0.83A 4j7xB-5uuuA:
undetectable		 4j7xB-5uuuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 3 LEU A 451
MET A 456
ASP A 411
 None
 0.79A 4j7xB-5v2dA:
undetectable		 4j7xB-5v2dA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 3 LEU A1910
MET A1856
ASP A1815
 None
 0.77A 4j7xB-5yz0A:
undetectable		 4j7xB-5yz0A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4c -

(-) 		no annotation 3 LEU A  60
MET A  65
ASP A 256
 None
 0.79A 4j7xB-6b4cA:
2.1		 4j7xB-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 LEU A 559
MET A 742
ASP A 564
 None
 0.81A 4j7xB-6bf6A:
undetectable		 4j7xB-6bf6A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq9 DNA TOPOISOMERASE 4
SUBUNIT A

(Pseudomonas
putida) 		no annotation 3 LEU A 318
MET A 288
ASP A 294
 None
 0.75A 4j7xB-6bq9A:
undetectable		 4j7xB-6bq9A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2

(Saccharomyces
cerevisiae) 		no annotation 3 LEU B 688
MET B 693
ASP B 649
 None
 0.76A 4j7xB-6bzgB:
3.2		 4j7xB-6bzgB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 3 LEU A  80
MET A 106
ASP A 142
 None
 0.69A 4j7xB-6h25A:
undetectable		 4j7xB-6h25A:
undetectable