SIMILAR PATTERNS OF AMINO ACIDS FOR 4J7X_B_SASB804_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae9 LAMBDA INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase) 		5 LEU A 246
PHE A 326
ALA A 315
GLY A 332
LEU A 331
 None
 1.13A 4j7xB-1ae9A:
undetectable		 4j7xB-1ae9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		5 LEU Y  52
PHE Y  17
ALA Y   9
GLY Y 128
LEU Y 129
 None
 1.24A 4j7xB-1bryY:
undetectable		 4j7xB-1bryY:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 SER A 126
PHE A  72
ALA A  79
GLY A 144
LEU A 142
 None
 1.19A 4j7xB-1bsgA:
undetectable		 4j7xB-1bsgA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 PHE A 798
TRP A 795
PRO A 753
GLY A 803
LEU A 837
 None
 1.11A 4j7xB-1c7tA:
2.0		 4j7xB-1c7tA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 157
PHE A 249
PRO A 161
GLY A 224
LEU A 223
 None
 1.21A 4j7xB-1dgsA:
undetectable		 4j7xB-1dgsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 PHE A  72
ALA A  79
MET A 148
GLY A 144
LEU A 142
 None
 1.17A 4j7xB-1dy6A:
undetectable		 4j7xB-1dy6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 SER A  99
TYR A  86
GLN A 159
ALA A 140
GLY A 147
 None
 1.26A 4j7xB-1dysA:
3.2		 4j7xB-1dysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 285
PHE A 358
MET A 518
GLY A 516
LEU A 515
 None
None
None
TSB  A2002 (-3.3A)
None
 1.23A 4j7xB-1evlA:
undetectable		 4j7xB-1evlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f45 INTERLEUKIN-12 ALPHA
CHAIN

(Homo sapiens) 		PF03039
(IL12) 		5 LEU B 177
TYR B 112
ALA B 184
MET B  29
LEU B  30
 None
 1.23A 4j7xB-1f45B:
undetectable		 4j7xB-1f45B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 SER A 331
LEU A 332
GLN A 297
GLY A 229
LEU A 294
 None
 1.29A 4j7xB-1gsoA:
5.0		 4j7xB-1gsoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io3 CYTOCHROME C2

(Blastochloris
viridis) 		PF00034
(Cytochrom_C) 		5 CYH A  13
PHE A  10
PRO A  29
GLY A  33
LEU A  34
 HEM  A 108 (-1.7A)
None
HEM  A 108 (-4.8A)
None
HEM  A 108 ( 4.8A)
 1.28A 4j7xB-1io3A:
undetectable		 4j7xB-1io3A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 CYH A  21
ALA A  73
MET A  58
GLY A  68
LEU A  69
 None
 1.21A 4j7xB-1jqiA:
undetectable		 4j7xB-1jqiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 SER A 599
LEU A 579
CYH A 607
ALA A 592
GLY A 583
 None
 1.30A 4j7xB-1l5jA:
undetectable		 4j7xB-1l5jA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		9 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ALA A 210
LEU A 223
 OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
None
 0.36A 4j7xB-1oaaA:
42.1		 4j7xB-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		5 SER A 158
LEU A 159
CYH A 160
TYR A 171
LEU A 219
 OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
OAA  A   1 ( 4.3A)
None
 1.04A 4j7xB-1oaaA:
42.1		 4j7xB-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		5 LEU A 285
PHE A 358
MET A 518
GLY A 516
LEU A 515
 None
None
None
AMP  A1002 (-3.0A)
None
 1.22A 4j7xB-1qf6A:
undetectable		 4j7xB-1qf6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 162
PHE A 252
PRO A 166
GLY A 229
LEU A 228
 None
 1.18A 4j7xB-1v9pA:
undetectable		 4j7xB-1v9pA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		5 LEU A 236
TRP A 220
ALA A 197
GLY A 200
LEU A 199
 None
 1.16A 4j7xB-1xfkA:
undetectable		 4j7xB-1xfkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		5 LEU A  87
PHE A 213
GLN A  93
GLY A 220
LEU A 221
 None
 1.23A 4j7xB-1xioA:
undetectable		 4j7xB-1xioA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.07A 4j7xB-2ad1A:
2.0		 4j7xB-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bri URIDYLATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 LEU A 126
PHE A  96
ALA A  39
MET A 111
GLY A 112
 None
 1.22A 4j7xB-2briA:
undetectable		 4j7xB-2briA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 400
PHE A 404
ALA A 438
GLY A 428
LEU A 439
 None
 1.17A 4j7xB-2cg9A:
undetectable		 4j7xB-2cg9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 SER A 285
LEU A 284
ALA A   4
GLY A  90
LEU A   6
 None
 1.27A 4j7xB-2h1yA:
undetectable		 4j7xB-2h1yA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 LEU A 372
TRP A 337
ALA A 384
GLY A 350
LEU A 349
 None
 1.13A 4j7xB-2imrA:
3.0		 4j7xB-2imrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		5 CYH A  54
PHE A  42
GLN A  19
ALA A  46
LEU A  15
 None
 1.30A 4j7xB-2jc4A:
3.2		 4j7xB-2jc4A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		5 PHE A  75
ALA A 144
MET A 140
GLY A 124
LEU A 123
 None
 0.97A 4j7xB-2k8dA:
undetectable		 4j7xB-2k8dA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 SER A  83
LEU A  76
ALA A 103
GLY A  52
LEU A  96
 None
 1.15A 4j7xB-2o5vA:
undetectable		 4j7xB-2o5vA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU X 248
ALA X 217
MET X 185
GLY X 190
LEU X 191
 None
 1.23A 4j7xB-2qvxX:
undetectable		 4j7xB-2qvxX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.16A 4j7xB-2rhzA:
undetectable		 4j7xB-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
GLN A  83
ALA A  79
GLY A 143
LEU A 142
 None
 1.05A 4j7xB-2wyxA:
undetectable		 4j7xB-2wyxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 555
GLN A 547
ALA A 591
GLY A 661
LEU A 639
 None
 1.16A 4j7xB-2xf2A:
4.3		 4j7xB-2xf2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 SER A 275
TYR A 254
GLN A 130
ALA A 132
GLY A 282
 None
None
None
None
PO4  A1466 (-3.3A)
 1.00A 4j7xB-2ypqA:
undetectable		 4j7xB-2ypqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		5 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 106
 None
 1.06A 4j7xB-2zm5A:
3.3		 4j7xB-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		5 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 107
 None
 1.08A 4j7xB-2zm5A:
3.3		 4j7xB-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 SER A  95
LEU A 250
ALA A 277
GLY A 268
LEU A 269
 None
 1.24A 4j7xB-2zukA:
2.6		 4j7xB-2zukA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		5 SER A 201
LEU A 202
PHE A 182
MET A 188
GLY A 157
 None
 1.06A 4j7xB-3a8rA:
undetectable		 4j7xB-3a8rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
GLN A  83
ALA A  79
GLY A 143
LEU A 142
 None
 1.03A 4j7xB-3bfgA:
undetectable		 4j7xB-3bfgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
GLN A  83
ALA A  79
GLY A 144
LEU A 142
 None
 1.07A 4j7xB-3bfgA:
undetectable		 4j7xB-3bfgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA

(Methylosinus
trichosporium) 		PF02461
(AMO) 		5 LEU B 235
GLN B  81
ALA B  94
GLY B 153
LEU B 136
 None
 1.29A 4j7xB-3chxB:
undetectable		 4j7xB-3chxB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctf GLUTAREDOXIN-2

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		5 SER A 104
TYR A 113
ALA A  56
GLY A  93
LEU A  87
 None
 1.22A 4j7xB-3ctfA:
undetectable		 4j7xB-3ctfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4m GLUTAREDOXIN-2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		5 SER A  70
TYR A  79
ALA A  22
GLY A  59
LEU A  53
 None
 1.18A 4j7xB-3d4mA:
undetectable		 4j7xB-3d4mA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 TYR A  29
PRO A 204
GLN A 207
ALA A   6
LEU A   3
 None
 1.26A 4j7xB-3e7wA:
undetectable		 4j7xB-3e7wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 LEU A  83
CYH A 129
PHE A  39
ALA A 108
GLY A 104
 None
None
None
None
FMN  A 700 ( 4.0A)
 1.24A 4j7xB-3eo7A:
undetectable		 4j7xB-3eo7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5o THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		5 LEU A  73
GLN A 109
ALA A 114
GLY A 139
LEU A 138
 None
None
None
COA  A 150 (-3.3A)
None
 1.18A 4j7xB-3f5oA:
undetectable		 4j7xB-3f5oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg9 PROTEIN OF UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		5 LEU A  84
PHE A  31
ALA A  38
GLY A  46
LEU A  45
 None
 1.30A 4j7xB-3fg9A:
3.2		 4j7xB-3fg9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ios DISULFIDE BOND
FORMING PROTEIN
(DSBF)

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A  50
PHE A 141
ALA A  54
GLY A 105
LEU A 130
 None
 1.26A 4j7xB-3iosA:
2.5		 4j7xB-3iosA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		5 TRP A  38
TYR A  56
ALA A  64
GLY A  25
LEU A  26
 None
 1.31A 4j7xB-3jtzA:
undetectable		 4j7xB-3jtzA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A 536
PRO A 630
MET A 604
GLY A 603
LEU A 652
 None
 1.14A 4j7xB-3k4xA:
undetectable		 4j7xB-3k4xA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A   2
PRO A  96
MET A  70
GLY A  69
LEU A 118
 None
 1.29A 4j7xB-3l10A:
undetectable		 4j7xB-3l10A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 SER A 612
LEU A 611
PHE A 609
TYR A 604
GLY A 360
 None
 1.20A 4j7xB-3ldrA:
undetectable		 4j7xB-3ldrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 LEU A 293
GLN A 283
ALA A 331
GLY A 301
LEU A 300
 None
None
None
EDO  A 412 (-3.5A)
None
 1.26A 4j7xB-3nfvA:
undetectable		 4j7xB-3nfvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		5 SER A 161
LEU A 159
PHE A 265
MET A 175
GLY A 176
 None
 1.25A 4j7xB-3oajA:
undetectable		 4j7xB-3oajA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oeb S-LAYER ASSOCIATED
MULTIDOMAIN
ENDOGLUCANASE

(Caldanaerobius
polysaccharolyticus) 		PF02018
(CBM_4_9) 		5 LEU A 124
PHE A  76
GLN A  21
ALA A  45
GLY A  41
 None
None
BMA  A 503 (-3.3A)
None
None
 1.15A 4j7xB-3oebA:
undetectable		 4j7xB-3oebA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 SER A  12
CYH A  74
PRO A  42
ALA A 118
GLY A 144
 DGL  A 266 (-2.8A)
DGL  A 266 ( 3.7A)
DGL  A 266 (-4.5A)
None
None
 0.98A 4j7xB-3outA:
undetectable		 4j7xB-3outA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 SER A 679
LEU A 640
ALA A 118
GLY A  66
LEU A 115
 None
 1.12A 4j7xB-3slkA:
17.2		 4j7xB-3slkA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 LEU B  31
ALA B  51
MET B  87
GLY B  85
LEU B  71
 None
 1.25A 4j7xB-3x17B:
undetectable		 4j7xB-3x17B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 SER A 430
LEU A 434
PHE A 379
GLN A 423
GLY A 376
 None
 1.30A 4j7xB-4bjuA:
undetectable		 4j7xB-4bjuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		5 SER A 182
LEU A 183
TYR A 178
GLY A 325
LEU A 326
 None
 1.19A 4j7xB-4h0oA:
2.7		 4j7xB-4h0oA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		5 SER A 227
CYH A 238
TYR A  17
MET A  62
LEU A  10
 None
 1.20A 4j7xB-4ha7A:
2.4		 4j7xB-4ha7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 PHE A 270
PRO A 287
GLN A 241
ALA A 239
GLY A 301
 None
 1.27A 4j7xB-4iqfA:
6.8		 4j7xB-4iqfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		5 SER A 222
LEU A 223
PHE A 236
TYR A 237
ALA A 242
 None
 1.25A 4j7xB-4iqlA:
undetectable		 4j7xB-4iqlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
PHE A 451
ALA A 443
MET A 321
LEU A 325
 None
 1.31A 4j7xB-4n1yA:
undetectable		 4j7xB-4n1yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noa TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILE

(Pseudomonas
aeruginosa) 		PF16732
(ComP_DUS) 		5 GLN A  47
ALA A  43
MET A  68
GLY A  67
LEU A  66
 None
 1.30A 4j7xB-4noaA:
undetectable		 4j7xB-4noaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		5 PHE A  31
TRP A  28
ALA A  64
GLY A  40
LEU A  76
 None
 1.25A 4j7xB-4q2bA:
undetectable		 4j7xB-4q2bA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A3583
PHE A3693
ALA A3572
GLY A3699
LEU A3698
 None
 1.30A 4j7xB-4rh7A:
undetectable		 4j7xB-4rh7A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 144
PHE A 186
TYR A 184
GLY A 115
LEU A 117
 None
 1.31A 4j7xB-4ri6A:
undetectable		 4j7xB-4ri6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl3 ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		5 LEU A  87
PHE A 213
GLN A  93
GLY A 220
LEU A 221
 None
 1.26A 4j7xB-4tl3A:
undetectable		 4j7xB-4tl3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		5 SER A 181
LEU A 148
CYH A 149
PRO A 204
GLY A 130
 None
None
None
PEG  A 504 ( 4.8A)
None
 1.12A 4j7xB-4u6bA:
undetectable		 4j7xB-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 LEU A 270
TYR A 425
PRO A 405
ALA A 182
GLY A 442
 None
 1.07A 4j7xB-4wj3A:
undetectable		 4j7xB-4wj3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		5 LEU A 123
CYH A 124
ALA A  80
GLY A 145
LEU A 143
 None
 1.21A 4j7xB-4yfmA:
undetectable		 4j7xB-4yfmA:
26.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		12 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
MET A 215
GLY A 218
LEU A 219
 4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
4KL  A 802 (-4.9A)
 0.47A 4j7xB-4z3kA:
45.2		 4j7xB-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		5 SER A 368
PRO A 234
MET A 316
GLY A 319
LEU A 320
 None
 0.64A 4j7xB-4zowA:
undetectable		 4j7xB-4zowA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		5 SER A 188
LEU A 115
PRO A 113
GLY A  88
LEU A  87
 None
 1.25A 4j7xB-4zr8A:
3.9		 4j7xB-4zr8A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		5 SER A 287
LEU A 286
PRO A 178
ALA A 232
GLY A 314
 None
None
PLP  A 401 ( 4.4A)
None
PLP  A 401 ( 4.0A)
 1.23A 4j7xB-5c3uA:
undetectable		 4j7xB-5c3uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		5 PHE A  52
TRP A  49
ALA A  84
GLY A  60
LEU A  96
 None
 1.19A 4j7xB-5cd2A:
undetectable		 4j7xB-5cd2A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 167
CYH A  20
ALA A  76
GLY A  87
LEU A  86
 None
 1.27A 4j7xB-5f07A:
undetectable		 4j7xB-5f07A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
CYH A 123
ALA A  79
GLY A 144
LEU A 142
 None
 1.17A 4j7xB-5gl9A:
undetectable		 4j7xB-5gl9A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h55 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 5 SER A 147
LEU A 136
PHE A 171
ALA A 176
LEU A 162
 None
 1.18A 4j7xB-5h55A:
undetectable		 4j7xB-5h55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 SER A 285
TYR A 264
GLN A 140
ALA A 142
GLY A 292
 None
None
None
None
PEP  A 502 (-3.2A)
 0.97A 4j7xB-5hucA:
undetectable		 4j7xB-5hucA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
CYH A 123
ALA A  79
GLY A 143
LEU A 142
 None
 1.31A 4j7xB-5hx9A:
undetectable		 4j7xB-5hx9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 LEU A 122
CYH A 123
ALA A  79
GLY A 144
LEU A 142
 None
 1.10A 4j7xB-5hx9A:
undetectable		 4j7xB-5hx9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 LEU A  99
CYH A 100
ALA A  56
GLY A 120
LEU A 119
 None
 1.28A 4j7xB-5ihvA:
undetectable		 4j7xB-5ihvA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 LEU A  99
CYH A 100
ALA A  56
GLY A 121
LEU A 119
 None
 1.07A 4j7xB-5ihvA:
undetectable		 4j7xB-5ihvA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 LEU A 234
PHE A 155
ALA A 169
GLY A 190
LEU A 189
 HEM  A 401 ( 4.4A)
None
None
2OH  A 402 ( 4.6A)
2OH  A 402 ( 4.3A)
 1.00A 4j7xB-5it1A:
undetectable		 4j7xB-5it1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 CYH A1586
GLN A1262
MET A1373
GLY A1308
LEU A1307
 None
 1.29A 4j7xB-5lcwA:
undetectable		 4j7xB-5lcwA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 SER A 146
CYH A 219
TYR A 214
GLY A 543
LEU A 542
 None
None
None
None
DMS  A 717 (-4.0A)
 1.13A 4j7xB-5myvA:
undetectable		 4j7xB-5myvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L5

(Mycolicibacterium
smegmatis) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 LEU F 107
PHE F 182
ALA F 179
GLY F 173
LEU F 176
 None
 1.28A 4j7xB-5o60F:
undetectable		 4j7xB-5o60F:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 SER A  80
CYH A  81
PHE A 178
MET A 146
LEU A 148
 GOL  A 300 (-2.8A)
GOL  A 300 ( 3.7A)
GOL  A 300 ( 4.9A)
None
None
 1.28A 4j7xB-5tdxA:
2.8		 4j7xB-5tdxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 SER A 258
TYR A 240
GLN A 112
ALA A 114
GLY A 265
 None
None
PEP  A 504 ( 4.8A)
None
PEP  A 504 (-3.3A)
 0.98A 4j7xB-5uxnA:
undetectable		 4j7xB-5uxnA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 PHE A 227
ALA A 277
MET A 262
GLY A 274
LEU A 275
 None
 1.15A 4j7xB-5w19A:
undetectable		 4j7xB-5w19A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 5 LEU A 465
PHE A 427
ALA A 446
GLY A 442
LEU A 441
 None
 1.19A 4j7xB-5ws4A:
undetectable		 4j7xB-5ws4A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgr SPIKE PROTEIN S1

(Pipistrellus
bat coronavirus
HKU5) 		PF09408
(Spike_rec_bind) 		5 LEU A   9
PHE A  38
TYR A  65
ALA A  67
LEU A 177
 None
 1.26A 4j7xB-5xgrA:
undetectable		 4j7xB-5xgrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 SER A 585
LEU A 584
PHE A 582
TYR A 577
GLY A 333
 None
 1.21A 4j7xB-5xh9A:
undetectable		 4j7xB-5xh9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8l -

(-) 		no annotation 5 LEU A  88
PHE A  50
TYR A  10
ALA A 129
LEU A   5
 None
 1.20A 4j7xB-6a8lA:
5.9		 4j7xB-6a8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 5 LEU A  58
PHE A  75
ALA A 357
GLY A  83
LEU A  80
 LOP  A 402 (-4.0A)
None
LOP  A 402 (-3.3A)
None
LOP  A 402 ( 4.4A)
 1.24A 4j7xB-6bqcA:
undetectable		 4j7xB-6bqcA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 122
GLN A  83
ALA A  79
GLY A 143
LEU A 142
 None
 1.16A 4j7xB-6bu3A:
undetectable		 4j7xB-6bu3A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 122
GLN A  83
ALA A  79
GLY A 144
LEU A 142
 None
 1.03A 4j7xB-6bu3A:
undetectable		 4j7xB-6bu3A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 SER A 155
LEU A 156
ALA A 227
GLY A 183
LEU A 184
 None
 1.27A 4j7xB-6c54A:
undetectable		 4j7xB-6c54A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 5 SER A  76
LEU A  75
ALA A 134
GLY A 105
LEU A 104
 None
 1.20A 4j7xB-6es9A:
undetectable		 4j7xB-6es9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 LEU A 214
PHE A 110
MET A 115
GLY A 117
LEU A 118
 None
HEM  A 501 ( 4.4A)
None
None
None
 1.24A 4j7xB-6gk6A:
undetectable		 4j7xB-6gk6A:
undetectable