SIMILAR PATTERNS OF AMINO ACIDS FOR 4J7U_D_YTZD802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 SER P 155
LEU P 152
PHE P 240
PRO P 231
 None
 1.01A 4j7uD-1cf2P:
4.9		 4j7uD-1cf2P:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		4 SER A  62
LEU A  59
PHE A  82
PRO A 100
 None
 1.21A 4j7uD-1d5yA:
undetectable		 4j7uD-1d5yA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.17A 4j7uD-1dbhA:
undetectable		 4j7uD-1dbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 SER A 123
LEU A 129
PHE A 159
GLN A 232
 None
 1.10A 4j7uD-1dy2A:
undetectable		 4j7uD-1dy2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A  94
CYH A  91
PHE A  60
GLN A  71
 None
 1.06A 4j7uD-1f80A:
undetectable		 4j7uD-1f80A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A 118
CYH A  25
PHE A 139
GLN A 134
 None
None
None
SGN  A 304 (-4.3A)
 1.06A 4j7uD-1fq9A:
undetectable		 4j7uD-1fq9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 SER A 401
LEU A 398
CYH A 427
PHE A 323
 None
 1.16A 4j7uD-1fuiA:
2.2		 4j7uD-1fuiA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A  34
CYH A  38
TYR A 144
PRO A 133
 None
 1.20A 4j7uD-1harA:
undetectable		 4j7uD-1harA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PHE A 271
TRP A 331
PRO A 227
GLN A 320
 None
 1.15A 4j7uD-1hkkA:
undetectable		 4j7uD-1hkkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koe ENDOSTATIN

(Mus musculus) 		PF06482
(Endostatin) 		4 SER A 182
LEU A 188
PHE A 218
GLN A 291
 None
 1.18A 4j7uD-1koeA:
undetectable		 4j7uD-1koeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		4 SER A  11
CYH A  20
PHE A 338
TYR A   7
 None
 1.21A 4j7uD-1ljyA:
undetectable		 4j7uD-1ljyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		4 SER D 428
LEU D 429
CYH D 426
PHE D 408
 None
 1.20A 4j7uD-1mtyD:
undetectable		 4j7uD-1mtyD:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		7 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
 OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
 0.29A 4j7uD-1oaaA:
42.1		 4j7uD-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqk FIBROBLAST GROWTH
FACTOR 7

(Rattus
norvegicus) 		PF00167
(FGF) 		4 LEU A 113
CYH A  17
PHE A 134
GLN A 129
 None
 1.11A 4j7uD-1qqkA:
undetectable		 4j7uD-1qqkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qql FIBROBLAST GROWTH
FACTOR 7/1 CHIMERA

(Homo sapiens;
Rattus
norvegicus) 		PF00167
(FGF) 		4 LEU A 111
CYH A  17
PHE A 132
GLN A 127
 None
 1.14A 4j7uD-1qqlA:
undetectable		 4j7uD-1qqlA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		4 LEU A 180
CYH A 181
PHE A  60
TYR A  68
 None
 0.93A 4j7uD-1tk9A:
3.9		 4j7uD-1tk9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxz CELLULASE B

(Cellvibrio
mixtus) 		PF03422
(CBM_6) 		4 SER A 105
LEU A 104
PHE A 111
PRO A  50
 None
 1.13A 4j7uD-1uxzA:
undetectable		 4j7uD-1uxzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 PHE A 250
TRP A 312
PRO A 206
GLN A 301
 None
 1.00A 4j7uD-1vf8A:
undetectable		 4j7uD-1vf8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PHE A 271
TRP A 333
PRO A 227
GLN A 322
 None
 1.09A 4j7uD-1wb0A:
undetectable		 4j7uD-1wb0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A1119
LEU A1120
PHE A1124
PRO A1343
 None
 1.09A 4j7uD-1wueA:
undetectable		 4j7uD-1wueA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.17A 4j7uD-1xdvA:
undetectable		 4j7uD-1xdvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 479
TYR A 532
PRO A 223
GLN A 218
 None
 1.21A 4j7uD-1xkhA:
undetectable		 4j7uD-1xkhA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 SER A 302
LEU A 299
PHE A 360
TYR A 294
 None
 1.10A 4j7uD-1yt8A:
undetectable		 4j7uD-1yt8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.16A 4j7uD-2ad1A:
undetectable		 4j7uD-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afg ACIDIC FIBROBLAST
GROWTH FACTOR

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A 111
CYH A  16
PHE A 132
GLN A 127
 None
 1.09A 4j7uD-2afgA:
undetectable		 4j7uD-2afgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN
INTERLEUKIN-2
RECEPTOR BETA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind)
no annotation 		4 LEU C 148
PHE C 199
PRO C 189
GLN B 164
 None
 1.01A 4j7uD-2b5iC:
undetectable		 4j7uD-2b5iC:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 SER A 772
LEU A 774
CYH A 732
PHE A 733
 None
 1.15A 4j7uD-2gv9A:
undetectable		 4j7uD-2gv9A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A  34
CYH A  38
TYR A 144
PRO A 133
 None
 1.09A 4j7uD-2hnzA:
undetectable		 4j7uD-2hnzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 SER A  73
LEU A  70
TYR A 160
PRO A  80
 None
 1.12A 4j7uD-2nq5A:
2.4		 4j7uD-2nq5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 LEU A 543
PHE A  85
TRP A  84
TYR A  88
 None
 1.09A 4j7uD-2qqpA:
undetectable		 4j7uD-2qqpA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 SER A 147
LEU A 148
CYH A 180
TYR A 199
 None
 1.20A 4j7uD-2x3hA:
undetectable		 4j7uD-2x3hA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 SER A  94
LEU A  95
PHE A 280
GLN A 205
 None
 1.21A 4j7uD-2xqwA:
undetectable		 4j7uD-2xqwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 433
PHE A 316
TRP A 319
PRO A 457
 None
 1.10A 4j7uD-2xu0A:
undetectable		 4j7uD-2xu0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 433
PHE A 316
TRP A 319
PRO A 457
 None
 1.17A 4j7uD-2yk0A:
undetectable		 4j7uD-2yk0A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU A 425
CYH A 426
TYR A 448
PRO A 421
 None
 1.12A 4j7uD-2ywgA:
2.4		 4j7uD-2ywgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		4 LEU A 130
CYH A 131
PHE A 111
TYR A  81
 None
 0.95A 4j7uD-2zsiA:
4.4		 4j7uD-2zsiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 SER A 299
LEU A 298
PHE A  34
TYR A 264
 None
 1.14A 4j7uD-3bjqA:
undetectable		 4j7uD-3bjqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		4 SER A 187
LEU A 185
CYH A 184
PHE A 106
 None
 0.98A 4j7uD-3cueA:
undetectable		 4j7uD-3cueA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		4 LEU A 137
CYH A 138
PHE A 118
TYR A  81
 None
 1.00A 4j7uD-3eblA:
3.9		 4j7uD-3eblA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 SER A 215
LEU A 214
PHE A 611
PRO A 190
 None
None
None
MD1  A1245 (-4.5A)
 1.11A 4j7uD-3egwA:
2.5		 4j7uD-3egwA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		4 LEU A  71
CYH A  67
PHE A  63
PRO A  28
 None
 1.20A 4j7uD-3h4yA:
undetectable		 4j7uD-3h4yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 SER A 213
LEU A 212
PHE A 204
TYR A 251
 None
 0.92A 4j7uD-3hq2A:
undetectable		 4j7uD-3hq2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 241
CYH A 311
PHE A 368
GLN A 100
 None
 0.82A 4j7uD-3iiwA:
undetectable		 4j7uD-3iiwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		4 SER A 120
LEU A 132
PHE A 134
TRP A 142
 None
 1.22A 4j7uD-3k2nA:
undetectable		 4j7uD-3k2nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.22A 4j7uD-3ksyA:
undetectable		 4j7uD-3ksyA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		4 LEU A  49
PHE A 124
PRO A  51
GLN A  67
 FAD  A1000 ( 4.5A)
FAD  A1000 (-4.9A)
None
None
 1.18A 4j7uD-3lzxA:
3.1		 4j7uD-3lzxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 SER A-275
PHE A  24
PRO A-300
GLN A-299
 None
 1.20A 4j7uD-3n94A:
undetectable		 4j7uD-3n94A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc9 UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Entamoeba
histolytica) 		PF01704
(UDPGP) 		4 LEU A  56
TRP A 350
TYR A 351
GLN A 401
 None
 1.21A 4j7uD-3oc9A:
2.0		 4j7uD-3oc9A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t20 CIS-ACONITATE PORIN
OPDH

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 SER A 116
LEU A 114
PRO A 119
GLN A 127
 None
 1.22A 4j7uD-3t20A:
undetectable		 4j7uD-3t20A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		4 SER A 290
LEU A 286
PHE A 317
TYR A 310
 None
 1.17A 4j7uD-3tqgA:
undetectable		 4j7uD-3tqgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		4 LEU A 316
PHE A 243
TRP A 264
GLN A 387
 None
 1.21A 4j7uD-3ty1A:
undetectable		 4j7uD-3ty1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 LEU A 161
TRP A 179
TYR A 189
PRO A  55
 None
 0.90A 4j7uD-3ufgA:
undetectable		 4j7uD-3ufgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwv PEROXIREDOXIN-4

(Mus musculus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 180
PHE A 116
TYR A 119
PRO A 178
 None
 1.02A 4j7uD-3vwvA:
undetectable		 4j7uD-3vwvA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PHE A 273
TRP A 333
PRO A 229
GLN A 322
 None
 1.00A 4j7uD-4ay1A:
2.2		 4j7uD-4ay1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 LEU A 281
PHE A 282
TRP A 314
PRO A 273
 None
 1.22A 4j7uD-4b8bA:
undetectable		 4j7uD-4b8bA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 233
LEU A 234
PHE A 257
TYR A 229
 None
 1.00A 4j7uD-4b9dA:
undetectable		 4j7uD-4b9dA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A 566
PHE A 533
TYR A 537
PRO A 562
 PG4  A1833 (-4.2A)
None
None
EDO  A1831 (-4.0A)
 1.21A 4j7uD-4b9yA:
2.0		 4j7uD-4b9yA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ca9 39 KDA FK506-BINDING
NUCLEAR PROTEIN

(Drosophila
melanogaster) 		no annotation 4 SER A  30
LEU A  88
PHE A   8
TYR A  90
 None
 0.98A 4j7uD-4ca9A:
undetectable		 4j7uD-4ca9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f07 STYRENE
MONOOXYGENASE
COMPONENT 2

(Pseudomonas sp.
Y2) 		PF01613
(Flavin_Reduct) 		4 SER A  79
LEU A 114
PHE A  92
PRO A 112
 None
 1.19A 4j7uD-4f07A:
undetectable		 4j7uD-4f07A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 SER A 118
LEU A 117
CYH A 159
PRO A 113
 None
 1.10A 4j7uD-4fioA:
undetectable		 4j7uD-4fioA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 SER A  75
TRP A 193
TYR A 202
GLN A 170
 None
 1.22A 4j7uD-4fn5A:
undetectable		 4j7uD-4fn5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA

(Mus musculus) 		PF14586
(MHC_I_2) 		4 LEU A  68
CYH A  69
TYR A  22
PRO A  64
 None
 1.05A 4j7uD-4g59A:
undetectable		 4j7uD-4g59A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		4 SER A 227
CYH A 238
TYR A  17
GLN A  12
 None
 1.08A 4j7uD-4ha7A:
undetectable		 4j7uD-4ha7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 SER A 222
LEU A 223
PHE A 236
TYR A 237
 None
 1.04A 4j7uD-4iqlA:
undetectable		 4j7uD-4iqlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 LEU A   4
CYH A  19
TYR A  17
GLN A 176
 None
 1.22A 4j7uD-4l9aA:
4.3		 4j7uD-4l9aA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 SER A  99
CYH A  49
PHE A  78
TRP A  91
 None
 1.22A 4j7uD-4nzmA:
3.1		 4j7uD-4nzmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 SER A 420
LEU A 421
TYR A 136
PRO A 425
 None
 1.21A 4j7uD-4ohtA:
4.9		 4j7uD-4ohtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		4 LEU A 450
CYH A 451
PHE A 414
PRO A 443
 None
 1.19A 4j7uD-4pmwA:
undetectable		 4j7uD-4pmwA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp8 RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-BETA

(Mus musculus) 		PF14586
(MHC_I_2) 		4 LEU C  68
CYH C  69
TYR C  22
PRO C  64
 None
 1.06A 4j7uD-4pp8C:
undetectable		 4j7uD-4pp8C:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B 577
PHE B 625
PRO B 589
GLN B 591
 None
 1.16A 4j7uD-4qkoB:
undetectable		 4j7uD-4qkoB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 SER A 265
CYH A 267
TYR A 261
PRO A 292
 None
 1.19A 4j7uD-4rgjA:
undetectable		 4j7uD-4rgjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 SER A 181
LEU A 148
CYH A 149
PRO A 204
 None
None
None
PEG  A 504 ( 4.8A)
 1.07A 4j7uD-4u6bA:
undetectable		 4j7uD-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		4 LEU A 529
PHE A 196
TYR A 195
GLN A 445
 None
 1.16A 4j7uD-4wisA:
undetectable		 4j7uD-4wisA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 LEU A 402
PHE A 339
PRO A 351
GLN A 350
 None
 1.17A 4j7uD-4xniA:
undetectable		 4j7uD-4xniA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 SER A 144
LEU A 145
TYR A 158
PRO A 190
 NAI  A 500 (-2.6A)
None
NAI  A 500 (-4.4A)
NAI  A 500 (-4.0A)
 0.89A 4j7uD-4yaiA:
22.8		 4j7uD-4yaiA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		8 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
 4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
 0.32A 4j7uD-4z3kA:
45.3		 4j7uD-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 SER A 766
PHE A 732
TRP A 735
TYR A 739
 None
 1.10A 4j7uD-4zm6A:
5.3		 4j7uD-4zm6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 SER A  34
CYH A 162
PHE W 339
TRP A 158
 None
 1.12A 4j7uD-4zxcA:
undetectable		 4j7uD-4zxcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		4 LEU E  90
TRP E 103
TYR E 108
PRO E  76
 None
 1.13A 4j7uD-5b04E:
2.4		 4j7uD-5b04E:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		4 CYH A 165
PHE A 190
PRO A 197
GLN A  24
 None
 1.01A 4j7uD-5b5sA:
2.4		 4j7uD-5b5sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 249
CYH A  31
TYR A  30
GLN A 213
 None
None
None
4UW  A 600 ( 4.7A)
 0.91A 4j7uD-5bswA:
3.5		 4j7uD-5bswA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE

(Colwellia
psychrerythraea) 		PF13580
(SIS_2) 		4 LEU A 182
CYH A 183
PHE A  59
TYR A  67
 None
 1.00A 4j7uD-5by2A:
3.9		 4j7uD-5by2A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 LEU A  88
PHE A 198
TRP A 205
PRO A  84
 None
 1.12A 4j7uD-5dajA:
undetectable		 4j7uD-5dajA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 SER A 495
LEU A 468
PHE A 489
TYR A 592
 None
 1.18A 4j7uD-5e9aA:
undetectable		 4j7uD-5e9aA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1

(Homo sapiens) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		4 SER A  89
LEU A  90
PHE A  64
TYR A 125
 None
 1.04A 4j7uD-5f4eA:
undetectable		 4j7uD-5f4eA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		4 LEU A 161
TRP A 179
TYR A 185
PRO A  55
 None
 1.02A 4j7uD-5f5wA:
undetectable		 4j7uD-5f5wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE

(Mangifera
indica) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 SER A 133
LEU A 134
PHE A 163
TYR A 102
 None
 1.15A 4j7uD-5g5fA:
undetectable		 4j7uD-5g5fA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 SER A 470
LEU A 460
PHE A 478
TYR A 487
 None
 1.18A 4j7uD-5h4eA:
undetectable		 4j7uD-5h4eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER A  85
LEU A  84
TRP A  81
GLN A  38
 None
 1.07A 4j7uD-5ijbA:
undetectable		 4j7uD-5ijbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6p KINETOCHORE PROTEIN
MIS18

(Schizosaccharomyces
pombe) 		no annotation 4 SER B  67
LEU B  71
CYH B  72
TYR B  90
 None
 0.93A 4j7uD-5j6pB:
undetectable		 4j7uD-5j6pB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		4 LEU A  98
PHE A  93
TRP A 115
PRO A 109
 None
 1.19A 4j7uD-5jijA:
4.0		 4j7uD-5jijA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 SER B  68
PHE B  36
PRO B  42
GLN B 287
 None
 1.07A 4j7uD-5mkkB:
undetectable		 4j7uD-5mkkB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 128
TYR A  41
PRO A 131
GLN A 481
 None
 1.14A 4j7uD-5necA:
undetectable		 4j7uD-5necA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 LEU A  12
PHE A  14
PRO A 199
GLN A 207
 None
 1.19A 4j7uD-5nywA:
undetectable		 4j7uD-5nywA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 SER T 942
LEU T 932
PHE T2846
PRO T 934
 None
 1.16A 4j7uD-5ojsT:
undetectable		 4j7uD-5ojsT:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 LEU 5 187
CYH 5 188
PHE 5 411
TYR 5 418
 None
 1.22A 4j7uD-5ool5:
undetectable		 4j7uD-5ool5:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 489
CYH A 490
PHE A 359
TYR A 529
 None
 0.86A 4j7uD-5wmbA:
undetectable		 4j7uD-5wmbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 PHE A 774
TRP A 837
PRO A 730
GLN A 826
 None
 0.92A 4j7uD-5wvgA:
undetectable		 4j7uD-5wvgA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 LEU K 548
CYH K 549
PHE K 512
PRO K 541
 None
 1.13A 4j7uD-6d6qK:
undetectable		 4j7uD-6d6qK:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 4 LEU A  97
PHE A 118
TYR A 119
PRO A  66
 None
 1.19A 4j7uD-6ekvA:
undetectable		 4j7uD-6ekvA:
15.63