SIMILAR PATTERNS OF AMINO ACIDS FOR 4J7U_A_YTZA802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1oaa	SEPIAPTERIN REDUCTASE (Mus musculus)	PF00106 (adh_short)	8	SER A 158 LEU A 159 CYH A 160 TRP A 168 TYR A 171 PRO A 201 MET A 206 GLN A 207	OAA A 1 (-2.5A) None OAA A 1 ( 3.9A) None OAA A 1 ( 4.3A) None OAA A 1 ( 3.5A) OAA A 1 ( 3.6A)	0.29A	4j7uA-1oaaA: 42.0	4j7uA-1oaaA: 72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ad1	SULFOTRANSFERASE 1C2 (Homo sapiens)	PF00685 (Sulfotransfer_1)	5	LEU A 164 PHE A 160 TRP A 156 TYR A 159 PRO A 133	None	1.14A	4j7uA-2ad1A: 2.0	4j7uA-2ad1A: 21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	PF00106 (adh_short)	10	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 MET A 215	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) None	0.58A	4j7uA-4z3kA: 45.3	4j7uA-4z3kA: 94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mkk	MULTIDRUG RESISTANCE ABC TRANSPORTER ATP-BINDING AND PERMEASE PROTEIN (Thermus thermophilus)	PF00005 (ABC_tran) PF00664 (ABC_membrane)	5	SER B 68 LEU B 40 PHE B 36 PRO B 42 GLN B 287	None	1.26A	4j7uA-5mkkB: 0.3	4j7uA-5mkkB: 21.53

[["4J7U_A_YTZA802_1","1oaa","Mus musculus","SEPIAPTERIN REDUCTASE","PF00106(adh_short)",8,"SER A 158;LEU A 159;CYH A 160;TRP A 168;TYR A 171;PRO A 201;MET A 206;GLN A 207","OAA A   1 (-2.5A);None;OAA A   1 ( 3.9A);None;OAA A   1 ( 4.3A);None;OAA A   1 ( 3.5A);OAA A   1 ( 3.6A)","0.29A","4j7uA-1oaaA:42.0","4j7uA-1oaaA:72.01"],["4J7U_A_YTZA802_1","2ad1","Homo sapiens","SULFOTRANSFERASE 1C2","PF00685(Sulfotransfer_1)",5,"LEU A 164;PHE A 160;TRP A 156;TYR A 159;PRO A 133","None","1.14A","4j7uA-2ad1A:2.0","4j7uA-2ad1A:21.08"],["4J7U_A_YTZA802_1","4z3k","Homo sapiens","SEPIAPTERIN REDUCTASE","PF00106(adh_short)",10,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;MET A 215","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);None","0.58A","4j7uA-4z3kA:45.3","4j7uA-4z3kA:94.44"],["4J7U_A_YTZA802_1","5mkk","Thermus thermophilus","MULTIDRUG RESISTANCE ABC TRANSPORTER ATP-BINDING AND PERMEASE PROTEIN","PF00005(ABC_tran);PF00664(ABC_membrane)",5,"SER B  68;LEU B  40;PHE B  36;PRO B  42;GLN B 287","None","1.26A","4j7uA-5mkkB:0.3","4j7uA-5mkkB:21.53"]]