SIMILAR PATTERNS OF AMINO ACIDS FOR 4J6D_B_TESB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 PHE A 274
PHE A 275
ALA A 258
ALA A 259
LEU A 146
 None
 1.07A 4j6dB-1c7jA:
0.0		 4j6dB-1c7jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.07A 4j6dB-1c8uA:
undetectable		 4j6dB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.11A 4j6dB-1ewkA:
0.0		 4j6dB-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLN A  87
ALA A  88
ALA A 114
VAL A 122
LEU A 138
 None
 1.10A 4j6dB-1f0kA:
undetectable		 4j6dB-1f0kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 ALA A 459
ALA A 266
ALA A 267
VAL A 363
LEU A 365
 None
 1.02A 4j6dB-1fc9A:
0.0		 4j6dB-1fc9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN

(Escherichia
coli) 		PF12804
(NTP_transf_3) 		6 PHE A 171
PHE A 178
ALA A 136
THR A 102
VAL A  39
LEU A  43
 None
 1.47A 4j6dB-1fr9A:
0.0		 4j6dB-1fr9A:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		6 PHE A 177
PHE A 178
GLN A 237
ALA A 241
ALA A 242
THR A 246
 None
None
None
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 1.26A 4j6dB-1gwiA:
52.9		 4j6dB-1gwiA:
51.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 ALA A 387
ALA A 390
ALA A 391
VAL A   3
LEU A   5
 None
 1.10A 4j6dB-1iirA:
undetectable		 4j6dB-1iirA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 425
ALA A 239
VAL A 312
LEU A 337
GLN A 310
 None
 1.09A 4j6dB-1iyxA:
0.5		 4j6dB-1iyxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 252
ALA A 254
ALA A 255
VAL A 208
GLN A 206
 None
 1.10A 4j6dB-1mroA:
undetectable		 4j6dB-1mroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 MET A 235
ALA A 252
ALA A 254
ALA A 255
GLN A 206
 None
 1.12A 4j6dB-1mroA:
undetectable		 4j6dB-1mroA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.87A 4j6dB-1odoA:
54.2		 4j6dB-1odoA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4j6dB-1smkA:
undetectable		 4j6dB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 MET A  19
ALA A  48
ALA A  51
ALA A  52
THR A  56
 None
 1.12A 4j6dB-1svdA:
undetectable		 4j6dB-1svdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.02A 4j6dB-1ulqA:
undetectable		 4j6dB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 ALA A 540
ALA A 480
ALA A 506
THR A 509
LEU A 379
 None
 1.09A 4j6dB-1un9A:
undetectable		 4j6dB-1un9A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb7 PDZ AND LIM DOMAIN 2

(Mus musculus) 		PF00595
(PDZ) 		5 GLN A  60
ALA A  56
ALA A  62
VAL A  34
LEU A  48
 None
 1.13A 4j6dB-1vb7A:
undetectable		 4j6dB-1vb7A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ALA A  59
ALA A  60
ALA A  61
THR A 331
LEU A 344
 None
 1.05A 4j6dB-1w5dA:
undetectable		 4j6dB-1w5dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.08A 4j6dB-2a0uA:
undetectable		 4j6dB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		5 PHE A 360
PHE A 356
ALA A 377
ALA A 380
LEU A 194
 None
 1.12A 4j6dB-2b3bA:
undetectable		 4j6dB-2b3bA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		6 GLN A 347
ALA A 328
ALA A 310
ALA A 309
THR A 306
LEU A 267
 None
 1.46A 4j6dB-2bmoA:
undetectable		 4j6dB-2bmoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 326
PHE A 337
ALA A 329
ALA A 331
VAL A 257
 None
 1.03A 4j6dB-2bvgA:
undetectable		 4j6dB-2bvgA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN C 382
ALA C 277
ALA C 275
VAL C 387
LEU C 373
 None
 1.05A 4j6dB-2d3tC:
undetectable		 4j6dB-2d3tC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.90A 4j6dB-2gcaA:
undetectable		 4j6dB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		5 GLN A 327
ALA A 326
ALA A 324
THR A 322
VAL A 276
 None
 1.09A 4j6dB-2grvA:
undetectable		 4j6dB-2grvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.02A 4j6dB-2hg4A:
undetectable		 4j6dB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.12A 4j6dB-2nztA:
undetectable		 4j6dB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhs LIPOYLTRANSFERASE

(Thermus
thermophilus) 		PF03099
(BPL_LplA_LipB) 		5 PHE A 102
PHE A  93
ALA A 109
VAL A   5
LEU A  38
 None
 1.11A 4j6dB-2qhsA:
undetectable		 4j6dB-2qhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA X 259
ALA X 261
ALA X 262
VAL X 240
LEU X 248
 None
 1.05A 4j6dB-2qvxX:
undetectable		 4j6dB-2qvxX:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA

(Bacillus
subtilis) 		PF00403
(HMA) 		5 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.11A 4j6dB-2rmlA:
undetectable		 4j6dB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.09A 4j6dB-2vrcA:
undetectable		 4j6dB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjk AFP

(Microbacterium
arborescens) 		PF00210
(Ferritin) 		5 ALA A  15
ALA A  18
ALA A  19
THR A  23
VAL A  26
 None
 1.09A 4j6dB-2yjkA:
undetectable		 4j6dB-2yjkA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 1.00A 4j6dB-2zbzA:
46.3		 4j6dB-2zbzA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		5 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.13A 4j6dB-3bkxA:
undetectable		 4j6dB-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		5 PHE A 501
GLN A 558
ALA A 557
ALA A 554
ALA A 553
 None
 1.05A 4j6dB-3cioA:
undetectable		 4j6dB-3cioA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.01A 4j6dB-3d8kA:
undetectable		 4j6dB-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 ALA A  83
ALA A  87
ALA A  86
VAL A  93
LEU A  18
 None
 1.01A 4j6dB-3da8A:
undetectable		 4j6dB-3da8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 GLN A 481
ALA A 480
ALA A 482
ALA A 483
LEU A 449
 None
 1.00A 4j6dB-3e1sA:
undetectable		 4j6dB-3e1sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		5 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.07A 4j6dB-3fa3A:
undetectable		 4j6dB-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 ALA A  34
ALA A  37
ALA A  36
VAL A  71
LEU A  76
 None
 1.07A 4j6dB-3h7uA:
undetectable		 4j6dB-3h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 PHE A 289
ALA A 269
ALA A 265
THR A 261
VAL A 257
 None
 1.12A 4j6dB-3hjlA:
undetectable		 4j6dB-3hjlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.11A 4j6dB-3hm8A:
undetectable		 4j6dB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 461
ALA A 464
ALA A 465
VAL A  64
LEU A  61
 None
 0.96A 4j6dB-3i8bA:
undetectable		 4j6dB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A  33
ALA A  54
ALA A  58
VAL A  64
LEU A  67
 None
 1.10A 4j6dB-3i8bA:
undetectable		 4j6dB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 ALA A  50
ALA A  53
ALA A  52
VAL A  66
LEU A 118
 None
 1.14A 4j6dB-3kxwA:
undetectable		 4j6dB-3kxwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		5 MET A 488
PHE A 475
ALA A 351
ALA A 353
ALA A 354
 None
 1.12A 4j6dB-3l19A:
undetectable		 4j6dB-3l19A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 ALA A 159
ALA A 162
ALA A 163
THR A 443
LEU A 449
 None
 1.09A 4j6dB-3lnpA:
undetectable		 4j6dB-3lnpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 ALA A 324
ALA A 327
ALA A 326
VAL A 287
LEU A 305
 None
 1.11A 4j6dB-3nf2A:
undetectable		 4j6dB-3nf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.04A 4j6dB-3nraA:
undetectable		 4j6dB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		5 ALA A 216
ALA A 219
ALA A 220
VAL A 327
LEU A 285
 None
 1.02A 4j6dB-3ox4A:
undetectable		 4j6dB-3ox4A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ALA A 231
ALA A 234
ALA A 235
THR A 239
LEU A  33
 None
 1.12A 4j6dB-3ppiA:
undetectable		 4j6dB-3ppiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.90A 4j6dB-3r9uA:
undetectable		 4j6dB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.09A 4j6dB-3rd7A:
undetectable		 4j6dB-3rd7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		5 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.12A 4j6dB-3ro8A:
undetectable		 4j6dB-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 247
ALA A 249
ALA A 250
LEU A 200
GLN A 204
 None
 0.99A 4j6dB-3snxA:
undetectable		 4j6dB-3snxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 GLN B 311
ALA B 312
ALA B 315
ALA B 316
VAL B  30
 None
 1.12A 4j6dB-3vrdB:
undetectable		 4j6dB-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		5 ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.07A 4j6dB-3vwoA:
undetectable		 4j6dB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		5 GLN A 169
ALA A 168
ALA A 164
VAL A 157
LEU A 304
 None
 0.91A 4j6dB-3vwoA:
undetectable		 4j6dB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		5 PHE A  11
ALA A  24
ALA A  28
ALA A  26
VAL A  36
 None
 1.04A 4j6dB-3w0dA:
undetectable		 4j6dB-3w0dA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 ALA A 108
ALA A 112
ALA A 111
VAL A  85
LEU A  88
 None
 1.09A 4j6dB-3zvtA:
undetectable		 4j6dB-3zvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.12A 4j6dB-4a3rA:
undetectable		 4j6dB-4a3rA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		5 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4j6dB-4a6uA:
undetectable		 4j6dB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A  35
ALA A  39
THR A  66
VAL A  68
LEU A  45
 None
 1.04A 4j6dB-4egfA:
undetectable		 4j6dB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.07A 4j6dB-4f9oA:
undetectable		 4j6dB-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hg2 METHYLTRANSFERASE
TYPE 11

(Anaeromyxobacter
dehalogenans) 		PF08241
(Methyltransf_11) 		5 PHE A 109
PHE A 114
ALA A 100
VAL A 121
LEU A  92
 None
 1.08A 4j6dB-4hg2A:
undetectable		 4j6dB-4hg2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 ALA A 314
ALA A 317
ALA A 316
THR A 354
LEU A 327
 None
 1.10A 4j6dB-4hh1A:
undetectable		 4j6dB-4hh1A:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		12 MET A  84
PHE A  92
PHE A 179
PHE A 180
GLN A 239
ALA A 240
ALA A 243
ALA A 244
THR A 248
VAL A 291
LEU A 294
GLN A 398
 STR  A 501 (-4.3A)
STR  A 501 (-4.0A)
STR  A 501 (-4.0A)
None
STR  A 501 ( 4.5A)
STR  A 501 (-3.6A)
STR  A 501 ( 3.7A)
HEM  A 502 (-3.2A)
HEM  A 502 ( 3.4A)
STR  A 501 (-4.5A)
HEM  A 502 ( 4.0A)
STR  A 501 (-3.1A)
 0.32A 4j6dB-4j6cA:
70.2		 4j6dB-4j6cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		5 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.13A 4j6dB-4k1oA:
undetectable		 4j6dB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb8 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16140
(DUF4848) 		6 PHE A 264
PHE A 216
ALA A 265
ALA A 235
VAL A 308
LEU A 239
 None
 1.43A 4j6dB-4lb8A:
undetectable		 4j6dB-4lb8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		6 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.46A 4j6dB-4lomA:
undetectable		 4j6dB-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		5 PHE A 116
ALA A 310
ALA A 313
ALA A 314
THR A 318
 None
 1.06A 4j6dB-4m88A:
undetectable		 4j6dB-4m88A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.08A 4j6dB-4mksA:
undetectable		 4j6dB-4mksA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.01A 4j6dB-4qfwA:
undetectable		 4j6dB-4qfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.03A 4j6dB-4qs9A:
undetectable		 4j6dB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.10A 4j6dB-4u4eA:
undetectable		 4j6dB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 163
ALA A 166
ALA A 165
VAL A  69
LEU A 194
 None
 1.10A 4j6dB-4yweA:
undetectable		 4j6dB-4yweA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		6 ALA A 278
ALA A 556
ALA A 559
THR A 562
VAL A 257
LEU A 259
 None
 1.45A 4j6dB-5aeeA:
undetectable		 4j6dB-5aeeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		5 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.09A 4j6dB-5ahoA:
undetectable		 4j6dB-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		6 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.46A 4j6dB-5cjuA:
undetectable		 4j6dB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLN A 288
ALA A 289
ALA A 292
ALA A 293
VAL A 567
 None
 1.08A 4j6dB-5cxwA:
undetectable		 4j6dB-5cxwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.96A 4j6dB-5dj4A:
undetectable		 4j6dB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 PHE A 504
ALA A 507
ALA A 470
VAL A 458
LEU A 435
 None
 1.09A 4j6dB-5dseA:
undetectable		 4j6dB-5dseA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		5 GLN A 319
ALA A 323
ALA A 326
VAL A 344
LEU A 121
 None
 1.04A 4j6dB-5dvjA:
undetectable		 4j6dB-5dvjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.89A 4j6dB-5ek8A:
undetectable		 4j6dB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		5 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.08A 4j6dB-5ey5A:
undetectable		 4j6dB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
 MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
 1.13A 4j6dB-5ez3A:
undetectable		 4j6dB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE B 514
ALA B 464
ALA B 488
ALA B 462
LEU B 472
 None
 1.07A 4j6dB-5gqrB:
undetectable		 4j6dB-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 PHE A  77
ALA A 121
ALA A 124
ALA A 125
GLN A  26
 None
 0.93A 4j6dB-5hdjA:
undetectable		 4j6dB-5hdjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.04A 4j6dB-5heiA:
undetectable		 4j6dB-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.05A 4j6dB-5jjpA:
undetectable		 4j6dB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 5 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.02A 4j6dB-5lfdA:
undetectable		 4j6dB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
 None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
 1.08A 4j6dB-5lunA:
undetectable		 4j6dB-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.94A 4j6dB-5lx8A:
undetectable		 4j6dB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.11A 4j6dB-5muxA:
undetectable		 4j6dB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 5 PHE A 278
ALA A 382
ALA A 383
LEU A 428
GLN A 347
 None
 1.08A 4j6dB-5nqaA:
undetectable		 4j6dB-5nqaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaz DNA PRIMASE

(Pseudomonas
aeruginosa) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13662
(Toprim_4) 		5 MET A 415
PHE A 377
PHE A 376
ALA A 399
ALA A 400
 None
 1.09A 4j6dB-5vazA:
undetectable		 4j6dB-5vazA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		5 PHE A 336
PHE A 382
GLN A 312
ALA A 311
LEU A 351
 None
 1.11A 4j6dB-5vprA:
undetectable		 4j6dB-5vprA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		5 PHE D 128
PHE D 129
ALA D 220
ALA D 218
ALA D 217
 None
 1.11A 4j6dB-5xfaD:
undetectable		 4j6dB-5xfaD:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 GLN A 345
ALA A 346
ALA A 350
VAL A 295
LEU A 292
 None
 1.11A 4j6dB-6bfiA:
undetectable		 4j6dB-6bfiA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.10A 4j6dB-6chjA:
undetectable		 4j6dB-6chjA:
12.41