SIMILAR PATTERNS OF AMINO ACIDS FOR 4J6C_B_STRB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius)
PF00161
(RIP)
5 ALA A 165
ALA A 166
ALA A 163
VAL A  66
LEU A  56
None
1.19A 4j6cB-1abrA:
0.0
4j6cB-1abrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica)
PF01112
(Asparaginase_2)
5 GLN B 230
ALA B 231
THR B 215
VAL B 193
LEU B 164
None
1.18A 4j6cB-1ayyB:
undetectable
4j6cB-1ayyB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II


(Escherichia
coli)
PF13622
(4HBT_3)
5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
None
1.03A 4j6cB-1c8uA:
0.0
4j6cB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE


(Vibrio harveyi)
PF00171
(Aldedh)
5 GLN A  34
ALA A  35
ALA A  38
ALA A  39
LEU A 192
None
1.03A 4j6cB-1eyyA:
0.0
4j6cB-1eyyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 TRANSLOCATED INTIMIN
RECEPTOR


(Escherichia
coli)
PF03549
(Tir_receptor_M)
5 GLN T 273
ALA T 274
ALA T 277
ALA T 278
THR T 282
None
0.77A 4j6cB-1f02T:
undetectable
4j6cB-1f02T:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE


(Escherichia
coli)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
5 GLN A  87
ALA A  88
ALA A 114
VAL A 122
LEU A 138
None
1.09A 4j6cB-1f0kA:
0.0
4j6cB-1f0kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE


(Tetradesmus
obliquus)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2)
5 ALA A 459
ALA A 266
ALA A 267
VAL A 363
LEU A 365
None
1.09A 4j6cB-1fc9A:
0.0
4j6cB-1fc9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
5 ALA A 252
ALA A 254
ALA A 255
VAL A 208
GLN A 206
None
1.11A 4j6cB-1mroA:
0.0
4j6cB-1mroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
5 MET A 235
ALA A 252
ALA A 254
ALA A 255
GLN A 206
None
1.14A 4j6cB-1mroA:
0.0
4j6cB-1mroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1


(Bos taurus)
PF00153
(Mito_carr)
5 GLN A  84
ALA A  18
ALA A  19
THR A  23
LEU A  74
CXT  A 401 ( 4.5A)
None
None
CDL  A 800 ( 4.1A)
CDL  A 800 ( 3.9A)
1.18A 4j6cB-1okcA:
3.8
4j6cB-1okcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL


(Citrullus
lanatus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
None
0.93A 4j6cB-1smkA:
undetectable
4j6cB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Halothiobacillus
neapolitanus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 MET A  19
ALA A  48
ALA A  51
ALA A  52
THR A  56
None
1.15A 4j6cB-1svdA:
undetectable
4j6cB-1svdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Escherichia
coli)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 ALA A 333
ALA A 336
ALA A 337
THR A 341
VAL A 392
None
1.09A 4j6cB-1t1sA:
undetectable
4j6cB-1t1sA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
None
1.14A 4j6cB-1ulqA:
undetectable
4j6cB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE


(Citrobacter
freundii)
PF02733
(Dak1)
PF02734
(Dak2)
5 ALA A 540
ALA A 480
ALA A 506
THR A 509
LEU A 379
None
1.16A 4j6cB-1un9A:
undetectable
4j6cB-1un9A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1)
PF00693
(Herpes_TK)
5 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
None
1.07A 4j6cB-1vtkA:
undetectable
4j6cB-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN


(Bacillus
subtilis)
PF02113
(Peptidase_S13)
5 ALA A  59
ALA A  60
ALA A  61
THR A 331
LEU A 344
None
1.08A 4j6cB-1w5dA:
undetectable
4j6cB-1w5dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
5 ALA A 224
ALA A 226
ALA A 221
VAL A 202
LEU A 181
None
1.15A 4j6cB-1wytA:
undetectable
4j6cB-1wytA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND


(Bacillus
subtilis)
PF00881
(Nitroreductase)
5 ALA A 121
ALA A 124
ALA A 125
VAL A  22
GLN A  26
None
1.16A 4j6cB-1zchA:
undetectable
4j6cB-1zchA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major)
PF01008
(IF-2B)
5 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
None
1.19A 4j6cB-2a0uA:
undetectable
4j6cB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Mycobacterium
tuberculosis)
PF00885
(DMRL_synthase)
5 GLN A 141
ALA A 142
ALA A 145
ALA A 146
LEU A 101
None
1.12A 4j6cB-2c94A:
undetectable
4j6cB-2c94A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE


(Pseudomonas
fragi)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 GLN C 382
ALA C 277
ALA C 275
VAL C 387
LEU C 373
None
1.11A 4j6cB-2d3tC:
undetectable
4j6cB-2d3tC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE


(Acidithiobacillus
thiooxidans)
PF00180
(Iso_dh)
5 GLN A 387
ALA A 388
ALA A 391
ALA A 392
THR A 396
None
0.82A 4j6cB-2d4vA:
undetectable
4j6cB-2d4vA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 MET A 237
ALA A 241
ALA A 298
THR A 296
VAL A 292
None
1.20A 4j6cB-2g04A:
undetectable
4j6cB-2g04A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE


(Lactobacillus
casei)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
None
0.87A 4j6cB-2gcaA:
undetectable
4j6cB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis)
PF00496
(SBP_bac_5)
5 GLN A 327
ALA A 326
ALA A 324
THR A 322
VAL A 276
None
1.14A 4j6cB-2grvA:
undetectable
4j6cB-2grvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc)
5 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
None
1.09A 4j6cB-2hg4A:
undetectable
4j6cB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
None
0.92A 4j6cB-2nlxA:
undetectable
4j6cB-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
None
1.15A 4j6cB-2nztA:
undetectable
4j6cB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA


(Bacillus
subtilis)
PF00403
(HMA)
5 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
None
1.14A 4j6cB-2rmlA:
undetectable
4j6cB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE


(Citrobacter sp.
MY-5)
PF05368
(NmrA)
5 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
None
1.09A 4j6cB-2vrcA:
undetectable
4j6cB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum)
PF00245
(Alk_phosphatase)
5 GLN A 186
ALA A 171
ALA A 174
ALA A 175
VAL A 146
None
PO4  A1474 ( 4.9A)
None
None
None
1.15A 4j6cB-2x98A:
undetectable
4j6cB-2x98A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjk AFP

(Microbacterium
arborescens)
PF00210
(Ferritin)
5 ALA A  15
ALA A  18
ALA A  19
THR A  23
VAL A  26
None
1.04A 4j6cB-2yjkA:
undetectable
4j6cB-2yjkA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
0.94A 4j6cB-2zbzA:
46.4
4j6cB-2zbzA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii)
PF00118
(Cpn60_TCP1)
5 GLN B 492
ALA B 493
ALA B 496
ALA B 497
THR B 501
None
0.77A 4j6cB-3aq1B:
undetectable
4j6cB-3aq1B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh3 ACETOACETATE
DECARBOXYLASE


(Chromobacterium
violaceum)
PF06314
(ADC)
5 ALA A  42
ALA A  43
THR A  39
VAL A  59
LEU A  95
None
1.18A 4j6cB-3bh3A:
undetectable
4j6cB-3bh3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN


(Mycobacterium
tuberculosis)
PF00551
(Formyl_trans_N)
5 ALA A  83
ALA A  87
ALA A  86
VAL A  93
LEU A  18
None
1.06A 4j6cB-3da8A:
undetectable
4j6cB-3da8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD


(Deinococcus
radiodurans)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4)
5 GLN A 481
ALA A 480
ALA A 482
ALA A 483
LEU A 449
None
1.05A 4j6cB-3e1sA:
undetectable
4j6cB-3e1sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE


(Aspergillus
niger)
PF13714
(PEP_mutase)
5 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
1.05A 4j6cB-3fa3A:
undetectable
4j6cB-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
5 ALA A 132
ALA A 135
ALA A 136
THR A 140
LEU A  80
None
1.12A 4j6cB-3fiwA:
undetectable
4j6cB-3fiwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana)
PF00248
(Aldo_ket_red)
5 ALA A  34
ALA A  37
ALA A  36
VAL A  71
LEU A  76
None
1.10A 4j6cB-3h7uA:
undetectable
4j6cB-3h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
None
1.13A 4j6cB-3hm8A:
undetectable
4j6cB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyq ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Salmonella
enterica)
PF00293
(NUDIX)
5 GLN A 170
ALA A 171
ALA A 166
VAL A 147
LEU A  46
None
1.18A 4j6cB-3hyqA:
undetectable
4j6cB-3hyqA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A 461
ALA A 464
ALA A 465
VAL A  64
LEU A  61
None
0.96A 4j6cB-3i8bA:
undetectable
4j6cB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 GLN A  33
ALA A  54
ALA A  58
VAL A  64
LEU A  67
None
1.12A 4j6cB-3i8bA:
undetectable
4j6cB-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 ALA A 157
ALA A 215
ALA A 159
THR A 125
GLN A 218
None
1.19A 4j6cB-3js8A:
undetectable
4j6cB-3js8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693


(Bordetella
bronchiseptica)
PF04909
(Amidohydro_2)
5 ALA A  55
ALA A  56
ALA A  57
THR A 251
LEU A   8
None
1.13A 4j6cB-3k4wA:
undetectable
4j6cB-3k4wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE


(Rhodobacter
sphaeroides)
PF00155
(Aminotran_1_2)
5 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
None
1.05A 4j6cB-3nraA:
undetectable
4j6cB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2


(Zymomonas
mobilis)
PF00465
(Fe-ADH)
5 ALA A 216
ALA A 219
ALA A 220
VAL A 327
LEU A 285
None
1.03A 4j6cB-3ox4A:
undetectable
4j6cB-3ox4A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ALA A 231
ALA A 234
ALA A 235
THR A 239
LEU A  33
None
1.19A 4j6cB-3ppiA:
undetectable
4j6cB-3ppiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE


(Campylobacter
jejuni)
PF07992
(Pyr_redox_2)
5 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
None
0.94A 4j6cB-3r9uA:
undetectable
4j6cB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 ALA A 247
ALA A 249
ALA A 250
LEU A 200
GLN A 204
None
1.00A 4j6cB-3snxA:
undetectable
4j6cB-3snxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t69 PUTATIVE
2-DEHYDRO-3-DEOXYGAL
ACTONOKINASE


(Sinorhizobium
meliloti)
PF05035
(DGOK)
5 PHE A 194
ALA A 204
ALA A 200
THR A 231
LEU A 184
None
1.11A 4j6cB-3t69A:
undetectable
4j6cB-3t69A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT


(Thermochromatium
tepidum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 GLN B 311
ALA B 312
ALA B 315
ALA B 316
VAL B  30
None
1.05A 4j6cB-3vrdB:
undetectable
4j6cB-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT


(Thermochromatium
tepidum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 GLN B 311
ALA B 312
ALA B 315
VAL B  30
LEU B  32
None
1.11A 4j6cB-3vrdB:
undetectable
4j6cB-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ


(Sphingomonas
sp. A1)
PF01832
(Glucosaminidase)
6 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
None
1.37A 4j6cB-3vwoA:
undetectable
4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ


(Sphingomonas
sp. A1)
PF01832
(Glucosaminidase)
6 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
None
1.03A 4j6cB-3vwoA:
undetectable
4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ


(Sphingomonas
sp. A1)
PF01832
(Glucosaminidase)
6 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
None
1.34A 4j6cB-3vwoA:
undetectable
4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Actinomadura
sp. R39)
PF02113
(Peptidase_S13)
5 ALA A 108
ALA A 112
ALA A 111
VAL A  85
LEU A  88
None
1.08A 4j6cB-3zvtA:
undetectable
4j6cB-3zvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum)
PF00202
(Aminotran_3)
5 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
None
1.09A 4j6cB-4a6uA:
undetectable
4j6cB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE


(Lachnoclostridium
phytofermentans)
PF00171
(Aldedh)
5 GLN A  37
ALA A  38
ALA A  41
ALA A  42
THR A 156
None
1.18A 4j6cB-4c3sA:
undetectable
4j6cB-4c3sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT


(Moorella
thermoacetica)
PF03599
(CdhD)
5 ALA D 151
ALA D 153
ALA D 154
VAL D 124
LEU D 100
None
1.12A 4j6cB-4djeD:
undetectable
4j6cB-4djeD:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
None
1.08A 4j6cB-4f9oA:
undetectable
4j6cB-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 ALA A  86
ALA A  85
ALA A 109
THR A 132
LEU A 116
None
1.15A 4j6cB-4fs7A:
undetectable
4j6cB-4fs7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides)
PF04940
(BLUF)
5 ALA A 314
ALA A 317
ALA A 316
THR A 354
LEU A 327
None
1.12A 4j6cB-4hh1A:
undetectable
4j6cB-4hh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
5 ALA A 339
ALA A 365
THR A 332
LEU A 185
GLN A 289
None
1.15A 4j6cB-4i3uA:
undetectable
4j6cB-4i3uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 GLN A  66
ALA A  65
ALA A  67
ALA A  68
VAL A  71
None
1.15A 4j6cB-4j8lA:
undetectable
4j6cB-4j8lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus)
PF01044
(Vinculin)
5 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
None
1.12A 4j6cB-4k1oA:
undetectable
4j6cB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE


(Sorghum bicolor)
PF02458
(Transferase)
5 ALA A 271
ALA A 275
ALA A 274
VAL A 429
LEU A 427
None
1.08A 4j6cB-4ke4A:
undetectable
4j6cB-4ke4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE


(Enterococcus
faecalis)
PF00186
(DHFR_1)
5 ALA A  85
ALA A  87
THR A  94
VAL A  41
LEU A  63
None
None
None
None
NAP  A 201 (-4.0A)
1.13A 4j6cB-4m7vA:
undetectable
4j6cB-4m7vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Legionella
pneumophila)
PF00701
(DHDPS)
5 ALA A  74
ALA A  40
ALA A  41
THR A  11
VAL A  18
None
1.14A 4j6cB-4nq1A:
undetectable
4j6cB-4nq1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA


(Escherichia
coli)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 ALA A  98
ALA A  97
ALA A  94
LEU A 381
GLN A  88
None
1.19A 4j6cB-4o8aA:
undetectable
4j6cB-4o8aA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A


(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB)
5 ALA A 270
ALA A 268
THR A 289
VAL A 291
LEU A 438
None
1.12A 4j6cB-4oonA:
undetectable
4j6cB-4oonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox8 CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK


(Prochlorococcus
marinus)
PF00936
(BMC)
5 ALA A  21
ALA A  24
ALA A  25
THR A  29
VAL A  34
None
1.18A 4j6cB-4ox8A:
undetectable
4j6cB-4ox8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE


(Acinetobacter
baumannii)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 GLN A 295
ALA A 297
ALA A 299
ALA A 300
VAL A 170
None
1.03A 4j6cB-4qdiA:
undetectable
4j6cB-4qdiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II


(Yersinia pestis)
PF13622
(4HBT_3)
5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
None
0.97A 4j6cB-4qfwA:
undetectable
4j6cB-4qfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE


(Arabidopsis
thaliana)
PF04321
(RmlD_sub_bind)
5 ALA A  68
ALA A  67
THR A  71
VAL A 166
LEU A 164
None
None
SO4  A 406 (-3.7A)
None
None
1.14A 4j6cB-4qqrA:
undetectable
4j6cB-4qqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
None
1.06A 4j6cB-4qs9A:
undetectable
4j6cB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus)
PF02803
(Thiolase_C)
5 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
None
1.12A 4j6cB-4u4eA:
undetectable
4j6cB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE


(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
None
1.08A 4j6cB-4wkyA:
undetectable
4j6cB-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY


(Thermococcus
kodakarensis)
no annotation 5 GLN A 236
ALA A 237
ALA A 241
THR A 245
LEU A  35
IOD  A 307 ( 4.7A)
None
None
ACP  A 302 (-3.8A)
None
0.85A 4j6cB-4xf7A:
undetectable
4j6cB-4xf7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
5 ALA A 163
ALA A 166
ALA A 165
VAL A  69
LEU A 194
None
1.15A 4j6cB-4yweA:
undetectable
4j6cB-4yweA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
5 PHE A 324
ALA A 320
ALA A 296
VAL A 219
LEU A 233
None
1.05A 4j6cB-5b4wA:
undetectable
4j6cB-5b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED


(Cupriavidus
metallidurans)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK)
6 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
None
1.42A 4j6cB-5cjuA:
undetectable
4j6cB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
5 GLN A 288
ALA A 289
ALA A 292
ALA A 293
VAL A 567
None
1.09A 4j6cB-5cxwA:
undetectable
4j6cB-5cxwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens)
PF04636
(PA26)
5 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
None
0.96A 4j6cB-5dj4A:
undetectable
4j6cB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER


(Pseudomonas
putida)
PF01547
(SBP_bac_1)
5 GLN A 319
ALA A 323
ALA A 326
VAL A 344
LEU A 121
None
1.04A 4j6cB-5dvjA:
undetectable
4j6cB-5dvjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801)
PF00305
(Lipoxygenase)
5 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
None
0.90A 4j6cB-5ek8A:
undetectable
4j6cB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct)
PF00290
(Trp_syntA)
5 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
None
1.07A 4j6cB-5ey5A:
undetectable
4j6cB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE


(Brucella
melitensis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
5 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.14A 4j6cB-5ez3A:
undetectable
4j6cB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE


(Escherichia
coli)
PF01814
(Hemerythrin)
PF04405
(ScdA_N)
5 GLN A  97
ALA A  98
THR A 173
VAL A 169
LEU A 166
None
1.19A 4j6cB-5fnpA:
undetectable
4j6cB-5fnpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE


(Streptomyces
sp. MJ635-86F5)
PF00501
(AMP-binding)
5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
None
1.10A 4j6cB-5jjpA:
undetectable
4j6cB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Streptomyces
sp. ML694-90F3)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
None
1.16A 4j6cB-5jjqA:
undetectable
4j6cB-5jjqA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans)
no annotation 5 ALA B  85
ALA B  88
ALA B  89
THR B  93
LEU B  74
None
0.83A 4j6cB-5khnB:
undetectable
4j6cB-5khnB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens)
no annotation 5 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
None
1.01A 4j6cB-5lfdA:
undetectable
4j6cB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
None
0.77A 4j6cB-5lx8A:
undetectable
4j6cB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE


(Bacillus
subtilis)
no annotation 5 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
None
1.15A 4j6cB-5muxA:
undetectable
4j6cB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w93 BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1


(Mus musculus)
PF12026
(DUF3513)
5 GLN A 754
ALA A 755
THR A 763
VAL A 766
LEU A 857
None
1.11A 4j6cB-5w93A:
undetectable
4j6cB-5w93A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 5 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
None
1.18A 4j6cB-6chjA:
undetectable
4j6cB-6chjA:
12.41