SIMILAR PATTERNS OF AMINO ACIDS FOR 4J6C_A_STRA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 GLN B 230
ALA B 231
THR B 215
VAL B 193
LEU B 164
 None
 1.15A 4j6cA-1ayyB:
undetectable		 4j6cA-1ayyB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.01A 4j6cA-1c8uA:
0.0		 4j6cA-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 GLN A  34
ALA A  35
ALA A  38
ALA A  39
LEU A 192
 None
 1.01A 4j6cA-1eyyA:
0.0		 4j6cA-1eyyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 TRANSLOCATED INTIMIN
RECEPTOR

(Escherichia
coli) 		PF03549
(Tir_receptor_M) 		5 GLN T 273
ALA T 274
ALA T 277
ALA T 278
THR T 282
 None
 0.77A 4j6cA-1f02T:
undetectable		 4j6cA-1f02T:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLN A  87
ALA A  88
ALA A 114
VAL A 122
LEU A 138
 None
 1.11A 4j6cA-1f0kA:
0.0		 4j6cA-1f0kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 ALA A 459
ALA A 266
ALA A 267
VAL A 363
LEU A 365
 None
 1.09A 4j6cA-1fc9A:
0.0		 4j6cA-1fc9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 ALA A 126
ALA A 129
THR A 162
VAL A 164
LEU A 138
 None
 0.98A 4j6cA-1hyqA:
0.0		 4j6cA-1hyqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 252
ALA A 254
ALA A 255
VAL A 208
GLN A 206
 None
 1.13A 4j6cA-1mroA:
0.0		 4j6cA-1mroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 MET A 235
ALA A 252
ALA A 254
ALA A 255
GLN A 206
 None
 1.15A 4j6cA-1mroA:
0.0		 4j6cA-1mroA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.83A 4j6cA-1odoA:
54.0		 4j6cA-1odoA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.92A 4j6cA-1smkA:
undetectable		 4j6cA-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 MET A  19
ALA A  48
ALA A  51
ALA A  52
THR A  56
 None
 1.13A 4j6cA-1svdA:
undetectable		 4j6cA-1svdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ALA A 333
ALA A 336
ALA A 337
THR A 341
VAL A 392
 None
 1.11A 4j6cA-1t1sA:
undetectable		 4j6cA-1t1sA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.14A 4j6cA-1ulqA:
undetectable		 4j6cA-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.06A 4j6cA-1vtkA:
1.5		 4j6cA-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ALA A  59
ALA A  60
ALA A  61
THR A 331
LEU A 344
 None
 1.08A 4j6cA-1w5dA:
undetectable		 4j6cA-1w5dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 ALA A 224
ALA A 226
ALA A 221
VAL A 202
LEU A 181
 None
 1.15A 4j6cA-1wytA:
undetectable		 4j6cA-1wytA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		6 MET A  93
PHE A  47
ALA A  53
ALA A  55
VAL A  77
LEU A  74
 None
 1.39A 4j6cA-1xeuA:
undetectable		 4j6cA-1xeuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z96 UBA-DOMAIN PROTEIN
MUD1

(Schizosaccharomyces
pombe) 		PF00627
(UBA) 		5 PHE A 308
GLN A 315
ALA A 313
ALA A 316
ALA A 327
 None
 1.15A 4j6cA-1z96A:
undetectable		 4j6cA-1z96A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT

(Homo sapiens) 		PF00676
(E1_dh) 		5 GLN A 170
ALA A 171
ALA A 174
ALA A 175
LEU A 103
 None
 0.89A 4j6cA-2bfeA:
undetectable		 4j6cA-2bfeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		5 GLN A 141
ALA A 142
ALA A 145
ALA A 146
LEU A 101
 None
 1.10A 4j6cA-2c94A:
undetectable		 4j6cA-2c94A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLN C 382
ALA C 277
ALA C 275
VAL C 387
LEU C 373
 None
 1.11A 4j6cA-2d3tC:
undetectable		 4j6cA-2d3tC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		5 GLN A 387
ALA A 388
ALA A 391
ALA A 392
THR A 396
 None
 0.83A 4j6cA-2d4vA:
1.2		 4j6cA-2d4vA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 PHE A 167
ALA A  85
ALA A  87
THR A 254
LEU A 111
 None
 1.15A 4j6cA-2dfuA:
undetectable		 4j6cA-2dfuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.87A 4j6cA-2gcaA:
undetectable		 4j6cA-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		5 GLN A 327
ALA A 326
ALA A 324
THR A 322
VAL A 276
 None
 1.14A 4j6cA-2grvA:
undetectable		 4j6cA-2grvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.09A 4j6cA-2hg4A:
undetectable		 4j6cA-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
 None
 0.90A 4j6cA-2nlxA:
undetectable		 4j6cA-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.15A 4j6cA-2nztA:
undetectable		 4j6cA-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA

(Bacillus
subtilis) 		PF00403
(HMA) 		5 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.16A 4j6cA-2rmlA:
undetectable		 4j6cA-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.09A 4j6cA-2vrcA:
undetectable		 4j6cA-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 GLN A 186
ALA A 171
ALA A 174
ALA A 175
VAL A 146
 None
PO4  A1474 ( 4.9A)
None
None
None
 1.14A 4j6cA-2x98A:
undetectable		 4j6cA-2x98A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjk AFP

(Microbacterium
arborescens) 		PF00210
(Ferritin) 		5 ALA A  15
ALA A  18
ALA A  19
THR A  23
VAL A  26
 None
 1.05A 4j6cA-2yjkA:
undetectable		 4j6cA-2yjkA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.94A 4j6cA-2zbzA:
46.3		 4j6cA-2zbzA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		5 GLN B 492
ALA B 493
ALA B 496
ALA B 497
THR B 501
 None
 0.77A 4j6cA-3aq1B:
undetectable		 4j6cA-3aq1B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		5 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.13A 4j6cA-3bkxA:
undetectable		 4j6cA-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.01A 4j6cA-3d8kA:
undetectable		 4j6cA-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 ALA A  83
ALA A  87
ALA A  86
VAL A  93
LEU A  18
 None
 1.06A 4j6cA-3da8A:
undetectable		 4j6cA-3da8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		5 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.04A 4j6cA-3fa3A:
undetectable		 4j6cA-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A 132
ALA A 135
ALA A 136
THR A 140
LEU A  80
 None
 1.13A 4j6cA-3fiwA:
undetectable		 4j6cA-3fiwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 ALA A  34
ALA A  37
ALA A  36
VAL A  71
LEU A  76
 None
 1.09A 4j6cA-3h7uA:
undetectable		 4j6cA-3h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.14A 4j6cA-3hm8A:
undetectable		 4j6cA-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 461
ALA A 464
ALA A 465
VAL A  64
LEU A  61
 None
 0.95A 4j6cA-3i8bA:
undetectable		 4j6cA-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A  33
ALA A  54
ALA A  58
VAL A  64
LEU A  67
 None
 1.14A 4j6cA-3i8bA:
undetectable		 4j6cA-3i8bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		5 ALA A  55
ALA A  56
ALA A  57
THR A 251
LEU A   8
 None
 1.15A 4j6cA-3k4wA:
undetectable		 4j6cA-3k4wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		5 PHE A 258
ALA A 230
ALA A 113
THR A 211
LEU A  26
 None
None
SO4  A 270 (-3.7A)
None
None
 1.01A 4j6cA-3la8A:
undetectable		 4j6cA-3la8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.02A 4j6cA-3nraA:
undetectable		 4j6cA-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		5 ALA A 216
ALA A 219
ALA A 220
VAL A 327
LEU A 285
 None
 1.03A 4j6cA-3ox4A:
undetectable		 4j6cA-3ox4A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.95A 4j6cA-3r9uA:
undetectable		 4j6cA-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 247
ALA A 249
ALA A 250
LEU A 200
GLN A 204
 None
 0.99A 4j6cA-3snxA:
undetectable		 4j6cA-3snxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t69 PUTATIVE
2-DEHYDRO-3-DEOXYGAL
ACTONOKINASE

(Sinorhizobium
meliloti) 		PF05035
(DGOK) 		5 PHE A 194
ALA A 204
ALA A 200
THR A 231
LEU A 184
 None
 1.10A 4j6cA-3t69A:
undetectable		 4j6cA-3t69A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 GLN B 311
ALA B 312
ALA B 315
ALA B 316
VAL B  30
 None
 1.02A 4j6cA-3vrdB:
undetectable		 4j6cA-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 GLN B 311
ALA B 312
ALA B 315
VAL B  30
LEU B  32
 None
 1.10A 4j6cA-3vrdB:
undetectable		 4j6cA-3vrdB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.38A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.04A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		6 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.36A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		5 PHE A  11
ALA A  24
ALA A  28
ALA A  26
VAL A  36
 None
 1.11A 4j6cA-3w0dA:
undetectable		 4j6cA-3w0dA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 ALA A 108
ALA A 112
ALA A 111
VAL A  85
LEU A  88
 None
 1.07A 4j6cA-3zvtA:
undetectable		 4j6cA-3zvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		5 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.10A 4j6cA-4a6uA:
undetectable		 4j6cA-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		5 ALA D 151
ALA D 153
ALA D 154
VAL D 124
LEU D 100
 None
 1.12A 4j6cA-4djeD:
undetectable		 4j6cA-4djeD:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.02A 4j6cA-4dokA:
undetectable		 4j6cA-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.08A 4j6cA-4f9oA:
undetectable		 4j6cA-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 ALA A  86
ALA A  85
ALA A 109
THR A 132
LEU A 116
 None
 1.15A 4j6cA-4fs7A:
undetectable		 4j6cA-4fs7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ALA A 339
ALA A 365
THR A 332
LEU A 185
GLN A 289
 None
 1.14A 4j6cA-4i3uA:
undetectable		 4j6cA-4i3uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		5 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.13A 4j6cA-4k1oA:
1.9		 4j6cA-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 ALA A 271
ALA A 275
ALA A 274
VAL A 429
LEU A 427
 None
 1.09A 4j6cA-4ke4A:
undetectable		 4j6cA-4ke4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ALA A  85
ALA A  87
THR A  94
VAL A  41
LEU A  63
 None
None
None
None
NAP  A 201 (-4.0A)
 1.11A 4j6cA-4m7vA:
undetectable		 4j6cA-4m7vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		5 ALA A  74
ALA A  40
ALA A  41
THR A  11
VAL A  18
 None
 1.12A 4j6cA-4nq1A:
undetectable		 4j6cA-4nq1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 270
ALA A 268
THR A 289
VAL A 291
LEU A 438
 None
 1.11A 4j6cA-4oonA:
undetectable		 4j6cA-4oonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 0.96A 4j6cA-4qfwA:
undetectable		 4j6cA-4qfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE

(Arabidopsis
thaliana) 		PF04321
(RmlD_sub_bind) 		5 ALA A  68
ALA A  67
THR A  71
VAL A 166
LEU A 164
 None
None
SO4  A 406 (-3.7A)
None
None
 1.13A 4j6cA-4qqrA:
undetectable		 4j6cA-4qqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.05A 4j6cA-4qs9A:
1.2		 4j6cA-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.13A 4j6cA-4u4eA:
undetectable		 4j6cA-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.07A 4j6cA-4wkyA:
undetectable		 4j6cA-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 GLN A 236
ALA A 237
ALA A 241
THR A 245
LEU A  35
 IOD  A 307 ( 4.7A)
None
None
ACP  A 302 (-3.8A)
None
 0.84A 4j6cA-4xf7A:
undetectable		 4j6cA-4xf7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.01A 4j6cA-4xgtA:
undetectable		 4j6cA-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq2 CALE6

(Micromonospora
echinospora) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A  73
ALA A  78
ALA A  81
ALA A  80
VAL A 190
 None
 1.16A 4j6cA-4xq2A:
undetectable		 4j6cA-4xq2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 163
ALA A 166
ALA A 165
VAL A  69
LEU A 194
 None
 1.15A 4j6cA-4yweA:
undetectable		 4j6cA-4yweA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 PHE C 435
GLN C 456
ALA C 457
ALA C 460
ALA C 461
 None
 1.09A 4j6cA-5aa5C:
undetectable		 4j6cA-5aa5C:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 PHE A 324
ALA A 320
ALA A 296
VAL A 219
LEU A 233
 None
 1.05A 4j6cA-5b4wA:
undetectable		 4j6cA-5b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		6 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.42A 4j6cA-5cjuA:
undetectable		 4j6cA-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLN A 288
ALA A 289
ALA A 292
ALA A 293
VAL A 567
 None
 1.09A 4j6cA-5cxwA:
undetectable		 4j6cA-5cxwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.94A 4j6cA-5dj4A:
undetectable		 4j6cA-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		5 GLN A 319
ALA A 323
ALA A 326
VAL A 344
LEU A 121
 None
 1.05A 4j6cA-5dvjA:
undetectable		 4j6cA-5dvjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.91A 4j6cA-5ek8A:
undetectable		 4j6cA-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		5 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.07A 4j6cA-5ey5A:
undetectable		 4j6cA-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
 MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
 1.15A 4j6cA-5ez3A:
0.7		 4j6cA-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 PHE A  77
ALA A 121
ALA A 124
ALA A 125
GLN A  26
 None
 0.89A 4j6cA-5hdjA:
undetectable		 4j6cA-5hdjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.09A 4j6cA-5jjpA:
undetectable		 4j6cA-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.15A 4j6cA-5jjqA:
undetectable		 4j6cA-5jjqA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 ALA B  85
ALA B  88
ALA B  89
THR B  93
LEU B  74
 None
 0.81A 4j6cA-5khnB:
3.3		 4j6cA-5khnB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 5 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.02A 4j6cA-5lfdA:
undetectable		 4j6cA-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.77A 4j6cA-5lx8A:
undetectable		 4j6cA-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.16A 4j6cA-5muxA:
undetectable		 4j6cA-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 5 PHE A 278
ALA A 382
ALA A 383
LEU A 428
GLN A 347
 None
 1.12A 4j6cA-5nqaA:
undetectable		 4j6cA-5nqaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w93 BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1

(Mus musculus) 		PF12026
(DUF3513) 		5 GLN A 754
ALA A 755
THR A 763
VAL A 766
LEU A 857
 None
 1.11A 4j6cA-5w93A:
undetectable		 4j6cA-5w93A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 PHE A1313
ALA A1283
ALA A1285
ALA A1286
LEU A1326
 None
 1.04A 4j6cA-5yudA:
undetectable		 4j6cA-5yudA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 5 GLN A 320
ALA A 311
ALA A 229
ALA A  95
VAL A 105
 None
 1.07A 4j6cA-5z0yA:
undetectable		 4j6cA-5z0yA:
13.61