SIMILAR PATTERNS OF AMINO ACIDS FOR 4J5J_B_478B402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
PRO A  79
 None
 0.87A 4j5jB-1hvcA:
13.0		 4j5jB-1hvcA:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
ARG A  57
 None
 1.11A 4j5jB-1hvcA:
13.0		 4j5jB-1hvcA:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
PRO A  79
 None
 0.41A 4j5jB-1hvcA:
13.0		 4j5jB-1hvcA:
38.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 PRO A 449
LYS A 447
ARG A 451
PRO A 445
 None
 1.20A 4j5jB-1pxyA:
undetectable		 4j5jB-1pxyA:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 TRP A  42
PRO A  44
LYS A  55
ARG A  57
PRO A  79
 None
 1.00A 4j5jB-2rkfA:
19.8		 4j5jB-2rkfA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		4 PRO B 449
LYS B 447
ARG B 451
PRO B 445
 None
 1.20A 4j5jB-3byhB:
undetectable		 4j5jB-3byhB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 TRP B 135
PRO B 134
ARG B 133
PRO B 130
 None
 1.41A 4j5jB-3h1lB:
0.0		 4j5jB-3h1lB:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz4 THIOREDOXIN

(Methanosarcina
mazei) 		PF00085
(Thioredoxin) 		4 PRO A  32
LYS A  38
ARG A  59
PRO A  42
 None
 1.50A 4j5jB-3hz4A:
undetectable		 4j5jB-3hz4A:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
PRO A  79
 None
 0.47A 4j5jB-3mwsA:
20.2		 4j5jB-3mwsA:
70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
PRO A  79
 None
 0.54A 4j5jB-3t3cA:
18.4		 4j5jB-3t3cA:
69.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
PRO A  79
 None
 0.47A 4j5jB-3ttpA:
19.7		 4j5jB-3ttpA:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
PRO A  79
 None
 0.62A 4j5jB-3uhlA:
16.5		 4j5jB-3uhlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgs POLYMERASE SUBUNIT
PA

(Dhori
thogotovirus) 		no annotation 4 TRP A  23
PRO A  29
ARG A  33
PRO A   6
 None
 1.39A 4j5jB-4cgsA:
0.0		 4j5jB-4cgsA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
PRO A  79
 None
 0.30A 4j5jB-5t2zA:
19.8		 4j5jB-5t2zA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
ARG A  57
 None
 0.68A 4j5jB-5t2zA:
19.8		 4j5jB-5t2zA:
77.78