SIMILAR PATTERNS OF AMINO ACIDS FOR 4J26_B_ESTB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
5 MET A  60
LEU A 131
LEU A 114
ILE A 183
LEU A  20
None
1.25A 4j26B-13pkA:
undetectable
4j26B-13pkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E


(Saccharomyces
cerevisiae)
PF01532
(Glyco_hydro_47)
5 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
None
1.19A 4j26B-1dl2A:
undetectable
4j26B-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 LEU A 403
LEU A 401
ILE A 387
ILE A 396
LEU A 309
None
1.13A 4j26B-1g8kA:
undetectable
4j26B-1g8kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))


(Desulfovibrio
vulgaris)
PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
5 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
None
1.20A 4j26B-1hfeL:
undetectable
4j26B-1hfeL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20


(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.05A 4j26B-1i51A:
undetectable
4j26B-1i51A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.14A 4j26B-1k86A:
undetectable
4j26B-1k86A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 GLU X 547
ARG X 168
ILE X 504
ILE X 501
LEU X 203
None
1.26A 4j26B-1mw9X:
1.3
4j26B-1mw9X:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa)
PF05184
(SapB_1)
5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
None
1.04A 4j26B-1nklA:
undetectable
4j26B-1nklA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT


(Bacillus
subtilis)
PF11563
(Protoglobin)
5 LEU A  96
LEU A  73
ILE A 126
ILE A  82
HIS A  86
CYN  A 181 ( 4.5A)
HEM  A 180 ( 4.7A)
HEM  A 180 (-4.5A)
HEM  A 180 (-3.5A)
HEM  A 180 (-4.7A)
1.29A 4j26B-1or4A:
1.0
4j26B-1or4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli)
no annotation 5 LEU B 147
LEU B 199
MET B 200
ILE B 166
ILE B 163
None
1.24A 4j26B-1p3wB:
undetectable
4j26B-1p3wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
None
2PG  A 441 (-4.7A)
None
None
None
1.20A 4j26B-1p43A:
undetectable
4j26B-1p43A:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 342
LEU A 349
GLU A 353
LEU A 391
ARG A 394
None
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
1.31A 4j26B-1pcgA:
32.9
4j26B-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.37A 4j26B-1pcgA:
32.9
4j26B-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 341
LEU A 342
ILE A 382
ILE A 394
LEU A 389
None
1.19A 4j26B-1pdzA:
undetectable
4j26B-1pdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE


(Thermotoga
maritima)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
5 LEU A 125
LEU A 119
ILE A 109
ILE A  90
LEU A  98
None
1.22A 4j26B-1pw5A:
undetectable
4j26B-1pw5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus)
PF01791
(DeoC)
5 LEU A 105
GLU A 108
LEU A  94
ILE A 135
LEU A 150
None
1.30A 4j26B-1ub3A:
undetectable
4j26B-1ub3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw0 DNA LIGASE III

(Homo sapiens)
PF00645
(zf-PARP)
5 LEU A  76
ILE A  53
ILE A  90
HIS A  93
LEU A  97
None
1.19A 4j26B-1uw0A:
undetectable
4j26B-1uw0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE


(Thermotoga
maritima)
PF00764
(Arginosuc_synth)
5 MET A 184
LEU A  76
ILE A  91
ILE A 319
LEU A  86
None
1.27A 4j26B-1vl2A:
undetectable
4j26B-1vl2A:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
None
0.61A 4j26B-1xb7A:
28.3
4j26B-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3


(Thermoplasma
acidophilum)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 MET A 674
LEU A 668
LEU A 662
ILE A 656
LEU A 640
None
1.25A 4j26B-1z1wA:
undetectable
4j26B-1z1wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE


(Homo sapiens)
PF00398
(RrnaAD)
5 GLU A 222
LEU A 226
ILE A 295
ILE A 177
LEU A 182
None
1.29A 4j26B-1zq9A:
undetectable
4j26B-1zq9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
None
1.16A 4j26B-2akzA:
undetectable
4j26B-2akzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN


(Saccharomyces
cerevisiae)
PF07728
(AAA_5)
5 LEU A 290
LEU A 270
LEU A 271
ILE A 350
ILE A 295
None
1.30A 4j26B-2ga8A:
undetectable
4j26B-2ga8A:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.51A 4j26B-2gpvA:
27.3
4j26B-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
5 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
None
1.08A 4j26B-2j5gD:
undetectable
4j26B-2j5gD:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.44A 4j26B-2ocfA:
33.9
4j26B-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 LEU A 126
ARG A 168
ILE A 132
ILE A 135
LEU A 116
None
1.20A 4j26B-2omvA:
undetectable
4j26B-2omvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes)
PF13614
(AAA_31)
5 LEU A  60
LEU A  66
ILE A  39
ILE A 159
LEU A  53
None
1.29A 4j26B-2ozeA:
undetectable
4j26B-2ozeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
None
1.18A 4j26B-2pa6A:
undetectable
4j26B-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 336
LEU A 337
ILE A 377
ILE A 389
LEU A 384
None
1.25A 4j26B-2pa6A:
undetectable
4j26B-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
None
PAH  A 600 (-4.8A)
None
None
None
1.30A 4j26B-2ptzA:
undetectable
4j26B-2ptzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql7 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.02A 4j26B-2ql7A:
undetectable
4j26B-2ql7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY


(Escherichia
coli)
PF06572
(DUF1131)
5 MET A  95
LEU A  55
ARG A  83
ILE A 107
LEU A  64
None
1.24A 4j26B-2qzbA:
undetectable
4j26B-2qzbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 LEU A 192
LEU A 262
ILE A 183
ILE A 335
HIS A 179
None
1.29A 4j26B-2rb9A:
undetectable
4j26B-2rb9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
5 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
None
0.94A 4j26B-2wbeC:
undetectable
4j26B-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
None
1.18A 4j26B-2xsxA:
undetectable
4j26B-2xsxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
None
1.16A 4j26B-3b97A:
undetectable
4j26B-3b97A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE


(Leeuwenhoekiella
blandensis)
PF01966
(HD)
5 LEU A  94
GLU A   5
MET A   2
ILE A 329
LEU A 245
None
1.04A 4j26B-3bg2A:
undetectable
4j26B-3bg2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE


(Bacillus phage
SPP1)
PF03796
(DnaB_C)
5 LEU A 354
LEU A 199
ILE A 333
ILE A 336
LEU A 319
None
1.12A 4j26B-3bh0A:
undetectable
4j26B-3bh0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.17A 4j26B-3csqA:
undetectable
4j26B-3csqA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.21A 4j26B-3cszA:
undetectable
4j26B-3cszA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
None
1.26A 4j26B-3dy5A:
undetectable
4j26B-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
5 LEU A 189
GLU A 191
ILE A 240
ILE A 241
LEU A  93
None
1.22A 4j26B-3ffhA:
undetectable
4j26B-3ffhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY


(Thermotoga
maritima)
PF00392
(GntR)
PF07729
(FCD)
5 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
None
None
ACT  A 302 (-3.0A)
None
None
1.17A 4j26B-3fmsA:
undetectable
4j26B-3fmsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
None
1.11A 4j26B-3g5iA:
undetectable
4j26B-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa)
no annotation 5 LEU X 561
LEU X 186
LEU X 230
ILE X 182
ILE X 142
None
1.26A 4j26B-3kvnX:
undetectable
4j26B-3kvnX:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7


(Streptomyces
avermitilis)
PF03259
(Robl_LC7)
5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
None
1.19A 4j26B-3kyeA:
undetectable
4j26B-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdk STRINGENT STARVATION
PROTEIN A


(Pseudomonas
putida)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A  23
GLU A  27
LEU A  84
ARG A 190
ILE A 102
None
0.98A 4j26B-3mdkA:
undetectable
4j26B-3mdkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(marine
actinobacterium
PHSC20C1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 MET A  95
LEU A 141
ILE A  28
ILE A  61
LEU A 137
None
1.19A 4j26B-3msyA:
undetectable
4j26B-3msyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae)
PF09349
(OHCU_decarbox)
5 GLU A 161
LEU A 158
ARG A  49
HIS A  80
LEU A  83
None
1.31A 4j26B-3o7jA:
undetectable
4j26B-3o7jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 352
LEU A 353
ILE A 393
ILE A 405
LEU A 400
None
1.15A 4j26B-3otrA:
undetectable
4j26B-3otrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT


(Yersinia pestis)
PF00359
(PTS_EIIA_2)
5 LEU A  80
MET A   1
LEU A   2
ILE A 115
HIS A 111
None
1.31A 4j26B-3oxpA:
undetectable
4j26B-3oxpA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE


(Mesorhizobium
loti)
PF13561
(adh_short_C2)
5 LEU A 168
LEU A  85
ILE A 118
ILE A  62
LEU A 113
None
None
None
NAD  A 251 (-3.9A)
None
1.22A 4j26B-3rwbA:
undetectable
4j26B-3rwbA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY


(Thermotoga
maritima)
PF07729
(FCD)
5 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
None
1.23A 4j26B-3sxmA:
undetectable
4j26B-3sxmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB


(Methanosarcina
barkeri)
PF04055
(Radical_SAM)
5 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
1.06A 4j26B-3t7vA:
undetectable
4j26B-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae)
PF07571
(TAF6_C)
5 LEU A 222
LEU A 211
ILE A 247
ILE A 205
LEU A 228
None
1.23A 4j26B-4atgA:
undetectable
4j26B-4atgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
5 LEU A 335
ARG A 321
ILE A 252
ILE A 253
LEU A 343
None
1.21A 4j26B-4baxA:
undetectable
4j26B-4baxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
5 MET A 708
LEU A 654
ILE A 671
ILE A 698
LEU A 734
None
1.18A 4j26B-4blaA:
undetectable
4j26B-4blaA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dej GLUTATHIONE
S-TRANSFERASE
RELATED PROTEIN


(Idiomarina
loihiensis)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A  27
GLU A  31
LEU A  89
ARG A 190
ILE A 107
None
1.17A 4j26B-4dejA:
undetectable
4j26B-4dejA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY


(Lactococcus
lactis)
PF02632
(BioY)
5 LEU A  97
LEU A  69
ILE A  20
ILE A  21
LEU A  75
None
None
None
BNG  A 202 ( 4.2A)
BTN  A 201 ( 3.8A)
1.30A 4j26B-4dveA:
undetectable
4j26B-4dveA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
None
1.23A 4j26B-4g7fA:
undetectable
4j26B-4g7fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
5 LEU A  82
LEU A 188
ILE A 120
ILE A  73
LEU A  21
None
1.30A 4j26B-4gp1A:
undetectable
4j26B-4gp1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5


(Homo sapiens)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
5 LEU A 258
LEU A 287
LEU A 284
ILE A 208
ILE A 235
None
1.30A 4j26B-4gqbA:
undetectable
4j26B-4gqbA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
5 LEU A 136
GLU A  89
LEU A 340
ILE A 336
ILE A 335
None
1.23A 4j26B-4hsuA:
undetectable
4j26B-4hsuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
5 LEU A 340
GLU A  89
LEU A 136
ILE A 335
ILE A 336
None
1.31A 4j26B-4hsuA:
undetectable
4j26B-4hsuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN


(Lactobacillus
brevis)
PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS)
5 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j26B-4hzuT:
undetectable
4j26B-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila)
no annotation 5 LEU A 376
GLU A 380
ILE A 478
ILE A 477
LEU A 471
None
1.31A 4j26B-4iruA:
undetectable
4j26B-4iruA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima)
PF00512
(HisKA)
PF02518
(HATPase_c)
5 LEU A 406
LEU A 398
ILE A 365
ILE A 370
HIS A 456
None
1.20A 4j26B-4jasA:
undetectable
4j26B-4jasA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B


(Danio rerio)
PF02854
(MIF4G)
5 GLU A 147
LEU A 136
LEU A 142
ILE A 198
HIS A 156
None
1.29A 4j26B-4jhjA:
undetectable
4j26B-4jhjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
5 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
None
1.22A 4j26B-4mpsA:
undetectable
4j26B-4mpsA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
6 LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
None
0.59A 4j26B-4n1yA:
31.3
4j26B-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
None
1.14A 4j26B-4o1oA:
undetectable
4j26B-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM


(Blomia
tropicalis)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.30A 4j26B-4q5nA:
undetectable
4j26B-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE


(Streptomyces
avermitilis)
PF00067
(p450)
5 LEU A 282
GLU A 279
MET A 274
ILE A 250
LEU A 257
None
PEG  A 511 ( 4.4A)
None
None
None
1.30A 4j26B-4ubsA:
undetectable
4j26B-4ubsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 772
MET A 807
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.51A 4j26B-4udbA:
27.7
4j26B-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Cellvibrio sp.
BR)
PF13738
(Pyr_redox_3)
5 GLU A  96
LEU A  26
ARG A 105
ILE A  16
ILE A 134
None
1.13A 4j26B-4usqA:
undetectable
4j26B-4usqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkz VALINE-TRNA LIGASE

(Pseudomonas
aeruginosa)
PF08264
(Anticodon_1)
5 LEU A 748
GLU A 682
LEU A 678
ILE A 764
ILE A 739
None
1.28A 4j26B-4xkzA:
undetectable
4j26B-4xkzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvs CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.14A 4j26B-4zvsA:
undetectable
4j26B-4zvsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3)
5 LEU A  18
LEU A  27
ILE A  98
ILE A  68
LEU A   5
None
1.22A 4j26B-5avoA:
undetectable
4j26B-5avoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 LEU A 320
LEU A 335
ILE A 550
ILE A 323
LEU A 559
None
1.22A 4j26B-5gjeA:
undetectable
4j26B-5gjeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis)
PF01177
(Asp_Glu_race)
5 GLU A 239
ARG A  66
ILE A  25
ILE A  24
LEU A  18
None
1.17A 4j26B-5hj7A:
undetectable
4j26B-5hj7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis)
PF01177
(Asp_Glu_race)
5 GLU A 239
LEU A  63
ARG A  66
ILE A  24
LEU A  18
None
1.25A 4j26B-5hj7A:
undetectable
4j26B-5hj7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis)
PF01177
(Asp_Glu_race)
5 GLU A 243
LEU A  63
ARG A  66
ILE A  24
LEU A  18
None
1.26A 4j26B-5ijwA:
undetectable
4j26B-5ijwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3


(Mus musculus)
PF07496
(zf-CW)
PF13589
(HATPase_c_3)
5 LEU A  19
MET A  80
LEU A  81
ILE A 198
ILE A 196
None
ANP  A 502 (-3.1A)
None
None
None
1.29A 4j26B-5ix1A:
undetectable
4j26B-5ix1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3)
5 LEU A 267
LEU A 269
ILE A 251
HIS A 221
LEU A 220
None
1.18A 4j26B-5jhqA:
undetectable
4j26B-5jhqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)


(Aquifex
aeolicus)
no annotation 5 GLU B 391
MET B 354
LEU B 334
ILE B 491
ILE B 522
None
1.27A 4j26B-5l22B:
undetectable
4j26B-5l22B:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
None
1.12A 4j26B-5m5pA:
undetectable
4j26B-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrg TAR DNA-BINDING
PROTEIN 43


(Homo sapiens)
no annotation 5 LEU A  68
LEU A  53
ILE A  30
ILE A  17
LEU A  39
None
1.29A 4j26B-5mrgA:
undetectable
4j26B-5mrgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans)
PF10220
(Smg8_Smg9)
5 LEU E 188
LEU E 242
ILE E 132
ILE E 225
LEU E 136
None
1.21A 4j26B-5nkmE:
undetectable
4j26B-5nkmE:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 294
LEU A 301
GLU A 305
LEU A 343
ARG A 346
ILE A 373
None
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
1.50A 4j26B-5toaA:
34.0
4j26B-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 295
LEU A 301
GLU A 305
MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 373
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.36A 4j26B-5toaA:
34.0
4j26B-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
LEU A 490
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
1.43A 4j26B-5toaA:
34.0
4j26B-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
None
1.04A 4j26B-5u4hA:
undetectable
4j26B-5u4hA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufk EFFECTOR PROTEIN
SIDK


(Legionella
pneumophila)
no annotation 5 MET A 115
MET A 103
LEU A 107
ILE A  36
LEU A  94
None
1.21A 4j26B-5ufkA:
undetectable
4j26B-5ufkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis)
PF08652
(RAI1)
5 MET A 111
MET A  80
LEU A  83
ILE A 104
LEU A 127
None
1.07A 4j26B-5uljA:
undetectable
4j26B-5uljA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 GLU A 690
LEU A 666
ILE A 862
ILE A 861
LEU A 716
None
0.97A 4j26B-5wblA:
undetectable
4j26B-5wblA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 408
LEU A 409
ILE A 449
ILE A 461
LEU A 456
None
1.22A 4j26B-5wroA:
undetectable
4j26B-5wroA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB


(Homo sapiens)
PF00373
(FERM_M)
PF00784
(MyTH4)
5 LEU A1611
LEU A1654
ILE A1674
ILE A1670
LEU A1649
None
1.27A 4j26B-5xbfA:
undetectable
4j26B-5xbfA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens)
no annotation 5 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
None
1.16A 4j26B-5yq5A:
undetectable
4j26B-5yq5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
None
1.15A 4j26B-6fkhC:
undetectable
4j26B-6fkhC:
16.09