SIMILAR PATTERNS OF AMINO ACIDS FOR 4J26_A_ESTA600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dl2 | CLASS IALPHA-1,2-MANNOSIDASE (Saccharomycescerevisiae) |
PF01532(Glyco_hydro_47) | 5 | MET A 301MET A 304LEU A 308ILE A 381LEU A 345 | None | 1.19A | 4j26A-1dl2A:undetectable | 4j26A-1dl2A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyn | FRUCTOSE-BISPHOSPHATE ALDOLASE II (Escherichiacoli) |
PF01116(F_bP_aldolase) | 5 | LEU A 116LEU A 115ILE A 83GLY A 121LEU A 123 | None | 0.89A | 4j26A-1gynA:undetectable | 4j26A-1gynA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfe | PROTEIN (FE-ONLYHYDROGENASE(E.C.1.18.99.1)(LARGER SUBUNIT)) (Desulfovibriovulgaris) |
PF02906(Fe_hyd_lg_C)PF13237(Fer4_10) | 5 | MET L 219LEU L 210ILE L 103HIS L 141LEU L 285 | None | 1.20A | 4j26A-1hfeL:undetectable | 4j26A-1hfeL:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hpl | LIPASE (Equus caballus) |
PF00151(Lipase)PF01477(PLAT) | 5 | LEU A 264MET A 234ILE A 206GLY A 231HIS A 203 | None | 0.97A | 4j26A-1hplA:undetectable | 4j26A-1hplA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i0a | DELTA CRYSTALLIN I (Meleagrisgallopavo) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | LEU A 49LEU A 60ILE A 100GLY A 66LEU A 67 | None | 1.25A | 4j26A-1i0aA:undetectable | 4j26A-1i0aA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkl | NK-LYSIN (Sus scrofa) |
PF05184(SapB_1) | 5 | MET A 49GLU A 24LEU A 61ILE A 69LEU A 14 | None | 1.04A | 4j26A-1nklA:0.6 | 4j26A-1nklA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p2x | RASGTPASE-ACTIVATING-LIKE PROTEIN (Schizosaccharomycespombe) |
PF00307(CH) | 5 | LEU A 143LEU A 78ILE A 104GLY A 72LEU A 69 | None | 0.86A | 4j26A-1p2xA:undetectable | 4j26A-1p2xA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p5s | RASGTPASE-ACTIVATING-LIKE PROTEIN RNG2 (Schizosaccharomycespombe) |
PF00307(CH) | 5 | LEU A 143LEU A 78ILE A 104GLY A 72LEU A 69 | HG A 191 ( 4.8A)NoneNoneNoneNone | 0.90A | 4j26A-1p5sA:undetectable | 4j26A-1p5sA:23.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | MET A 343LEU A 349GLU A 353LEU A 387MET A 388LEU A 391ARG A 394ILE A 424GLY A 521HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.5A)EST A 1 ( 4.1A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.39A | 4j26A-1pcgA:32.7 | 4j26A-1pcgA:59.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 5 | GLU A 136LEU A 126ILE A 200GLY A 196LEU A 195 | None | 1.14A | 4j26A-1s5pA:undetectable | 4j26A-1s5pA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6k | PHENAZINEBIOSYNTHESIS PROTEINPHZF (Pseudomonasfluorescens) |
PF02567(PhzC-PhzF) | 5 | LEU A 83LEU A 94GLY A 73HIS A 74LEU A 77 | NoneNoneSO4 A 301 (-3.6A)SO4 A 301 (-4.2A)None | 1.26A | 4j26A-1t6kA:undetectable | 4j26A-1t6kA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t98 | CHROMOSOME PARTITIONPROTEIN MUKF (Escherichiacoli) |
PF03882(KicB)PF17192(MukF_M) | 5 | MET A 178LEU A 208LEU A 207GLY A 213LEU A 215 | None | 1.26A | 4j26A-1t98A:undetectable | 4j26A-1t98A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhk | HYPOTHETICAL PROTEINYQEU (Bacillussubtilis) |
PF04452(Methyltrans_RNA) | 5 | MET A 164LEU A 200LEU A 199GLY A 222LEU A 217 | None | 1.26A | 4j26A-1vhkA:undetectable | 4j26A-1vhkA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz8 | ENOYL-COA HYDRATASE (Thermusthermophilus) |
PF00378(ECH_1) | 5 | LEU A 75GLU A 78ARG A 88GLY A 242LEU A 248 | MPD A3003 (-4.7A)NoneNoneNoneNone | 1.26A | 4j26A-1wz8A:undetectable | 4j26A-1wz8A:22.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 327GLU A 331MET A 362LEU A 365ARG A 372HIS A 494 | None | 0.61A | 4j26A-1xb7A:28.4 | 4j26A-1xb7A:34.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xxi | DNA POLYMERASE IIISUBUNIT GAMMA (Escherichiacoli) |
PF12169(DNA_pol3_gamma3)PF13177(DNA_pol3_delta2) | 5 | LEU B 353LEU B 282LEU B 281GLY B 287LEU B 289 | None | 1.17A | 4j26A-1xxiB:undetectable | 4j26A-1xxiB:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybf | AMP NUCLEOSIDASE (Bacteroidesthetaiotaomicron) |
PF01048(PNP_UDP_1) | 5 | LEU A 207LEU A 206ILE A 92GLY A 239LEU A 236 | None | 1.12A | 4j26A-1ybfA:undetectable | 4j26A-1ybfA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yve | ACETOHYDROXY ACIDISOMEROREDUCTASE (Spinaciaoleracea) |
PF01450(IlvC)PF07991(IlvN) | 5 | LEU I 224ILE I 412GLY I 231HIS I 232LEU I 233 | None | 1.26A | 4j26A-1yveI:undetectable | 4j26A-1yveI:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1w | TRICORN PROTEASEINTERACTING FACTORF3 (Thermoplasmaacidophilum) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | MET A 674LEU A 668LEU A 662ILE A 656LEU A 640 | None | 1.25A | 4j26A-1z1wA:undetectable | 4j26A-1z1wA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z48 | PROBABLENADH-DEPENDENTFLAVINOXIDOREDUCTASE YQJM (Bacillussubtilis) |
PF00724(Oxidored_FMN) | 5 | GLU A 162ARG A 215ILE A 20GLY A 54LEU A 16 | NoneFMN A1500 (-3.2A)NoneNoneNone | 1.27A | 4j26A-1z48A:undetectable | 4j26A-1z48A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | MET A 287LEU A 290ILE A 113GLY A 282LEU A 264 | None | 1.20A | 4j26A-2cy8A:undetectable | 4j26A-2cy8A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d9q | GRANULOCYTECOLONY-STIMULATINGFACTOR RECEPTOR (Homo sapiens) |
PF06328(Lep_receptor_Ig) | 5 | LEU B 171LEU B 170ARG B 167ILE B 178GLY B 177 | None | 1.20A | 4j26A-2d9qB:undetectable | 4j26A-2d9qB:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpy | FLAGELLUM-SPECIFICATP SYNTHASE (Salmonellaenterica) |
PF00006(ATP-synt_ab) | 5 | LEU A 269MET A 178ILE A 155GLY A 173LEU A 159 | None | 1.23A | 4j26A-2dpyA:undetectable | 4j26A-2dpyA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg3 | PROBABLE THIOSULFATESULFURTRANSFERASE (Thermusthermophilus) |
PF00581(Rhodanese) | 5 | LEU A 66LEU A 60GLY A 25HIS A 22LEU A 23 | None | 1.13A | 4j26A-2eg3A:undetectable | 4j26A-2eg3A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g8l | 287AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF01937(DUF89) | 5 | LEU A 93LEU A 129MET A 128ILE A 110GLY A 107 | None | 1.26A | 4j26A-2g8lA:undetectable | 4j26A-2g8lA:21.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 271GLU A 275MET A 306LEU A 309ARG A 316HIS A 434 | OHT A 500 ( 4.4A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.51A | 4j26A-2gpvA:27.3 | 4j26A-2gpvA:37.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5g | ALR4455 PROTEIN (Nostoc sp. PCC7120) |
PF00378(ECH_1) | 5 | LEU D 103LEU D 104ARG D 221ILE D 236GLY D 96 | None | 1.09A | 4j26A-2j5gD:undetectable | 4j26A-2j5gD:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | MET A 343LEU A 349GLU A 353LEU A 387MET A 388LEU A 391ARG A 394ILE A 424GLY A 521HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 ( 4.7A)EST A 596 ( 4.0A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.45A | 4j26A-2ocfA:33.7 | 4j26A-2ocfA:57.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opt | ACTII PROTEIN (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | GLU A 102LEU A 230ARG A 109GLY A 236LEU A 238 | None | 1.28A | 4j26A-2optA:undetectable | 4j26A-2optA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmi | CYCLIN-DEPENDENTPROTEIN KINASE PHO85 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | LEU A 139LEU A 140ILE A 65GLY A 120LEU A 121 | None | 1.17A | 4j26A-2pmiA:undetectable | 4j26A-2pmiA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r32 | GCN4-PII/TUMORNECROSIS FACTORLIGAND SUPERFAMILYMEMBER 18 FUSIONPROTEIN (Homo sapiens;Saccharomycescerevisiae) |
no annotation | 5 | LEU A 170ILE A 176GLY A 93HIS A 143LEU A 142 | None | 1.24A | 4j26A-2r32A:undetectable | 4j26A-2r32A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xnf | MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 25 (Homo sapiens) |
PF11232(Med25) | 5 | LEU A 511LEU A 525LEU A 514GLY A 462LEU A 464 | None | 1.30A | 4j26A-2xnfA:undetectable | 4j26A-2xnfA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEALPHA SUBUNITSULFITE REDUCTASEBETA SUBUNIT (Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF12838(Fer4_7) | 5 | GLU A 26MET B 73ARG A 30ILE B 101GLY B 69 | None | 1.23A | 4j26A-2xsjA:undetectable | 4j26A-2xsjA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkj | [PYRUVATEDEHYDROGENASE[LIPOAMIDE]] KINASEISOZYME 4 (Homo sapiens) |
PF02518(HATPase_c)PF10436(BCDHK_Adom3) | 5 | GLU A 373LEU A 35ARG A 64ILE A 179GLY A 44 | None | 1.29A | 4j26A-2zkjA:undetectable | 4j26A-2zkjA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkj | [PYRUVATEDEHYDROGENASE[LIPOAMIDE]] KINASEISOZYME 4 (Homo sapiens) |
PF02518(HATPase_c)PF10436(BCDHK_Adom3) | 5 | LEU A 172ARG A 64ILE A 179GLY A 44LEU A 41 | None | 1.30A | 4j26A-2zkjA:undetectable | 4j26A-2zkjA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axi | OLIGO-1,6-GLUCOSIDASE IMA1 (Saccharomycescerevisiae) |
PF00128(Alpha-amylase) | 5 | LEU A 330LEU A 379ILE A 357GLY A 372LEU A 374 | None | 1.19A | 4j26A-3axiA:undetectable | 4j26A-3axiA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg2 | DGTPTRIPHOSPHOHYDROLASE (Leeuwenhoekiellablandensis) |
PF01966(HD) | 5 | LEU A 94GLU A 5MET A 2ILE A 329LEU A 245 | None | 1.04A | 4j26A-3bg2A:undetectable | 4j26A-3bg2A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djd | FRUCTOSYL AMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | LEU A 392GLU A 344LEU A 73ILE A 377GLY A 359 | None | 1.26A | 4j26A-3djdA:undetectable | 4j26A-3djdA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dv9 | BETA-PHOSPHOGLUCOMUTASE (Bacteroidesvulgatus) |
PF13419(HAD_2) | 5 | LEU A 183MET A 125LEU A 122GLY A 175LEU A 172 | None | 1.15A | 4j26A-3dv9A:undetectable | 4j26A-3dv9A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5j | SUPPRESSOR OF FUSEDFAMILY PROTEIN (Neisseriagonorrhoeae) |
PF05076(SUFU) | 5 | GLU A 146LEU A 158ARG A 174ILE A 118GLY A 98 | None | 1.04A | 4j26A-3k5jA:undetectable | 4j26A-3k5jA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kum | DIPEPTIDE EPIMERASE (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 118LEU A 344ILE A 301GLY A 300LEU A 265 | None | 1.05A | 4j26A-3kumA:undetectable | 4j26A-3kumA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kye | ROADBLOCK/LC7DOMAIN, ROBL_LC7 (Streptomycesavermitilis) |
PF03259(Robl_LC7) | 5 | LEU A 16MET A 17LEU A 20ARG A 23LEU A 128 | None | 1.19A | 4j26A-3kyeA:undetectable | 4j26A-3kyeA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6i | L-ARABINITOL4-DEHYDROGENASE (Neurosporacrassa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 197LEU A 165ILE A 282GLY A 171LEU A 172 | None | 1.13A | 4j26A-3m6iA:undetectable | 4j26A-3m6iA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfk | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | LEU A 297GLU A 298ARG A 362GLY A 31LEU A 33 | None | 1.24A | 4j26A-3qfkA:undetectable | 4j26A-3qfkA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r6k | VP1 PROTEIN (Norwalk virus) |
PF08435(Calici_coat_C) | 5 | LEU A 249LEU A 237ILE A 453GLY A 264LEU A 447 | None | 1.22A | 4j26A-3r6kA:undetectable | 4j26A-3r6kA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t36 | ENDO-TYPEMEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE A (Escherichiacoli) |
PF01464(SLT) | 5 | LEU A 138GLU A 125LEU A 121GLY A 149LEU A 153 | None | 1.27A | 4j26A-3t36A:undetectable | 4j26A-3t36A:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tcr | MOLYBDOPTERINBIOSYNTHESIS PROTEIN (Mycobacteroidesabscessus) |
PF00994(MoCF_biosynth) | 5 | LEU A 162LEU A 50ILE A 29GLY A 43LEU A 45 | None | 1.21A | 4j26A-3tcrA:undetectable | 4j26A-3tcrA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1j | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Pseudomonasaeruginosa) |
PF01467(CTP_transf_like) | 5 | LEU A 5ILE A 13GLY A 18HIS A 17LEU A 20 | NoneNoneDMS A 208 (-3.5A)ACO A 201 (-4.1A)None | 1.29A | 4j26A-3x1jA:undetectable | 4j26A-3x1jA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayx | ATP-BINDING CASSETTESUB-FAMILY B MEMBER10 (Homo sapiens) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | LEU A 314MET A 436LEU A 435ILE A 196GLY A 193 | None | 1.14A | 4j26A-4ayxA:undetectable | 4j26A-4ayxA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btf | MIXED LINEAGE KINASEDOMAIN-LIKE PROTEIN (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | LEU A 45LEU A 111GLY A 37HIS A 36LEU A 39 | None | 1.25A | 4j26A-4btfA:undetectable | 4j26A-4btfA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | LEU A 383LEU A 272ILE A 410GLY A 266LEU A 265 | None | 1.21A | 4j26A-4c9mA:1.9 | 4j26A-4c9mA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccw | CARBOXYL ESTERASE NP (Bacillussubtilis) |
PF12697(Abhydrolase_6) | 5 | LEU A 160LEU A 241ILE A 152GLY A 133LEU A 134 | None | 1.10A | 4j26A-4ccwA:undetectable | 4j26A-4ccwA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egv | ACETYL-COAACETYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | LEU A 262LEU A 263ILE A 116GLY A 113LEU A 283 | None | 1.22A | 4j26A-4egvA:undetectable | 4j26A-4egvA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h5u | PROBABLE HYDROLASENIT2 (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 5 | LEU A 164LEU A 220MET A 221ILE A 172GLY A 208 | NoneNoneNoneCAF A 169 ( 3.6A)None | 1.18A | 4j26A-4h5uA:undetectable | 4j26A-4h5uA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhj | MIF4GDOMAIN-CONTAININGPROTEIN B (Danio rerio) |
PF02854(MIF4G) | 5 | GLU A 147LEU A 136LEU A 142ILE A 198HIS A 156 | None | 1.29A | 4j26A-4jhjA:undetectable | 4j26A-4jhjA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLU A3143LEU A3257MET A3258GLY A3293HIS A3404 | None | 1.04A | 4j26A-4kc5A:undetectable | 4j26A-4kc5A:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A3257MET A3258ILE A3292GLY A3293HIS A3404 | None | 1.14A | 4j26A-4kc5A:undetectable | 4j26A-4kc5A:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mps | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE 1 (Rattusnorvegicus) |
PF00777(Glyco_transf_29) | 5 | MET A 328LEU A 323MET A 149LEU A 293ILE A 250 | None | 1.22A | 4j26A-4mpsA:undetectable | 4j26A-4mpsA:22.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 5 | LEU A 286GLU A 290LEU A 324ARG A 331GLY A 444 | None | 1.24A | 4j26A-4n1yA:31.2 | 4j26A-4n1yA:38.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 7 | LEU A 286GLU A 290MET A 321LEU A 324ARG A 331ILE A 361GLY A 447 | None | 0.58A | 4j26A-4n1yA:31.2 | 4j26A-4n1yA:38.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnb | OBCA, OXALATEBIOSYNTHETICCOMPONENT A (Burkholderiaglumae) |
PF05853(BKACE) | 5 | LEU A 456LEU A 455ILE A 425GLY A 462LEU A 465 | None | 1.28A | 4j26A-4nnbA:undetectable | 4j26A-4nnbA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 108LEU A 106ILE A 96HIS A 62LEU A 61 | None | 1.14A | 4j26A-4o1oA:undetectable | 4j26A-4o1oA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovm | UNCHARACTERIZEDPROTEIN SGCJ (Streptomycescarzinostaticus) |
PF14534(DUF4440) | 5 | LEU A 132LEU A 43ARG A 27ILE A 64GLY A 60 | None | 1.28A | 4j26A-4ovmA:undetectable | 4j26A-4ovmA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5n | GLUTHATIONES-TRANSFERASE BLO T8 ISOFORM (Blomiatropicalis) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | MET A 90GLU A 105LEU A 171HIS A 24LEU A 21 | None | 1.29A | 4j26A-4q5nA:undetectable | 4j26A-4q5nA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgz | XAA-PROAMINOPEPTIDASE (Thermococcussibiricus) |
no annotation | 5 | MET A 6GLU A 72ILE A 308GLY A 236LEU A 235 | None | 1.12A | 4j26A-4rgzA:undetectable | 4j26A-4rgzA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzz | PEPTIDASE M24 (Ruegerialacuscaerulensis) |
PF00557(Peptidase_M24) | 5 | GLU A 132LEU A 162ILE A 67GLY A 74LEU A 76 | None | 1.25A | 4j26A-4rzzA:undetectable | 4j26A-4rzzA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 772MET A 807LEU A 810LEU A 814ARG A 817 | CV7 A1987 ( 4.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.51A | 4j26A-4udbA:27.5 | 4j26A-4udbA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | LEU A 103GLU A 133ILE A 28GLY A 31LEU A 413 | None | 1.26A | 4j26A-4wgxA:undetectable | 4j26A-4wgxA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xae | FERULOYL COAORTHO-HYDROXYLASE 1 (Arabidopsisthaliana) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | GLU A 323LEU A 321ILE A 332GLY A 286LEU A 287 | None | 1.19A | 4j26A-4xaeA:undetectable | 4j26A-4xaeA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yot | 3-5 EXONUCLEASEPHOEXO I (Pyrococcushorikoshii) |
PF13680(DUF4152) | 5 | LEU A 79LEU A 112LEU A 91ILE A 101GLY A 105 | None | 1.29A | 4j26A-4yotA:undetectable | 4j26A-4yotA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a12 | CHLORITE DISMUTASE (Magnetospirillumsp.) |
PF06778(Chlor_dismutase) | 5 | LEU A 116LEU A 185ARG A 183ILE A 112GLY A 19 | HEM A 250 (-3.8A)AZI A 251 ( 4.0A)AZI A 251 ( 3.8A)NoneNone | 1.21A | 4j26A-5a12A:undetectable | 4j26A-5a12A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c65 | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 3 (Homo sapiens) |
PF00083(Sugar_tr) | 5 | LEU A 276LEU A 339ILE A 285GLY A 284LEU A 282 | None | 1.28A | 4j26A-5c65A:undetectable | 4j26A-5c65A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci6 | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | LEU A 195LEU A 196ILE A 122GLY A 176LEU A 177 | None | 1.30A | 4j26A-5ci6A:undetectable | 4j26A-5ci6A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homo sapiens) |
PF00644(PARP) | 5 | LEU A 471MET A 556LEU A 356GLY A 429LEU A 430 | NoneNoneNoneNoneUHB A1001 ( 4.7A) | 1.29A | 4j26A-5dsyA:undetectable | 4j26A-5dsyA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2f | BETA-LACTAMASE YBXI (Bacillussubtilis) |
PF00905(Transpeptidase) | 5 | LEU A 84LEU A 179ILE A 170GLY A 151LEU A 145 | None | 1.26A | 4j26A-5e2fA:undetectable | 4j26A-5e2fA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7p | CELL DIVISIONCONTROL PROTEINCDC48 (Mycolicibacteriumsmegmatis) |
PF00004(AAA)PF02359(CDC48_N) | 5 | LEU A 24LEU A 60LEU A 101GLY A 93LEU A 89 | None | 1.09A | 4j26A-5e7pA:undetectable | 4j26A-5e7pA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ee7 | GLUCAGONRECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR (Escherichiavirus T4;Homo sapiens) |
PF00002(7tm_2)PF00959(Phage_lysozyme) | 5 | LEU A 316ILE A 325GLY A 246HIS A 250LEU A 247 | NoneNoneNoneOLA A1209 (-3.8A)None | 1.26A | 4j26A-5ee7A:undetectable | 4j26A-5ee7A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 5 | LEU A 36GLU A 14ILE A 74GLY A 117LEU A 116 | None | 1.26A | 4j26A-5h9dA:undetectable | 4j26A-5h9dA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i7k | BPI FOLD-CONTAININGFAMILY A MEMBER 1 (Homo sapiens) |
PF01273(LBP_BPI_CETP) | 5 | LEU A 175LEU A 129LEU A 164GLY A 249HIS A 248 | None | 1.25A | 4j26A-5i7kA:undetectable | 4j26A-5i7kA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd3 | LAE5 (unculturedbacterium) |
PF13472(Lipase_GDSL_2) | 5 | LEU A 158MET A 159ARG A 165ILE A 90GLY A 91 | None | 0.99A | 4j26A-5jd3A:undetectable | 4j26A-5jd3A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kg9 | ANTIBODY RE505-22FAB LIGHT CHAIN (Homo sapiens;Mus musculus) |
no annotation | 5 | LEU L 50LEU L 73ILE L 87GLY L 99LEU L 4 | None | 1.25A | 4j26A-5kg9L:undetectable | 4j26A-5kg9L:25.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5law | E3 UBIQUITIN-PROTEINLIGASE MDM2 (Homo sapiens) |
PF02201(SWIB) | 5 | LEU A 38LEU A 37ILE A 61GLY A 58LEU A 54 | NoneNone6SJ A 201 (-3.6A)6SJ A 201 ( 3.8A)6SJ A 201 (-4.2A) | 1.10A | 4j26A-5lawA:undetectable | 4j26A-5lawA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 5 | LEU A 670LEU A 518ILE A 908HIS A 640LEU A 638 | None | 1.12A | 4j26A-5m5pA:undetectable | 4j26A-5m5pA:8.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg3 | PROTEIN TRANSLOCASESUBUNIT SECF (Escherichiacoli) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | GLU F 194ARG F 97ILE F 40GLY F 186LEU F 185 | None | 1.30A | 4j26A-5mg3F:undetectable | 4j26A-5mg3F:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5my0 | FATTY ACID SYNTHASE (Mus musculus) |
no annotation | 5 | LEU B 191MET B 201LEU B 206GLY B 46LEU B 44 | None | 1.26A | 4j26A-5my0B:undetectable | 4j26A-5my0B:16.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | MET A 294LEU A 301GLU A 305LEU A 343ARG A 346 | NoneEST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.4A)EST A 601 (-4.1A) | 1.13A | 4j26A-5toaA:33.8 | 4j26A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 301GLU A 305MET A 336LEU A 339MET A 340LEU A 343ARG A 346ILE A 376GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.4A)EST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.36A | 4j26A-5toaA:33.8 | 4j26A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 295LEU A 354ILE A 376GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)NoneEST A 601 ( 4.4A)EST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 1.31A | 4j26A-5toaA:33.8 | 4j26A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 336LEU A 339MET A 340LEU A 343ARG A 346LEU A 490 | EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)None | 1.42A | 4j26A-5toaA:33.8 | 4j26A-5toaA:99.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | LEU A 96GLU A 168LEU A 195ILE A 39LEU A 34 | None | 1.04A | 4j26A-5u4hA:undetectable | 4j26A-5u4hA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 5 | MET A 377LEU A 418LEU A 338LEU A 336GLY A 402 | None | 1.15A | 4j26A-5ubkA:undetectable | 4j26A-5ubkA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ufk | EFFECTOR PROTEINSIDK (Legionellapneumophila) |
no annotation | 5 | MET A 115MET A 103LEU A 107ILE A 36LEU A 94 | None | 1.21A | 4j26A-5ufkA:undetectable | 4j26A-5ufkA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhd | RNA POLYMERASE SIGMAFACTOR SIGA (Mycobacteriumtuberculosis) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2)PF04545(Sigma70_r4) | 5 | GLU F 398LEU F 386ARG F 392GLY F 380LEU F 379 | None | 1.29A | 4j26A-5uhdF:undetectable | 4j26A-5uhdF:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhe | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA' (Mycobacteriumtuberculosis) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | LEU D1221LEU D 417LEU D 418GLY D 411LEU D 406 | None | 1.28A | 4j26A-5uheD:undetectable | 4j26A-5uheD:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2q | TASTE RECEPTOR, TYPE1, MEMBER 2A (Oryzias latipes) |
PF01094(ANF_receptor) | 5 | MET A 74LEU A 30LEU A 35ILE A 376GLY A 135 | None | 1.21A | 4j26A-5x2qA:undetectable | 4j26A-5x2qA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yq5 | OSTEOMODULIN (Homo sapiens) |
no annotation | 5 | MET A 182LEU A 164LEU A 168LEU A 148ILE A 174 | None | 1.16A | 4j26A-5yq5A:undetectable | 4j26A-5yq5A:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c49 | ALCOHOLDEHYDROGENASE (Acinetobacterbaumannii) |
no annotation | 5 | MET A 212LEU A 237ILE A 184GLY A 180HIS A 183 | NoneNoneNoneGOL A 406 ( 3.6A)None | 1.28A | 4j26A-6c49A:undetectable | 4j26A-6c49A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 5 | LEU A 65MET A 62LEU A 63ILE A 83GLY A 80 | None | 0.89A | 4j26A-6c7vA:undetectable | 4j26A-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 5 | LEU A 65MET A 62LEU A 63ILE A 83GLY A 81 | None | 1.19A | 4j26A-6c7vA:undetectable | 4j26A-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 5 | LEU E 458LEU E 457GLY E 463HIS E 464LEU E 465 | None | 1.11A | 4j26A-6d04E:undetectable | 4j26A-6d04E:12.92 |