SIMILAR PATTERNS OF AMINO ACIDS FOR 4J26_A_ESTA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E


(Saccharomyces
cerevisiae)
PF01532
(Glyco_hydro_47)
5 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
None
1.19A 4j26A-1dl2A:
undetectable
4j26A-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II


(Escherichia
coli)
PF01116
(F_bP_aldolase)
5 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
None
0.89A 4j26A-1gynA:
undetectable
4j26A-1gynA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))


(Desulfovibrio
vulgaris)
PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
5 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
None
1.20A 4j26A-1hfeL:
undetectable
4j26A-1hfeL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus)
PF00151
(Lipase)
PF01477
(PLAT)
5 LEU A 264
MET A 234
ILE A 206
GLY A 231
HIS A 203
None
0.97A 4j26A-1hplA:
undetectable
4j26A-1hplA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
5 LEU A  49
LEU A  60
ILE A 100
GLY A  66
LEU A  67
None
1.25A 4j26A-1i0aA:
undetectable
4j26A-1i0aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa)
PF05184
(SapB_1)
5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
None
1.04A 4j26A-1nklA:
0.6
4j26A-1nklA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN


(Schizosaccharomyces
pombe)
PF00307
(CH)
5 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
None
0.86A 4j26A-1p2xA:
undetectable
4j26A-1p2xA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2


(Schizosaccharomyces
pombe)
PF00307
(CH)
5 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
HG  A 191 ( 4.8A)
None
None
None
None
0.90A 4j26A-1p5sA:
undetectable
4j26A-1p5sA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
11 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
GLY A 521
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.39A 4j26A-1pcgA:
32.7
4j26A-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE


(Escherichia
coli)
PF02146
(SIR2)
5 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
None
1.14A 4j26A-1s5pA:
undetectable
4j26A-1s5pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF


(Pseudomonas
fluorescens)
PF02567
(PhzC-PhzF)
5 LEU A  83
LEU A  94
GLY A  73
HIS A  74
LEU A  77
None
None
SO4  A 301 (-3.6A)
SO4  A 301 (-4.2A)
None
1.26A 4j26A-1t6kA:
undetectable
4j26A-1t6kA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF


(Escherichia
coli)
PF03882
(KicB)
PF17192
(MukF_M)
5 MET A 178
LEU A 208
LEU A 207
GLY A 213
LEU A 215
None
1.26A 4j26A-1t98A:
undetectable
4j26A-1t98A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU


(Bacillus
subtilis)
PF04452
(Methyltrans_RNA)
5 MET A 164
LEU A 200
LEU A 199
GLY A 222
LEU A 217
None
1.26A 4j26A-1vhkA:
undetectable
4j26A-1vhkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus)
PF00378
(ECH_1)
5 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
MPD  A3003 (-4.7A)
None
None
None
None
1.26A 4j26A-1wz8A:
undetectable
4j26A-1wz8A:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
None
0.61A 4j26A-1xb7A:
28.4
4j26A-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA


(Escherichia
coli)
PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2)
5 LEU B 353
LEU B 282
LEU B 281
GLY B 287
LEU B 289
None
1.17A 4j26A-1xxiB:
undetectable
4j26A-1xxiB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron)
PF01048
(PNP_UDP_1)
5 LEU A 207
LEU A 206
ILE A  92
GLY A 239
LEU A 236
None
1.12A 4j26A-1ybfA:
undetectable
4j26A-1ybfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE


(Spinacia
oleracea)
PF01450
(IlvC)
PF07991
(IlvN)
5 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
None
1.26A 4j26A-1yveI:
undetectable
4j26A-1yveI:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3


(Thermoplasma
acidophilum)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 MET A 674
LEU A 668
LEU A 662
ILE A 656
LEU A 640
None
1.25A 4j26A-1z1wA:
undetectable
4j26A-1z1wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM


(Bacillus
subtilis)
PF00724
(Oxidored_FMN)
5 GLU A 162
ARG A 215
ILE A  20
GLY A  54
LEU A  16
None
FMN  A1500 (-3.2A)
None
None
None
1.27A 4j26A-1z48A:
undetectable
4j26A-1z48A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
5 MET A 287
LEU A 290
ILE A 113
GLY A 282
LEU A 264
None
1.20A 4j26A-2cy8A:
undetectable
4j26A-2cy8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9q GRANULOCYTE
COLONY-STIMULATING
FACTOR RECEPTOR


(Homo sapiens)
PF06328
(Lep_receptor_Ig)
5 LEU B 171
LEU B 170
ARG B 167
ILE B 178
GLY B 177
None
1.20A 4j26A-2d9qB:
undetectable
4j26A-2d9qB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
5 LEU A 269
MET A 178
ILE A 155
GLY A 173
LEU A 159
None
1.23A 4j26A-2dpyA:
undetectable
4j26A-2dpyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE


(Thermus
thermophilus)
PF00581
(Rhodanese)
5 LEU A  66
LEU A  60
GLY A  25
HIS A  22
LEU A  23
None
1.13A 4j26A-2eg3A:
undetectable
4j26A-2eg3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF01937
(DUF89)
5 LEU A  93
LEU A 129
MET A 128
ILE A 110
GLY A 107
None
1.26A 4j26A-2g8lA:
undetectable
4j26A-2g8lA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.51A 4j26A-2gpvA:
27.3
4j26A-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
5 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
None
1.09A 4j26A-2j5gD:
undetectable
4j26A-2j5gD:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
11 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
GLY A 521
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.45A 4j26A-2ocfA:
33.7
4j26A-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
5 GLU A 102
LEU A 230
ARG A 109
GLY A 236
LEU A 238
None
1.28A 4j26A-2optA:
undetectable
4j26A-2optA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 LEU A 139
LEU A 140
ILE A  65
GLY A 120
LEU A 121
None
1.17A 4j26A-2pmiA:
undetectable
4j26A-2pmiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r32 GCN4-PII/TUMOR
NECROSIS FACTOR
LIGAND SUPERFAMILY
MEMBER 18 FUSION
PROTEIN


(Homo sapiens;
Saccharomyces
cerevisiae)
no annotation 5 LEU A 170
ILE A 176
GLY A  93
HIS A 143
LEU A 142
None
1.24A 4j26A-2r32A:
undetectable
4j26A-2r32A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnf MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 25


(Homo sapiens)
PF11232
(Med25)
5 LEU A 511
LEU A 525
LEU A 514
GLY A 462
LEU A 464
None
1.30A 4j26A-2xnfA:
undetectable
4j26A-2xnfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT


(Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7)
5 GLU A  26
MET B  73
ARG A  30
ILE B 101
GLY B  69
None
1.23A 4j26A-2xsjA:
undetectable
4j26A-2xsjA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
5 GLU A 373
LEU A  35
ARG A  64
ILE A 179
GLY A  44
None
1.29A 4j26A-2zkjA:
undetectable
4j26A-2zkjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
5 LEU A 172
ARG A  64
ILE A 179
GLY A  44
LEU A  41
None
1.30A 4j26A-2zkjA:
undetectable
4j26A-2zkjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1


(Saccharomyces
cerevisiae)
PF00128
(Alpha-amylase)
5 LEU A 330
LEU A 379
ILE A 357
GLY A 372
LEU A 374
None
1.19A 4j26A-3axiA:
undetectable
4j26A-3axiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE


(Leeuwenhoekiella
blandensis)
PF01966
(HD)
5 LEU A  94
GLU A   5
MET A   2
ILE A 329
LEU A 245
None
1.04A 4j26A-3bg2A:
undetectable
4j26A-3bg2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
5 LEU A 392
GLU A 344
LEU A  73
ILE A 377
GLY A 359
None
1.26A 4j26A-3djdA:
undetectable
4j26A-3djdA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE


(Bacteroides
vulgatus)
PF13419
(HAD_2)
5 LEU A 183
MET A 125
LEU A 122
GLY A 175
LEU A 172
None
1.15A 4j26A-3dv9A:
undetectable
4j26A-3dv9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN


(Neisseria
gonorrhoeae)
PF05076
(SUFU)
5 GLU A 146
LEU A 158
ARG A 174
ILE A 118
GLY A  98
None
1.04A 4j26A-3k5jA:
undetectable
4j26A-3k5jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
None
1.05A 4j26A-3kumA:
undetectable
4j26A-3kumA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7


(Streptomyces
avermitilis)
PF03259
(Robl_LC7)
5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
None
1.19A 4j26A-3kyeA:
undetectable
4j26A-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE


(Neurospora
crassa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 197
LEU A 165
ILE A 282
GLY A 171
LEU A 172
None
1.13A 4j26A-3m6iA:
undetectable
4j26A-3m6iA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 LEU A 297
GLU A 298
ARG A 362
GLY A  31
LEU A  33
None
1.24A 4j26A-3qfkA:
undetectable
4j26A-3qfkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus)
PF08435
(Calici_coat_C)
5 LEU A 249
LEU A 237
ILE A 453
GLY A 264
LEU A 447
None
1.22A 4j26A-3r6kA:
undetectable
4j26A-3r6kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A


(Escherichia
coli)
PF01464
(SLT)
5 LEU A 138
GLU A 125
LEU A 121
GLY A 149
LEU A 153
None
1.27A 4j26A-3t36A:
undetectable
4j26A-3t36A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN


(Mycobacteroides
abscessus)
PF00994
(MoCF_biosynth)
5 LEU A 162
LEU A  50
ILE A  29
GLY A  43
LEU A  45
None
1.21A 4j26A-3tcrA:
undetectable
4j26A-3tcrA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF01467
(CTP_transf_like)
5 LEU A   5
ILE A  13
GLY A  18
HIS A  17
LEU A  20
None
None
DMS  A 208 (-3.5A)
ACO  A 201 (-4.1A)
None
1.29A 4j26A-3x1jA:
undetectable
4j26A-3x1jA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 LEU A 314
MET A 436
LEU A 435
ILE A 196
GLY A 193
None
1.14A 4j26A-4ayxA:
undetectable
4j26A-4ayxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 LEU A  45
LEU A 111
GLY A  37
HIS A  36
LEU A  39
None
1.25A 4j26A-4btfA:
undetectable
4j26A-4btfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A 383
LEU A 272
ILE A 410
GLY A 266
LEU A 265
None
1.21A 4j26A-4c9mA:
1.9
4j26A-4c9mA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
5 LEU A 160
LEU A 241
ILE A 152
GLY A 133
LEU A 134
None
1.10A 4j26A-4ccwA:
undetectable
4j26A-4ccwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE


(Mycolicibacterium
smegmatis)
no annotation 5 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
None
1.22A 4j26A-4egvA:
undetectable
4j26A-4egvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2


(Saccharomyces
cerevisiae)
PF00795
(CN_hydrolase)
5 LEU A 164
LEU A 220
MET A 221
ILE A 172
GLY A 208
None
None
None
CAF  A 169 ( 3.6A)
None
1.18A 4j26A-4h5uA:
undetectable
4j26A-4h5uA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B


(Danio rerio)
PF02854
(MIF4G)
5 GLU A 147
LEU A 136
LEU A 142
ILE A 198
HIS A 156
None
1.29A 4j26A-4jhjA:
undetectable
4j26A-4jhjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLU A3143
LEU A3257
MET A3258
GLY A3293
HIS A3404
None
1.04A 4j26A-4kc5A:
undetectable
4j26A-4kc5A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A3257
MET A3258
ILE A3292
GLY A3293
HIS A3404
None
1.14A 4j26A-4kc5A:
undetectable
4j26A-4kc5A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
5 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
None
1.22A 4j26A-4mpsA:
undetectable
4j26A-4mpsA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 286
GLU A 290
LEU A 324
ARG A 331
GLY A 444
None
1.24A 4j26A-4n1yA:
31.2
4j26A-4n1yA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
7 LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
GLY A 447
None
0.58A 4j26A-4n1yA:
31.2
4j26A-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A


(Burkholderia
glumae)
PF05853
(BKACE)
5 LEU A 456
LEU A 455
ILE A 425
GLY A 462
LEU A 465
None
1.28A 4j26A-4nnbA:
undetectable
4j26A-4nnbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
None
1.14A 4j26A-4o1oA:
undetectable
4j26A-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovm UNCHARACTERIZED
PROTEIN SGCJ


(Streptomyces
carzinostaticus)
PF14534
(DUF4440)
5 LEU A 132
LEU A  43
ARG A  27
ILE A  64
GLY A  60
None
1.28A 4j26A-4ovmA:
undetectable
4j26A-4ovmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM


(Blomia
tropicalis)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.29A 4j26A-4q5nA:
undetectable
4j26A-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgz XAA-PRO
AMINOPEPTIDASE


(Thermococcus
sibiricus)
no annotation 5 MET A   6
GLU A  72
ILE A 308
GLY A 236
LEU A 235
None
1.12A 4j26A-4rgzA:
undetectable
4j26A-4rgzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis)
PF00557
(Peptidase_M24)
5 GLU A 132
LEU A 162
ILE A  67
GLY A  74
LEU A  76
None
1.25A 4j26A-4rzzA:
undetectable
4j26A-4rzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 772
MET A 807
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.51A 4j26A-4udbA:
27.5
4j26A-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax)
PF01979
(Amidohydro_1)
5 LEU A 103
GLU A 133
ILE A  28
GLY A  31
LEU A 413
None
1.26A 4j26A-4wgxA:
undetectable
4j26A-4wgxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1


(Arabidopsis
thaliana)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
None
1.19A 4j26A-4xaeA:
undetectable
4j26A-4xaeA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I


(Pyrococcus
horikoshii)
PF13680
(DUF4152)
5 LEU A  79
LEU A 112
LEU A  91
ILE A 101
GLY A 105
None
1.29A 4j26A-4yotA:
undetectable
4j26A-4yotA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.)
PF06778
(Chlor_dismutase)
5 LEU A 116
LEU A 185
ARG A 183
ILE A 112
GLY A  19
HEM  A 250 (-3.8A)
AZI  A 251 ( 4.0A)
AZI  A 251 ( 3.8A)
None
None
1.21A 4j26A-5a12A:
undetectable
4j26A-5a12A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3


(Homo sapiens)
PF00083
(Sugar_tr)
5 LEU A 276
LEU A 339
ILE A 285
GLY A 284
LEU A 282
None
1.28A 4j26A-5c65A:
undetectable
4j26A-5c65A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 LEU A 195
LEU A 196
ILE A 122
GLY A 176
LEU A 177
None
1.30A 4j26A-5ci6A:
undetectable
4j26A-5ci6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2


(Homo sapiens)
PF00644
(PARP)
5 LEU A 471
MET A 556
LEU A 356
GLY A 429
LEU A 430
None
None
None
None
UHB  A1001 ( 4.7A)
1.29A 4j26A-5dsyA:
undetectable
4j26A-5dsyA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis)
PF00905
(Transpeptidase)
5 LEU A  84
LEU A 179
ILE A 170
GLY A 151
LEU A 145
None
1.26A 4j26A-5e2fA:
undetectable
4j26A-5e2fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
5 LEU A  24
LEU A  60
LEU A 101
GLY A  93
LEU A  89
None
1.09A 4j26A-5e7pA:
undetectable
4j26A-5e7pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR


(Escherichia
virus T4;
Homo sapiens)
PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
5 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
None
None
None
OLA  A1209 (-3.8A)
None
1.26A 4j26A-5ee7A:
undetectable
4j26A-5ee7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  36
GLU A  14
ILE A  74
GLY A 117
LEU A 116
None
1.26A 4j26A-5h9dA:
undetectable
4j26A-5h9dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1


(Homo sapiens)
PF01273
(LBP_BPI_CETP)
5 LEU A 175
LEU A 129
LEU A 164
GLY A 249
HIS A 248
None
1.25A 4j26A-5i7kA:
undetectable
4j26A-5i7kA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd3 LAE5

(uncultured
bacterium)
PF13472
(Lipase_GDSL_2)
5 LEU A 158
MET A 159
ARG A 165
ILE A  90
GLY A  91
None
0.99A 4j26A-5jd3A:
undetectable
4j26A-5jd3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kg9 ANTIBODY RE505-22
FAB LIGHT CHAIN


(Homo sapiens;
Mus musculus)
no annotation 5 LEU L  50
LEU L  73
ILE L  87
GLY L  99
LEU L   4
None
1.25A 4j26A-5kg9L:
undetectable
4j26A-5kg9L:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2


(Homo sapiens)
PF02201
(SWIB)
5 LEU A  38
LEU A  37
ILE A  61
GLY A  58
LEU A  54
None
None
6SJ  A 201 (-3.6A)
6SJ  A 201 ( 3.8A)
6SJ  A 201 (-4.2A)
1.10A 4j26A-5lawA:
undetectable
4j26A-5lawA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
None
1.12A 4j26A-5m5pA:
undetectable
4j26A-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF


(Escherichia
coli)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 GLU F 194
ARG F  97
ILE F  40
GLY F 186
LEU F 185
None
1.30A 4j26A-5mg3F:
undetectable
4j26A-5mg3F:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus)
no annotation 5 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
None
1.26A 4j26A-5my0B:
undetectable
4j26A-5my0B:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 294
LEU A 301
GLU A 305
LEU A 343
ARG A 346
None
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
1.13A 4j26A-5toaA:
33.8
4j26A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 295
LEU A 301
GLU A 305
MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 376
GLY A 472
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.36A 4j26A-5toaA:
33.8
4j26A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 295
LEU A 354
ILE A 376
GLY A 472
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
1.31A 4j26A-5toaA:
33.8
4j26A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
LEU A 490
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
1.42A 4j26A-5toaA:
33.8
4j26A-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
None
1.04A 4j26A-5u4hA:
undetectable
4j26A-5u4hA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
5 MET A 377
LEU A 418
LEU A 338
LEU A 336
GLY A 402
None
1.15A 4j26A-5ubkA:
undetectable
4j26A-5ubkA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufk EFFECTOR PROTEIN
SIDK


(Legionella
pneumophila)
no annotation 5 MET A 115
MET A 103
LEU A 107
ILE A  36
LEU A  94
None
1.21A 4j26A-5ufkA:
undetectable
4j26A-5ufkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd RNA POLYMERASE SIGMA
FACTOR SIGA


(Mycobacterium
tuberculosis)
PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
5 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
None
1.29A 4j26A-5uhdF:
undetectable
4j26A-5uhdF:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'


(Mycobacterium
tuberculosis)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU D1221
LEU D 417
LEU D 418
GLY D 411
LEU D 406
None
1.28A 4j26A-5uheD:
undetectable
4j26A-5uheD:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A


(Oryzias latipes)
PF01094
(ANF_receptor)
5 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
None
1.21A 4j26A-5x2qA:
undetectable
4j26A-5x2qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens)
no annotation 5 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
None
1.16A 4j26A-5yq5A:
undetectable
4j26A-5yq5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE


(Acinetobacter
baumannii)
no annotation 5 MET A 212
LEU A 237
ILE A 184
GLY A 180
HIS A 183
None
None
None
GOL  A 406 ( 3.6A)
None
1.28A 4j26A-6c49A:
undetectable
4j26A-6c49A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 5 LEU A  65
MET A  62
LEU A  63
ILE A  83
GLY A  80
None
0.89A 4j26A-6c7vA:
undetectable
4j26A-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 5 LEU A  65
MET A  62
LEU A  63
ILE A  83
GLY A  81
None
1.19A 4j26A-6c7vA:
undetectable
4j26A-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE


(Plasmodium
vivax)
no annotation 5 LEU E 458
LEU E 457
GLY E 463
HIS E 464
LEU E 465
None
1.11A 4j26A-6d04E:
undetectable
4j26A-6d04E:
12.92