SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_C_ESTC600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8m | HUMAN RHINOVIRUS 16COAT PROTEIN (Rhinovirus A) |
PF00073(Rhv) | 5 | LEU 2 86MET 2 247ILE 2 23ILE 2 16HIS 2 109 | None | 1.30A | 4j24C-1c8m2:undetectable | 4j24C-1c8m2:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dl2 | CLASS IALPHA-1,2-MANNOSIDASE (Saccharomycescerevisiae) |
PF01532(Glyco_hydro_47) | 5 | MET A 301MET A 304LEU A 308ILE A 381LEU A 345 | None | 1.17A | 4j24C-1dl2A:0.0 | 4j24C-1dl2A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i51 | CASPASE-7 SUBUNITP20 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | MET A 119LEU A 123ILE A 183ILE A 150LEU A 142 | None | 1.06A | 4j24C-1i51A:undetectable | 4j24C-1i51A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k86 | CASPASE-7 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | MET A 119LEU A 123ILE A 183ILE A 150LEU A 142 | None | 1.15A | 4j24C-1k86A:undetectable | 4j24C-1k86A:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mw9 | DNA TOPOISOMERASE I (Escherichiacoli) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | GLU X 547ARG X 168ILE X 504ILE X 501LEU X 203 | None | 1.31A | 4j24C-1mw9X:0.9 | 4j24C-1mw9X:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkl | NK-LYSIN (Sus scrofa) |
PF05184(SapB_1) | 5 | MET A 49GLU A 24LEU A 61ILE A 69LEU A 14 | None | 1.05A | 4j24C-1nklA:undetectable | 4j24C-1nklA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3w | CYSTEINE DESULFURASE (Escherichiacoli) |
no annotation | 5 | LEU B 147LEU B 199MET B 200ILE B 166ILE B 163 | None | 1.27A | 4j24C-1p3wB:undetectable | 4j24C-1p3wB:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p43 | ENOLASE 1 (Saccharomycescerevisiae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 342LEU A 343ILE A 383ILE A 395LEU A 390 | None2PG A 441 (-4.7A)NoneNoneNone | 1.27A | 4j24C-1p43A:undetectable | 4j24C-1p43A:20.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 342LEU A 349GLU A 353LEU A 387LEU A 391ARG A 394 | NoneEST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)EST A 1 ( 3.9A)EST A 1 (-3.7A) | 1.32A | 4j24C-1pcgA:33.4 | 4j24C-1pcgA:59.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 349GLU A 353LEU A 387MET A 388LEU A 391ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.5A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.38A | 4j24C-1pcgA:33.4 | 4j24C-1pcgA:59.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdz | ENOLASE (Homarusgammarus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 341LEU A 342ILE A 382ILE A 394LEU A 389 | None | 1.26A | 4j24C-1pdzA:undetectable | 4j24C-1pdzA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ub3 | ALDOLASE PROTEIN (Thermusthermophilus) |
PF01791(DeoC) | 5 | LEU A 105GLU A 108LEU A 94ILE A 135LEU A 150 | None | 1.30A | 4j24C-1ub3A:undetectable | 4j24C-1ub3A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uw0 | DNA LIGASE III (Homo sapiens) |
PF00645(zf-PARP) | 5 | LEU A 76ILE A 53ILE A 90HIS A 93LEU A 97 | None | 1.22A | 4j24C-1uw0A:undetectable | 4j24C-1uw0A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl2 | ARGININOSUCCINATESYNTHASE (Thermotogamaritima) |
PF00764(Arginosuc_synth) | 5 | MET A 184LEU A 76ILE A 91ILE A 319LEU A 86 | None | 1.26A | 4j24C-1vl2A:undetectable | 4j24C-1vl2A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wjt | TRANSCRIPTIONELONGATION FACTORS-II PROTEIN 3 (Mus musculus) |
PF08711(Med26) | 5 | LEU A 15GLU A 11MET A 45LEU A 49LEU A 40 | None | 1.32A | 4j24C-1wjtA:undetectable | 4j24C-1wjtA:19.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 327GLU A 331MET A 362LEU A 365ARG A 372HIS A 494 | None | 0.59A | 4j24C-1xb7A:28.2 | 4j24C-1xb7A:34.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | MET A 506LEU A 327GLU A 331MET A 362LEU A 365 | None | 1.31A | 4j24C-1xb7A:28.2 | 4j24C-1xb7A:34.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akz | GAMMA ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 339LEU A 340ILE A 380ILE A 392LEU A 387 | None | 1.24A | 4j24C-2akzA:undetectable | 4j24C-2akzA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bx6 | XRP2 PROTEIN (Homo sapiens) |
PF07986(TBCC) | 5 | LEU A 189LEU A 188ARG A 228ILE A 137LEU A 125 | NoneNoneSO4 A1348 (-3.9A)NoneNone | 1.27A | 4j24C-2bx6A:undetectable | 4j24C-2bx6A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuk | GLYCERATEDEHYDROGENASE/GLYOXYLATE REDUCTASE (Thermusthermophilus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 252LEU A 226LEU A 199ILE A 155LEU A 105 | None | 1.32A | 4j24C-2cukA:undetectable | 4j24C-2cukA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ga8 | HYPOTHETICAL 39.9KDA PROTEIN (Saccharomycescerevisiae) |
PF07728(AAA_5) | 5 | LEU A 290LEU A 270LEU A 271ILE A 350ILE A 295 | None | 1.26A | 4j24C-2ga8A:undetectable | 4j24C-2ga8A:22.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 271GLU A 275MET A 306LEU A 309ARG A 316HIS A 434 | OHT A 500 ( 4.4A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.50A | 4j24C-2gpvA:27.6 | 4j24C-2gpvA:37.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5g | ALR4455 PROTEIN (Nostoc sp. PCC7120) |
PF00378(ECH_1) | 6 | LEU D 103LEU D 104ARG D 221ILE D 157ILE D 236HIS D 156 | None | 1.44A | 4j24C-2j5gD:undetectable | 4j24C-2j5gD:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | LEU A 329MET A 170LEU A 330ILE A 291ILE A 317 | LEU A 329 ( 0.6A)ILE A 167 ( 3.7A)LEU A 330 ( 0.6A)ILE A 291 ( 0.7A)ILE A 317 ( 0.7A) | 1.32A | 4j24C-2nvvA:undetectable | 4j24C-2nvvA:20.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 349GLU A 353LEU A 387MET A 388LEU A 391ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 ( 4.7A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.44A | 4j24C-2ocfA:34.3 | 4j24C-2ocfA:57.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2omv | INTERNALIN-A (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4) | 5 | LEU A 126ARG A 168ILE A 132ILE A 135LEU A 116 | None | 1.25A | 4j24C-2omvA:undetectable | 4j24C-2omvA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa6 | ENOLASE (Methanocaldococcusjannaschii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 272LEU A 273ILE A 309ILE A 311LEU A 247 | None | 1.16A | 4j24C-2pa6A:undetectable | 4j24C-2pa6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa6 | ENOLASE (Methanocaldococcusjannaschii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 336LEU A 337ILE A 377ILE A 389LEU A 384 | None | 1.30A | 4j24C-2pa6A:undetectable | 4j24C-2pa6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pge | MENC (Desulfotaleapsychrophila) |
PF13378(MR_MLE_C) | 5 | MET A 5LEU A 69ILE A 103ILE A 106LEU A 132 | None | 1.30A | 4j24C-2pgeA:undetectable | 4j24C-2pgeA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ql7 | CASPASE-7 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | MET A 119LEU A 123ILE A 183ILE A 150LEU A 142 | None | 1.01A | 4j24C-2ql7A:undetectable | 4j24C-2ql7A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbe | BIPOLAR KINESINKRP-130 (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | LEU C 247LEU C 75ILE C 317ILE C 8LEU C 305 | None | 1.01A | 4j24C-2wbeC:undetectable | 4j24C-2wbeC:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsx | BETA-ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 340LEU A 341ILE A 381ILE A 393LEU A 388 | None | 1.24A | 4j24C-2xsxA:undetectable | 4j24C-2xsxA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y05 | PROSTAGLANDINREDUCTASE 1 (Homo sapiens) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | LEU A 86GLU A 103LEU A 284ARG A 280ILE A 113 | NoneNoneNoneEDO A1332 (-4.3A)None | 1.31A | 4j24C-2y05A:undetectable | 4j24C-2y05A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yx0 | RADICAL SAM ENZYME (Pyrococcushorikoshii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 5 | MET A 159LEU A 231MET A 232LEU A 235ILE A 175 | None | 1.00A | 4j24C-2yx0A:undetectable | 4j24C-2yx0A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b97 | ALPHA-ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 339LEU A 340ILE A 380ILE A 392LEU A 387 | None | 1.23A | 4j24C-3b97A:undetectable | 4j24C-3b97A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg9 | PYRUVATECARBOXYLASE,MITOCHONDRIAL (Homo sapiens) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 5 | GLU A 865LEU A 746ARG A 715ILE A 704ILE A 740 | None | 1.27A | 4j24C-3bg9A:undetectable | 4j24C-3bg9A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgw | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF00772(DnaB)PF03796(DnaB_C) | 5 | LEU A 354LEU A 199ILE A 333ILE A 336LEU A 319 | None | 1.19A | 4j24C-3bgwA:undetectable | 4j24C-3bgwA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bh0 | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF03796(DnaB_C) | 5 | LEU A 354LEU A 199ILE A 333ILE A 336LEU A 319 | None | 1.09A | 4j24C-3bh0A:undetectable | 4j24C-3bh0A:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clw | CONSERVED EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF14587(Glyco_hydr_30_2) | 5 | LEU A 251LEU A 149ILE A 241ILE A 246LEU A 187 | None | 1.04A | 4j24C-3clwA:undetectable | 4j24C-3clwA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csq | MORPHOGENESISPROTEIN 1 (Bacillus virusphi29) |
no annotation | 5 | LEU A 22MET A 42LEU A 39MET A 38ILE A 98 | None | 1.17A | 4j24C-3csqA:undetectable | 4j24C-3csqA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csz | MORPHOGENESISPROTEIN 1 (Bacillus virusphi29) |
no annotation | 5 | LEU A 22MET A 42LEU A 39MET A 38ILE A 98 | None | 1.20A | 4j24C-3cszA:undetectable | 4j24C-3cszA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 5 | LEU A 46LEU A 22LEU A 21ILE A 369LEU A 235 | NoneNoneNoneNoneFAD A 609 (-4.2A) | 1.29A | 4j24C-3da1A:undetectable | 4j24C-3da1A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dka | DINB-LIKE PROTEIN (Bacillussubtilis) |
PF05163(DinB) | 5 | LEU A 120LEU A 121ILE A 92HIS A 53LEU A 54 | None | 1.32A | 4j24C-3dkaA:undetectable | 4j24C-3dkaA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | GLU A 894LEU A 776ARG A 505ILE A 878LEU A 932 | None | 1.31A | 4j24C-3dy5A:undetectable | 4j24C-3dy5A:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffh | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Listeriainnocua) |
PF00155(Aminotran_1_2) | 5 | LEU A 189GLU A 191ILE A 240ILE A 241LEU A 93 | None | 1.23A | 4j24C-3ffhA:undetectable | 4j24C-3ffhA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhu | PREPILIN (Salmonellaenterica) |
PF08805(PilS) | 5 | MET A 133LEU A 36ILE A 98ILE A 116LEU A 175 | None | 1.26A | 4j24C-3fhuA:undetectable | 4j24C-3fhuA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5i | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | LEU A 21LEU A 28ILE A 33ILE A 61LEU A 56 | None | 1.09A | 4j24C-3g5iA:undetectable | 4j24C-3g5iA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S9,MITOCHONDRIAL (Bos taurus) |
PF00380(Ribosomal_S9) | 5 | LEU I 346MET I 364LEU I 369ILE I 257LEU I 352 | None | 1.28A | 4j24C-3jd5I:undetectable | 4j24C-3jd5I:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kye | ROADBLOCK/LC7DOMAIN, ROBL_LC7 (Streptomycesavermitilis) |
PF03259(Robl_LC7) | 5 | LEU A 16MET A 17LEU A 20ARG A 23LEU A 128 | None | 1.22A | 4j24C-3kyeA:undetectable | 4j24C-3kyeA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lre | KINESIN-LIKE PROTEINKIF18A (Homo sapiens) |
PF00225(Kinesin) | 5 | MET A 123LEU A 135ILE A 329ILE A 327LEU A 256 | None | 1.16A | 4j24C-3lreA:undetectable | 4j24C-3lreA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdk | STRINGENT STARVATIONPROTEIN A (Pseudomonasputida) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | LEU A 23GLU A 27LEU A 84ARG A 190ILE A 102 | None | 1.07A | 4j24C-3mdkA:undetectable | 4j24C-3mdkA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7j | OHCU DECARBOXYLASE (Klebsiellapneumoniae) |
PF09349(OHCU_decarbox) | 5 | GLU A 161LEU A 158ARG A 49HIS A 80LEU A 83 | None | 1.31A | 4j24C-3o7jA:undetectable | 4j24C-3o7jA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otr | ENOLASE (Toxoplasmagondii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 352LEU A 353ILE A 393ILE A 405LEU A 400 | None | 1.22A | 4j24C-3otrA:undetectable | 4j24C-3otrA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT JNADH-QUINONEOXIDOREDUCTASESUBUNIT K (Escherichiacoli) |
no annotation | 5 | MET K 38LEU K 35ILE K 24ILE J 20LEU K 19 | None | 1.32A | 4j24C-3rkoK:undetectable | 4j24C-3rkoK:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwb | PYRIDOXAL4-DEHYDROGENASE (Mesorhizobiumloti) |
PF13561(adh_short_C2) | 5 | LEU A 168LEU A 85ILE A 118ILE A 62LEU A 113 | NoneNoneNoneNAD A 251 (-3.9A)None | 1.22A | 4j24C-3rwbA:undetectable | 4j24C-3rwbA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 5 | LEU A 209GLU A 171MET A 226ILE A 262ILE A 274 | SAM A 992 (-4.8A)SAM A 992 (-2.8A)NoneNoneNone | 1.11A | 4j24C-3t7vA:undetectable | 4j24C-3t7vA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wib | HALOALKANEDEHALOGENASE (Agrobacteriumfabrum) |
PF00561(Abhydrolase_1) | 5 | LEU A 239GLU A 267LEU A 287ARG A 294ILE A 37 | None | 1.26A | 4j24C-3wibA:undetectable | 4j24C-3wibA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atg | TAF6 (Antonosporalocustae) |
PF07571(TAF6_C) | 5 | LEU A 222LEU A 211ILE A 247ILE A 205LEU A 228 | None | 1.23A | 4j24C-4atgA:undetectable | 4j24C-4atgA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bax | GLUTAMINE SYNTHETASE (Streptomycescoelicolor) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | LEU A 335ARG A 321ILE A 252ILE A 253LEU A 343 | None | 1.25A | 4j24C-4baxA:undetectable | 4j24C-4baxA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bla | MALTOSE-BINDINGPERIPLASMIC PROTEIN,SUPPRESSOR OF FUSEDHOMOLOG (Escherichiacoli;Homo sapiens) |
PF05076(SUFU)PF12470(SUFU_C)PF13416(SBP_bac_8) | 5 | MET A 708LEU A 654ILE A 671ILE A 698LEU A 734 | None | 1.22A | 4j24C-4blaA:undetectable | 4j24C-4blaA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7f | ENOLASE (Trypanosomacruzi) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 340LEU A 341ILE A 381ILE A 393LEU A 388 | None | 1.29A | 4j24C-4g7fA:undetectable | 4j24C-4g7fA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 5 | LEU A 136GLU A 89LEU A 340ILE A 336ILE A 335 | None | 1.21A | 4j24C-4hsuA:undetectable | 4j24C-4hsuA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 5 | LEU A 340GLU A 89LEU A 136ILE A 335ILE A 336 | None | 1.29A | 4j24C-4hsuA:undetectable | 4j24C-4hsuA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERTRANSMEMBRANEPROTEIN ECFTPREDICTED MEMBRANEPROTEIN (Lactobacillusbrevis) |
PF02361(CbiQ)PF07155(ECF-ribofla_trS) | 5 | LEU T 171MET T 205LEU T 208ILE S 44LEU S 39 | None | 1.08A | 4j24C-4hzuT:undetectable | 4j24C-4hzuT:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 5 | MET D 399LEU D 438ILE D 413ILE D 414LEU D 380 | None | 1.29A | 4j24C-4igbD:undetectable | 4j24C-4igbD:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iru | LEPB (Legionellapneumophila) |
no annotation | 5 | LEU A 376GLU A 380ILE A 478ILE A 477LEU A 471 | None | 1.29A | 4j24C-4iruA:undetectable | 4j24C-4iruA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jas | HISTIDINE KINASE (Thermotogamaritima) |
PF00512(HisKA)PF02518(HATPase_c) | 5 | LEU A 406LEU A 398ILE A 365ILE A 370HIS A 456 | None | 1.19A | 4j24C-4jasA:undetectable | 4j24C-4jasA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhj | MIF4GDOMAIN-CONTAININGPROTEIN B (Danio rerio) |
PF02854(MIF4G) | 5 | GLU A 147LEU A 136LEU A 142ILE A 198HIS A 156 | None | 1.31A | 4j24C-4jhjA:undetectable | 4j24C-4jhjA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mps | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE 1 (Rattusnorvegicus) |
PF00777(Glyco_transf_29) | 5 | MET A 328LEU A 323MET A 149LEU A 293ILE A 250 | None | 1.19A | 4j24C-4mpsA:undetectable | 4j24C-4mpsA:22.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 6 | LEU A 286GLU A 290MET A 321LEU A 324ARG A 331ILE A 361 | None | 0.64A | 4j24C-4n1yA:31.1 | 4j24C-4n1yA:38.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 108LEU A 106ILE A 96HIS A 62LEU A 61 | None | 1.15A | 4j24C-4o1oA:undetectable | 4j24C-4o1oA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5n | GLUTHATIONES-TRANSFERASE BLO T8 ISOFORM (Blomiatropicalis) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | MET A 90GLU A 105LEU A 171HIS A 24LEU A 21 | None | 1.27A | 4j24C-4q5nA:undetectable | 4j24C-4q5nA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rca | SLIT AND NTRK-LIKEPROTEIN 1 (Homo sapiens) |
PF13855(LRR_8) | 5 | LEU B 184LEU B 208ILE B 230ILE B 204LEU B 198 | None | 1.30A | 4j24C-4rcaB:undetectable | 4j24C-4rcaB:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 772MET A 807LEU A 810LEU A 814ARG A 817 | CV7 A1987 ( 4.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.45A | 4j24C-4udbA:28.0 | 4j24C-4udbA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | LEU A 335LEU A 154LEU A 155ILE A 285LEU A 329 | None | 1.29A | 4j24C-4y6oA:undetectable | 4j24C-4y6oA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yoo | RETINOBLASTOMA-LIKEPROTEIN1,RETINOBLASTOMA-LIKE PROTEIN 1 (Homo sapiens) |
PF01857(RB_B)PF01858(RB_A) | 5 | LEU A 506ILE A 427ILE A 430HIS A 498LEU A 501 | None | 1.27A | 4j24C-4yooA:undetectable | 4j24C-4yooA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zvs | CASPASE-7 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | MET A 119LEU A 123ILE A 183ILE A 150LEU A 142 | None | 1.14A | 4j24C-4zvsA:undetectable | 4j24C-4zvsA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | LEU A 435LEU A 436ILE A 354ILE A 401HIS A 211 | None | 1.31A | 4j24C-4zxiA:undetectable | 4j24C-4zxiA:11.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | LEU A 435MET A 432LEU A 436ILE A 276ILE A 354 | None | 1.22A | 4j24C-4zxiA:undetectable | 4j24C-4zxiA:11.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT RRP42 (Saccharomycescerevisiae) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | GLU E 205MET E 197ARG E 26ILE E 214ILE E 215 | None | 1.24A | 4j24C-5g06E:undetectable | 4j24C-5g06E:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gje | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 6 (Homo sapiens) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 5 | LEU A 320LEU A 335ILE A 550ILE A 323LEU A 559 | None | 1.18A | 4j24C-5gjeA:undetectable | 4j24C-5gjeA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 5 | GLU A 239ARG A 66ILE A 25ILE A 24LEU A 18 | None | 1.23A | 4j24C-5hj7A:undetectable | 4j24C-5hj7A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 5 | GLU A 239LEU A 63ARG A 66ILE A 24LEU A 18 | None | 1.24A | 4j24C-5hj7A:undetectable | 4j24C-5hj7A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ie2 | OXALATE--COA LIGASE (Arabidopsisthaliana) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 218LEU A 61ILE A 40ILE A 71LEU A 23 | None | 1.22A | 4j24C-5ie2A:undetectable | 4j24C-5ie2A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijw | GLUTAMATE RACEMASE (Mycolicibacteriumsmegmatis) |
PF01177(Asp_Glu_race) | 5 | GLU A 243LEU A 63ARG A 66ILE A 24LEU A 18 | None | 1.23A | 4j24C-5ijwA:undetectable | 4j24C-5ijwA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 5 | LEU A 670LEU A 518ILE A 908HIS A 640LEU A 638 | None | 1.10A | 4j24C-5m5pA:undetectable | 4j24C-5m5pA:8.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | LEU A 382LEU A 379ILE A 582ILE A 576HIS A 534 | None | 1.29A | 4j24C-5t0lA:undetectable | 4j24C-5t0lA:18.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 339GLU A 305LEU A 301ILE A 376ILE A 373LEU A 354 | EST A 601 (-3.9A)EST A 601 (-2.4A)EST A 601 ( 4.3A)EST A 601 ( 4.4A)NoneNone | 1.32A | 4j24C-5toaA:34.3 | 4j24C-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | MET A 294LEU A 301GLU A 305MET A 340LEU A 343ARG A 346ILE A 373 | NoneEST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)None | 1.44A | 4j24C-5toaA:34.3 | 4j24C-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 301GLU A 305MET A 336LEU A 339MET A 340LEU A 343ARG A 346ILE A 373ILE A 376HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.32A | 4j24C-5toaA:34.3 | 4j24C-5toaA:99.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | LEU A 96GLU A 168LEU A 195ILE A 39LEU A 34 | None | 1.06A | 4j24C-5u4hA:undetectable | 4j24C-5u4hA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ulj | RAI1 (Scheffersomycesstipitis) |
PF08652(RAI1) | 5 | MET A 111MET A 80LEU A 83ILE A 104LEU A 127 | None | 1.08A | 4j24C-5uljA:undetectable | 4j24C-5uljA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgu | MICROCOMPARTMENTSPROTEIN (Halothece sp.PCC 7418) |
no annotation | 5 | MET A 24LEU A 18ILE A 47ILE A 46LEU A 9 | None | 1.29A | 4j24C-5vguA:undetectable | 4j24C-5vguA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 5 | GLU A 690LEU A 666ILE A 862ILE A 861LEU A 716 | None | 0.97A | 4j24C-5wblA:undetectable | 4j24C-5wblA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wro | ENOLASE (Drosophilamelanogaster) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 408LEU A 409ILE A 449ILE A 461LEU A 456 | None | 1.28A | 4j24C-5wroA:undetectable | 4j24C-5wroA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy5 | NON-STRUCTURALMAINTENANCE OFCHROMOSOMES ELEMENT1 HOMOLOG (Homo sapiens) |
PF07574(SMC_Nse1)PF08746(zf-RING-like) | 5 | LEU A 21LEU A 28ILE A 60ILE A 57LEU A 86 | None | 1.30A | 4j24C-5wy5A:undetectable | 4j24C-5wy5A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbf | UNCONVENTIONALMYOSIN-VIIB (Homo sapiens) |
PF00373(FERM_M)PF00784(MyTH4) | 5 | LEU A1611LEU A1654ILE A1674ILE A1670LEU A1649 | None | 1.30A | 4j24C-5xbfA:undetectable | 4j24C-5xbfA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMONOVALENT CATION/H+ANTIPORTER SUBUNIT C (Pyrococcusfuriosus) |
no annotation | 5 | LEU G 21LEU I 101ILE G 36ILE G 13LEU G 15 | None | 1.24A | 4j24C-6cfwG:undetectable | 4j24C-6cfwG:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn1 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasputida) |
no annotation | 5 | LEU A 97GLU A 170LEU A 197ILE A 74LEU A 34 | NoneEPU A 501 ( 4.9A)NoneNoneNone | 1.14A | 4j24C-6cn1A:undetectable | 4j24C-6cn1A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkh | ATP SYNTHASE SUBUNITALPHA, CHLOROPLASTIC (Spinaciaoleracea) |
no annotation | 5 | GLU C 131LEU C 294ARG C 297ILE C 199LEU C 235 | None | 1.20A | 4j24C-6fkhC:undetectable | 4j24C-6fkhC:16.09 |