SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_C_ESTC600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN


(Rhinovirus A)
PF00073
(Rhv)
5 LEU 2  86
MET 2 247
ILE 2  23
ILE 2  16
HIS 2 109
None
1.30A 4j24C-1c8m2:
undetectable
4j24C-1c8m2:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E


(Saccharomyces
cerevisiae)
PF01532
(Glyco_hydro_47)
5 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
None
1.17A 4j24C-1dl2A:
0.0
4j24C-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20


(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.06A 4j24C-1i51A:
undetectable
4j24C-1i51A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.15A 4j24C-1k86A:
undetectable
4j24C-1k86A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 GLU X 547
ARG X 168
ILE X 504
ILE X 501
LEU X 203
None
1.31A 4j24C-1mw9X:
0.9
4j24C-1mw9X:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa)
PF05184
(SapB_1)
5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
None
1.05A 4j24C-1nklA:
undetectable
4j24C-1nklA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli)
no annotation 5 LEU B 147
LEU B 199
MET B 200
ILE B 166
ILE B 163
None
1.27A 4j24C-1p3wB:
undetectable
4j24C-1p3wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
None
2PG  A 441 (-4.7A)
None
None
None
1.27A 4j24C-1p43A:
undetectable
4j24C-1p43A:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 342
LEU A 349
GLU A 353
LEU A 387
LEU A 391
ARG A 394
None
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
1.32A 4j24C-1pcgA:
33.4
4j24C-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.38A 4j24C-1pcgA:
33.4
4j24C-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 341
LEU A 342
ILE A 382
ILE A 394
LEU A 389
None
1.26A 4j24C-1pdzA:
undetectable
4j24C-1pdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus)
PF01791
(DeoC)
5 LEU A 105
GLU A 108
LEU A  94
ILE A 135
LEU A 150
None
1.30A 4j24C-1ub3A:
undetectable
4j24C-1ub3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw0 DNA LIGASE III

(Homo sapiens)
PF00645
(zf-PARP)
5 LEU A  76
ILE A  53
ILE A  90
HIS A  93
LEU A  97
None
1.22A 4j24C-1uw0A:
undetectable
4j24C-1uw0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE


(Thermotoga
maritima)
PF00764
(Arginosuc_synth)
5 MET A 184
LEU A  76
ILE A  91
ILE A 319
LEU A  86
None
1.26A 4j24C-1vl2A:
undetectable
4j24C-1vl2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjt TRANSCRIPTION
ELONGATION FACTOR
S-II PROTEIN 3


(Mus musculus)
PF08711
(Med26)
5 LEU A  15
GLU A  11
MET A  45
LEU A  49
LEU A  40
None
1.32A 4j24C-1wjtA:
undetectable
4j24C-1wjtA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
None
0.59A 4j24C-1xb7A:
28.2
4j24C-1xb7A:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 506
LEU A 327
GLU A 331
MET A 362
LEU A 365
None
1.31A 4j24C-1xb7A:
28.2
4j24C-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
None
1.24A 4j24C-2akzA:
undetectable
4j24C-2akzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens)
PF07986
(TBCC)
5 LEU A 189
LEU A 188
ARG A 228
ILE A 137
LEU A 125
None
None
SO4  A1348 (-3.9A)
None
None
1.27A 4j24C-2bx6A:
undetectable
4j24C-2bx6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE


(Thermus
thermophilus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 252
LEU A 226
LEU A 199
ILE A 155
LEU A 105
None
1.32A 4j24C-2cukA:
undetectable
4j24C-2cukA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN


(Saccharomyces
cerevisiae)
PF07728
(AAA_5)
5 LEU A 290
LEU A 270
LEU A 271
ILE A 350
ILE A 295
None
1.26A 4j24C-2ga8A:
undetectable
4j24C-2ga8A:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.50A 4j24C-2gpvA:
27.6
4j24C-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
6 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
HIS D 156
None
1.44A 4j24C-2j5gD:
undetectable
4j24C-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
5 LEU A 329
MET A 170
LEU A 330
ILE A 291
ILE A 317
LEU  A 329 ( 0.6A)
ILE  A 167 ( 3.7A)
LEU  A 330 ( 0.6A)
ILE  A 291 ( 0.7A)
ILE  A 317 ( 0.7A)
1.32A 4j24C-2nvvA:
undetectable
4j24C-2nvvA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.44A 4j24C-2ocfA:
34.3
4j24C-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 LEU A 126
ARG A 168
ILE A 132
ILE A 135
LEU A 116
None
1.25A 4j24C-2omvA:
undetectable
4j24C-2omvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
None
1.16A 4j24C-2pa6A:
undetectable
4j24C-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 336
LEU A 337
ILE A 377
ILE A 389
LEU A 384
None
1.30A 4j24C-2pa6A:
undetectable
4j24C-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila)
PF13378
(MR_MLE_C)
5 MET A   5
LEU A  69
ILE A 103
ILE A 106
LEU A 132
None
1.30A 4j24C-2pgeA:
undetectable
4j24C-2pgeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql7 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.01A 4j24C-2ql7A:
undetectable
4j24C-2ql7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
5 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
None
1.01A 4j24C-2wbeC:
undetectable
4j24C-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
None
1.24A 4j24C-2xsxA:
undetectable
4j24C-2xsxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 LEU A  86
GLU A 103
LEU A 284
ARG A 280
ILE A 113
None
None
None
EDO  A1332 (-4.3A)
None
1.31A 4j24C-2y05A:
undetectable
4j24C-2y05A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii)
PF04055
(Radical_SAM)
PF08608
(Wyosine_form)
5 MET A 159
LEU A 231
MET A 232
LEU A 235
ILE A 175
None
1.00A 4j24C-2yx0A:
undetectable
4j24C-2yx0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
None
1.23A 4j24C-3b97A:
undetectable
4j24C-3b97A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
5 GLU A 865
LEU A 746
ARG A 715
ILE A 704
ILE A 740
None
1.27A 4j24C-3bg9A:
undetectable
4j24C-3bg9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE


(Bacillus phage
SPP1)
PF00772
(DnaB)
PF03796
(DnaB_C)
5 LEU A 354
LEU A 199
ILE A 333
ILE A 336
LEU A 319
None
1.19A 4j24C-3bgwA:
undetectable
4j24C-3bgwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE


(Bacillus phage
SPP1)
PF03796
(DnaB_C)
5 LEU A 354
LEU A 199
ILE A 333
ILE A 336
LEU A 319
None
1.09A 4j24C-3bh0A:
undetectable
4j24C-3bh0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
5 LEU A 251
LEU A 149
ILE A 241
ILE A 246
LEU A 187
None
1.04A 4j24C-3clwA:
undetectable
4j24C-3clwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.17A 4j24C-3csqA:
undetectable
4j24C-3csqA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.20A 4j24C-3cszA:
undetectable
4j24C-3cszA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
5 LEU A  46
LEU A  22
LEU A  21
ILE A 369
LEU A 235
None
None
None
None
FAD  A 609 (-4.2A)
1.29A 4j24C-3da1A:
undetectable
4j24C-3da1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis)
PF05163
(DinB)
5 LEU A 120
LEU A 121
ILE A  92
HIS A  53
LEU A  54
None
1.32A 4j24C-3dkaA:
undetectable
4j24C-3dkaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
None
1.31A 4j24C-3dy5A:
undetectable
4j24C-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
5 LEU A 189
GLU A 191
ILE A 240
ILE A 241
LEU A  93
None
1.23A 4j24C-3ffhA:
undetectable
4j24C-3ffhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhu PREPILIN

(Salmonella
enterica)
PF08805
(PilS)
5 MET A 133
LEU A  36
ILE A  98
ILE A 116
LEU A 175
None
1.26A 4j24C-3fhuA:
undetectable
4j24C-3fhuA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
None
1.09A 4j24C-3g5iA:
undetectable
4j24C-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL


(Bos taurus)
PF00380
(Ribosomal_S9)
5 LEU I 346
MET I 364
LEU I 369
ILE I 257
LEU I 352
None
1.28A 4j24C-3jd5I:
undetectable
4j24C-3jd5I:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7


(Streptomyces
avermitilis)
PF03259
(Robl_LC7)
5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
None
1.22A 4j24C-3kyeA:
undetectable
4j24C-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A


(Homo sapiens)
PF00225
(Kinesin)
5 MET A 123
LEU A 135
ILE A 329
ILE A 327
LEU A 256
None
1.16A 4j24C-3lreA:
undetectable
4j24C-3lreA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdk STRINGENT STARVATION
PROTEIN A


(Pseudomonas
putida)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A  23
GLU A  27
LEU A  84
ARG A 190
ILE A 102
None
1.07A 4j24C-3mdkA:
undetectable
4j24C-3mdkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae)
PF09349
(OHCU_decarbox)
5 GLU A 161
LEU A 158
ARG A  49
HIS A  80
LEU A  83
None
1.31A 4j24C-3o7jA:
undetectable
4j24C-3o7jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 352
LEU A 353
ILE A 393
ILE A 405
LEU A 400
None
1.22A 4j24C-3otrA:
undetectable
4j24C-3otrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K


(Escherichia
coli)
no annotation 5 MET K  38
LEU K  35
ILE K  24
ILE J  20
LEU K  19
None
1.32A 4j24C-3rkoK:
undetectable
4j24C-3rkoK:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE


(Mesorhizobium
loti)
PF13561
(adh_short_C2)
5 LEU A 168
LEU A  85
ILE A 118
ILE A  62
LEU A 113
None
None
None
NAD  A 251 (-3.9A)
None
1.22A 4j24C-3rwbA:
undetectable
4j24C-3rwbA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB


(Methanosarcina
barkeri)
PF04055
(Radical_SAM)
5 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
1.11A 4j24C-3t7vA:
undetectable
4j24C-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE


(Agrobacterium
fabrum)
PF00561
(Abhydrolase_1)
5 LEU A 239
GLU A 267
LEU A 287
ARG A 294
ILE A  37
None
1.26A 4j24C-3wibA:
undetectable
4j24C-3wibA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae)
PF07571
(TAF6_C)
5 LEU A 222
LEU A 211
ILE A 247
ILE A 205
LEU A 228
None
1.23A 4j24C-4atgA:
undetectable
4j24C-4atgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
5 LEU A 335
ARG A 321
ILE A 252
ILE A 253
LEU A 343
None
1.25A 4j24C-4baxA:
undetectable
4j24C-4baxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
5 MET A 708
LEU A 654
ILE A 671
ILE A 698
LEU A 734
None
1.22A 4j24C-4blaA:
undetectable
4j24C-4blaA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
None
1.29A 4j24C-4g7fA:
undetectable
4j24C-4g7fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
5 LEU A 136
GLU A  89
LEU A 340
ILE A 336
ILE A 335
None
1.21A 4j24C-4hsuA:
undetectable
4j24C-4hsuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
5 LEU A 340
GLU A  89
LEU A 136
ILE A 335
ILE A 336
None
1.29A 4j24C-4hsuA:
undetectable
4j24C-4hsuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN


(Lactobacillus
brevis)
PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS)
5 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j24C-4hzuT:
undetectable
4j24C-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN


(Streptococcus
gordonii)
no annotation 5 MET D 399
LEU D 438
ILE D 413
ILE D 414
LEU D 380
None
1.29A 4j24C-4igbD:
undetectable
4j24C-4igbD:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila)
no annotation 5 LEU A 376
GLU A 380
ILE A 478
ILE A 477
LEU A 471
None
1.29A 4j24C-4iruA:
undetectable
4j24C-4iruA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima)
PF00512
(HisKA)
PF02518
(HATPase_c)
5 LEU A 406
LEU A 398
ILE A 365
ILE A 370
HIS A 456
None
1.19A 4j24C-4jasA:
undetectable
4j24C-4jasA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B


(Danio rerio)
PF02854
(MIF4G)
5 GLU A 147
LEU A 136
LEU A 142
ILE A 198
HIS A 156
None
1.31A 4j24C-4jhjA:
undetectable
4j24C-4jhjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
5 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
None
1.19A 4j24C-4mpsA:
undetectable
4j24C-4mpsA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
6 LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
None
0.64A 4j24C-4n1yA:
31.1
4j24C-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
None
1.15A 4j24C-4o1oA:
undetectable
4j24C-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM


(Blomia
tropicalis)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.27A 4j24C-4q5nA:
undetectable
4j24C-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1


(Homo sapiens)
PF13855
(LRR_8)
5 LEU B 184
LEU B 208
ILE B 230
ILE B 204
LEU B 198
None
1.30A 4j24C-4rcaB:
undetectable
4j24C-4rcaB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 772
MET A 807
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.45A 4j24C-4udbA:
28.0
4j24C-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 LEU A 335
LEU A 154
LEU A 155
ILE A 285
LEU A 329
None
1.29A 4j24C-4y6oA:
undetectable
4j24C-4y6oA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
5 LEU A 506
ILE A 427
ILE A 430
HIS A 498
LEU A 501
None
1.27A 4j24C-4yooA:
undetectable
4j24C-4yooA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvs CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
None
1.14A 4j24C-4zvsA:
undetectable
4j24C-4zvsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 LEU A 435
LEU A 436
ILE A 354
ILE A 401
HIS A 211
None
1.31A 4j24C-4zxiA:
undetectable
4j24C-4zxiA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 LEU A 435
MET A 432
LEU A 436
ILE A 276
ILE A 354
None
1.22A 4j24C-4zxiA:
undetectable
4j24C-4zxiA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42


(Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
5 GLU E 205
MET E 197
ARG E  26
ILE E 214
ILE E 215
None
1.24A 4j24C-5g06E:
undetectable
4j24C-5g06E:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 LEU A 320
LEU A 335
ILE A 550
ILE A 323
LEU A 559
None
1.18A 4j24C-5gjeA:
undetectable
4j24C-5gjeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis)
PF01177
(Asp_Glu_race)
5 GLU A 239
ARG A  66
ILE A  25
ILE A  24
LEU A  18
None
1.23A 4j24C-5hj7A:
undetectable
4j24C-5hj7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis)
PF01177
(Asp_Glu_race)
5 GLU A 239
LEU A  63
ARG A  66
ILE A  24
LEU A  18
None
1.24A 4j24C-5hj7A:
undetectable
4j24C-5hj7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 218
LEU A  61
ILE A  40
ILE A  71
LEU A  23
None
1.22A 4j24C-5ie2A:
undetectable
4j24C-5ie2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis)
PF01177
(Asp_Glu_race)
5 GLU A 243
LEU A  63
ARG A  66
ILE A  24
LEU A  18
None
1.23A 4j24C-5ijwA:
undetectable
4j24C-5ijwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
None
1.10A 4j24C-5m5pA:
undetectable
4j24C-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 LEU A 382
LEU A 379
ILE A 582
ILE A 576
HIS A 534
None
1.29A 4j24C-5t0lA:
undetectable
4j24C-5t0lA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 339
GLU A 305
LEU A 301
ILE A 376
ILE A 373
LEU A 354
EST  A 601 (-3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.3A)
EST  A 601 ( 4.4A)
None
None
1.32A 4j24C-5toaA:
34.3
4j24C-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 MET A 294
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
ILE A 373
None
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
1.44A 4j24C-5toaA:
34.3
4j24C-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 295
LEU A 301
GLU A 305
MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 373
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.32A 4j24C-5toaA:
34.3
4j24C-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
None
1.06A 4j24C-5u4hA:
undetectable
4j24C-5u4hA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis)
PF08652
(RAI1)
5 MET A 111
MET A  80
LEU A  83
ILE A 104
LEU A 127
None
1.08A 4j24C-5uljA:
undetectable
4j24C-5uljA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgu MICROCOMPARTMENTS
PROTEIN


(Halothece sp.
PCC 7418)
no annotation 5 MET A  24
LEU A  18
ILE A  47
ILE A  46
LEU A   9
None
1.29A 4j24C-5vguA:
undetectable
4j24C-5vguA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 GLU A 690
LEU A 666
ILE A 862
ILE A 861
LEU A 716
None
0.97A 4j24C-5wblA:
undetectable
4j24C-5wblA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 408
LEU A 409
ILE A 449
ILE A 461
LEU A 456
None
1.28A 4j24C-5wroA:
undetectable
4j24C-5wroA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG


(Homo sapiens)
PF07574
(SMC_Nse1)
PF08746
(zf-RING-like)
5 LEU A  21
LEU A  28
ILE A  60
ILE A  57
LEU A  86
None
1.30A 4j24C-5wy5A:
undetectable
4j24C-5wy5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB


(Homo sapiens)
PF00373
(FERM_M)
PF00784
(MyTH4)
5 LEU A1611
LEU A1654
ILE A1674
ILE A1670
LEU A1649
None
1.30A 4j24C-5xbfA:
undetectable
4j24C-5xbfA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C


(Pyrococcus
furiosus)
no annotation 5 LEU G  21
LEU I 101
ILE G  36
ILE G  13
LEU G  15
None
1.24A 4j24C-6cfwG:
undetectable
4j24C-6cfwG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
None
EPU  A 501 ( 4.9A)
None
None
None
1.14A 4j24C-6cn1A:
undetectable
4j24C-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
None
1.20A 4j24C-6fkhC:
undetectable
4j24C-6fkhC:
16.09