SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_B_ESTB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE


(Acinetobacter
glutaminasificans)
PF00710
(Asparaginase)
5 LEU A 313
LEU A 310
ILE A 210
ILE A 207
LEU A  67
None
1.12A 4j24B-1agxA:
0.0
4j24B-1agxA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C


(Enterovirus C)
PF00548
(Peptidase_C3)
5 MET A  27
LEU A  37
GLU A  71
ILE A  47
ILE A  56
None
1.20A 4j24B-1l1nA:
undetectable
4j24B-1l1nA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa)
PF05184
(SapB_1)
5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
None
1.06A 4j24B-1nklA:
undetectable
4j24B-1nklA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA


(Escherichia
coli)
PF13646
(HEAT_2)
5 MET A 260
LEU A 257
LEU A 254
ILE A 242
ILE A 241
None
1.22A 4j24B-1oyzA:
undetectable
4j24B-1oyzA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
LEU A 349
GLU A 353
LEU A 387
MET A 388
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.39A 4j24B-1pcgA:
33.0
4j24B-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
GOL  A 700 ( 4.4A)
None
None
None
None
1.09A 4j24B-1q3xA:
undetectable
4j24B-1q3xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
5 LEU A  28
MET A  36
ILE A 110
ILE A 108
LEU A  55
None
None
SAM  A 302 (-3.8A)
None
None
1.08A 4j24B-1ve3A:
undetectable
4j24B-1ve3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN


(Escherichia
coli)
PF04257
(Exonuc_V_gamma)
5 LEU C 720
LEU C 717
LEU C 747
ILE C 374
LEU C 677
None
1.05A 4j24B-1w36C:
0.7
4j24B-1w36C:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 MET A 219
LEU A 191
LEU A 166
ILE A 211
ILE A 199
None
1.21A 4j24B-1wwkA:
undetectable
4j24B-1wwkA:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 324
LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
None
0.60A 4j24B-1xb7A:
28.6
4j24B-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqi NUCLEOSIDE
DIPHOSPHATE KINASE


(Pyrobaculum
aerophilum)
PF00334
(NDK)
5 LEU A  20
LEU A  19
ILE A  35
ILE A  36
LEU A  44
None
1.12A 4j24B-1xqiA:
undetectable
4j24B-1xqiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
None
1.08A 4j24B-1zjkA:
undetectable
4j24B-1zjkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE


(Saccharomyces
cerevisiae)
PF00977
(His_biosynth)
5 LEU A 193
LEU A 192
LEU A 227
ILE A 177
ILE A 209
None
1.23A 4j24B-2agkA:
undetectable
4j24B-2agkA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2


(Homo sapiens)
PF12937
(F-box-like)
5 LEU B2356
LEU B2362
ILE B2348
ILE B2370
LEU B2379
None
1.22A 4j24B-2assB:
undetectable
4j24B-2assB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU X 195
LEU X 196
LEU X 256
ILE X 146
HIS X 128
None
1.01A 4j24B-2dq7X:
undetectable
4j24B-2dq7X:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 268
LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.52A 4j24B-2gpvA:
27.5
4j24B-2gpvA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
LEU A 349
GLU A 353
LEU A 387
MET A 388
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.42A 4j24B-2ocfA:
34.1
4j24B-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 429
LEU A 430
LEU A 490
ILE A 380
HIS A 362
None
0.87A 4j24B-2og8A:
undetectable
4j24B-2og8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 LEU A 409
LEU A 425
MET A 426
ILE A 462
ILE A 463
None
0.96A 4j24B-2xymA:
undetectable
4j24B-2xymA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 LEU A 432
LEU A 433
LEU A 493
ILE A 383
HIS A 365
None
1.01A 4j24B-2zv7A:
undetectable
4j24B-2zv7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE


(Mus musculus)
PF00685
(Sulfotransfer_1)
5 LEU X 211
LEU X 208
ILE X  41
ILE X  43
LEU X 189
None
1.23A 4j24B-2zyvX:
undetectable
4j24B-2zyvX:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajy ANCESTRAL CONGERIN
CON-ANC


(-)
PF00337
(Gal-bind_lectin)
5 LEU A  43
LEU A  41
ILE A  98
ILE A  87
LEU A  17
None
1.20A 4j24B-3ajyA:
undetectable
4j24B-3ajyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY


(Thermus
thermophilus)
no annotation 5 LEU C 139
ARG C 196
ILE C 135
ILE C 132
LEU C 151
None
1.04A 4j24B-3anpC:
undetectable
4j24B-3anpC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 689
LEU A 690
LEU A 750
ILE A 639
HIS A 621
None
0.98A 4j24B-3c4fA:
undetectable
4j24B-3c4fA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB


(Methylosinus
trichosporium)
PF02461
(AMO)
PF04744
(Monooxygenase_B)
5 LEU B 172
LEU B 185
LEU A 187
ILE A 195
ILE B 121
None
1.16A 4j24B-3chxB:
undetectable
4j24B-3chxB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
5 LEU A 251
LEU A 149
ILE A 241
ILE A 246
LEU A 187
None
1.05A 4j24B-3clwA:
undetectable
4j24B-3clwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.13A 4j24B-3csqA:
undetectable
4j24B-3csqA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1


(Bacillus virus
phi29)
no annotation 5 LEU A  22
MET A  42
LEU A  39
MET A  38
ILE A  98
None
1.16A 4j24B-3cszA:
undetectable
4j24B-3cszA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e19 FEOA

(Thermococcus
thioreducens)
PF04023
(FeoA)
5 MET A  34
LEU A  36
ILE A  55
ILE A  53
LEU A  68
None
1.15A 4j24B-3e19A:
undetectable
4j24B-3e19A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN


(Escherichia
coli)
PF02665
(Nitrate_red_gam)
5 LEU C 133
LEU C 132
ILE C  59
ILE C  62
LEU C 102
HEM  C 806 ( 4.8A)
None
HEM  C 806 (-4.3A)
HEM  C 807 (-4.0A)
None
0.87A 4j24B-3egwC:
undetectable
4j24B-3egwC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN


(Escherichia
coli)
PF02665
(Nitrate_red_gam)
5 LEU C 133
LEU C 139
ILE C  59
ILE C  62
LEU C 102
HEM  C 806 ( 4.8A)
None
HEM  C 806 (-4.3A)
HEM  C 807 (-4.0A)
None
0.89A 4j24B-3egwC:
undetectable
4j24B-3egwC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE


(Bacillus
subtilis)
PF05995
(CDO_I)
5 MET A 127
MET A 148
ILE A  64
ILE A  62
HIS A 139
FE  A 202 ( 4.8A)
None
None
None
None
1.18A 4j24B-3eqeA:
undetectable
4j24B-3eqeA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2)
PF00665
(rve)
PF02022
(Integrase_Zn)
5 LEU A 102
LEU A  99
MET A  63
ILE A 133
ILE A 135
None
1.14A 4j24B-3f9kA:
undetectable
4j24B-3f9kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY


(Thermotoga
maritima)
PF00392
(GntR)
PF07729
(FCD)
5 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
None
None
ACT  A 302 (-3.0A)
None
None
1.17A 4j24B-3fmsA:
undetectable
4j24B-3fmsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR


(Staphylococcus
aureus)
PF13377
(Peripla_BP_3)
5 LEU A 263
GLU A 265
LEU A 229
ILE A 248
ILE A 189
None
1.23A 4j24B-3hcwA:
undetectable
4j24B-3hcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A1088
LEU A1089
LEU A1150
ILE A1038
HIS A1020
None
None
None
None
8ST  A2001 ( 4.8A)
0.94A 4j24B-3hngA:
undetectable
4j24B-3hngA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
5 MET A 173
LEU A 176
LEU A 179
ILE A   6
LEU A  57
None
1.06A 4j24B-3iuuA:
undetectable
4j24B-3iuuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdk STRINGENT STARVATION
PROTEIN A


(Pseudomonas
putida)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A  23
GLU A  27
LEU A  84
ARG A 190
ILE A 102
None
1.07A 4j24B-3mdkA:
undetectable
4j24B-3mdkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae)
PF01417
(ENTH)
5 LEU A  94
LEU A  97
ILE A 116
ILE A 113
LEU A 146
None
1.10A 4j24B-3onkA:
undetectable
4j24B-3onkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 MET A 208
LEU A 211
ILE A 173
ILE A 176
LEU A 231
None
0.93A 4j24B-3opbA:
undetectable
4j24B-3opbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN


(Thermotoga
maritima)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A 269
LEU A 268
ILE A 229
ILE A 228
LEU A 274
None
1.22A 4j24B-3p4xA:
undetectable
4j24B-3p4xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE


(Pseudomonas
aeruginosa)
PF03702
(AnmK)
5 MET A 300
LEU A 303
LEU A 306
LEU A 278
ILE A 163
None
1.15A 4j24B-3qbwA:
undetectable
4j24B-3qbwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 LEU A 409
LEU A 425
MET A 426
ILE A 462
ILE A 463
None
None
None
63F  A 601 (-4.0A)
None
0.99A 4j24B-3qghA:
undetectable
4j24B-3qghA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB


(Methanosarcina
barkeri)
PF04055
(Radical_SAM)
5 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
1.08A 4j24B-3t7vA:
undetectable
4j24B-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB


(Yersinia pestis)
PF13407
(Peripla_BP_4)
5 LEU A  55
GLU A  27
LEU A 282
ILE A 295
ILE A 293
None
1.21A 4j24B-3t95A:
undetectable
4j24B-3t95A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 689
LEU A 690
LEU A 750
ILE A 639
HIS A 621
None
1.04A 4j24B-3tt0A:
undetectable
4j24B-3tt0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE


(Schizosaccharomyces
pombe)
PF00180
(Iso_dh)
5 MET A 312
LEU A 313
LEU A  28
ILE A   7
LEU A  75
None
1.22A 4j24B-3ty4A:
undetectable
4j24B-3ty4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Burkholderia
ambifaria)
no annotation 5 MET A  40
LEU A 237
ARG A 141
ILE A  23
ILE A  27
None
None
AKG  A 302 (-3.7A)
None
None
1.16A 4j24B-3w21A:
undetectable
4j24B-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
5 MET A 201
LEU A 204
ILE A 186
ILE A 215
LEU A 243
None
1.10A 4j24B-3w25A:
undetectable
4j24B-3w25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae)
PF07571
(TAF6_C)
5 LEU A 222
LEU A 211
ILE A 247
ILE A 205
LEU A 228
None
1.19A 4j24B-4atgA:
undetectable
4j24B-4atgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
5 LEU B 867
LEU B 895
ILE B 885
HIS B 901
LEU B 902
None
1.18A 4j24B-4fhnB:
undetectable
4j24B-4fhnB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 LEU H 473
LEU H 472
LEU H 538
ILE H 679
ILE H 682
None
1.11A 4j24B-4fxgH:
undetectable
4j24B-4fxgH:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
5 LEU M 699
LEU M 615
LEU M 725
ILE M 649
ILE M 653
None
1.05A 4j24B-4gq2M:
undetectable
4j24B-4gq2M:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN


(Lactobacillus
brevis)
PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS)
5 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.07A 4j24B-4hzuT:
undetectable
4j24B-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
5 LEU A 609
LEU A 612
LEU A 639
ILE A 569
ILE A 645
None
1.16A 4j24B-4ifqA:
undetectable
4j24B-4ifqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 683
LEU A 684
LEU A 744
ILE A 633
HIS A 615
None
0.95A 4j24B-4k33A:
undetectable
4j24B-4k33A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8)
5 MET A 421
LEU A 419
LEU A 392
ILE A 405
ILE A 409
None
1.18A 4j24B-4lxrA:
undetectable
4j24B-4lxrA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
5 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
None
1.18A 4j24B-4mpsA:
undetectable
4j24B-4mpsA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
7 LEU A 283
LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
None
0.60A 4j24B-4n1yA:
31.0
4j24B-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE


(Thermotoga
maritima)
PF09861
(DUF2088)
5 MET A 223
LEU A 236
LEU A   5
ILE A 148
LEU A  47
None
1.21A 4j24B-4narA:
undetectable
4j24B-4narA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 219
LEU A 222
LEU A 299
ILE A 249
ILE A 250
None
0.95A 4j24B-4nhdA:
undetectable
4j24B-4nhdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus)
PF00915
(Calici_coat)
5 LEU A 201
LEU A 204
MET A 279
ILE A 215
LEU A 196
None
1.19A 4j24B-4pb6A:
undetectable
4j24B-4pb6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
5 LEU A 466
LEU A 229
ARG A  75
ILE A 807
ILE A 818
None
1.12A 4j24B-4q2cA:
undetectable
4j24B-4q2cA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Saccharomyces
cerevisiae)
PF00929
(RNase_T)
PF13423
(UCH_1)
5 LEU A 550
LEU A 547
ILE A 520
ILE A 519
LEU A 574
None
1.16A 4j24B-4q8hA:
undetectable
4j24B-4q8hA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
5 LEU A 219
LEU A 291
MET A 290
ILE A 126
ILE A 130
None
1.07A 4j24B-4qnyA:
undetectable
4j24B-4qnyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 769
LEU A 772
MET A 807
LEU A 810
ARG A 817
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.7A)
0.47A 4j24B-4udbA:
27.9
4j24B-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF00331
(Glyco_hydro_10)
5 MET A 542
LEU A 545
ILE A 527
ILE A 556
LEU A 585
None
1.08A 4j24B-4w8lA:
undetectable
4j24B-4w8lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
5 LEU A 352
LEU A 353
ILE A  12
ILE A  17
LEU A 313
None
1.05A 4j24B-4wu0A:
undetectable
4j24B-4wu0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 678
LEU A 679
LEU A 739
ILE A 628
HIS A 610
None
0.97A 4j24B-4xcuA:
undetectable
4j24B-4xcuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 877
LEU A 878
LEU A 939
ILE A 827
HIS A 809
None
None
None
P30  A1001 (-4.7A)
P30  A1001 (-4.4A)
0.98A 4j24B-4xufA:
undetectable
4j24B-4xufA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE


(Methanospirillum
hungatei)
PF00485
(PRK)
5 LEU A  80
LEU A  79
ILE A 119
ILE A 117
LEU A 133
None
1.15A 4j24B-5b3fA:
undetectable
4j24B-5b3fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 LEU A  54
LEU A  50
LEU A  39
ILE A 155
ILE A 151
None
1.09A 4j24B-5e4vA:
undetectable
4j24B-5e4vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio)
PF00850
(Hist_deacetyl)
5 LEU A 171
LEU A 180
MET A 376
ILE A 186
LEU A 357
None
1.15A 4j24B-5eefA:
undetectable
4j24B-5eefA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2a KLLA0C04147P

(Kluyveromyces
lactis)
PF00023
(Ank)
5 LEU A  34
LEU A  37
ILE A  73
ILE A  89
LEU A  87
None
1.06A 4j24B-5h2aA:
undetectable
4j24B-5h2aA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 LEU A  61
LEU A  58
GLU A  54
LEU A  98
ILE A 281
None
1.14A 4j24B-5h3aA:
undetectable
4j24B-5h3aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC


(Escherichia
coli)
PF09344
(Cas_CT1975)
5 LEU D 239
GLU D 118
ARG D 165
ILE D 250
ILE D  58
None
1.18A 4j24B-5h9fD:
undetectable
4j24B-5h9fD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus)
no annotation 5 LEU C 194
LEU C 190
LEU C 172
ILE C 290
ILE C 161
None
1.22A 4j24B-5hr4C:
undetectable
4j24B-5hr4C:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY


(Thermomonospora
curvata)
PF04261
(Dyp_perox)
5 LEU A 164
LEU A  71
MET A  88
LEU A  91
ILE A 387
None
1.23A 4j24B-5jxuA:
undetectable
4j24B-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE


(Klebsiella
pneumoniae)
PF03739
(YjgP_YjgQ)
5 MET F  88
LEU F  93
ILE F   3
ILE F   4
LEU F  98
None
0.83A 4j24B-5l75F:
undetectable
4j24B-5l75F:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE


(Jeotgalicoccus
sp. ATCC 8456)
PF00067
(p450)
5 LEU A 247
MET A 103
LEU A 102
ILE A 374
ILE A 373
HEM  A 501 (-4.4A)
None
None
None
None
1.03A 4j24B-5m0oA:
undetectable
4j24B-5m0oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2


(Homo sapiens)
PF00227
(Proteasome)
5 LEU J 104
LEU J 102
MET J  35
ILE J 183
LEU J 115
None
1.21A 4j24B-5m32J:
undetectable
4j24B-5m32J:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-)
no annotation 5 MET G 202
LEU G 219
LEU G 177
MET G 176
ILE G 428
None
1.12A 4j24B-5mlvG:
undetectable
4j24B-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN


(Sulfolobus
solfataricus)
no annotation 5 LEU B  31
LEU B  37
ILE B 199
ILE B  76
LEU B 206
None
1.12A 4j24B-5ofnB:
undetectable
4j24B-5ofnB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE


(Amycolatopsis
methanolica)
no annotation 5 LEU A 119
LEU A 180
ILE A 111
HIS A 162
LEU A 161
None
1.21A 4j24B-5ogxA:
undetectable
4j24B-5ogxA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1


(Leeuwenhoekiella
blandensis)
no annotation 5 LEU A 214
GLU A 219
LEU A 164
ILE A 287
ILE A 274
None
1.16A 4j24B-5olkA:
undetectable
4j24B-5olkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 5 MET B 383
LEU B 342
GLU B 350
ILE B 363
ILE B 362
None
1.17A 4j24B-5swiB:
undetectable
4j24B-5swiB:
15.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 339
GLU A 305
LEU A 301
ILE A 376
ILE A 373
LEU A 354
EST  A 601 (-3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.3A)
EST  A 601 ( 4.4A)
None
None
1.38A 4j24B-5toaA:
34.2
4j24B-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 336
LEU A 339
MET A 340
ARG A 346
ILE A 373
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.35A 4j24B-5toaA:
34.2
4j24B-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
8 MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 340
ILE A 373
ILE A 376
HIS A 475
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
1.35A 4j24B-5toaA:
34.2
4j24B-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
None
1.03A 4j24B-5u4hA:
undetectable
4j24B-5u4hA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2


(Saccharomyces
cerevisiae)
PF10345
(Cohesin_load)
no annotation
5 LEU A 489
LEU A 545
ILE B  15
ILE B  14
LEU A 552
None
1.18A 4j24B-5w94A:
undetectable
4j24B-5w94A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 GLU A 690
LEU A 666
ILE A 862
ILE A 861
LEU A 716
None
0.95A 4j24B-5wblA:
undetectable
4j24B-5wblA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum)
no annotation 5 LEU A 230
LEU A 231
LEU A 405
ILE A 385
ILE A 411
None
1.09A 4j24B-5wixA:
undetectable
4j24B-5wixA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Acinetobacter
baumannii)
no annotation 5 LEU A  31
LEU A   7
ILE A 223
ILE A 218
LEU A  12
None
1.21A 4j24B-5ws4A:
undetectable
4j24B-5ws4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)


(Helicobacter
pylori)
PF02154
(FliM)
5 LEU E 154
LEU E 153
MET E  75
ILE E 120
ILE E 124
None
1.13A 4j24B-5x0zE:
undetectable
4j24B-5x0zE:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
no annotation 5 MET A 103
LEU A 107
LEU A 108
ILE A  30
HIS A  81
None
1.17A 4j24B-5xstA:
undetectable
4j24B-5xstA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 LEU C 501
LEU C 500
ILE C 535
ILE C 556
LEU C 551
None
1.21A 4j24B-5zyaC:
undetectable
4j24B-5zyaC:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE


(Helicobacter
pylori)
no annotation 5 LEU A  66
LEU A  63
MET A 221
ILE A  25
ILE A  19
None
1.22A 4j24B-6byqA:
undetectable
4j24B-6byqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
None
EPU  A 501 ( 4.9A)
None
None
None
1.10A 4j24B-6cn1A:
undetectable
4j24B-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE


(Chaetomium
thermophilum)
no annotation 5 LEU A 100
LEU A 101
GLU A 134
ARG A 164
ILE A 143
None
1.22A 4j24B-6dg4A:
undetectable
4j24B-6dg4A:
17.33