SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_B_ESTB600
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1agx | GLUTAMINASE-ASPARAGINASE (Acinetobacterglutaminasificans) |
PF00710(Asparaginase) | 5 | LEU A 313LEU A 310ILE A 210ILE A 207LEU A 67 | None | 1.12A | 4j24B-1agxA:0.0 | 4j24B-1agxA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1n | GENOME POLYPROTEIN:PICORNAIN 3C (Enterovirus C) |
PF00548(Peptidase_C3) | 5 | MET A 27LEU A 37GLU A 71ILE A 47ILE A 56 | None | 1.20A | 4j24B-1l1nA:undetectable | 4j24B-1l1nA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkl | NK-LYSIN (Sus scrofa) |
PF05184(SapB_1) | 5 | MET A 49GLU A 24LEU A 61ILE A 69LEU A 14 | None | 1.06A | 4j24B-1nklA:undetectable | 4j24B-1nklA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oyz | HYPOTHETICAL PROTEINYIBA (Escherichiacoli) |
PF13646(HEAT_2) | 5 | MET A 260LEU A 257LEU A 254ILE A 242ILE A 241 | None | 1.22A | 4j24B-1oyzA:undetectable | 4j24B-1oyzA:23.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 346LEU A 349GLU A 353LEU A 387MET A 388ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 (-3.7A)EST A 1 ( 4.5A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.39A | 4j24B-1pcgA:33.0 | 4j24B-1pcgA:59.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | LEU A 473LEU A 472LEU A 538ILE A 679ILE A 682 | GOL A 700 ( 4.4A)NoneNoneNoneNone | 1.09A | 4j24B-1q3xA:undetectable | 4j24B-1q3xA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | LEU A 28MET A 36ILE A 110ILE A 108LEU A 55 | NoneNoneSAM A 302 (-3.8A)NoneNone | 1.08A | 4j24B-1ve3A:undetectable | 4j24B-1ve3A:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w36 | EXODEOXYRIBONUCLEASEV GAMMA CHAIN (Escherichiacoli) |
PF04257(Exonuc_V_gamma) | 5 | LEU C 720LEU C 717LEU C 747ILE C 374LEU C 677 | None | 1.05A | 4j24B-1w36C:0.7 | 4j24B-1w36C:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wwk | PHOSPHOGLYCERATEDEHYDROGENASE (Pyrococcushorikoshii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | MET A 219LEU A 191LEU A 166ILE A 211ILE A 199 | None | 1.21A | 4j24B-1wwkA:undetectable | 4j24B-1wwkA:23.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 324LEU A 327GLU A 331MET A 362LEU A 365ARG A 372HIS A 494 | None | 0.60A | 4j24B-1xb7A:28.6 | 4j24B-1xb7A:34.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqi | NUCLEOSIDEDIPHOSPHATE KINASE (Pyrobaculumaerophilum) |
PF00334(NDK) | 5 | LEU A 20LEU A 19ILE A 35ILE A 36LEU A 44 | None | 1.12A | 4j24B-1xqiA:undetectable | 4j24B-1xqiA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjk | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | LEU A 473LEU A 472LEU A 538ILE A 679ILE A 682 | None | 1.08A | 4j24B-1zjkA:undetectable | 4j24B-1zjkA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2agk | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Saccharomycescerevisiae) |
PF00977(His_biosynth) | 5 | LEU A 193LEU A 192LEU A 227ILE A 177ILE A 209 | None | 1.23A | 4j24B-2agkA:undetectable | 4j24B-2agkA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ass | S-PHASEKINASE-ASSOCIATEDPROTEIN 2 (Homo sapiens) |
PF12937(F-box-like) | 5 | LEU B2356LEU B2362ILE B2348ILE B2370LEU B2379 | None | 1.22A | 4j24B-2assB:undetectable | 4j24B-2assB:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU X 195LEU X 196LEU X 256ILE X 146HIS X 128 | None | 1.01A | 4j24B-2dq7X:undetectable | 4j24B-2dq7X:20.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 268LEU A 271GLU A 275MET A 306LEU A 309ARG A 316HIS A 434 | OHT A 500 (-4.1A)OHT A 500 ( 4.4A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.52A | 4j24B-2gpvA:27.5 | 4j24B-2gpvA:37.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 346LEU A 349GLU A 353LEU A 387MET A 388ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 (-4.0A)EST A 596 ( 4.7A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.42A | 4j24B-2ocfA:34.1 | 4j24B-2ocfA:57.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 429LEU A 430LEU A 490ILE A 380HIS A 362 | None | 0.87A | 4j24B-2og8A:undetectable | 4j24B-2og8A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xym | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | LEU A 409LEU A 425MET A 426ILE A 462ILE A 463 | None | 0.96A | 4j24B-2xymA:undetectable | 4j24B-2xymA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | LEU A 432LEU A 433LEU A 493ILE A 383HIS A 365 | None | 1.01A | 4j24B-2zv7A:undetectable | 4j24B-2zv7A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyv | TYROSINE-ESTERSULFOTRANSFERASE (Mus musculus) |
PF00685(Sulfotransfer_1) | 5 | LEU X 211LEU X 208ILE X 41ILE X 43LEU X 189 | None | 1.23A | 4j24B-2zyvX:undetectable | 4j24B-2zyvX:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ajy | ANCESTRAL CONGERINCON-ANC (-) |
PF00337(Gal-bind_lectin) | 5 | LEU A 43LEU A 41ILE A 98ILE A 87LEU A 17 | None | 1.20A | 4j24B-3ajyA:undetectable | 4j24B-3ajyA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anp | TRANSCRIPTIONALREPRESSOR, TETRFAMILY (Thermusthermophilus) |
no annotation | 5 | LEU C 139ARG C 196ILE C 135ILE C 132LEU C 151 | None | 1.04A | 4j24B-3anpC:undetectable | 4j24B-3anpC:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 689LEU A 690LEU A 750ILE A 639HIS A 621 | None | 0.98A | 4j24B-3c4fA:undetectable | 4j24B-3c4fA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3chx | PMOAPMOB (Methylosinustrichosporium) |
PF02461(AMO)PF04744(Monooxygenase_B) | 5 | LEU B 172LEU B 185LEU A 187ILE A 195ILE B 121 | None | 1.16A | 4j24B-3chxB:undetectable | 4j24B-3chxB:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clw | CONSERVED EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF14587(Glyco_hydr_30_2) | 5 | LEU A 251LEU A 149ILE A 241ILE A 246LEU A 187 | None | 1.05A | 4j24B-3clwA:undetectable | 4j24B-3clwA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csq | MORPHOGENESISPROTEIN 1 (Bacillus virusphi29) |
no annotation | 5 | LEU A 22MET A 42LEU A 39MET A 38ILE A 98 | None | 1.13A | 4j24B-3csqA:undetectable | 4j24B-3csqA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csz | MORPHOGENESISPROTEIN 1 (Bacillus virusphi29) |
no annotation | 5 | LEU A 22MET A 42LEU A 39MET A 38ILE A 98 | None | 1.16A | 4j24B-3cszA:undetectable | 4j24B-3cszA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e19 | FEOA (Thermococcusthioreducens) |
PF04023(FeoA) | 5 | MET A 34LEU A 36ILE A 55ILE A 53LEU A 68 | None | 1.15A | 4j24B-3e19A:undetectable | 4j24B-3e19A:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 GAMMACHAIN (Escherichiacoli) |
PF02665(Nitrate_red_gam) | 5 | LEU C 133LEU C 132ILE C 59ILE C 62LEU C 102 | HEM C 806 ( 4.8A)NoneHEM C 806 (-4.3A)HEM C 807 (-4.0A)None | 0.87A | 4j24B-3egwC:undetectable | 4j24B-3egwC:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 GAMMACHAIN (Escherichiacoli) |
PF02665(Nitrate_red_gam) | 5 | LEU C 133LEU C 139ILE C 59ILE C 62LEU C 102 | HEM C 806 ( 4.8A)NoneHEM C 806 (-4.3A)HEM C 807 (-4.0A)None | 0.89A | 4j24B-3egwC:undetectable | 4j24B-3egwC:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqe | PUTATIVE CYSTEINDIOXYGENASE (Bacillussubtilis) |
PF05995(CDO_I) | 5 | MET A 127MET A 148ILE A 64ILE A 62HIS A 139 | FE A 202 ( 4.8A)NoneNoneNoneNone | 1.18A | 4j24B-3eqeA:undetectable | 4j24B-3eqeA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9k | INTEGRASE (Humanimmunodeficiencyvirus 2) |
PF00665(rve)PF02022(Integrase_Zn) | 5 | LEU A 102LEU A 99MET A 63ILE A 133ILE A 135 | None | 1.14A | 4j24B-3f9kA:undetectable | 4j24B-3f9kA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fms | TRANSCRIPTIONALREGULATOR, GNTRFAMILY (Thermotogamaritima) |
PF00392(GntR)PF07729(FCD) | 5 | LEU A 193GLU A 90ARG A 86ILE A 114LEU A 107 | NoneNoneACT A 302 (-3.0A)NoneNone | 1.17A | 4j24B-3fmsA:undetectable | 4j24B-3fmsA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hcw | MALTOSE OPERONTRANSCRIPTIONALREPRESSOR (Staphylococcusaureus) |
PF13377(Peripla_BP_3) | 5 | LEU A 263GLU A 265LEU A 229ILE A 248ILE A 189 | None | 1.23A | 4j24B-3hcwA:undetectable | 4j24B-3hcwA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A1088LEU A1089LEU A1150ILE A1038HIS A1020 | NoneNoneNoneNone8ST A2001 ( 4.8A) | 0.94A | 4j24B-3hngA:undetectable | 4j24B-3hngA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 5 | MET A 173LEU A 176LEU A 179ILE A 6LEU A 57 | None | 1.06A | 4j24B-3iuuA:undetectable | 4j24B-3iuuA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdk | STRINGENT STARVATIONPROTEIN A (Pseudomonasputida) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | LEU A 23GLU A 27LEU A 84ARG A 190ILE A 102 | None | 1.07A | 4j24B-3mdkA:undetectable | 4j24B-3mdkA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3onk | EPSIN-3 (Saccharomycescerevisiae) |
PF01417(ENTH) | 5 | LEU A 94LEU A 97ILE A 116ILE A 113LEU A 146 | None | 1.10A | 4j24B-3onkA:undetectable | 4j24B-3onkA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 5 | MET A 208LEU A 211ILE A 173ILE A 176LEU A 231 | None | 0.93A | 4j24B-3opbA:undetectable | 4j24B-3opbA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4x | REVERSE GYRASEHELICASE-LIKE DOMAIN (Thermotogamaritima) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 269LEU A 268ILE A 229ILE A 228LEU A 274 | None | 1.22A | 4j24B-3p4xA:undetectable | 4j24B-3p4xA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbw | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Pseudomonasaeruginosa) |
PF03702(AnmK) | 5 | MET A 300LEU A 303LEU A 306LEU A 278ILE A 163 | None | 1.15A | 4j24B-3qbwA:undetectable | 4j24B-3qbwA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgh | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | LEU A 409LEU A 425MET A 426ILE A 462ILE A 463 | NoneNoneNone63F A 601 (-4.0A)None | 0.99A | 4j24B-3qghA:undetectable | 4j24B-3qghA:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 5 | LEU A 209GLU A 171MET A 226ILE A 262ILE A 274 | SAM A 992 (-4.8A)SAM A 992 (-2.8A)NoneNoneNone | 1.08A | 4j24B-3t7vA:undetectable | 4j24B-3t7vA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t95 | AUTOINDUCER2-BINDING PROTEINLSRB (Yersinia pestis) |
PF13407(Peripla_BP_4) | 5 | LEU A 55GLU A 27LEU A 282ILE A 295ILE A 293 | None | 1.21A | 4j24B-3t95A:undetectable | 4j24B-3t95A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 689LEU A 690LEU A 750ILE A 639HIS A 621 | None | 1.04A | 4j24B-3tt0A:undetectable | 4j24B-3tt0A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty4 | PROBABLEHOMOISOCITRATEDEHYDROGENASE (Schizosaccharomycespombe) |
PF00180(Iso_dh) | 5 | MET A 312LEU A 313LEU A 28ILE A 7LEU A 75 | None | 1.22A | 4j24B-3ty4A:undetectable | 4j24B-3ty4A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w21 | PUTATIVEUNCHARACTERIZEDPROTEIN (Burkholderiaambifaria) |
no annotation | 5 | MET A 40LEU A 237ARG A 141ILE A 23ILE A 27 | NoneNoneAKG A 302 (-3.7A)NoneNone | 1.16A | 4j24B-3w21A:undetectable | 4j24B-3w21A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w25 | GLYCOSIDE HYDROLASEFAMILY 10 (Thermoanaerobacteriumsaccharolyticum) |
PF00331(Glyco_hydro_10) | 5 | MET A 201LEU A 204ILE A 186ILE A 215LEU A 243 | None | 1.10A | 4j24B-3w25A:undetectable | 4j24B-3w25A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atg | TAF6 (Antonosporalocustae) |
PF07571(TAF6_C) | 5 | LEU A 222LEU A 211ILE A 247ILE A 205LEU A 228 | None | 1.19A | 4j24B-4atgA:undetectable | 4j24B-4atgA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fhn | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | LEU B 867LEU B 895ILE B 885HIS B 901LEU B 902 | None | 1.18A | 4j24B-4fhnB:undetectable | 4j24B-4fhnB:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxg | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 B CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU H 473LEU H 472LEU H 538ILE H 679ILE H 682 | None | 1.11A | 4j24B-4fxgH:undetectable | 4j24B-4fxgH:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq2 | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | LEU M 699LEU M 615LEU M 725ILE M 649ILE M 653 | None | 1.05A | 4j24B-4gq2M:undetectable | 4j24B-4gq2M:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERTRANSMEMBRANEPROTEIN ECFTPREDICTED MEMBRANEPROTEIN (Lactobacillusbrevis) |
PF02361(CbiQ)PF07155(ECF-ribofla_trS) | 5 | LEU T 171MET T 205LEU T 208ILE S 44LEU S 39 | None | 1.07A | 4j24B-4hzuT:undetectable | 4j24B-4hzuT:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | LEU A 609LEU A 612LEU A 639ILE A 569ILE A 645 | None | 1.16A | 4j24B-4ifqA:undetectable | 4j24B-4ifqA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 683LEU A 684LEU A 744ILE A 633HIS A 615 | None | 0.95A | 4j24B-4k33A:undetectable | 4j24B-4k33A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxr | PROTEIN TOLL (Drosophilamelanogaster) |
PF00560(LRR_1)PF01462(LRRNT)PF13306(LRR_5)PF13855(LRR_8) | 5 | MET A 421LEU A 419LEU A 392ILE A 405ILE A 409 | None | 1.18A | 4j24B-4lxrA:undetectable | 4j24B-4lxrA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mps | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE 1 (Rattusnorvegicus) |
PF00777(Glyco_transf_29) | 5 | MET A 328LEU A 323MET A 149LEU A 293ILE A 250 | None | 1.18A | 4j24B-4mpsA:undetectable | 4j24B-4mpsA:22.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 7 | LEU A 283LEU A 286GLU A 290MET A 321LEU A 324ARG A 331ILE A 361 | None | 0.60A | 4j24B-4n1yA:31.0 | 4j24B-4n1yA:38.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nar | PUTATIVE URONATEISOMERASE (Thermotogamaritima) |
PF09861(DUF2088) | 5 | MET A 223LEU A 236LEU A 5ILE A 148LEU A 47 | None | 1.21A | 4j24B-4narA:undetectable | 4j24B-4narA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 1 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | LEU A 219LEU A 222LEU A 299ILE A 249ILE A 250 | None | 0.95A | 4j24B-4nhdA:undetectable | 4j24B-4nhdA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pb6 | VP1 (Felinecalicivirus) |
PF00915(Calici_coat) | 5 | LEU A 201LEU A 204MET A 279ILE A 215LEU A 196 | None | 1.19A | 4j24B-4pb6A:undetectable | 4j24B-4pb6A:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 5 | LEU A 466LEU A 229ARG A 75ILE A 807ILE A 818 | None | 1.12A | 4j24B-4q2cA:undetectable | 4j24B-4q2cA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8h | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Saccharomycescerevisiae) |
PF00929(RNase_T)PF13423(UCH_1) | 5 | LEU A 550LEU A 547ILE A 520ILE A 519LEU A 574 | None | 1.16A | 4j24B-4q8hA:undetectable | 4j24B-4q8hA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qny | MITOGEN ACTIVATEDPROTEIN KINASE,PUTATIVE (Leishmaniadonovani) |
PF00069(Pkinase) | 5 | LEU A 219LEU A 291MET A 290ILE A 126ILE A 130 | None | 1.07A | 4j24B-4qnyA:undetectable | 4j24B-4qnyA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 769LEU A 772MET A 807LEU A 810ARG A 817 | CV7 A1987 (-4.1A)CV7 A1987 ( 4.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 (-3.7A) | 0.47A | 4j24B-4udbA:27.9 | 4j24B-4udbA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8l | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF00331(Glyco_hydro_10) | 5 | MET A 542LEU A 545ILE A 527ILE A 556LEU A 585 | None | 1.08A | 4j24B-4w8lA:undetectable | 4j24B-4w8lA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wu0 | SIMILAR TO YTER(BACILUS SUBTILIS) (Clostridiumacetobutylicum) |
PF07470(Glyco_hydro_88) | 5 | LEU A 352LEU A 353ILE A 12ILE A 17LEU A 313 | None | 1.05A | 4j24B-4wu0A:undetectable | 4j24B-4wu0A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 678LEU A 679LEU A 739ILE A 628HIS A 610 | None | 0.97A | 4j24B-4xcuA:undetectable | 4j24B-4xcuA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 877LEU A 878LEU A 939ILE A 827HIS A 809 | NoneNoneNoneP30 A1001 (-4.7A)P30 A1001 (-4.4A) | 0.98A | 4j24B-4xufA:undetectable | 4j24B-4xufA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3f | PHOSPHORIBULOKINASE/URIDINE KINASE (Methanospirillumhungatei) |
PF00485(PRK) | 5 | LEU A 80LEU A 79ILE A 119ILE A 117LEU A 133 | None | 1.15A | 4j24B-5b3fA:undetectable | 4j24B-5b3fA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4v | NUCLEOPROTEIN,PHOSPHOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap)PF13825(Paramyxo_PNT) | 5 | LEU A 54LEU A 50LEU A 39ILE A 155ILE A 151 | None | 1.09A | 4j24B-5e4vA:undetectable | 4j24B-5e4vA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | LEU A 171LEU A 180MET A 376ILE A 186LEU A 357 | None | 1.15A | 4j24B-5eefA:undetectable | 4j24B-5eefA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2a | KLLA0C04147P (Kluyveromyceslactis) |
PF00023(Ank) | 5 | LEU A 34LEU A 37ILE A 73ILE A 89LEU A 87 | None | 1.06A | 4j24B-5h2aA:undetectable | 4j24B-5h2aA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | LEU A 61LEU A 58GLU A 54LEU A 98ILE A 281 | None | 1.14A | 4j24B-5h3aA:undetectable | 4j24B-5h3aA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9f | CRISPR SYSTEMCASCADE SUBUNIT CASC (Escherichiacoli) |
PF09344(Cas_CT1975) | 5 | LEU D 239GLU D 118ARG D 165ILE D 250ILE D 58 | None | 1.18A | 4j24B-5h9fD:undetectable | 4j24B-5h9fD:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hr4 | MMEI (Methylophilusmethylotrophus) |
no annotation | 5 | LEU C 194LEU C 190LEU C 172ILE C 290ILE C 161 | None | 1.22A | 4j24B-5hr4C:undetectable | 4j24B-5hr4C:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxu | DYP-TYPE PEROXIDASEFAMILY (Thermomonosporacurvata) |
PF04261(Dyp_perox) | 5 | LEU A 164LEU A 71MET A 88LEU A 91ILE A 387 | None | 1.23A | 4j24B-5jxuA:undetectable | 4j24B-5jxuA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l75 | FIG000988: PREDICTEDPERMEASE (Klebsiellapneumoniae) |
PF03739(YjgP_YjgQ) | 5 | MET F 88LEU F 93ILE F 3ILE F 4LEU F 98 | None | 0.83A | 4j24B-5l75F:undetectable | 4j24B-5l75F:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0o | TERMINALOLEFIN-FORMING FATTYACID DECARBOXYLASE (Jeotgalicoccussp. ATCC 8456) |
PF00067(p450) | 5 | LEU A 247MET A 103LEU A 102ILE A 374ILE A 373 | HEM A 501 (-4.4A)NoneNoneNoneNone | 1.03A | 4j24B-5m0oA:undetectable | 4j24B-5m0oA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | PROTEASOME SUBUNITBETA TYPE-2 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU J 104LEU J 102MET J 35ILE J 183LEU J 115 | None | 1.21A | 4j24B-5m32J:undetectable | 4j24B-5m32J:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlv | - (-) |
no annotation | 5 | MET G 202LEU G 219LEU G 177MET G 176ILE G 428 | None | 1.12A | 4j24B-5mlvG:undetectable | 4j24B-5mlvG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofn | DNA PRIMASE LARGESUBUNIT PRIL,PRIL-XFUSION PROTEIN (Sulfolobussolfataricus) |
no annotation | 5 | LEU B 31LEU B 37ILE B 199ILE B 76LEU B 206 | None | 1.12A | 4j24B-5ofnB:undetectable | 4j24B-5ofnB:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogx | CYTOCHROME P450REDUCTASE (Amycolatopsismethanolica) |
no annotation | 5 | LEU A 119LEU A 180ILE A 111HIS A 162LEU A 161 | None | 1.21A | 4j24B-5ogxA:undetectable | 4j24B-5ogxA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olk | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE,BETA SUBUNIT 1 (Leeuwenhoekiellablandensis) |
no annotation | 5 | LEU A 214GLU A 219LEU A 164ILE A 287ILE A 274 | None | 1.16A | 4j24B-5olkA:undetectable | 4j24B-5olkA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 5 | MET B 383LEU B 342GLU B 350ILE B 363ILE B 362 | None | 1.17A | 4j24B-5swiB:undetectable | 4j24B-5swiB:15.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 339GLU A 305LEU A 301ILE A 376ILE A 373LEU A 354 | EST A 601 (-3.9A)EST A 601 (-2.4A)EST A 601 ( 4.3A)EST A 601 ( 4.4A)NoneNone | 1.38A | 4j24B-5toaA:34.2 | 4j24B-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 298LEU A 301GLU A 305MET A 336LEU A 339MET A 340ARG A 346ILE A 373ILE A 376HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 (-4.1A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.35A | 4j24B-5toaA:34.2 | 4j24B-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 8 | MET A 295LEU A 298LEU A 301GLU A 305MET A 340ILE A 373ILE A 376HIS A 475 | EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.8A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A) | 1.35A | 4j24B-5toaA:34.2 | 4j24B-5toaA:99.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | LEU A 96GLU A 168LEU A 195ILE A 39LEU A 34 | None | 1.03A | 4j24B-5u4hA:undetectable | 4j24B-5u4hA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w94 | MAU2 CHROMATIDCOHESION FACTORHOMOLOGSISTER CHROMATIDCOHESION PROTEIN 2 (Saccharomycescerevisiae) |
PF10345(Cohesin_load)no annotation | 5 | LEU A 489LEU A 545ILE B 15ILE B 14LEU A 552 | None | 1.18A | 4j24B-5w94A:undetectable | 4j24B-5w94A:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 5 | GLU A 690LEU A 666ILE A 862ILE A 861LEU A 716 | None | 0.95A | 4j24B-5wblA:undetectable | 4j24B-5wblA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wix | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 5 | LEU A 230LEU A 231LEU A 405ILE A 385ILE A 411 | None | 1.09A | 4j24B-5wixA:undetectable | 4j24B-5wixA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ws4 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Acinetobacterbaumannii) |
no annotation | 5 | LEU A 31LEU A 7ILE A 223ILE A 218LEU A 12 | None | 1.21A | 4j24B-5ws4A:undetectable | 4j24B-5ws4A:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x0z | FLAGELLAR MOTORSWITCH PROTEIN(FLIM) (Helicobacterpylori) |
PF02154(FliM) | 5 | LEU E 154LEU E 153MET E 75ILE E 120ILE E 124 | None | 1.13A | 4j24B-5x0zE:undetectable | 4j24B-5x0zE:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xst | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
no annotation | 5 | MET A 103LEU A 107LEU A 108ILE A 30HIS A 81 | None | 1.17A | 4j24B-5xstA:undetectable | 4j24B-5xstA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | LEU C 501LEU C 500ILE C 535ILE C 556LEU C 551 | None | 1.21A | 4j24B-5zyaC:undetectable | 4j24B-5zyaC:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byq | TYROSINE--TRNALIGASE (Helicobacterpylori) |
no annotation | 5 | LEU A 66LEU A 63MET A 221ILE A 25ILE A 19 | None | 1.22A | 4j24B-6byqA:undetectable | 4j24B-6byqA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn1 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasputida) |
no annotation | 5 | LEU A 97GLU A 170LEU A 197ILE A 74LEU A 34 | NoneEPU A 501 ( 4.9A)NoneNoneNone | 1.10A | 4j24B-6cn1A:undetectable | 4j24B-6cn1A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dg4 | ULP1-LIKE SUMOPROTEASE (Chaetomiumthermophilum) |
no annotation | 5 | LEU A 100LEU A 101GLU A 134ARG A 164ILE A 143 | None | 1.22A | 4j24B-6dg4A:undetectable | 4j24B-6dg4A:17.33 |