SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_A_ESTA600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1agx | GLUTAMINASE-ASPARAGINASE (Acinetobacterglutaminasificans) |
PF00710(Asparaginase) | 5 | LEU A 313LEU A 310ILE A 210ILE A 207LEU A 67 | None | 1.12A | 4j24A-1agxA:undetectable | 4j24A-1agxA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8q | HYALURONATE LYASE (Streptococcusagalactiae) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | LEU A 496LEU A 492LEU A 430ILE A 503ILE A 438 | None | 1.06A | 4j24A-1i8qA:0.5 | 4j24A-1i8qA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcf | RODSHAPE-DETERMININGPROTEIN MREB (Thermotogamaritima) |
PF06723(MreB_Mbl) | 5 | LEU A 332LEU A 128ILE A 328ILE A 137LEU A 323 | None | 1.15A | 4j24A-1jcfA:undetectable | 4j24A-1jcfA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkl | NK-LYSIN (Sus scrofa) |
PF05184(SapB_1) | 5 | MET A 49GLU A 24LEU A 61ILE A 69LEU A 14 | None | 1.04A | 4j24A-1nklA:undetectable | 4j24A-1nklA:12.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | MET A 342LEU A 346LEU A 349GLU A 353LEU A 387LEU A 391ARG A 394 | NoneEST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)EST A 1 ( 3.9A)EST A 1 (-3.7A) | 1.48A | 4j24A-1pcgA:33.5 | 4j24A-1pcgA:59.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 346LEU A 349GLU A 353LEU A 387LEU A 391ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)EST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.5A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.39A | 4j24A-1pcgA:33.5 | 4j24A-1pcgA:59.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 343LEU A 346LEU A 402ILE A 424HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 (-4.4A)NoneEST A 1 ( 4.5A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 1.40A | 4j24A-1pcgA:33.5 | 4j24A-1pcgA:59.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | LEU A 473LEU A 472LEU A 538ILE A 679ILE A 682 | GOL A 700 ( 4.4A)NoneNoneNoneNone | 1.12A | 4j24A-1q3xA:undetectable | 4j24A-1q3xA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w36 | EXODEOXYRIBONUCLEASEV GAMMA CHAIN (Escherichiacoli) |
PF04257(Exonuc_V_gamma) | 5 | LEU C 720LEU C 717LEU C 747ILE C 374LEU C 677 | None | 1.08A | 4j24A-1w36C:1.1 | 4j24A-1w36C:12.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 324LEU A 327GLU A 331MET A 362LEU A 365ARG A 372HIS A 494 | None | 0.60A | 4j24A-1xb7A:28.3 | 4j24A-1xb7A:34.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqi | NUCLEOSIDEDIPHOSPHATE KINASE (Pyrobaculumaerophilum) |
PF00334(NDK) | 5 | LEU A 20LEU A 19ILE A 35ILE A 36LEU A 44 | None | 1.10A | 4j24A-1xqiA:undetectable | 4j24A-1xqiA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjk | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | LEU A 473LEU A 472LEU A 538ILE A 679ILE A 682 | None | 1.10A | 4j24A-1zjkA:undetectable | 4j24A-1zjkA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU X 195LEU X 196LEU X 256ILE X 146HIS X 128 | None | 1.02A | 4j24A-2dq7X:undetectable | 4j24A-2dq7X:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk6 | RIBONUCLEASE Z (Bacillussubtilis) |
PF12706(Lactamase_B_2) | 5 | LEU A 72LEU A 75LEU A 88ILE A 96ILE A 117 | None | 0.77A | 4j24A-2fk6A:undetectable | 4j24A-2fk6A:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 268LEU A 271GLU A 275MET A 306LEU A 309ARG A 316HIS A 434 | OHT A 500 (-4.1A)OHT A 500 ( 4.4A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.58A | 4j24A-2gpvA:27.7 | 4j24A-2gpvA:37.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5g | ALR4455 PROTEIN (Nostoc sp. PCC7120) |
PF00378(ECH_1) | 6 | LEU D 103LEU D 104ARG D 221ILE D 157ILE D 236HIS D 156 | None | 1.44A | 4j24A-2j5gD:undetectable | 4j24A-2j5gD:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5g | ALR4455 PROTEIN (Nostoc sp. PCC7120) |
PF00378(ECH_1) | 6 | LEU D 158LEU D 103LEU D 104ARG D 221ILE D 236HIS D 156 | None | 1.42A | 4j24A-2j5gD:undetectable | 4j24A-2j5gD:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m45 | MINICHROMOSOMEMAINTENANCE PROTEINMCM (Sulfolobussolfataricus) |
no annotation | 5 | MET A 669LEU A 666LEU A 649ILE A 633ILE A 632 | None | 1.16A | 4j24A-2m45A:undetectable | 4j24A-2m45A:17.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | MET A 343LEU A 346LEU A 349GLU A 353LEU A 387LEU A 391ARG A 394ILE A 424HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.2A)EST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 ( 4.7A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.45A | 4j24A-2ocfA:34.3 | 4j24A-2ocfA:57.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 429LEU A 430LEU A 490ILE A 380HIS A 362 | None | 0.85A | 4j24A-2og8A:undetectable | 4j24A-2og8A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oze | ORF DELTA' (Streptococcuspyogenes) |
PF13614(AAA_31) | 5 | LEU A 144LEU A 143LEU A 105ILE A 160ILE A 158 | None | 1.09A | 4j24A-2ozeA:undetectable | 4j24A-2ozeA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa6 | ENOLASE (Methanocaldococcusjannaschii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 272LEU A 273ILE A 309ILE A 311LEU A 247 | None | 1.15A | 4j24A-2pa6A:undetectable | 4j24A-2pa6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1CA A 247 (-4.0A)1CA A 247 ( 4.4A)1CA A 247 ( 3.8A)1CA A 247 ( 3.9A)1CA A 247 (-3.8A) | 0.26A | 4j24A-2q3yA:29.1 | 4j24A-2q3yA:29.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvx | PROTEIN A52 (Vaccinia virus) |
PF06227(Poxvirus) | 5 | MET A 137LEU A 140LEU A 106ILE A 119ILE A 116 | None | 0.94A | 4j24A-2vvxA:undetectable | 4j24A-2vvxA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbe | BIPOLAR KINESINKRP-130 (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | LEU C 247LEU C 75ILE C 317ILE C 8LEU C 305 | None | 1.00A | 4j24A-2wbeC:undetectable | 4j24A-2wbeC:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | LEU A 432LEU A 433LEU A 493ILE A 383HIS A 365 | None | 1.00A | 4j24A-2zv7A:undetectable | 4j24A-2zv7A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anp | TRANSCRIPTIONALREPRESSOR, TETRFAMILY (Thermusthermophilus) |
no annotation | 5 | LEU C 139ARG C 196ILE C 135ILE C 132LEU C 151 | None | 1.03A | 4j24A-3anpC:undetectable | 4j24A-3anpC:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bh0 | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF03796(DnaB_C) | 5 | LEU A 354LEU A 199ILE A 333ILE A 336LEU A 319 | None | 1.09A | 4j24A-3bh0A:undetectable | 4j24A-3bh0A:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 689LEU A 690LEU A 750ILE A 639HIS A 621 | None | 0.96A | 4j24A-3c4fA:undetectable | 4j24A-3c4fA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3chx | PMOAPMOB (Methylosinustrichosporium) |
PF02461(AMO)PF04744(Monooxygenase_B) | 5 | LEU B 172LEU B 185LEU A 187ILE A 195ILE B 121 | None | 1.15A | 4j24A-3chxB:undetectable | 4j24A-3chxB:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clw | CONSERVED EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF14587(Glyco_hydr_30_2) | 5 | LEU A 251LEU A 149ILE A 241ILE A 246LEU A 187 | None | 1.03A | 4j24A-3clwA:undetectable | 4j24A-3clwA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e19 | FEOA (Thermococcusthioreducens) |
PF04023(FeoA) | 5 | MET A 34LEU A 36ILE A 55ILE A 53LEU A 68 | None | 1.15A | 4j24A-3e19A:undetectable | 4j24A-3e19A:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 GAMMACHAIN (Escherichiacoli) |
PF02665(Nitrate_red_gam) | 5 | LEU C 133LEU C 132ILE C 59ILE C 62LEU C 102 | HEM C 806 ( 4.8A)NoneHEM C 806 (-4.3A)HEM C 807 (-4.0A)None | 0.88A | 4j24A-3egwC:undetectable | 4j24A-3egwC:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 GAMMACHAIN (Escherichiacoli) |
PF02665(Nitrate_red_gam) | 5 | LEU C 133LEU C 139ILE C 59ILE C 62LEU C 102 | HEM C 806 ( 4.8A)NoneHEM C 806 (-4.3A)HEM C 807 (-4.0A)None | 0.92A | 4j24A-3egwC:undetectable | 4j24A-3egwC:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5i | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | LEU A 21LEU A 28ILE A 33ILE A 61LEU A 56 | None | 1.09A | 4j24A-3g5iA:undetectable | 4j24A-3g5iA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A1088LEU A1089LEU A1150ILE A1038HIS A1020 | NoneNoneNoneNone8ST A2001 ( 4.8A) | 0.91A | 4j24A-3hngA:undetectable | 4j24A-3hngA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 5 | MET A 173LEU A 176LEU A 179ILE A 6LEU A 57 | None | 1.04A | 4j24A-3iuuA:undetectable | 4j24A-3iuuA:21.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 718LEU A 721MET A 756LEU A 763ARG A 766 | WOW A 1 (-4.2A)WOW A 1 ( 4.3A)WOW A 1 ( 4.1A)WOW A 1 ( 4.0A)WOW A 1 (-3.8A) | 0.31A | 4j24A-3kbaA:27.8 | 4j24A-3kbaA:30.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llt | SERINE/THREONINEKINASE-1, PFLAMMER (Plasmodiumfalciparum) |
PF00069(Pkinase) | 5 | LEU A 874LEU A 868LEU A 764ILE A 651LEU A 846 | None | 1.11A | 4j24A-3lltA:undetectable | 4j24A-3lltA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lre | KINESIN-LIKE PROTEINKIF18A (Homo sapiens) |
PF00225(Kinesin) | 5 | MET A 123LEU A 135ILE A 329ILE A 327LEU A 256 | None | 1.16A | 4j24A-3lreA:undetectable | 4j24A-3lreA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdk | STRINGENT STARVATIONPROTEIN A (Pseudomonasputida) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | LEU A 23GLU A 27LEU A 84ARG A 190ILE A 102 | None | 1.09A | 4j24A-3mdkA:undetectable | 4j24A-3mdkA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3onk | EPSIN-3 (Saccharomycescerevisiae) |
PF01417(ENTH) | 5 | LEU A 94LEU A 97ILE A 116ILE A 113LEU A 146 | None | 1.12A | 4j24A-3onkA:undetectable | 4j24A-3onkA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 5 | MET A 208LEU A 211ILE A 173ILE A 176LEU A 231 | None | 0.96A | 4j24A-3opbA:undetectable | 4j24A-3opbA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbw | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Pseudomonasaeruginosa) |
PF03702(AnmK) | 5 | MET A 300LEU A 303LEU A 306LEU A 278ILE A 163 | None | 1.10A | 4j24A-3qbwA:undetectable | 4j24A-3qbwA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qz1 | STEROID21-HYDROXYLASE (Bos taurus) |
PF00067(p450) | 5 | LEU A 441LEU A 444LEU A 306ILE A 348LEU A 341 | None | 1.13A | 4j24A-3qz1A:undetectable | 4j24A-3qz1A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1CA A 249 (-3.9A)1CA A 249 ( 4.4A)1CA A 249 ( 3.8A)1CA A 249 ( 4.1A)1CA A 249 (-3.5A) | 0.30A | 4j24A-3ry9A:28.5 | 4j24A-3ry9A:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 5 | LEU A 209GLU A 171MET A 226ILE A 262ILE A 274 | SAM A 992 (-4.8A)SAM A 992 (-2.8A)NoneNoneNone | 1.12A | 4j24A-3t7vA:undetectable | 4j24A-3t7vA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 689LEU A 690LEU A 750ILE A 639HIS A 621 | None | 1.02A | 4j24A-3tt0A:undetectable | 4j24A-3tt0A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | LEU A2131LEU A2134LEU A2139ILE A2199LEU A2152 | None | 1.11A | 4j24A-3vkgA:undetectable | 4j24A-3vkgA:5.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w21 | PUTATIVEUNCHARACTERIZEDPROTEIN (Burkholderiaambifaria) |
no annotation | 5 | MET A 40LEU A 237ARG A 141ILE A 23ILE A 27 | NoneNoneAKG A 302 (-3.7A)NoneNone | 1.14A | 4j24A-3w21A:undetectable | 4j24A-3w21A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w21 | PUTATIVEUNCHARACTERIZEDPROTEIN (Burkholderiaambifaria) |
no annotation | 5 | MET A 40LEU A 237LEU A 260ILE A 23ILE A 27 | None | 1.13A | 4j24A-3w21A:undetectable | 4j24A-3w21A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w25 | GLYCOSIDE HYDROLASEFAMILY 10 (Thermoanaerobacteriumsaccharolyticum) |
PF00331(Glyco_hydro_10) | 5 | MET A 201LEU A 204ILE A 186ILE A 215LEU A 243 | None | 1.11A | 4j24A-3w25A:undetectable | 4j24A-3w25A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3c | INHIBITOR OF NUCLEARFACTOR KAPPA-BKINASE SUBUNIT BETA (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 167LEU A 146ILE A 141ILE A 142LEU A 178 | None | 1.14A | 4j24A-4e3cA:undetectable | 4j24A-4e3cA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | MET A 71LEU A 74LEU A 77LEU A 103ILE A 37 | None | 1.16A | 4j24A-4eviA:undetectable | 4j24A-4eviA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxg | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 B CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU H 473LEU H 472LEU H 538ILE H 679ILE H 682 | None | 1.13A | 4j24A-4fxgH:undetectable | 4j24A-4fxgH:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERTRANSMEMBRANEPROTEIN ECFTPREDICTED MEMBRANEPROTEIN (Lactobacillusbrevis) |
PF02361(CbiQ)PF07155(ECF-ribofla_trS) | 5 | LEU T 171MET T 205LEU T 208ILE S 44LEU S 39 | None | 1.08A | 4j24A-4hzuT:undetectable | 4j24A-4hzuT:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | LEU A 609LEU A 612LEU A 639ILE A 569ILE A 645 | None | 1.14A | 4j24A-4ifqA:undetectable | 4j24A-4ifqA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 683LEU A 684LEU A 744ILE A 633HIS A 615 | None | 0.94A | 4j24A-4k33A:undetectable | 4j24A-4k33A:23.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 7 | LEU A 283LEU A 286GLU A 290MET A 321LEU A 324ARG A 331ILE A 361 | None | 0.62A | 4j24A-4n1yA:31.2 | 4j24A-4n1yA:38.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 1 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | LEU A 219LEU A 222LEU A 299ILE A 249ILE A 250 | None | 0.91A | 4j24A-4nhdA:undetectable | 4j24A-4nhdA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 108LEU A 106ILE A 96HIS A 62LEU A 61 | None | 1.16A | 4j24A-4o1oA:undetectable | 4j24A-4o1oA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o3m | BLOOM SYNDROMEPROTEIN (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF00570(HRDC)PF09382(RQC)PF16124(RecQ_Zn_bind) | 5 | LEU A 780LEU A 783LEU A 763ILE A 770ILE A 713 | None | 0.94A | 4j24A-4o3mA:undetectable | 4j24A-4o3mA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 563LEU A 566MET A 601LEU A 608ARG A 611 | MOF A 801 (-3.9A)MOF A 801 ( 4.6A)MOF A 801 (-3.7A)MOF A 801 ( 4.6A)MOF A 801 (-4.2A) | 0.72A | 4j24A-4p6wA:28.2 | 4j24A-4p6wA:29.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | MET A 560LEU A 566MET A 601LEU A 608ARG A 611 | MOF A 801 (-3.9A)MOF A 801 ( 4.6A)MOF A 801 (-3.7A)MOF A 801 ( 4.6A)MOF A 801 (-4.2A) | 0.87A | 4j24A-4p6wA:28.2 | 4j24A-4p6wA:29.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 5 | LEU A 466LEU A 229ARG A 75ILE A 807ILE A 818 | None | 1.13A | 4j24A-4q2cA:undetectable | 4j24A-4q2cA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u08 | LIC11098 (Leptospirainterrogans) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | LEU A 386LEU A 376ILE A 411ILE A 423LEU A 417 | None | 1.09A | 4j24A-4u08A:undetectable | 4j24A-4u08A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u90 | GEPHYRIN (Rattusnorvegicus) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 5 | LEU A 586LEU A 555LEU A 554ILE A 568LEU A 612 | None | 1.13A | 4j24A-4u90A:undetectable | 4j24A-4u90A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 769LEU A 772MET A 807LEU A 810LEU A 814ARG A 817 | CV7 A1987 (-4.1A)CV7 A1987 ( 4.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.44A | 4j24A-4udbA:28.1 | 4j24A-4udbA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8l | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF00331(Glyco_hydro_10) | 5 | MET A 542LEU A 545ILE A 527ILE A 556LEU A 585 | None | 1.09A | 4j24A-4w8lA:undetectable | 4j24A-4w8lA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wu0 | SIMILAR TO YTER(BACILUS SUBTILIS) (Clostridiumacetobutylicum) |
PF07470(Glyco_hydro_88) | 5 | LEU A 352LEU A 353ILE A 12ILE A 17LEU A 313 | None | 1.06A | 4j24A-4wu0A:undetectable | 4j24A-4wu0A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 678LEU A 679LEU A 739ILE A 628HIS A 610 | None | 0.96A | 4j24A-4xcuA:undetectable | 4j24A-4xcuA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 877LEU A 878LEU A 939ILE A 827HIS A 809 | NoneNoneNoneP30 A1001 (-4.7A)P30 A1001 (-4.4A) | 0.94A | 4j24A-4xufA:undetectable | 4j24A-4xufA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | LEU A 331LEU A 154LEU A 155ILE A 285LEU A 329 | None | 1.12A | 4j24A-4y6oA:undetectable | 4j24A-4y6oA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3f | PHOSPHORIBULOKINASE/URIDINE KINASE (Methanospirillumhungatei) |
PF00485(PRK) | 5 | LEU A 80LEU A 79ILE A 119ILE A 117LEU A 133 | None | 1.14A | 4j24A-5b3fA:undetectable | 4j24A-5b3fA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dac | PUTATIVEUNCHARACTERIZEDPROTEIN,PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF13476(AAA_23) | 5 | LEU A1236MET A1283LEU A1251ILE A1258LEU A 29 | NoneNoneNoneAES A1403 (-4.1A)None | 1.09A | 4j24A-5dacA:undetectable | 4j24A-5dacA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4v | NUCLEOPROTEIN,PHOSPHOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap)PF13825(Paramyxo_PNT) | 5 | LEU A 54LEU A 50LEU A 39ILE A 155ILE A 151 | None | 1.04A | 4j24A-5e4vA:undetectable | 4j24A-5e4vA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | LEU A 171LEU A 180MET A 376ILE A 186LEU A 357 | None | 1.16A | 4j24A-5eefA:undetectable | 4j24A-5eefA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ekd | TRYPTOPHAN--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF00579(tRNA-synt_1b) | 5 | LEU A 99LEU A 100LEU A 331LEU A 335ILE A 41 | NoneNoneNoneNoneATP A 402 (-3.8A) | 1.11A | 4j24A-5ekdA:undetectable | 4j24A-5ekdA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2a | KLLA0C04147P (Kluyveromyceslactis) |
PF00023(Ank) | 5 | LEU A 34LEU A 37ILE A 73ILE A 89LEU A 87 | None | 1.05A | 4j24A-5h2aA:undetectable | 4j24A-5h2aA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | LEU A 61LEU A 58GLU A 54LEU A 98ILE A 281 | None | 1.10A | 4j24A-5h3aA:undetectable | 4j24A-5h3aA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l75 | FIG000988: PREDICTEDPERMEASE (Klebsiellapneumoniae) |
PF03739(YjgP_YjgQ) | 5 | MET F 88LEU F 93ILE F 3ILE F 4LEU F 98 | None | 0.84A | 4j24A-5l75F:undetectable | 4j24A-5l75F:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0o | TERMINALOLEFIN-FORMING FATTYACID DECARBOXYLASE (Jeotgalicoccussp. ATCC 8456) |
PF00067(p450) | 5 | LEU A 247MET A 103LEU A 102ILE A 374ILE A 373 | HEM A 501 (-4.4A)NoneNoneNoneNone | 1.03A | 4j24A-5m0oA:undetectable | 4j24A-5m0oA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3h | POLYMERASE ACIDICPROTEIN (Influenza Avirus) |
PF00603(Flu_PA) | 5 | LEU A 341LEU A 342LEU A 558ILE A 500ILE A 516 | None | 0.96A | 4j24A-5m3hA:undetectable | 4j24A-5m3hA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 5 | LEU A 670LEU A 518ILE A 908HIS A 640LEU A 638 | None | 1.09A | 4j24A-5m5pA:undetectable | 4j24A-5m5pA:8.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 5 | LEU A 769LEU A 772MET A 807LEU A 814ARG A 817 | ECV A1101 (-4.7A)ECV A1101 ( 3.9A)ECV A1101 (-3.6A)ECV A1101 (-4.1A)ECV A1101 (-4.0A) | 0.38A | 4j24A-5mwpA:28.3 | 4j24A-5mwpA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofn | DNA PRIMASE LARGESUBUNIT PRIL,PRIL-XFUSION PROTEIN (Sulfolobussolfataricus) |
no annotation | 5 | LEU B 31LEU B 37ILE B 199ILE B 76LEU B 206 | None | 1.10A | 4j24A-5ofnB:undetectable | 4j24A-5ofnB:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 5 | MET B 383LEU B 342GLU B 350ILE B 363ILE B 362 | None | 1.17A | 4j24A-5swiB:undetectable | 4j24A-5swiB:15.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 298LEU A 301GLU A 305MET A 340ILE A 373ILE A 376HIS A 475 | EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.8A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A) | 1.36A | 4j24A-5toaA:34.3 | 4j24A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 339GLU A 305LEU A 301ILE A 376ILE A 373LEU A 354 | EST A 601 (-3.9A)EST A 601 (-2.4A)EST A 601 ( 4.3A)EST A 601 ( 4.4A)NoneNone | 1.30A | 4j24A-5toaA:34.3 | 4j24A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 298LEU A 301GLU A 305MET A 336LEU A 339LEU A 343ARG A 346ILE A 373ILE A 376HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.4A)EST A 601 (-4.1A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.33A | 4j24A-5toaA:34.3 | 4j24A-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 295LEU A 298LEU A 354ILE A 376HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)NoneEST A 601 ( 4.4A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 1.49A | 4j24A-5toaA:34.3 | 4j24A-5toaA:99.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | LEU A 96GLU A 168LEU A 195ILE A 39LEU A 34 | None | 1.07A | 4j24A-5u4hA:undetectable | 4j24A-5u4hA:22.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1TA A 301 (-3.5A)1TA A 301 ( 3.6A)1TA A 301 ( 3.1A)1TA A 301 ( 3.4A)1TA A 301 (-3.5A) | 0.51A | 4j24A-5ufsA:29.2 | 4j24A-5ufsA:31.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usl | IMV MEMBRANE PROTEIN (Vaccinia virus) |
no annotation | 5 | LEU X 159LEU X 160LEU X 93ILE X 134ILE X 45 | None | 1.15A | 4j24A-5uslX:undetectable | 4j24A-5uslX:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w94 | MAU2 CHROMATIDCOHESION FACTORHOMOLOGSISTER CHROMATIDCOHESION PROTEIN 2 (Saccharomycescerevisiae) |
PF10345(Cohesin_load)no annotation | 5 | LEU A 489LEU A 545ILE B 15ILE B 14LEU A 552 | None | 1.16A | 4j24A-5w94A:undetectable | 4j24A-5w94A:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 5 | GLU A 690LEU A 666ILE A 862ILE A 861LEU A 716 | None | 0.99A | 4j24A-5wblA:undetectable | 4j24A-5wblA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wix | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 5 | LEU A 230LEU A 231LEU A 405ILE A 385ILE A 411 | None | 1.13A | 4j24A-5wixA:undetectable | 4j24A-5wixA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x0z | FLAGELLAR MOTORSWITCH PROTEIN(FLIM) (Helicobacterpylori) |
PF02154(FliM) | 5 | LEU E 154LEU E 153MET E 75ILE E 120ILE E 124 | None | 1.15A | 4j24A-5x0zE:undetectable | 4j24A-5x0zE:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn1 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasputida) |
no annotation | 5 | LEU A 97GLU A 170LEU A 197ILE A 74LEU A 34 | NoneEPU A 501 ( 4.9A)NoneNoneNone | 1.14A | 4j24A-6cn1A:undetectable | 4j24A-6cn1A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ek4 | PAXB (Photorhabdusluminescens) |
no annotation | 5 | LEU A 149LEU A 146ARG A 295ILE A 40ILE A 42 | None | 1.10A | 4j24A-6ek4A:undetectable | 4j24A-6ek4A:15.00 |