SIMILAR PATTERNS OF AMINO ACIDS FOR 4J24_A_ESTA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE


(Acinetobacter
glutaminasificans)
PF00710
(Asparaginase)
5 LEU A 313
LEU A 310
ILE A 210
ILE A 207
LEU A  67
None
1.12A 4j24A-1agxA:
undetectable
4j24A-1agxA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 LEU A 496
LEU A 492
LEU A 430
ILE A 503
ILE A 438
None
1.06A 4j24A-1i8qA:
0.5
4j24A-1i8qA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB


(Thermotoga
maritima)
PF06723
(MreB_Mbl)
5 LEU A 332
LEU A 128
ILE A 328
ILE A 137
LEU A 323
None
1.15A 4j24A-1jcfA:
undetectable
4j24A-1jcfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa)
PF05184
(SapB_1)
5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
None
1.04A 4j24A-1nklA:
undetectable
4j24A-1nklA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
7 MET A 342
LEU A 346
LEU A 349
GLU A 353
LEU A 387
LEU A 391
ARG A 394
None
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
1.48A 4j24A-1pcgA:
33.5
4j24A-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
LEU A 349
GLU A 353
LEU A 387
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.39A 4j24A-1pcgA:
33.5
4j24A-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 343
LEU A 346
LEU A 402
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
1.40A 4j24A-1pcgA:
33.5
4j24A-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
GOL  A 700 ( 4.4A)
None
None
None
None
1.12A 4j24A-1q3xA:
undetectable
4j24A-1q3xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN


(Escherichia
coli)
PF04257
(Exonuc_V_gamma)
5 LEU C 720
LEU C 717
LEU C 747
ILE C 374
LEU C 677
None
1.08A 4j24A-1w36C:
1.1
4j24A-1w36C:
12.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 324
LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
None
0.60A 4j24A-1xb7A:
28.3
4j24A-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqi NUCLEOSIDE
DIPHOSPHATE KINASE


(Pyrobaculum
aerophilum)
PF00334
(NDK)
5 LEU A  20
LEU A  19
ILE A  35
ILE A  36
LEU A  44
None
1.10A 4j24A-1xqiA:
undetectable
4j24A-1xqiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
None
1.10A 4j24A-1zjkA:
undetectable
4j24A-1zjkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU X 195
LEU X 196
LEU X 256
ILE X 146
HIS X 128
None
1.02A 4j24A-2dq7X:
undetectable
4j24A-2dq7X:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis)
PF12706
(Lactamase_B_2)
5 LEU A  72
LEU A  75
LEU A  88
ILE A  96
ILE A 117
None
0.77A 4j24A-2fk6A:
undetectable
4j24A-2fk6A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 268
LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.58A 4j24A-2gpvA:
27.7
4j24A-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
6 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
HIS D 156
None
1.44A 4j24A-2j5gD:
undetectable
4j24A-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
6 LEU D 158
LEU D 103
LEU D 104
ARG D 221
ILE D 236
HIS D 156
None
1.42A 4j24A-2j5gD:
undetectable
4j24A-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m45 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM


(Sulfolobus
solfataricus)
no annotation 5 MET A 669
LEU A 666
LEU A 649
ILE A 633
ILE A 632
None
1.16A 4j24A-2m45A:
undetectable
4j24A-2m45A:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
LEU A 349
GLU A 353
LEU A 387
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.45A 4j24A-2ocfA:
34.3
4j24A-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 429
LEU A 430
LEU A 490
ILE A 380
HIS A 362
None
0.85A 4j24A-2og8A:
undetectable
4j24A-2og8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes)
PF13614
(AAA_31)
5 LEU A 144
LEU A 143
LEU A 105
ILE A 160
ILE A 158
None
1.09A 4j24A-2ozeA:
undetectable
4j24A-2ozeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
None
1.15A 4j24A-2pa6A:
undetectable
4j24A-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
5 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
0.26A 4j24A-2q3yA:
29.1
4j24A-2q3yA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvx PROTEIN A52

(Vaccinia virus)
PF06227
(Poxvirus)
5 MET A 137
LEU A 140
LEU A 106
ILE A 119
ILE A 116
None
0.94A 4j24A-2vvxA:
undetectable
4j24A-2vvxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
5 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
None
1.00A 4j24A-2wbeC:
undetectable
4j24A-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 LEU A 432
LEU A 433
LEU A 493
ILE A 383
HIS A 365
None
1.00A 4j24A-2zv7A:
undetectable
4j24A-2zv7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY


(Thermus
thermophilus)
no annotation 5 LEU C 139
ARG C 196
ILE C 135
ILE C 132
LEU C 151
None
1.03A 4j24A-3anpC:
undetectable
4j24A-3anpC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE


(Bacillus phage
SPP1)
PF03796
(DnaB_C)
5 LEU A 354
LEU A 199
ILE A 333
ILE A 336
LEU A 319
None
1.09A 4j24A-3bh0A:
undetectable
4j24A-3bh0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 689
LEU A 690
LEU A 750
ILE A 639
HIS A 621
None
0.96A 4j24A-3c4fA:
undetectable
4j24A-3c4fA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB


(Methylosinus
trichosporium)
PF02461
(AMO)
PF04744
(Monooxygenase_B)
5 LEU B 172
LEU B 185
LEU A 187
ILE A 195
ILE B 121
None
1.15A 4j24A-3chxB:
undetectable
4j24A-3chxB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
5 LEU A 251
LEU A 149
ILE A 241
ILE A 246
LEU A 187
None
1.03A 4j24A-3clwA:
undetectable
4j24A-3clwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e19 FEOA

(Thermococcus
thioreducens)
PF04023
(FeoA)
5 MET A  34
LEU A  36
ILE A  55
ILE A  53
LEU A  68
None
1.15A 4j24A-3e19A:
undetectable
4j24A-3e19A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN


(Escherichia
coli)
PF02665
(Nitrate_red_gam)
5 LEU C 133
LEU C 132
ILE C  59
ILE C  62
LEU C 102
HEM  C 806 ( 4.8A)
None
HEM  C 806 (-4.3A)
HEM  C 807 (-4.0A)
None
0.88A 4j24A-3egwC:
undetectable
4j24A-3egwC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN


(Escherichia
coli)
PF02665
(Nitrate_red_gam)
5 LEU C 133
LEU C 139
ILE C  59
ILE C  62
LEU C 102
HEM  C 806 ( 4.8A)
None
HEM  C 806 (-4.3A)
HEM  C 807 (-4.0A)
None
0.92A 4j24A-3egwC:
undetectable
4j24A-3egwC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
None
1.09A 4j24A-3g5iA:
undetectable
4j24A-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A1088
LEU A1089
LEU A1150
ILE A1038
HIS A1020
None
None
None
None
8ST  A2001 ( 4.8A)
0.91A 4j24A-3hngA:
undetectable
4j24A-3hngA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
5 MET A 173
LEU A 176
LEU A 179
ILE A   6
LEU A  57
None
1.04A 4j24A-3iuuA:
undetectable
4j24A-3iuuA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 718
LEU A 721
MET A 756
LEU A 763
ARG A 766
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
0.31A 4j24A-3kbaA:
27.8
4j24A-3kbaA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER


(Plasmodium
falciparum)
PF00069
(Pkinase)
5 LEU A 874
LEU A 868
LEU A 764
ILE A 651
LEU A 846
None
1.11A 4j24A-3lltA:
undetectable
4j24A-3lltA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A


(Homo sapiens)
PF00225
(Kinesin)
5 MET A 123
LEU A 135
ILE A 329
ILE A 327
LEU A 256
None
1.16A 4j24A-3lreA:
undetectable
4j24A-3lreA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdk STRINGENT STARVATION
PROTEIN A


(Pseudomonas
putida)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A  23
GLU A  27
LEU A  84
ARG A 190
ILE A 102
None
1.09A 4j24A-3mdkA:
undetectable
4j24A-3mdkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae)
PF01417
(ENTH)
5 LEU A  94
LEU A  97
ILE A 116
ILE A 113
LEU A 146
None
1.12A 4j24A-3onkA:
undetectable
4j24A-3onkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 MET A 208
LEU A 211
ILE A 173
ILE A 176
LEU A 231
None
0.96A 4j24A-3opbA:
undetectable
4j24A-3opbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE


(Pseudomonas
aeruginosa)
PF03702
(AnmK)
5 MET A 300
LEU A 303
LEU A 306
LEU A 278
ILE A 163
None
1.10A 4j24A-3qbwA:
undetectable
4j24A-3qbwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE


(Bos taurus)
PF00067
(p450)
5 LEU A 441
LEU A 444
LEU A 306
ILE A 348
LEU A 341
None
1.13A 4j24A-3qz1A:
undetectable
4j24A-3qz1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
5 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
0.30A 4j24A-3ry9A:
28.5
4j24A-3ry9A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB


(Methanosarcina
barkeri)
PF04055
(Radical_SAM)
5 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
1.12A 4j24A-3t7vA:
undetectable
4j24A-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 689
LEU A 690
LEU A 750
ILE A 639
HIS A 621
None
1.02A 4j24A-3tt0A:
undetectable
4j24A-3tt0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 LEU A2131
LEU A2134
LEU A2139
ILE A2199
LEU A2152
None
1.11A 4j24A-3vkgA:
undetectable
4j24A-3vkgA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Burkholderia
ambifaria)
no annotation 5 MET A  40
LEU A 237
ARG A 141
ILE A  23
ILE A  27
None
None
AKG  A 302 (-3.7A)
None
None
1.14A 4j24A-3w21A:
undetectable
4j24A-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Burkholderia
ambifaria)
no annotation 5 MET A  40
LEU A 237
LEU A 260
ILE A  23
ILE A  27
None
1.13A 4j24A-3w21A:
undetectable
4j24A-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
5 MET A 201
LEU A 204
ILE A 186
ILE A 215
LEU A 243
None
1.11A 4j24A-3w25A:
undetectable
4j24A-3w25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A 167
LEU A 146
ILE A 141
ILE A 142
LEU A 178
None
1.14A 4j24A-4e3cA:
undetectable
4j24A-4e3cA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E


(Linum
nodiflorum)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 MET A  71
LEU A  74
LEU A  77
LEU A 103
ILE A  37
None
1.16A 4j24A-4eviA:
undetectable
4j24A-4eviA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 LEU H 473
LEU H 472
LEU H 538
ILE H 679
ILE H 682
None
1.13A 4j24A-4fxgH:
undetectable
4j24A-4fxgH:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN


(Lactobacillus
brevis)
PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS)
5 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j24A-4hzuT:
undetectable
4j24A-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
5 LEU A 609
LEU A 612
LEU A 639
ILE A 569
ILE A 645
None
1.14A 4j24A-4ifqA:
undetectable
4j24A-4ifqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 683
LEU A 684
LEU A 744
ILE A 633
HIS A 615
None
0.94A 4j24A-4k33A:
undetectable
4j24A-4k33A:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
7 LEU A 283
LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
None
0.62A 4j24A-4n1yA:
31.2
4j24A-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 219
LEU A 222
LEU A 299
ILE A 249
ILE A 250
None
0.91A 4j24A-4nhdA:
undetectable
4j24A-4nhdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
None
1.16A 4j24A-4o1oA:
undetectable
4j24A-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind)
5 LEU A 780
LEU A 783
LEU A 763
ILE A 770
ILE A 713
None
0.94A 4j24A-4o3mA:
undetectable
4j24A-4o3mA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 563
LEU A 566
MET A 601
LEU A 608
ARG A 611
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
0.72A 4j24A-4p6wA:
28.2
4j24A-4p6wA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 560
LEU A 566
MET A 601
LEU A 608
ARG A 611
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
0.87A 4j24A-4p6wA:
28.2
4j24A-4p6wA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
5 LEU A 466
LEU A 229
ARG A  75
ILE A 807
ILE A 818
None
1.13A 4j24A-4q2cA:
undetectable
4j24A-4q2cA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A 386
LEU A 376
ILE A 411
ILE A 423
LEU A 417
None
1.09A 4j24A-4u08A:
undetectable
4j24A-4u08A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus)
PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C)
5 LEU A 586
LEU A 555
LEU A 554
ILE A 568
LEU A 612
None
1.13A 4j24A-4u90A:
undetectable
4j24A-4u90A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 769
LEU A 772
MET A 807
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.44A 4j24A-4udbA:
28.1
4j24A-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF00331
(Glyco_hydro_10)
5 MET A 542
LEU A 545
ILE A 527
ILE A 556
LEU A 585
None
1.09A 4j24A-4w8lA:
undetectable
4j24A-4w8lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
5 LEU A 352
LEU A 353
ILE A  12
ILE A  17
LEU A 313
None
1.06A 4j24A-4wu0A:
undetectable
4j24A-4wu0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 678
LEU A 679
LEU A 739
ILE A 628
HIS A 610
None
0.96A 4j24A-4xcuA:
undetectable
4j24A-4xcuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 877
LEU A 878
LEU A 939
ILE A 827
HIS A 809
None
None
None
P30  A1001 (-4.7A)
P30  A1001 (-4.4A)
0.94A 4j24A-4xufA:
undetectable
4j24A-4xufA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 LEU A 331
LEU A 154
LEU A 155
ILE A 285
LEU A 329
None
1.12A 4j24A-4y6oA:
undetectable
4j24A-4y6oA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE


(Methanospirillum
hungatei)
PF00485
(PRK)
5 LEU A  80
LEU A  79
ILE A 119
ILE A 117
LEU A 133
None
1.14A 4j24A-5b3fA:
undetectable
4j24A-5b3fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF13476
(AAA_23)
5 LEU A1236
MET A1283
LEU A1251
ILE A1258
LEU A  29
None
None
None
AES  A1403 (-4.1A)
None
1.09A 4j24A-5dacA:
undetectable
4j24A-5dacA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 LEU A  54
LEU A  50
LEU A  39
ILE A 155
ILE A 151
None
1.04A 4j24A-5e4vA:
undetectable
4j24A-5e4vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio)
PF00850
(Hist_deacetyl)
5 LEU A 171
LEU A 180
MET A 376
ILE A 186
LEU A 357
None
1.16A 4j24A-5eefA:
undetectable
4j24A-5eefA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL


(Homo sapiens)
PF00579
(tRNA-synt_1b)
5 LEU A  99
LEU A 100
LEU A 331
LEU A 335
ILE A  41
None
None
None
None
ATP  A 402 (-3.8A)
1.11A 4j24A-5ekdA:
undetectable
4j24A-5ekdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2a KLLA0C04147P

(Kluyveromyces
lactis)
PF00023
(Ank)
5 LEU A  34
LEU A  37
ILE A  73
ILE A  89
LEU A  87
None
1.05A 4j24A-5h2aA:
undetectable
4j24A-5h2aA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 LEU A  61
LEU A  58
GLU A  54
LEU A  98
ILE A 281
None
1.10A 4j24A-5h3aA:
undetectable
4j24A-5h3aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE


(Klebsiella
pneumoniae)
PF03739
(YjgP_YjgQ)
5 MET F  88
LEU F  93
ILE F   3
ILE F   4
LEU F  98
None
0.84A 4j24A-5l75F:
undetectable
4j24A-5l75F:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE


(Jeotgalicoccus
sp. ATCC 8456)
PF00067
(p450)
5 LEU A 247
MET A 103
LEU A 102
ILE A 374
ILE A 373
HEM  A 501 (-4.4A)
None
None
None
None
1.03A 4j24A-5m0oA:
undetectable
4j24A-5m0oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN


(Influenza A
virus)
PF00603
(Flu_PA)
5 LEU A 341
LEU A 342
LEU A 558
ILE A 500
ILE A 516
None
0.96A 4j24A-5m3hA:
undetectable
4j24A-5m3hA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
None
1.09A 4j24A-5m5pA:
undetectable
4j24A-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 5 LEU A 769
LEU A 772
MET A 807
LEU A 814
ARG A 817
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
0.38A 4j24A-5mwpA:
28.3
4j24A-5mwpA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN


(Sulfolobus
solfataricus)
no annotation 5 LEU B  31
LEU B  37
ILE B 199
ILE B  76
LEU B 206
None
1.10A 4j24A-5ofnB:
undetectable
4j24A-5ofnB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 5 MET B 383
LEU B 342
GLU B 350
ILE B 363
ILE B 362
None
1.17A 4j24A-5swiB:
undetectable
4j24A-5swiB:
15.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 298
LEU A 301
GLU A 305
MET A 340
ILE A 373
ILE A 376
HIS A 475
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
1.36A 4j24A-5toaA:
34.3
4j24A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 339
GLU A 305
LEU A 301
ILE A 376
ILE A 373
LEU A 354
EST  A 601 (-3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.3A)
EST  A 601 ( 4.4A)
None
None
1.30A 4j24A-5toaA:
34.3
4j24A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 336
LEU A 339
LEU A 343
ARG A 346
ILE A 373
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.33A 4j24A-5toaA:
34.3
4j24A-5toaA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 295
LEU A 298
LEU A 354
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
1.49A 4j24A-5toaA:
34.3
4j24A-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
None
1.07A 4j24A-5u4hA:
undetectable
4j24A-5u4hA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2


(unidentified)
PF00104
(Hormone_recep)
5 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
0.51A 4j24A-5ufsA:
29.2
4j24A-5ufsA:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usl IMV MEMBRANE PROTEIN

(Vaccinia virus)
no annotation 5 LEU X 159
LEU X 160
LEU X  93
ILE X 134
ILE X  45
None
1.15A 4j24A-5uslX:
undetectable
4j24A-5uslX:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2


(Saccharomyces
cerevisiae)
PF10345
(Cohesin_load)
no annotation
5 LEU A 489
LEU A 545
ILE B  15
ILE B  14
LEU A 552
None
1.16A 4j24A-5w94A:
undetectable
4j24A-5w94A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 GLU A 690
LEU A 666
ILE A 862
ILE A 861
LEU A 716
None
0.99A 4j24A-5wblA:
undetectable
4j24A-5wblA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum)
no annotation 5 LEU A 230
LEU A 231
LEU A 405
ILE A 385
ILE A 411
None
1.13A 4j24A-5wixA:
undetectable
4j24A-5wixA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)


(Helicobacter
pylori)
PF02154
(FliM)
5 LEU E 154
LEU E 153
MET E  75
ILE E 120
ILE E 124
None
1.15A 4j24A-5x0zE:
undetectable
4j24A-5x0zE:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
None
EPU  A 501 ( 4.9A)
None
None
None
1.14A 4j24A-6cn1A:
undetectable
4j24A-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek4 PAXB

(Photorhabdus
luminescens)
no annotation 5 LEU A 149
LEU A 146
ARG A 295
ILE A  40
ILE A  42
None
1.10A 4j24A-6ek4A:
undetectable
4j24A-6ek4A:
15.00