SIMILAR PATTERNS OF AMINO ACIDS FOR 4J14_A_X2NA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		5 ALA A 162
LEU A  24
PHE A  20
THR A  66
ALA A  68
 None
 1.10A 4j14A-1ce7A:
0.0		 4j14A-1ce7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 448
LEU A 406
VAL A 425
ARG A 442
ILE A 397
 None
 0.99A 4j14A-1dmsA:
0.0		 4j14A-1dmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 121
LEU A 117
PHE A 118
ALA A  89
THR A  93
 None
 1.06A 4j14A-1e5fA:
0.0		 4j14A-1e5fA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 313
LEU A 301
ILE A 293
ALA A 287
THR A   8
 None
 0.98A 4j14A-1eblA:
undetectable		 4j14A-1eblA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 448
LEU A 406
VAL A 425
ARG A 442
ILE A 397
 None
 0.95A 4j14A-1eu1A:
0.0		 4j14A-1eu1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g43 SCAFFOLDING PROTEIN

([Clostridium]
cellulolyticum) 		PF00942
(CBM_3) 		5 ALA A  98
PHE A  26
VAL A  28
ILE A 146
ALA A 155
 None
 1.11A 4j14A-1g43A:
undetectable		 4j14A-1g43A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 ALA A 501
LEU A 500
ILE A 565
ALA A 564
ALA A 557
 None
 0.98A 4j14A-1kehA:
0.0		 4j14A-1kehA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 346
LEU A 347
ILE A 358
ALA A 200
ALA A 205
 None
 1.04A 4j14A-1kolA:
0.0		 4j14A-1kolA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 ALA A 312
LEU A 309
ILE A 230
ALA A 258
ALA A 275
 None
 0.97A 4j14A-1la1A:
0.0		 4j14A-1la1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		5 ALA A 412
LEU A 415
ILE A 394
ALA A 391
THR A 430
 None
None
None
None
PLD  A2005 ( 4.8A)
 1.11A 4j14A-1lshA:
undetectable		 4j14A-1lshA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		5 ALA A 116
VAL A 153
ILE A 157
THR A  75
ALA A 103
 None
 0.95A 4j14A-1lt8A:
undetectable		 4j14A-1lt8A:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		6 ALA A  70
LEU A  71
ALA A 221
THR A 225
ALA A 268
THR A 372
 None
EDO  A 715 ( 4.9A)
HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
None
 0.97A 4j14A-1n97A:
39.3		 4j14A-1n97A:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli) 		PF02685
(Glucokinase) 		5 ALA A 186
LEU A 139
ILE A 260
ALA A 261
ALA A 142
 None
 0.88A 4j14A-1q18A:
0.6		 4j14A-1q18A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A 225
ILE A 234
ALA A 202
THR A 131
ALA A 133
 None
 1.09A 4j14A-1szsA:
undetectable		 4j14A-1szsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 ALA A 112
VAL A  66
ILE A  38
ALA A 177
THR A 181
 None
 1.10A 4j14A-1upxA:
2.4		 4j14A-1upxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		5 ALA A 192
LEU A  91
ILE A 110
ALA A 109
ALA A 106
 None
 1.02A 4j14A-1xs5A:
undetectable		 4j14A-1xs5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		5 ALA A 161
LEU A  24
PHE A  20
THR A  66
ALA A  68
 None
 1.10A 4j14A-1yf8A:
undetectable		 4j14A-1yf8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		6 ALA A 435
LEU A 408
PHE A 402
ALA A 380
THR A 384
ALA A 414
 None
 1.33A 4j14A-1zczA:
undetectable		 4j14A-1zczA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 451
LEU A 448
ILE A 425
ALA A 422
ALA A 354
 None
 1.08A 4j14A-1zk7A:
undetectable		 4j14A-1zk7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		5 ALA A  83
LEU A  84
PHE A  88
ALA A 208
ALA A 213
 None
 1.10A 4j14A-1zzgA:
undetectable		 4j14A-1zzgA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 ALA C 332
LEU C 331
ILE C 396
ALA C 395
ALA C 388
 None
 1.01A 4j14A-2advC:
undetectable		 4j14A-2advC:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 LEU A 324
PHE A 290
VAL A 293
ILE A 244
ALA A 276
 None
 1.10A 4j14A-2as0A:
undetectable		 4j14A-2as0A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e63 KIAA1787 PROTEIN

(Homo sapiens) 		PF07177
(Neuralized) 		5 ALA A 147
LEU A 134
VAL A 126
ALA A 156
ALA A  85
 None
 1.01A 4j14A-2e63A:
undetectable		 4j14A-2e63A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 317
LEU A 318
ALA A 294
ALA A 299
THR A 133
 None
 1.06A 4j14A-2f00A:
undetectable		 4j14A-2f00A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5g TRANSPOSASE,
PUTATIVE

(Sulfolobus
solfataricus) 		PF01797
(Y1_Tnp) 		5 ALA A  72
LEU A  76
VAL A  65
ILE A  43
ALA A  44
 None
 1.04A 4j14A-2f5gA:
undetectable		 4j14A-2f5gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		5 ALA A 339
LEU A 302
ALA A 279
THR A 220
ALA A 323
 None
 0.99A 4j14A-2h9fA:
undetectable		 4j14A-2h9fA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ALA A 111
LEU A 110
PHE A  62
ALA A  90
ALA A  87
 None
 1.11A 4j14A-2jbmA:
undetectable		 4j14A-2jbmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		5 ALA A 283
LEU A 284
VAL A  30
ILE A   3
ALA A  47
 None
 1.08A 4j14A-2livA:
undetectable		 4j14A-2livA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 VAL A  26
ILE A  40
ALA A  50
ALA A  55
THR A  56
 None
 1.09A 4j14A-2nlzA:
1.6		 4j14A-2nlzA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obb HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A  40
VAL A   5
ILE A 110
ALA A  26
THR A  29
 None
 1.00A 4j14A-2obbA:
undetectable		 4j14A-2obbA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		6 ALA A 390
LEU A 412
PHE A 486
VAL A 477
ALA A 402
THR A 399
 None
 1.18A 4j14A-2omvA:
undetectable		 4j14A-2omvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		5 ALA A 343
LEU A 306
ALA A 283
THR A 224
ALA A 327
 None
 0.93A 4j14A-2pvzA:
undetectable		 4j14A-2pvzA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		9 ALA A 111
LEU A 112
PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
THR A 475
 None
None
None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
 0.59A 4j14A-2q9gA:
63.4		 4j14A-2q9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 PHE A  64
VAL A  99
ILE A  32
ALA A   4
ALA A 103
 None
 1.10A 4j14A-2vrcA:
undetectable		 4j14A-2vrcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		5 ALA A 174
VAL A 179
ARG A 327
ILE A 230
THR A 143
 None
 1.11A 4j14A-2waaA:
undetectable		 4j14A-2waaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		6 ALA A  51
LEU A  48
ILE A  63
ALA A  65
ALA A  93
THR A  17
 None
None
None
None
NAD  A 500 (-3.6A)
None
 1.26A 4j14A-2wsbA:
undetectable		 4j14A-2wsbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ALA A 600
LEU A 641
PHE A 638
ILE A 634
ALA A 477
 None
None
B12  A 800 ( 4.9A)
B12  A 800 (-4.0A)
None
 1.06A 4j14A-2xijA:
undetectable		 4j14A-2xijA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		5 LEU A 340
VAL A 342
ARG A 359
ILE A 407
THR A 389
 None
 1.08A 4j14A-2y8fA:
undetectable		 4j14A-2y8fA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxb COENZYME
B12-DEPENDENT MUTASE

(Aeropyrum
pernix) 		PF02310
(B12-binding) 		5 ALA A  43
LEU A  44
PHE A  49
VAL A  23
ALA A 145
 None
 0.85A 4j14A-2yxbA:
undetectable		 4j14A-2yxbA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		5 ALA A  47
LEU A  51
PHE A  55
VAL A  57
ALA A  10
 None
 1.05A 4j14A-3ai2A:
undetectable		 4j14A-3ai2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 ALA A 357
VAL A 204
ALA A 164
THR A 160
THR A 185
 None
 1.08A 4j14A-3cinA:
undetectable		 4j14A-3cinA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ALA A  16
LEU A  13
VAL A  53
ILE A  64
ALA A  63
 None
 1.02A 4j14A-3ctzA:
undetectable		 4j14A-3ctzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		5 ALA A 157
LEU A 158
ILE A 239
ALA A 238
ALA A 175
 None
 1.05A 4j14A-3e4dA:
undetectable		 4j14A-3e4dA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		5 ALA A  77
LEU A 103
ILE A  11
ALA A   8
ALA A 144
 None
 1.01A 4j14A-3fkjA:
undetectable		 4j14A-3fkjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 ALA B  25
VAL B  38
ILE B  56
ALA B  57
ALA B 104
 None
 0.97A 4j14A-3hrdB:
undetectable		 4j14A-3hrdB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		5 ALA A 210
LEU A 211
PHE A 216
VAL A 222
ALA A 135
 None
 1.08A 4j14A-3k4hA:
undetectable		 4j14A-3k4hA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ALA A 295
LEU A 296
PHE A 301
VAL A 315
ILE A 321
 None
 1.05A 4j14A-3pgyA:
undetectable		 4j14A-3pgyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		5 LEU A 236
PHE A 257
ILE A 213
ALA A 214
THR A 192
 None
 1.11A 4j14A-3qm3A:
undetectable		 4j14A-3qm3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT

(Legionella
pneumophila) 		PF01596
(Methyltransf_3) 		5 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
 None
 0.79A 4j14A-3r3hA:
undetectable		 4j14A-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		5 LEU A  27
ILE A  40
ALA A  30
THR A  59
ALA A 105
 None
 1.10A 4j14A-3rm5A:
undetectable		 4j14A-3rm5A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 5 ALA A 202
LEU A 203
ILE A  40
ALA A  37
ALA A  32
 None
 1.01A 4j14A-3slrA:
undetectable		 4j14A-3slrA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		6 LEU A  82
PHE A 103
VAL A 106
ILE A  38
THR A  40
THR A  73
 None
None
None
None
JLN  A1528 (-4.0A)
JLN  A1528 (-2.7A)
 1.17A 4j14A-4a1oA:
1.2		 4j14A-4a1oA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		5 PHE A 447
VAL A 157
ALA A 132
THR A 134
THR A 142
 None
 1.11A 4j14A-4c3sA:
undetectable		 4j14A-4c3sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 208
LEU A 209
ILE A 252
ALA A 253
ALA A 231
 None
 1.04A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 208
LEU A 209
PHE A 214
ILE A 252
ALA A 253
 None
 0.91A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 274
LEU A 275
ILE A 318
ALA A 297
THR A 300
 None
 1.10A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 274
LEU A 275
ILE A 318
ALA A 319
ALA A 297
 None
 1.09A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 274
LEU A 275
PHE A 280
ILE A 318
ALA A 319
 None
 1.06A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 274
LEU A 275
PHE A 280
ILE A 318
THR A 300
 None
 0.80A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 LEU A 139
PHE A 143
VAL A 136
ILE A 156
ALA A 157
 None
 1.11A 4j14A-4cjaA:
undetectable		 4j14A-4cjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 453
LEU A 454
ILE A 508
ALA A 509
ALA A 464
 TPP  A1589 (-3.3A)
None
None
None
None
 1.05A 4j14A-4d5gA:
undetectable		 4j14A-4d5gA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		5 LEU A 315
PHE A 281
VAL A 284
ALA A 270
THR A 273
 None
None
None
SAM  A 401 (-3.7A)
None
 0.94A 4j14A-4dmgA:
undetectable		 4j14A-4dmgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 290
VAL A 261
ILE A 278
ALA A 274
ALA A 301
 None
 1.05A 4j14A-4emwA:
undetectable		 4j14A-4emwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN

(Salmon isavirus) 		no annotation 5 ALA A 150
LEU A 151
PHE A 155
ARG A 230
ALA A 172
 None
 1.05A 4j14A-4ewcA:
undetectable		 4j14A-4ewcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE

(Rhodobacter
sphaeroides) 		PF02230
(Abhydrolase_2) 		5 ALA A 230
LEU A 231
PHE A 236
VAL A 208
ALA A 171
 None
 0.99A 4j14A-4ftwA:
undetectable		 4j14A-4ftwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ALA A 251
LEU A 246
VAL A 242
ILE A 181
ALA A 170
 None
 0.99A 4j14A-4fwtA:
undetectable		 4j14A-4fwtA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 5 ALA A 249
LEU A 216
VAL A 178
ILE A 165
ALA A 202
 None
 1.11A 4j14A-4gjiA:
undetectable		 4j14A-4gjiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 ALA A 272
LEU A 273
PHE A  78
ARG A 278
ALA A 107
 None
 1.00A 4j14A-4gr4A:
undetectable		 4j14A-4gr4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 ALA A 272
LEU A 273
PHE A  78
ARG A 278
ALA A 107
 None
 1.00A 4j14A-4gr5A:
undetectable		 4j14A-4gr5A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 ALA A  18
LEU A  19
VAL A 300
ALA A 276
ALA A 254
 None
 1.08A 4j14A-4h27A:
undetectable		 4j14A-4h27A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 ALA C 956
LEU C 959
PHE C 940
VAL C 936
THR C1019
 None
None
None
None
EDO  C1103 ( 4.0A)
 0.96A 4j14A-4hb4C:
undetectable		 4j14A-4hb4C:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		5 ALA A 167
LEU A  24
PHE A  20
THR A  67
ALA A  69
 None
 1.09A 4j14A-4jkxA:
undetectable		 4j14A-4jkxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ALA A 103
LEU A  53
ILE A  42
ALA A  38
ALA A  90
 None
 0.79A 4j14A-4k2nA:
undetectable		 4j14A-4k2nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 LEU A  53
ILE A  42
ALA A  38
ALA A  90
THR A  93
 None
 1.10A 4j14A-4k2nA:
undetectable		 4j14A-4k2nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 ALA A 170
PHE A 128
ILE A 156
ALA A 147
ALA A 151
 None
 1.04A 4j14A-4lt6A:
undetectable		 4j14A-4lt6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 ALA A 321
LEU A 270
PHE A 115
VAL A 273
THR A 289
 UNX  A 404 ( 3.9A)
None
None
None
SAH  A 401 (-3.8A)
 0.96A 4j14A-4rg1A:
undetectable		 4j14A-4rg1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 LEU A 287
PHE A 282
VAL A 278
ILE A 240
ALA A 253
 None
 0.95A 4j14A-4tmuA:
undetectable		 4j14A-4tmuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 ALA A 238
LEU A 239
ALA A 260
ALA A 228
THR A 231
 TRP  A 601 ( 3.9A)
None
None
None
NA  A 702 ( 3.3A)
 0.89A 4j14A-4us4A:
0.6		 4j14A-4us4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 ALA A 238
LEU A 239
VAL A  63
ALA A 260
ALA A 228
 TRP  A 601 ( 3.9A)
None
None
None
None
 1.08A 4j14A-4us4A:
0.6		 4j14A-4us4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 ALA A 989
LEU A1039
VAL A1043
ARG A1025
ALA A 980
 None
 1.03A 4j14A-4uwaA:
undetectable		 4j14A-4uwaA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		5 ALA A 286
VAL A 246
ALA A 131
THR A 134
ALA A 293
 None
 1.04A 4j14A-4zm4A:
undetectable		 4j14A-4zm4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 ALA A 437
VAL A 548
ILE A 532
ALA A 357
THR A 361
 None
 1.08A 4j14A-5a2oA:
undetectable		 4j14A-5a2oA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 ALA A 280
LEU A 281
VAL A 261
ALA A 546
ALA A 356
 None
 1.09A 4j14A-5allA:
undetectable		 4j14A-5allA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnl ICML-LIKE

(Legionella
pneumophila) 		PF11393
(T4BSS_DotI_IcmL) 		5 LEU A 149
ILE A  55
ALA A  39
THR A  42
ALA A  89
 None
 1.07A 4j14A-5cnlA:
undetectable		 4j14A-5cnlA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 ALA A 413
LEU A 429
VAL A 350
ILE A 361
ALA A 397
 None
 0.92A 4j14A-5e0cA:
undetectable		 4j14A-5e0cA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		6 LEU A  75
ILE A 263
ALA A 264
THR A 268
ALA A 328
THR A 438
 None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
None
 0.91A 4j14A-5e78A:
42.4		 4j14A-5e78A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		5 ALA A 308
LEU A 239
ILE A 163
ALA A 164
ALA A 171
 None
 1.06A 4j14A-5fb3A:
undetectable		 4j14A-5fb3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 ALA A  53
LEU A  86
PHE A  85
ILE A 222
ALA A 223
 None
 0.97A 4j14A-5jjpA:
undetectable		 4j14A-5jjpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksp MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF00071
(Ras) 		6 ALA A 458
LEU A 438
PHE A 570
VAL A 462
ILE A 569
ALA A 577
 None
 1.36A 4j14A-5kspA:
undetectable		 4j14A-5kspA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		5 ALA A 187
LEU A 188
PHE A 193
VAL A 196
ALA A 122
 None
 1.01A 4j14A-5lzlA:
undetectable		 4j14A-5lzlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		5 ALA A 217
VAL A 103
ARG A 214
ILE A  79
ALA A 122
 None
 1.10A 4j14A-5lzlA:
undetectable		 4j14A-5lzlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 ALA A 173
LEU A 178
VAL A 150
ILE A  27
ALA A 398
 None
 0.96A 4j14A-5mb9A:
undetectable		 4j14A-5mb9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 VAL A 134
ARG A 349
ILE A 215
ALA A 214
ALA A 197
 None
 0.99A 4j14A-5medA:
undetectable		 4j14A-5medA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nji PHTHIOCEROL/PHENOLPH
THIOCEROL SYNTHESIS
POLYKETIDE SYNTHASE
TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF14765
(PS-DH) 		5 ALA A1187
LEU A1192
VAL A1161
ALA A1145
THR A1142
 None
None
8Z2  A1301 (-3.3A)
None
None
 0.94A 4j14A-5njiA:
undetectable		 4j14A-5njiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syn ACYL-PROTEIN
THIOESTERASE 2

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 ALA A 159
LEU A 133
ALA A 144
ALA A 188
THR A 187
 None
None
None
None
71T  A 301 (-3.3A)
 1.02A 4j14A-5synA:
undetectable		 4j14A-5synA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 ALA A 177
LEU A  56
ILE A  63
ALA A  61
ALA A 210
 None
 0.97A 4j14A-5tr1A:
0.0		 4j14A-5tr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA A 141
LEU A 140
PHE A  97
ILE A  91
ALA A 307
 None
 1.05A 4j14A-5vpuA:
undetectable		 4j14A-5vpuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 5 ALA A 546
ILE A 703
ALA A 704
ALA A 608
THR A 607
 None
 1.04A 4j14A-6brsA:
undetectable		 4j14A-6brsA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 ALA A 216
LEU A 212
VAL A 230
ALA A 270
THR A 273
 None
 1.04A 4j14A-6cboA:
undetectable		 4j14A-6cboA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 5 LEU A 185
PHE A 161
VAL A  54
ALA A  66
THR A  69
 None
 1.01A 4j14A-6guoA:
undetectable		 4j14A-6guoA:
undetectable