SIMILAR PATTERNS OF AMINO ACIDS FOR 4J03_A_FVSA603_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 SER A 161
GLN A 111
MET A 349
ASN A 202
 None
 1.46A 4j03A-1lbqA:
3.2		 4j03A-1lbqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		4 TRP A 283
SER A 317
MET A  34
ASN A 233
 None
None
LLP  A 230 ( 4.2A)
None
 1.19A 4j03A-3t32A:
1.4		 4j03A-3t32A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 TRP A 336
SER A 374
GLN A 384
ASN A 472
 1LF  A 601 (-3.4A)
None
1LF  A 601 ( 4.1A)
None
 0.47A 4j03A-4jncA:
52.9		 4j03A-4jncA:
85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 TRP A 336
SER A 374
GLN A 384
MET A 469
ASN A 472
 SO4  A1550 (-3.3A)
None
None
None
None
 0.39A 4j03A-5allA:
56.8		 4j03A-5allA:
100.00