SIMILAR PATTERNS OF AMINO ACIDS FOR 4IQQ_A_D16A402
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 5 | ASP A 303LEU A 306GLY A 302PHE A 301TYR A 14 | None | 1.23A | 4iqqA-1am5A:0.0 | 4iqqA-1am5A:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bsf | THYMIDYLATE SYNTHASEA (Bacillussubtilis) |
PF00303(Thymidylat_synt) | 5 | ILE A 93ASP A 184GLY A 188PHE A 191TYR A 224 | None | 0.73A | 4iqqA-1bsfA:30.8 | 4iqqA-1bsfA:34.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 6 | ILE A 86ASP A 202LEU A 205GLY A 206PHE A 209TYR A 242 | CB3 A 768 (-3.6A)CB3 A 768 ( 3.6A)CB3 A 768 ( 4.4A)UMP A 767 (-3.7A)CB3 A 768 (-3.6A)CB3 A 768 ( 4.7A) | 0.66A | 4iqqA-1ci7A:41.2 | 4iqqA-1ci7A:53.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cov | COXSACKIEVIRUS COATPROTEIN (Enterovirus B) |
PF00073(Rhv) | 4 | ILE 3 114LEU 3 104GLY 3 101PHE 3 95 | None | 0.78A | 4iqqA-1cov3:undetectable | 4iqqA-1cov3:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6h | CHALCONE SYNTHASE (Medicago sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | ILE A 114LEU A 150GLY A 149TYR A 153 | None | 0.88A | 4iqqA-1d6hA:undetectable | 4iqqA-1d6hA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6n | PROTEIN(HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE) (Homo sapiens) |
PF00156(Pribosyltran) | 4 | TYR A 194ILE A 207GLY A 189PHE A 198 | None | 0.82A | 4iqqA-1d6nA:0.0 | 4iqqA-1d6nA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7e | PHOTOACTIVE YELLOWPROTEIN (Halorhodospirahalophila) |
PF00989(PAS) | 5 | TYR A 42ILE A 31ASP A 34GLY A 37PHE A 62 | HC4 A 126 (-4.2A)NoneNoneNoneHC4 A 126 (-4.7A) | 1.47A | 4iqqA-1d7eA:undetectable | 4iqqA-1d7eA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg7 | FORMYLTETRAHYDROFOLATE SYNTHETASE (Moorellathermoacetica) |
PF01268(FTHFS) | 4 | ILE A1060ASP A1056LEU A1292GLY A1057 | None | 0.91A | 4iqqA-1eg7A:0.0 | 4iqqA-1eg7A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6q | HNRNP ARGININEN-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF06325(PrmA) | 4 | TYR 1 178ILE 1 206LEU 1 173GLY 1 253 | None | 0.80A | 4iqqA-1g6q1:0.0 | 4iqqA-1g6q1:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxl | CHROMOSOMESEGREGATION SMCPROTEIN (Thermotogamaritima) |
PF06470(SMC_hinge) | 4 | ILE A 524LEU A 609GLY A 610PHE A 614 | None | 0.88A | 4iqqA-1gxlA:undetectable | 4iqqA-1gxlA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkk | CHITOTRIOSIDASE-1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 4 | ILE A 325LEU A 301GLY A 268PHE A 334 | None | 0.90A | 4iqqA-1hkkA:undetectable | 4iqqA-1hkkA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htw | HI0065 (Haemophilusinfluenzae) |
PF02367(TsaE) | 4 | ILE A 24ASP A 126LEU A 148GLY A 149 | None | 0.93A | 4iqqA-1htwA:undetectable | 4iqqA-1htwA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hv5 | STROMELYSIN 3 (Mus musculus) |
PF00413(Peptidase_M10) | 4 | ILE A 159LEU A 225GLY A 222PHE A 221 | None | 0.85A | 4iqqA-1hv5A:undetectable | 4iqqA-1hv5A:20.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvy | THYMIDYLATE SYNTHASE (Homo sapiens) |
PF00303(Thymidylat_synt) | 6 | ILE A 108ASP A 218LEU A 221GLY A 222PHE A 225TYR A 258 | D16 A 414 (-3.7A)D16 A 414 ( 3.6A)D16 A 414 (-4.0A)D16 A 414 (-3.3A)D16 A 414 (-3.6A)UMP A 314 ( 4.4A) | 0.57A | 4iqqA-1hvyA:42.1 | 4iqqA-1hvyA:62.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | ASP A 300LEU A 303GLY A 299PHE A 298TYR A 17 | None | 1.19A | 4iqqA-1izeA:undetectable | 4iqqA-1izeA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | ASP A 655GLY A 658PHE A 661TYR A 598 | None | 0.88A | 4iqqA-1j1wA:undetectable | 4iqqA-1j1wA:19.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j3j | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00303(Thymidylat_synt) | 4 | ASP C 513LEU C 516GLY C 517TYR C 553 | UMP C 611 (-4.9A)NoneUMP C 611 (-3.5A)UMP C 611 (-4.9A) | 0.70A | 4iqqA-1j3jC:40.0 | 4iqqA-1j3jC:49.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j3j | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00303(Thymidylat_synt) | 4 | ILE C 403ASP C 513GLY C 517TYR C 553 | NoneUMP C 611 (-4.9A)UMP C 611 (-3.5A)UMP C 611 (-4.9A) | 0.52A | 4iqqA-1j3jC:40.0 | 4iqqA-1j3jC:49.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j8s | PYELONEPHRITICADHESIN (Escherichiacoli) |
PF03627(PapG_N) | 4 | TYR A 7ASP A 11LEU A 9GLY A 10 | None | 0.90A | 4iqqA-1j8sA:undetectable | 4iqqA-1j8sA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mdu | GELSOLIN PRECURSOR (Homo sapiens) |
PF00626(Gelsolin) | 4 | TYR A 109ILE A 46LEU A 114GLY A 36 | NoneNoneNoneTRS A 472 ( 4.7A) | 0.92A | 4iqqA-1mduA:undetectable | 4iqqA-1mduA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzu | PPR (Rhodospirillumcentenum) |
PF00989(PAS) | 5 | TYR A 42ILE A 31ASP A 34GLY A 37PHE A 62 | HC4 A 130 (-4.6A)NoneNoneNoneNone | 1.49A | 4iqqA-1mzuA:undetectable | 4iqqA-1mzuA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n71 | AAC(6')-II (Enterococcusfaecium) |
PF00583(Acetyltransf_1) | 4 | TYR A 144ILE A 154LEU A 109GLY A 110 | None | 0.71A | 4iqqA-1n71A:undetectable | 4iqqA-1n71A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odv | PHOTOACTIVE YELLOWPROTEIN (Halorhodospirahalophila) |
PF00989(PAS) | 5 | TYR A 42ILE A 31ASP A 34GLY A 37PHE A 62 | HC4 A 126 (-4.2A)NoneNoneNoneHC4 A 126 ( 4.9A) | 1.49A | 4iqqA-1odvA:undetectable | 4iqqA-1odvA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pmj | BETA-1,4-MANNANASE (Caldicellulosiruptorsaccharolyticus) |
PF09212(CBM27) | 4 | ILE X 173ASP X 61GLY X 164PHE X 103 | None | 0.89A | 4iqqA-1pmjX:undetectable | 4iqqA-1pmjX:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q6y | HYPOTHETICAL PROTEINYFDW (Escherichiacoli) |
PF02515(CoA_transf_3) | 4 | TYR A 225ASP A 239GLY A 238PHE A 237 | None | 0.82A | 4iqqA-1q6yA:undetectable | 4iqqA-1q6yA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qox | BETA-GLUCOSIDASE (Bacilluscirculans) |
PF00232(Glyco_hydro_1) | 5 | TYR A 146ILE A 80ASP A 99LEU A 98GLY A 97 | None | 1.25A | 4iqqA-1qoxA:undetectable | 4iqqA-1qoxA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rgi | GELSOLIN (Equus caballus) |
PF00626(Gelsolin) | 4 | TYR G 133ILE G 70LEU G 138GLY G 60 | None | 0.89A | 4iqqA-1rgiG:undetectable | 4iqqA-1rgiG:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rhy | IMIDAZOLE GLYCEROLPHOSPHATEDEHYDRATASE (Cryptococcusneoformans) |
PF00475(IGPD) | 4 | ILE A 181LEU A 81GLY A 82PHE A 85 | None | 0.80A | 4iqqA-1rhyA:undetectable | 4iqqA-1rhyA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtr | GERANYLTRANSTRANSFERASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 4 | ILE A 45LEU A 210GLY A 211PHE A 214 | None | 0.55A | 4iqqA-1rtrA:undetectable | 4iqqA-1rtrA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4e | GALACTOKINASE (Pyrococcusfuriosus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 4 | ILE A 164ASP A 151LEU A 150PHE A 153 | NoneGLA A 500 (-3.0A)GLA A 500 ( 4.4A)None | 0.89A | 4iqqA-1s4eA:undetectable | 4iqqA-1s4eA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE ALPHASUBUNIT (Thaueraaromatica) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | ILE A 534ASP A 714GLY A 720PHE A 719 | None | 0.89A | 4iqqA-1sb3A:undetectable | 4iqqA-1sb3A:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxr | PEPTIDOGLYCANRECOGNITION PROTEINSA CG11709-PA (Drosophilamelanogaster) |
PF01510(Amidase_2) | 4 | TYR A 76ILE A 74GLY A 91TYR A 30 | EDO A 404 (-4.4A)NoneNoneNone | 0.75A | 4iqqA-1sxrA:undetectable | 4iqqA-1sxrA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | TYR B 348ILE B 386LEU B 315PHE B 312 | None | 0.89A | 4iqqA-1t3qB:undetectable | 4iqqA-1t3qB:17.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 4 | ASP A 179GLY A 183PHE A 186TYR A 219 | None | 0.52A | 4iqqA-1tisA:30.4 | 4iqqA-1tisA:39.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 4 | ASP A 179LEU A 182GLY A 183TYR A 219 | None | 0.57A | 4iqqA-1tisA:30.4 | 4iqqA-1tisA:39.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uky | URIDYLATE KINASE (Saccharomycescerevisiae) |
PF00406(ADK) | 4 | TYR A 40ILE A 200ASP A 103PHE A 42 | NoneNoneADP A 205 ( 4.9A)None | 0.93A | 4iqqA-1ukyA:undetectable | 4iqqA-1ukyA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1upn | ECHOVIRUS 11 COATPROTEIN VP3 (Enterovirus B) |
PF00073(Rhv) | 4 | ILE C 114LEU C 104GLY C 101PHE C 95 | None | 0.89A | 4iqqA-1upnC:undetectable | 4iqqA-1upnC:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgm | 378AA LONGHYPOTHETICAL CITRATESYNTHASE (Sulfurisphaeratokodaii) |
PF00285(Citrate_synt) | 4 | TYR A 310ASP A 314GLY A 256PHE A 257 | NoneGOL A 401 ( 4.5A)NoneNone | 0.77A | 4iqqA-1vgmA:undetectable | 4iqqA-1vgmA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgp | 373AA LONGHYPOTHETICAL CITRATESYNTHASE (Sulfurisphaeratokodaii) |
PF00285(Citrate_synt) | 4 | TYR A 306ASP A 310GLY A 251PHE A 252 | None | 0.88A | 4iqqA-1vgpA:undetectable | 4iqqA-1vgpA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrm | HYPOTHETICAL PROTEINTM1553 (Thermotogamaritima) |
PF02424(ApbE) | 5 | TYR A 196ILE A 82ASP A 188LEU A 189GLY A 190 | NoneNoneUNL A 4 (-3.2A)NoneUNL A 4 (-3.8A) | 1.36A | 4iqqA-1vrmA:undetectable | 4iqqA-1vrmA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x40 | ARAP2 (Homo sapiens) |
PF00536(SAM_1) | 4 | TYR A 30ILE A 67ASP A 20PHE A 34 | None | 0.90A | 4iqqA-1x40A:undetectable | 4iqqA-1x40A:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 5 | ILE A 374ASP A 384GLY A 385PHE A 9TYR A 248 | None | 1.49A | 4iqqA-1yw1A:undetectable | 4iqqA-1yw1A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7m | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Lactococcuslactis) |
PF13393(tRNA-synt_His) | 4 | ILE A 129GLY A 288PHE A 307TYR A 268 | None | 0.77A | 4iqqA-1z7mA:undetectable | 4iqqA-1z7mA:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 6 | ILE A 100ASP A 219LEU A 222GLY A 223PHE A 226TYR A 259 | CB3 A2351 (-3.6A)CB3 A2351 ( 3.6A)CB3 A2351 (-4.1A)CB3 A2351 ( 3.2A)CB3 A2351 (-3.8A)CB3 A2351 ( 4.3A) | 1.02A | 4iqqA-2aazA:undetectable | 4iqqA-2aazA:49.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amy | PHOSPHOMANNOMUTASE 2 (Homo sapiens) |
PF03332(PMM) | 4 | ILE A 240ASP A 209GLY A 208PHE A 207 | None | 0.84A | 4iqqA-2amyA:undetectable | 4iqqA-2amyA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bg9 | ACETYLCHOLINERECEPTOR PROTEIN,GAMMA CHAIN (Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 4 | ILE E 209ASP E 173LEU E 212PHE E 211 | None | 0.92A | 4iqqA-2bg9E:undetectable | 4iqqA-2bg9E:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2exr | CYTOKININDEHYDROGENASE 7 (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 4 | ILE A 339ASP A 272LEU A 320GLY A 319 | None | 0.86A | 4iqqA-2exrA:undetectable | 4iqqA-2exrA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ff6 | GELSOLIN (Homo sapiens) |
PF00626(Gelsolin) | 4 | TYR G 133ILE G 70LEU G 138GLY G 60 | None | 0.91A | 4iqqA-2ff6G:undetectable | 4iqqA-2ff6G:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqd | BLUE COPPER OXIDASECUEO (Escherichiacoli) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ILE A 447LEU A 512GLY A 513PHE A 514 | None | 0.86A | 4iqqA-2fqdA:undetectable | 4iqqA-2fqdA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gxf | HYPOTHETICAL PROTEINYYBH (Bacillussubtilis) |
PF13474(SnoaL_3) | 4 | TYR A 104ILE A 9LEU A 72PHE A 106 | MES A 201 (-3.3A)MES A 201 (-4.2A)NoneMES A 201 (-4.7A) | 0.85A | 4iqqA-2gxfA:undetectable | 4iqqA-2gxfA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h12 | CITRATE SYNTHASE (Acetobacteraceti) |
PF00285(Citrate_synt) | 4 | TYR A 367ASP A 371GLY A 310PHE A 311 | NoneCMX A5001 (-2.8A)CMX A5001 (-3.4A)None | 0.78A | 4iqqA-2h12A:undetectable | 4iqqA-2h12A:22.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ASP A 426LEU A 429GLY A 430PHE A 433TYR A 466 | NoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 0.75A | 4iqqA-2h2qA:41.0 | 4iqqA-2h2qA:36.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 316ASP A 426GLY A 430PHE A 433TYR A 466 | NoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 0.49A | 4iqqA-2h2qA:41.0 | 4iqqA-2h2qA:36.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hh6 | BH3980 PROTEIN (Bacillushalodurans) |
PF06304(DUF1048) | 5 | ILE A 38ASP A 63LEU A 62GLY A 59PHE A 58 | None | 1.30A | 4iqqA-2hh6A:undetectable | 4iqqA-2hh6A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i53 | CYCLIN K (Homo sapiens) |
PF00134(Cyclin_N)PF02984(Cyclin_C) | 4 | ILE A 117ASP A 134GLY A 133PHE A 132 | None | 0.89A | 4iqqA-2i53A:undetectable | 4iqqA-2i53A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idv | EUKARYOTICTRANSLATIONINITIATION FACTOR4E-1 (Triticumaestivum) |
PF01652(IF4E) | 4 | ILE A 166ASP A 148GLY A 147PHE A 144 | None | 0.76A | 4iqqA-2idvA:undetectable | 4iqqA-2idvA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbh | PHOSPHORIBOSYLTRANSFERASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00156(Pribosyltran) | 4 | TYR A 202ILE A 215GLY A 197PHE A 206 | None | 0.65A | 4iqqA-2jbhA:undetectable | 4iqqA-2jbhA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4j | PUTATIVETRANSCRIPTIONALREGULATOR (Helicobacterpylori) |
PF00486(Trans_reg_C) | 4 | ILE A 23LEU A 113GLY A 58TYR A 111 | None | 0.86A | 4iqqA-2k4jA:undetectable | 4iqqA-2k4jA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kxp | F-ACTIN-CAPPINGPROTEIN SUBUNITALPHA-1F-ACTIN-CAPPINGPROTEIN SUBUNIT BETAISOFORMS 1 AND 2 (Gallus gallus) |
PF01115(F_actin_cap_B)PF01267(F-actin_cap_A) | 4 | TYR A 198ILE B 531LEU B 489GLY B 490 | None | 0.89A | 4iqqA-2kxpA:undetectable | 4iqqA-2kxpA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ntt | STAPHYLOCOCCALENTEROTOXIN K (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C) | 4 | TYR A 137ILE A 99LEU A 180GLY A 164 | NoneNoneNoneEDO A7009 (-4.7A) | 0.93A | 4iqqA-2nttA:undetectable | 4iqqA-2nttA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1o | PUTATIVE FARNESYLPYROPHOSPHATESYNTHASE (Cryptosporidiumparvum) |
PF00348(polyprenyl_synt) | 4 | ILE A 355GLY A 247PHE A 249TYR A 214 | None | 0.79A | 4iqqA-2o1oA:undetectable | 4iqqA-2o1oA:19.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 315ASP A 426LEU A 429GLY A 430TYR A 466 | CB3 A 604 ( 3.7A)CB3 A 604 ( 3.9A)CB3 A 604 ( 4.4A)CB3 A 604 ( 3.4A)UMP A 603 ( 4.3A) | 0.77A | 4iqqA-2oipA:40.5 | 4iqqA-2oipA:32.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 315LEU A 429GLY A 430PHE A 433TYR A 466 | CB3 A 604 ( 3.7A)CB3 A 604 ( 4.4A)CB3 A 604 ( 3.4A)CB3 A 604 ( 3.9A)UMP A 603 ( 4.3A) | 1.18A | 4iqqA-2oipA:40.5 | 4iqqA-2oipA:32.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p76 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Staphylococcusaureus) |
PF03009(GDPD) | 4 | TYR A 166ILE A 156LEU A 90TYR A 176 | None | 0.89A | 4iqqA-2p76A:undetectable | 4iqqA-2p76A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r26 | CITRATE SYNTHASE (Thermoplasmaacidophilum) |
PF00285(Citrate_synt) | 4 | ILE A 251ASP A 301GLY A 303PHE A 307 | NoneNoneNoneCMC A 701 ( 4.3A) | 0.93A | 4iqqA-2r26A:undetectable | 4iqqA-2r26A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r26 | CITRATE SYNTHASE (Thermoplasmaacidophilum) |
PF00285(Citrate_synt) | 4 | TYR A 313ASP A 317GLY A 259PHE A 260 | NoneCMC A 701 (-2.7A)CMC A 701 (-3.3A)None | 0.82A | 4iqqA-2r26A:undetectable | 4iqqA-2r26A:20.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | ASP A 221LEU A 224GLY A 225PHE A 228TYR A 261 | UFP A 529 (-4.7A)THF A 568 (-3.6A)UFP A 529 ( 4.0A)THF A 568 (-4.8A)UFP A 529 (-4.7A) | 0.98A | 4iqqA-2tddA:32.8 | 4iqqA-2tddA:41.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | ILE A 81ASP A 221GLY A 225PHE A 228TYR A 261 | THF A 568 ( 4.8A)UFP A 529 (-4.7A)UFP A 529 ( 4.0A)THF A 568 (-4.8A)UFP A 529 (-4.7A) | 1.22A | 4iqqA-2tddA:32.8 | 4iqqA-2tddA:41.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | ASP A 300LEU A 303GLY A 299PHE A 298TYR A 17 | None | 1.24A | 4iqqA-2wedA:undetectable | 4iqqA-2wedA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wmc | EUKARYOTICTRANSLATIONINITIATION FACTOR 4E (Pisum sativum) |
PF01652(IF4E) | 4 | ILE A 179ASP A 161GLY A 160PHE A 157 | None | 0.67A | 4iqqA-2wmcA:undetectable | 4iqqA-2wmcA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xxl | GRAM-POSITIVESPECIFIC SERINEPROTEASE, ISOFORM B (Drosophilamelanogaster) |
PF00089(Trypsin)PF12032(CLIP) | 4 | ILE A 257LEU A 322GLY A 340PHE A 339 | None | 0.91A | 4iqqA-2xxlA:undetectable | 4iqqA-2xxlA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy4 | ZINC ABCTRANSPORTER,PERIPLASMICZINC-BINDING PROTEIN (Salmonellaenterica) |
PF01297(ZnuA) | 4 | TYR A 296ILE A 38ASP A 44PHE A 184 | None | 0.90A | 4iqqA-2xy4A:undetectable | 4iqqA-2xy4A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4o | PHENYLACETATE-COENZYME A LIGASE (Burkholderiacenocepacia) |
PF00501(AMP-binding)PF14535(AMP-binding_C_2) | 4 | ILE A 240GLY A 147PHE A 140TYR A 109 | DLL A1441 (-4.7A)DLL A1441 (-3.6A)DLL A1441 (-3.6A)None | 0.92A | 4iqqA-2y4oA:undetectable | 4iqqA-2y4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxx | DIAMINOPIMELATEDECARBOXYLASE (Thermotogamaritima) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | ILE A 173ASP A 162LEU A 161PHE A 164 | None | 0.89A | 4iqqA-2yxxA:undetectable | 4iqqA-2yxxA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a31 | PROBABLETHREONYL-TRNASYNTHETASE 1 (Aeropyrumpernix) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 4 | ILE A 18LEU A 154GLY A 322TYR A 152 | None | 0.70A | 4iqqA-3a31A:undetectable | 4iqqA-3a31A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo7 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASECYCLOPHILIN-TYPE (Toxoplasmagondii) |
PF00160(Pro_isomerase) | 4 | ILE A 121ASP A 144LEU A 143GLY A 142 | None | 0.78A | 4iqqA-3bo7A:undetectable | 4iqqA-3bo7A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d0c | DIHYDRODIPICOLINATESYNTHASE (Oceanobacillusiheyensis) |
PF00701(DHDPS) | 4 | TYR A 166ILE A 152GLY A 163PHE A 189 | None | 0.87A | 4iqqA-3d0cA:undetectable | 4iqqA-3d0cA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3s | L-2,4-DIAMINOBUTYRICACIDACETYLTRANSFERASE (Bordetellaparapertussis) |
PF00583(Acetyltransf_1) | 5 | TYR A 33ASP A 55LEU A 18GLY A 56PHE A 57 | NoneGOL A 168 (-4.0A)GOL A 168 (-4.1A)NoneNone | 1.48A | 4iqqA-3d3sA:undetectable | 4iqqA-3d3sA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 5 | ASP A 304LEU A 307GLY A 303PHE A 302TYR A 14 | None | 1.17A | 4iqqA-3emyA:undetectable | 4iqqA-3emyA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evr | MYOSIN LIGHT CHAINKINASE, GREENFLUORESCENT PROTEIN,CALMODULIN-1 CHIMERA (Aequoreavictoria;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 4 | ILE A 256ASP A 287GLY A 262PHE A 258 | None | 0.91A | 4iqqA-3evrA:undetectable | 4iqqA-3evrA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f0h | AMINOTRANSFERASE ([Eubacterium]rectale) |
PF00266(Aminotran_5) | 4 | TYR A 121LEU A 129GLY A 128PHE A 126 | GOL A 361 (-4.1A)NoneNoneNone | 0.80A | 4iqqA-3f0hA:undetectable | 4iqqA-3f0hA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gme | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 4 | ILE A 533LEU A 448GLY A 445PHE A 343 | None | 0.92A | 4iqqA-3gmeA:undetectable | 4iqqA-3gmeA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gve | YFKN PROTEIN (Bacillussubtilis) |
PF00149(Metallophos) | 4 | TYR A 140ILE A 119ASP A 58GLY A 101 | None | 0.85A | 4iqqA-3gveA:undetectable | 4iqqA-3gveA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3heb | RESPONSE REGULATORRECEIVER DOMAINPROTEIN (CHEY) (Rhodospirillumrubrum) |
PF00072(Response_reg) | 4 | ILE A 10LEU A 135GLY A 136PHE A 139 | None | 0.68A | 4iqqA-3hebA:undetectable | 4iqqA-3hebA:19.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix6 | THYMIDYLATE SYNTHASE (Brucellamelitensis) |
PF00303(Thymidylat_synt) | 4 | ASP A 169LEU A 172GLY A 173TYR A 209 | None | 0.85A | 4iqqA-3ix6A:32.5 | 4iqqA-3ix6A:38.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix6 | THYMIDYLATE SYNTHASE (Brucellamelitensis) |
PF00303(Thymidylat_synt) | 4 | ILE A 79ASP A 169GLY A 173TYR A 209 | None | 0.62A | 4iqqA-3ix6A:32.5 | 4iqqA-3ix6A:38.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyj | MAJOR CAPSID PROTEINL1 (Deltapapillomavirus4) |
no annotation | 4 | ILE F 99LEU F 461GLY F 462PHE F 465 | None | 0.82A | 4iqqA-3iyjF:undetectable | 4iqqA-3iyjF:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jxz | ALKYLPURINE DNAGLYCOSYLASE ALKD (Bacillus cereus) |
PF08713(DNA_alkylation) | 5 | ILE A 131ASP A 122LEU A 125GLY A 121PHE A 153 | None | 1.29A | 4iqqA-3jxzA:undetectable | 4iqqA-3jxzA:19.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kgb | THYMIDYLATE SYNTHASE1/2 (Encephalitozooncuniculi) |
PF00303(Thymidylat_synt) | 4 | LEU A 200GLY A 201PHE A 204TYR A 237 | None | 0.72A | 4iqqA-3kgbA:36.5 | 4iqqA-3kgbA:50.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ASP A 416LEU A 419GLY A 420TYR A 456 | None | 0.72A | 4iqqA-3kjrA:40.0 | 4iqqA-3kjrA:35.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq5 | HYPOTHETICALCYTOSOLIC PROTEIN (Coxiellaburnetii) |
PF07515(TraI_2_C) | 4 | ILE A 367LEU A 320GLY A 319PHE A 318 | None | 0.72A | 4iqqA-3kq5A:undetectable | 4iqqA-3kq5A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nng | UNCHARACTERIZEDPROTEIN (Bacteroidesfragilis) |
PF00754(F5_F8_type_C) | 4 | ILE A 273LEU A 251GLY A 253PHE A 254 | None | 0.93A | 4iqqA-3nngA:undetectable | 4iqqA-3nngA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7t | CYCLOPHILIN A (Moniliophthoraperniciosa) |
PF00160(Pro_isomerase) | 4 | ILE A 112ASP A 135LEU A 134GLY A 133 | None | 0.84A | 4iqqA-3o7tA:undetectable | 4iqqA-3o7tA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob8 | BETA-GALACTOSIDASE (Kluyveromyceslactis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N) | 4 | TYR A 890ILE A 943GLY A 949PHE A 945 | None | 0.83A | 4iqqA-3ob8A:undetectable | 4iqqA-3ob8A:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on4 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Legionellapneumophila) |
PF00440(TetR_N) | 4 | TYR A 25ILE A 120LEU A 105GLY A 106 | None | 0.82A | 4iqqA-3on4A:undetectable | 4iqqA-3on4A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3org | CMCLC (Cyanidioschyzonmerolae) |
PF00654(Voltage_CLC) | 4 | ILE A 436LEU A 333GLY A 334PHE A 337 | None | 0.88A | 4iqqA-3orgA:undetectable | 4iqqA-3orgA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3osr | MALTOSE-BINDINGPERIPLASMICPROTEIN,GREENFLUORESCENT PROTEIN (Aequoreavictoria;Escherichiacoli) |
PF01353(GFP)PF01547(SBP_bac_1) | 4 | ILE A 510ASP A 541GLY A 516PHE A 512 | None | 0.88A | 4iqqA-3osrA:undetectable | 4iqqA-3osrA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 4 | TYR B 93ILE B 156ASP B 172PHE B 97 | None | 0.90A | 4iqqA-3p8cB:undetectable | 4iqqA-3p8cB:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qm3 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Campylobacterjejuni) |
PF01116(F_bP_aldolase) | 4 | TYR A 68ILE A 42ASP A 284PHE A 60 | None | 0.80A | 4iqqA-3qm3A:undetectable | 4iqqA-3qm3A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qmj | ENOYL-COA HYDRATASE,ECHA8_6 (Mycobacteriummarinum) |
PF00378(ECH_1) | 4 | ILE A 112LEU A 127GLY A 105PHE A 58 | None | 0.92A | 4iqqA-3qmjA:undetectable | 4iqqA-3qmjA:20.43 |