SIMILAR PATTERNS OF AMINO ACIDS FOR 4IMA_D_ADND604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)


(Hordeum vulgare)
PF01373
(Glyco_hydro_14)
3 ARG A 394
GLU A 358
ASN A 395
None
0.79A 4imaD-1b1yA:
13.8
4imaD-1b1yA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Thermotoga
maritima)
PF01135
(PCMT)
3 ARG A 122
GLU A  29
ASN A 119
None
0.86A 4imaD-1dl5A:
3.4
4imaD-1dl5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE


(Rattus
norvegicus)
PF00106
(adh_short)
3 ARG A 130
GLU A  68
ASN A 127
None
0.90A 4imaD-1e6wA:
2.4
4imaD-1e6wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 3 ARG B 508
GLU B 478
ASN B 725
None
0.85A 4imaD-1ej6B:
undetectable
4imaD-1ej6B:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE


(Homo sapiens)
PF04209
(HgmA)
3 ARG A  63
GLU A 168
ASN A 264
None
0.92A 4imaD-1ey2A:
undetectable
4imaD-1ey2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfi TRANSCRIPTION
REGULATOR NC2 BETA
CHAIN


(Homo sapiens)
PF00808
(CBFD_NFYB_HMF)
3 ARG B 115
GLU B 137
ASN B 133
None
0.86A 4imaD-1jfiB:
undetectable
4imaD-1jfiB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
3 ARG A 492
GLU A 462
ASN A 485
None
0.88A 4imaD-1js4A:
undetectable
4imaD-1js4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0v PROTEIN-TYROSINE
PHOSPHATASE YOPH


(Yersinia
pseudotuberculosis)
PF09013
(YopH_N)
3 ARG A  49
GLU A  36
ASN A  34
None
0.91A 4imaD-1m0vA:
undetectable
4imaD-1m0vA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE


(Klebsiella sp.
LX3)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
3 ARG A 335
GLU A 446
ASN A 450
None
0.87A 4imaD-1m53A:
9.7
4imaD-1m53A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naf ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1


(Homo sapiens)
PF03127
(GAT)
3 ARG A 255
GLU A 220
ASN A 224
None
0.83A 4imaD-1nafA:
undetectable
4imaD-1nafA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12937
(F-box-like)
3 ARG B 700
GLU B 323
ASN B 324
None
0.80A 4imaD-1nexB:
undetectable
4imaD-1nexB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxz ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1


(Homo sapiens)
PF03127
(GAT)
3 ARG A 255
GLU A 220
ASN A 224
None
0.74A 4imaD-1oxzA:
undetectable
4imaD-1oxzA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 ARG B 388
GLU B 769
ASN B 758
None
0.75A 4imaD-1t3qB:
undetectable
4imaD-1t3qB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor)
PF00232
(Glyco_hydro_1)
3 ARG A 234
GLU A 160
ASN A 231
None
0.48A 4imaD-1v02A:
9.6
4imaD-1v02A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE


(Escherichia
coli)
PF04962
(KduI)
3 ARG A 101
GLU A 183
ASN A 164
None
0.55A 4imaD-1xruA:
undetectable
4imaD-1xruA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE


(Streptococcus
pneumoniae)
PF01048
(PNP_UDP_1)
3 ARG A 193
GLU A 174
ASN A  73
MTM  A 301 (-3.2A)
MTM  A 301 (-2.6A)
None
0.78A 4imaD-1zosA:
undetectable
4imaD-1zosA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnx DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
3 ARG A 203
GLU A 207
ASN A 204
None
0.79A 4imaD-2bnxA:
undetectable
4imaD-2bnxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR


(Homo sapiens)
PF00515
(TPR_1)
PF13432
(TPR_16)
3 ARG A 557
GLU A 385
ASN A 602
None
0.78A 4imaD-2c0lA:
undetectable
4imaD-2c0lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb4 MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
no annotation 3 ARG A  94
GLU A 154
ASN A  91
None
0.87A 4imaD-2cb4A:
undetectable
4imaD-2cb4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE


(Coffea
canephora)
PF03492
(Methyltransf_7)
3 ARG A  73
GLU A 124
ASN A 125
None
0.85A 4imaD-2eg5A:
2.4
4imaD-2eg5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL


(Sus scrofa)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2)
3 ARG B 355
GLU A 168
ASN B 324
None
0.88A 4imaD-2fpgB:
4.4
4imaD-2fpgB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM


(Homo sapiens)
PF01603
(B56)
3 ARG A 345
GLU A 309
ASN A 306
None
0.77A 4imaD-2jakA:
undetectable
4imaD-2jakA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C


(Saccharomyces
cerevisiae)
PF16796
(Microtub_bd)
3 ARG A 376
GLU A 370
ASN A 366
None
0.87A 4imaD-2o0aA:
undetectable
4imaD-2o0aA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF


(Deinococcus
radiodurans)
PF02463
(SMC_N)
3 ARG A 160
GLU A 238
ASN A 161
None
0.86A 4imaD-2o5vA:
2.1
4imaD-2o5vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1


(Fasciola
hepatica)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
3 ARG A 257
GLU A 237
ASN A 259
None
0.92A 4imaD-2o6xA:
undetectable
4imaD-2o6xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1


(Saccharomyces
cerevisiae)
PF04072
(LCM)
3 ARG A 111
GLU A 201
ASN A 103
PO4  A2001 (-3.4A)
None
None
0.78A 4imaD-2ob1A:
3.5
4imaD-2ob1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE


(Bacillus
anthracis)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
3 ARG A 178
GLU A 207
ASN A 175
None
0.87A 4imaD-2pfmA:
undetectable
4imaD-2pfmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1


(Saccharomyces
cerevisiae)
PF00012
(HSP70)
3 ARG A 582
GLU A 609
ASN A 606
None
0.90A 4imaD-2qxlA:
undetectable
4imaD-2qxlA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vgi PYRUVATE KINASE
ISOZYMES R/L


(Homo sapiens)
PF00224
(PK)
PF02887
(PK_C)
3 ARG A  99
GLU A 129
ASN A 133
None
0.76A 4imaD-2vgiA:
62.6
4imaD-2vgiA:
99.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvx PROTEIN A52

(Vaccinia virus)
PF06227
(Poxvirus)
3 ARG A 105
GLU A 110
ASN A 114
None
0.83A 4imaD-2vvxA:
undetectable
4imaD-2vvxA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Staphylococcus
aureus)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
3 ARG A 373
GLU A 410
ASN A 414
None
0.63A 4imaD-2wqdA:
17.8
4imaD-2wqdA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli)
PF00535
(Glycos_transf_2)
3 ARG A 550
GLU A 100
ASN A 561
None
0.64A 4imaD-2z87A:
4.7
4imaD-2z87A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima)
PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c)
3 ARG A 738
GLU A 736
ASN A 737
None
0.87A 4imaD-3a0rA:
undetectable
4imaD-3a0rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
3 ARG A 159
GLU A 177
ASN A 134
None
0.88A 4imaD-3ckbA:
undetectable
4imaD-3ckbA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  17
GLU A 108
ASN A  21
None
0.90A 4imaD-3cvwA:
undetectable
4imaD-3cvwA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
3 ARG B 378
GLU B 237
ASN B 241
None
0.83A 4imaD-3ejbB:
undetectable
4imaD-3ejbB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  16
GLU A 110
ASN A  20
None
0.81A 4imaD-3fy4A:
undetectable
4imaD-3fy4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
3 ARG A 136
GLU A  81
ASN A  82
None
0.73A 4imaD-3gp0A:
undetectable
4imaD-3gp0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Marinobacter
hydrocarbonoclasticus)
PF00365
(PFK)
3 ARG A 230
GLU A 208
ASN A 371
None
0.69A 4imaD-3k2qA:
3.1
4imaD-3k2qA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)


(Pyrococcus
abyssi)
PF00795
(CN_hydrolase)
3 ARG A 119
GLU A  51
ASN A  49
None
0.88A 4imaD-3ki8A:
2.4
4imaD-3ki8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)


(Chaetomium
thermophilum)
PF04190
(DUF410)
3 ARG A 230
GLU A 228
ASN A 221
None
0.82A 4imaD-3lpzA:
undetectable
4imaD-3lpzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
3 ARG A 669
GLU A 625
ASN A 668
None
0.85A 4imaD-3ne5A:
undetectable
4imaD-3ne5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqc UFM1-SPECIFIC
PROTEASE 2


(Mus musculus)
PF07910
(Peptidase_C78)
3 ARG A   6
GLU A 246
ASN A 108
None
0.85A 4imaD-3oqcA:
undetectable
4imaD-3oqcA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A


(Bacillus
subtilis)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
3 ARG A 325
GLU A 327
ASN A 277
None
0.84A 4imaD-3oqnA:
3.1
4imaD-3oqnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2


(Mycobacterium
avium)
PF13561
(adh_short_C2)
3 ARG A 127
GLU A  66
ASN A 124
None
0.90A 4imaD-3ppiA:
1.7
4imaD-3ppiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta)
PF00561
(Abhydrolase_1)
3 ARG A 129
GLU A 156
ASN A 157
None
0.85A 4imaD-3rksA:
3.1
4imaD-3rksA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN


(Bdellovibrio
bacteriovorus)
PF13487
(HD_5)
3 ARG A   7
GLU A 102
ASN A  98
None
0.87A 4imaD-3tmcA:
undetectable
4imaD-3tmcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE


(Bacillus sp.
(in: Bacteria))
PF00180
(Iso_dh)
3 ARG A  96
GLU A 276
ASN A 104
None
0.72A 4imaD-3u1hA:
undetectable
4imaD-3u1hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
3 ARG A3957
GLU A4125
ASN A4234
None
0.81A 4imaD-3vkgA:
undetectable
4imaD-3vkgA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus)
PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd)
3 ARG A 181
GLU A 131
ASN A 178
None
0.82A 4imaD-3wfoA:
undetectable
4imaD-3wfoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct)
PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd)
3 ARG A 181
GLU A 131
ASN A 178
None
0.82A 4imaD-3wfpA:
undetectable
4imaD-3wfpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
3 ARG B 103
GLU B 395
ASN B 100
None
0.87A 4imaD-3ze7B:
undetectable
4imaD-3ze7B:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5


(Escherichia
coli;
Macaca mulatta)
PF00622
(SPRY)
PF01547
(SBP_bac_1)
3 ARG A1484
GLU A1395
ASN A1482
None
0.90A 4imaD-4b3nA:
undetectable
4imaD-4b3nA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4br6 SUPEROXIDE DISMUTASE

(Chaetomium
thermophilum)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
3 ARG A 173
GLU A 171
ASN A 172
None
NA  A 801 (-4.2A)
None
0.85A 4imaD-4br6A:
undetectable
4imaD-4br6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1


(Saccharomyces
cerevisiae)
PF16796
(Microtub_bd)
3 ARG B 376
GLU B 370
ASN B 366
None
0.90A 4imaD-4etpB:
undetectable
4imaD-4etpB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1


(Caenorhabditis
elegans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 ARG A 858
GLU A 729
ASN A 733
None
0.90A 4imaD-4f4cA:
undetectable
4imaD-4f4cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B


(Mus musculus)
PF02301
(HORMA)
3 ARG C 158
GLU C 154
ASN C 159
None
0.84A 4imaD-4fjoC:
undetectable
4imaD-4fjoC:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana)
PF00128
(Alpha-amylase)
3 ARG A 347
GLU A 369
ASN A 365
None
0.81A 4imaD-4gklA:
4.6
4imaD-4gklA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
3 ARG A 335
GLU A 446
ASN A 450
None
0.71A 4imaD-4hozA:
9.8
4imaD-4hozA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD


(Escherichia
coli)
PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N)
3 ARG D 712
GLU D 687
ASN D 688
None
0.85A 4imaD-4j3oD:
undetectable
4imaD-4j3oD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  16
GLU A 107
ASN A  20
None
0.78A 4imaD-4jzyA:
undetectable
4imaD-4jzyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  14
GLU A  99
ASN A  18
None
0.79A 4imaD-4k0rA:
undetectable
4imaD-4k0rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA


(Escherichia
coli;
Homo sapiens)
PF00002
(7tm_2)
PF07361
(Cytochrom_B562)
3 ARG A 173
GLU A 406
ASN A 174
None
0.87A 4imaD-4l6rA:
undetectable
4imaD-4l6rA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE


(Drosophila
melanogaster)
PF05822
(UMPH-1)
3 ARG A  13
GLU A  36
ASN A  40
PGE  A 401 (-2.8A)
PGE  A 401 (-3.9A)
PGE  A 401 (-3.8A)
0.88A 4imaD-4nv0A:
undetectable
4imaD-4nv0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
3 ARG A 161
GLU A 104
ASN A 105
None
0.68A 4imaD-4o2zA:
undetectable
4imaD-4o2zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Thermococcus
kodakarensis)
PF03009
(GDPD)
3 ARG A  99
GLU A  95
ASN A 123
None
0.86A 4imaD-4oecA:
13.0
4imaD-4oecA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqx UNCHARACTERIZED
PROTEIN


(Bacteroides
caccae)
PF12667
(NigD_N)
PF17415
(NigD_C)
3 ARG A 190
GLU A 121
ASN A 166
EDO  A 301 ( 4.1A)
EDO  A 301 (-4.0A)
EDO  A 301 ( 4.0A)
0.87A 4imaD-4pqxA:
undetectable
4imaD-4pqxA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
3 ARG A 152
GLU A  98
ASN A  99
EDO  A 402 (-4.2A)
EDO  A 402 (-4.4A)
EDO  A 402 (-3.1A)
0.77A 4imaD-4qtbA:
undetectable
4imaD-4qtbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmo CPTN TOXIN

([Eubacterium]
rectale)
no annotation 3 ARG A   3
GLU A 123
ASN A   4
None
0.88A 4imaD-4rmoA:
undetectable
4imaD-4rmoA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 ARG A  73
GLU A 118
ASN A  71
None
0.87A 4imaD-4ud8A:
undetectable
4imaD-4ud8A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
3 ARG B 204
GLU B 252
ASN B 256
None
0.89A 4imaD-4uftB:
undetectable
4imaD-4uftB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 ARG A 234
GLU A 274
ASN A 230
None
0.80A 4imaD-4w8jA:
undetectable
4imaD-4w8jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB


(Mycolicibacterium
thermoresistibile)
PF03781
(FGE-sulfatase)
PF12867
(DinB_2)
3 ARG A 259
GLU A 272
ASN A 216
None
0.88A 4imaD-4x8dA:
undetectable
4imaD-4x8dA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00106
(adh_short)
3 ARG A 120
GLU A  61
ASN A 117
None
0.92A 4imaD-4xgnA:
2.8
4imaD-4xgnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
3 ARG A 133
GLU A  79
ASN A  80
None
0.71A 4imaD-4xrlA:
undetectable
4imaD-4xrlA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE


(Rhizomucor
miehei)
PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3)
3 ARG A 755
GLU A 720
ASN A 760
None
0.92A 4imaD-4zm6A:
11.7
4imaD-4zm6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L9


(Dictyostelium
discoideum)
PF00347
(Ribosomal_L6)
3 ARG B  31
GLU B 186
ASN B 188
None
0.84A 4imaD-5an9B:
undetectable
4imaD-5an9B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila)
PF01048
(PNP_UDP_1)
3 ARG A 240
GLU A 221
ASN A 101
SAH  A 301 (-3.9A)
SAH  A 301 (-2.6A)
None
0.78A 4imaD-5b7nA:
undetectable
4imaD-5b7nA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
3 ARG A 175
GLU A 120
ASN A 121
None
0.73A 4imaD-5ci6A:
undetectable
4imaD-5ci6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 ARG A 535
GLU A 656
ASN A 625
None
0.85A 4imaD-5dtuA:
undetectable
4imaD-5dtuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2


(Homo sapiens)
PF12157
(DUF3591)
no annotation
3 ARG G 687
GLU G 674
ASN I 509
None
0.75A 4imaD-5furG:
undetectable
4imaD-5furG:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus)
PF07245
(Phlebovirus_G2)
3 ARG A 624
GLU A 867
ASN A 626
None
0.79A 4imaD-5g47A:
undetectable
4imaD-5g47A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB12


(Homo sapiens)
PF03604
(DNA_RNApol_7kD)
3 ARG L  37
GLU L  27
ASN L  26
None
0.90A 4imaD-5iy7L:
undetectable
4imaD-5iy7L:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdx PUTATIVE PEPTIDYL
CARRIER PROTEIN


(Serratia sp.)
no annotation 3 ARG A  76
GLU A  58
ASN A  63
None
0.79A 4imaD-5jdxA:
undetectable
4imaD-5jdxA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6u PROTEIN SIDEKICK-1

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
3 ARG A 336
GLU A 353
ASN A 334
None
0.88A 4imaD-5k6uA:
undetectable
4imaD-5k6uA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA


(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
3 ARG A 336
GLU A 353
ASN A 334
None
0.82A 4imaD-5k6zA:
undetectable
4imaD-5k6zA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18


(Ogataea angusta)
no annotation 3 ARG A 130
GLU A 129
ASN A 172
None
0.91A 4imaD-5ltgA:
undetectable
4imaD-5ltgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE


(Pyrococcus
furiosus)
PF00535
(Glycos_transf_2)
PF04138
(GtrA)
3 ARG A 204
GLU A  18
ASN A  15
None
0.90A 4imaD-5mlzA:
4.7
4imaD-5mlzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis)
no annotation 3 ARG K 289
GLU K 360
ASN K 286
None
0.78A 4imaD-5mm4K:
undetectable
4imaD-5mm4K:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC


(Vibrio cholerae)
PF05943
(VipB)
3 ARG A 293
GLU A 110
ASN A 111
None
0.90A 4imaD-5myuA:
undetectable
4imaD-5myuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN


(Mojiang
henipavirus)
PF00423
(HN)
3 ARG A 466
GLU A 380
ASN A 462
None
0.87A 4imaD-5nopA:
undetectable
4imaD-5nopA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  14
GLU A  99
ASN A  18
CL  A 501 (-3.3A)
CL  A 501 (-2.8A)
None
0.74A 4imaD-5t5xA:
undetectable
4imaD-5t5xA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1


(Homo sapiens)
PF00752
(XPG_N)
PF00867
(XPG_I)
3 ARG A  59
GLU A  37
ASN A  55
None
0.82A 4imaD-5t9jA:
2.1
4imaD-5t9jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trv DENOVO NTF2

(synthetic
construct)
PF12680
(SnoaL_2)
3 ARG A  72
GLU A  70
ASN A  71
None
0.85A 4imaD-5trvA:
undetectable
4imaD-5trvA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
3 ARG A 300
GLU A  40
ASN A  10
None
0.72A 4imaD-5weoA:
2.5
4imaD-5weoA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus)
no annotation 3 ARG D 240
GLU D  55
ASN D 221
None
0.89A 4imaD-5x2bD:
undetectable
4imaD-5x2bD:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861


(Pseudomonas
aeruginosa)
no annotation 3 ARG A 398
GLU A 462
ASN A 402
None
0.77A 4imaD-5xgeA:
6.2
4imaD-5xgeA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE


(Aquifex
aeolicus)
no annotation 3 ARG A 183
GLU A 179
ASN A 182
None
0.69A 4imaD-5xj6A:
undetectable
4imaD-5xj6A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens)
no annotation 3 ARG A  73
GLU A 114
ASN A  71
None
0.80A 4imaD-6eo5A:
undetectable
4imaD-6eo5A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-)
no annotation 3 ARG A  16
GLU A 103
ASN A  20
None
0.83A 4imaD-6fn0A:
undetectable
4imaD-6fn0A:
undetectable