SIMILAR PATTERNS OF AMINO ACIDS FOR 4IMA_D_ADND604
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b1y | PROTEIN(BETA-AMYLASE) (Hordeum vulgare) |
PF01373(Glyco_hydro_14) | 3 | ARG A 394GLU A 358ASN A 395 | None | 0.79A | 4imaD-1b1yA:13.8 | 4imaD-1b1yA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dl5 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Thermotogamaritima) |
PF01135(PCMT) | 3 | ARG A 122GLU A 29ASN A 119 | None | 0.86A | 4imaD-1dl5A:3.4 | 4imaD-1dl5A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6w | SHORT CHAIN3-HYDROXYACYL-COADEHYDROGENASE (Rattusnorvegicus) |
PF00106(adh_short) | 3 | ARG A 130GLU A 68ASN A 127 | None | 0.90A | 4imaD-1e6wA:2.4 | 4imaD-1e6wA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 3 | ARG B 508GLU B 478ASN B 725 | None | 0.85A | 4imaD-1ej6B:undetectable | 4imaD-1ej6B:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ey2 | HOMOGENTISATE1,2-DIOXYGENASE (Homo sapiens) |
PF04209(HgmA) | 3 | ARG A 63GLU A 168ASN A 264 | None | 0.92A | 4imaD-1ey2A:undetectable | 4imaD-1ey2A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jfi | TRANSCRIPTIONREGULATOR NC2 BETACHAIN (Homo sapiens) |
PF00808(CBFD_NFYB_HMF) | 3 | ARG B 115GLU B 137ASN B 133 | None | 0.86A | 4imaD-1jfiB:undetectable | 4imaD-1jfiB:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js4 | ENDO/EXOCELLULASE E4 (Thermobifidafusca) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 3 | ARG A 492GLU A 462ASN A 485 | None | 0.88A | 4imaD-1js4A:undetectable | 4imaD-1js4A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m0v | PROTEIN-TYROSINEPHOSPHATASE YOPH (Yersiniapseudotuberculosis) |
PF09013(YopH_N) | 3 | ARG A 49GLU A 36ASN A 34 | None | 0.91A | 4imaD-1m0vA:undetectable | 4imaD-1m0vA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m53 | ISOMALTULOSESYNTHASE (Klebsiella sp.LX3) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | ARG A 335GLU A 446ASN A 450 | None | 0.87A | 4imaD-1m53A:9.7 | 4imaD-1m53A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1naf | ADP-RIBOSYLATIONFACTOR BINDINGPROTEIN GGA1 (Homo sapiens) |
PF03127(GAT) | 3 | ARG A 255GLU A 220ASN A 224 | None | 0.83A | 4imaD-1nafA:undetectable | 4imaD-1nafA:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nex | CDC4 PROTEIN (Saccharomycescerevisiae) |
PF00400(WD40)PF12937(F-box-like) | 3 | ARG B 700GLU B 323ASN B 324 | None | 0.80A | 4imaD-1nexB:undetectable | 4imaD-1nexB:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oxz | ADP-RIBOSYLATIONFACTOR BINDINGPROTEIN GGA1 (Homo sapiens) |
PF03127(GAT) | 3 | ARG A 255GLU A 220ASN A 224 | None | 0.74A | 4imaD-1oxzA:undetectable | 4imaD-1oxzA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | ARG B 388GLU B 769ASN B 758 | None | 0.75A | 4imaD-1t3qB:undetectable | 4imaD-1t3qB:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v02 | DHURRINASE (Sorghum bicolor) |
PF00232(Glyco_hydro_1) | 3 | ARG A 234GLU A 160ASN A 231 | None | 0.48A | 4imaD-1v02A:9.6 | 4imaD-1v02A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xru | 4-DEOXY-L-THREO-5-HEXOSULOSE-URONATEKETOL-ISOMERASE (Escherichiacoli) |
PF04962(KduI) | 3 | ARG A 101GLU A 183ASN A 164 | None | 0.55A | 4imaD-1xruA:undetectable | 4imaD-1xruA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 3 | ARG A 193GLU A 174ASN A 73 | MTM A 301 (-3.2A)MTM A 301 (-2.6A)None | 0.78A | 4imaD-1zosA:undetectable | 4imaD-1zosA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnx | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 3 | ARG A 203GLU A 207ASN A 204 | None | 0.79A | 4imaD-2bnxA:undetectable | 4imaD-2bnxA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0l | PEROXISOMALTARGETING SIGNAL 1RECEPTOR (Homo sapiens) |
PF00515(TPR_1)PF13432(TPR_16) | 3 | ARG A 557GLU A 385ASN A 602 | None | 0.78A | 4imaD-2c0lA:undetectable | 4imaD-2c0lA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb4 | MOSQUITOCIDAL TOXIN (Lysinibacillussphaericus) |
no annotation | 3 | ARG A 94GLU A 154ASN A 91 | None | 0.87A | 4imaD-2cb4A:undetectable | 4imaD-2cb4A:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg5 | XANTHOSINEMETHYLTRANSFERASE (Coffeacanephora) |
PF03492(Methyltransf_7) | 3 | ARG A 73GLU A 124ASN A 125 | None | 0.85A | 4imaD-2eg5A:2.4 | 4imaD-2eg5A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpg | SUCCINYL-COA LIGASE[GDP-FORMING]ALPHA-CHAIN,MITOCHONDRIALSUCCINYL-COA LIGASE[GDP-FORMING]BETA-CHAIN,MITOCHONDRIAL (Sus scrofa) |
PF00549(Ligase_CoA)PF02629(CoA_binding)PF08442(ATP-grasp_2) | 3 | ARG B 355GLU A 168ASN B 324 | None | 0.88A | 4imaD-2fpgB:4.4 | 4imaD-2fpgB:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jak | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A56 KDA REGULATORYSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF01603(B56) | 3 | ARG A 345GLU A 309ASN A 306 | None | 0.77A | 4imaD-2jakA:undetectable | 4imaD-2jakA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0a | S.CEREVISIAECHROMOSOME XVIREADING FRAME ORFYPL253C (Saccharomycescerevisiae) |
PF16796(Microtub_bd) | 3 | ARG A 376GLU A 370ASN A 366 | None | 0.87A | 4imaD-2o0aA:undetectable | 4imaD-2o0aA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5v | DNA REPLICATION ANDREPAIR PROTEIN RECF (Deinococcusradiodurans) |
PF02463(SMC_N) | 3 | ARG A 160GLU A 238ASN A 161 | None | 0.86A | 4imaD-2o5vA:2.1 | 4imaD-2o5vA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6x | SECRETED CATHEPSIN L1 (Fasciolahepatica) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 3 | ARG A 257GLU A 237ASN A 259 | None | 0.92A | 4imaD-2o6xA:undetectable | 4imaD-2o6xA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ob1 | LEUCINE CARBOXYLMETHYLTRANSFERASE 1 (Saccharomycescerevisiae) |
PF04072(LCM) | 3 | ARG A 111GLU A 201ASN A 103 | PO4 A2001 (-3.4A)NoneNone | 0.78A | 4imaD-2ob1A:3.5 | 4imaD-2ob1A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfm | ADENYLOSUCCINATELYASE (Bacillusanthracis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 3 | ARG A 178GLU A 207ASN A 175 | None | 0.87A | 4imaD-2pfmA:undetectable | 4imaD-2pfmA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qxl | HEAT SHOCK PROTEINHOMOLOG SSE1 (Saccharomycescerevisiae) |
PF00012(HSP70) | 3 | ARG A 582GLU A 609ASN A 606 | None | 0.90A | 4imaD-2qxlA:undetectable | 4imaD-2qxlA:21.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vgi | PYRUVATE KINASEISOZYMES R/L (Homo sapiens) |
PF00224(PK)PF02887(PK_C) | 3 | ARG A 99GLU A 129ASN A 133 | None | 0.76A | 4imaD-2vgiA:62.6 | 4imaD-2vgiA:99.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvx | PROTEIN A52 (Vaccinia virus) |
PF06227(Poxvirus) | 3 | ARG A 105GLU A 110ASN A 114 | None | 0.83A | 4imaD-2vvxA:undetectable | 4imaD-2vvxA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqd | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcusaureus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 3 | ARG A 373GLU A 410ASN A 414 | None | 0.63A | 4imaD-2wqdA:17.8 | 4imaD-2wqdA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z87 | CHONDROITIN SYNTHASE (Escherichiacoli) |
PF00535(Glycos_transf_2) | 3 | ARG A 550GLU A 100ASN A 561 | None | 0.64A | 4imaD-2z87A:4.7 | 4imaD-2z87A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0r | SENSOR PROTEIN (Thermotogamaritima) |
PF00512(HisKA)PF00989(PAS)PF02518(HATPase_c) | 3 | ARG A 738GLU A 736ASN A 737 | None | 0.87A | 4imaD-3a0rA:undetectable | 4imaD-3a0rA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckb | SUSD (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB) | 3 | ARG A 159GLU A 177ASN A 134 | None | 0.88A | 4imaD-3ckbA:undetectable | 4imaD-3ckbA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvw | RE11660P (Drosophilamelanogaster) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 17GLU A 108ASN A 21 | None | 0.90A | 4imaD-3cvwA:undetectable | 4imaD-3cvwA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejb | BIOTIN BIOSYNTHESISCYTOCHROME P450-LIKEENZYME (Bacillussubtilis) |
PF00067(p450) | 3 | ARG B 378GLU B 237ASN B 241 | None | 0.83A | 4imaD-3ejbB:undetectable | 4imaD-3ejbB:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy4 | 6-4 PHOTOLYASE (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 16GLU A 110ASN A 20 | None | 0.81A | 4imaD-3fy4A:undetectable | 4imaD-3fy4A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 3 | ARG A 136GLU A 81ASN A 82 | None | 0.73A | 4imaD-3gp0A:undetectable | 4imaD-3gp0A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2q | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Marinobacterhydrocarbonoclasticus) |
PF00365(PFK) | 3 | ARG A 230GLU A 208ASN A 371 | None | 0.69A | 4imaD-3k2qA:3.1 | 4imaD-3k2qA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ki8 | BETAUREIDOPROPIONASE(BETA-ALANINESYNTHASE) (Pyrococcusabyssi) |
PF00795(CN_hydrolase) | 3 | ARG A 119GLU A 51ASN A 49 | None | 0.88A | 4imaD-3ki8A:2.4 | 4imaD-3ki8A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpz | GET4 (YOR164CHOMOLOG) (Chaetomiumthermophilum) |
PF04190(DUF410) | 3 | ARG A 230GLU A 228ASN A 221 | None | 0.82A | 4imaD-3lpzA:undetectable | 4imaD-3lpzA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne5 | CATION EFFLUX SYSTEMPROTEIN CUSA (Escherichiacoli) |
PF00873(ACR_tran) | 3 | ARG A 669GLU A 625ASN A 668 | None | 0.85A | 4imaD-3ne5A:undetectable | 4imaD-3ne5A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqc | UFM1-SPECIFICPROTEASE 2 (Mus musculus) |
PF07910(Peptidase_C78) | 3 | ARG A 6GLU A 246ASN A 108 | None | 0.85A | 4imaD-3oqcA:undetectable | 4imaD-3oqcA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqn | CATABOLITE CONTROLPROTEIN A (Bacillussubtilis) |
PF00356(LacI)PF13377(Peripla_BP_3) | 3 | ARG A 325GLU A 327ASN A 277 | None | 0.84A | 4imaD-3oqnA:3.1 | 4imaD-3oqnA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppi | 3-HYDROXYACYL-COADEHYDROGENASE TYPE-2 (Mycobacteriumavium) |
PF13561(adh_short_C2) | 3 | ARG A 127GLU A 66ASN A 124 | None | 0.90A | 4imaD-3ppiA:1.7 | 4imaD-3ppiA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rks | HYDROXYNITRILASE (Manihotesculenta) |
PF00561(Abhydrolase_1) | 3 | ARG A 129GLU A 156ASN A 157 | None | 0.85A | 4imaD-3rksA:3.1 | 4imaD-3rksA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tmc | UNCHARACTERIZEDPROTEIN (Bdellovibriobacteriovorus) |
PF13487(HD_5) | 3 | ARG A 7GLU A 102ASN A 98 | None | 0.87A | 4imaD-3tmcA:undetectable | 4imaD-3tmcA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1h | 3-ISOPROPYLMALATEDEHYDROGENASE (Bacillus sp.(in: Bacteria)) |
PF00180(Iso_dh) | 3 | ARG A 96GLU A 276ASN A 104 | None | 0.72A | 4imaD-3u1hA:undetectable | 4imaD-3u1hA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 3 | ARG A3957GLU A4125ASN A4234 | None | 0.81A | 4imaD-3vkgA:undetectable | 4imaD-3vkgA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfo | POLY A POLYMERASE (Aquifexaeolicus) |
PF01743(PolyA_pol)PF01966(HD)PF12627(PolyA_pol_RNAbd) | 3 | ARG A 181GLU A 131ASN A 178 | None | 0.82A | 4imaD-3wfoA:undetectable | 4imaD-3wfoA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfp | POLY A POLYMERASE (Aquifexaeolicus;syntheticconstruct) |
PF01743(PolyA_pol)PF01966(HD)PF12627(PolyA_pol_RNAbd) | 3 | ARG A 181GLU A 131ASN A 178 | None | 0.82A | 4imaD-3wfpA:undetectable | 4imaD-3wfpA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze7 | PERIPLASMIC [NIFESE]HYDROGENASE, LARGESUBUNIT,SELENOCYSTEINE-CONTAINING (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases) | 3 | ARG B 103GLU B 395ASN B 100 | None | 0.87A | 4imaD-3ze7B:undetectable | 4imaD-3ze7B:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3n | MALTOSE-BINDINGPERIPLASMIC PROTEIN,TRIPARTITEMOTIF-CONTAININGPROTEIN 5 (Escherichiacoli;Macaca mulatta) |
PF00622(SPRY)PF01547(SBP_bac_1) | 3 | ARG A1484GLU A1395ASN A1482 | None | 0.90A | 4imaD-4b3nA:undetectable | 4imaD-4b3nA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4br6 | SUPEROXIDE DISMUTASE (Chaetomiumthermophilum) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 3 | ARG A 173GLU A 171ASN A 172 | None NA A 801 (-4.2A)None | 0.85A | 4imaD-4br6A:undetectable | 4imaD-4br6A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4etp | SPINDLE POLEBODY-ASSOCIATEDPROTEIN VIK1 (Saccharomycescerevisiae) |
PF16796(Microtub_bd) | 3 | ARG B 376GLU B 370ASN B 366 | None | 0.90A | 4imaD-4etpB:undetectable | 4imaD-4etpB:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | ARG A 858GLU A 729ASN A 733 | None | 0.90A | 4imaD-4f4cA:undetectable | 4imaD-4f4cA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fjo | MITOTIC SPINDLEASSEMBLY CHECKPOINTPROTEIN MAD2B (Mus musculus) |
PF02301(HORMA) | 3 | ARG C 158GLU C 154ASN C 159 | None | 0.84A | 4imaD-4fjoC:undetectable | 4imaD-4fjoC:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gkl | ALPHA-AMYLASE (Thermotoganeapolitana) |
PF00128(Alpha-amylase) | 3 | ARG A 347GLU A 369ASN A 365 | None | 0.81A | 4imaD-4gklA:4.6 | 4imaD-4gklA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hoz | SUCROSE ISOMERASE (Erwiniarhapontici) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | ARG A 335GLU A 446ASN A 450 | None | 0.71A | 4imaD-4hozA:9.8 | 4imaD-4hozA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3o | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher)PF13953(PapC_C)PF13954(PapC_N) | 3 | ARG D 712GLU D 687ASN D 688 | None | 0.85A | 4imaD-4j3oD:undetectable | 4imaD-4j3oD:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jzy | CRYPTOCHROME-1 (Drosophilamelanogaster) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 16GLU A 107ASN A 20 | None | 0.78A | 4imaD-4jzyA:undetectable | 4imaD-4jzyA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0r | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 14GLU A 99ASN A 18 | None | 0.79A | 4imaD-4k0rA:undetectable | 4imaD-4k0rA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l6r | SOLUBLE CYTOCHROMEB562 AND GLUCAGONRECEPTOR CHIMERA (Escherichiacoli;Homo sapiens) |
PF00002(7tm_2)PF07361(Cytochrom_B562) | 3 | ARG A 173GLU A 406ASN A 174 | None | 0.87A | 4imaD-4l6rA:undetectable | 4imaD-4l6rA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv0 | 7-METHYLGUANOSINEPHOSPHATE-SPECIFIC5'-NUCLEOTIDASE (Drosophilamelanogaster) |
PF05822(UMPH-1) | 3 | ARG A 13GLU A 36ASN A 40 | PGE A 401 (-2.8A)PGE A 401 (-3.9A)PGE A 401 (-3.8A) | 0.88A | 4imaD-4nv0A:undetectable | 4imaD-4nv0A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o2z | MITOGEN-ACTIVATEDPROTEIN KINASE 3,PUTATIVE (Leishmaniadonovani) |
PF00069(Pkinase) | 3 | ARG A 161GLU A 104ASN A 105 | None | 0.68A | 4imaD-4o2zA:undetectable | 4imaD-4o2zA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oec | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Thermococcuskodakarensis) |
PF03009(GDPD) | 3 | ARG A 99GLU A 95ASN A 123 | None | 0.86A | 4imaD-4oecA:13.0 | 4imaD-4oecA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pqx | UNCHARACTERIZEDPROTEIN (Bacteroidescaccae) |
PF12667(NigD_N)PF17415(NigD_C) | 3 | ARG A 190GLU A 121ASN A 166 | EDO A 301 ( 4.1A)EDO A 301 (-4.0A)EDO A 301 ( 4.0A) | 0.87A | 4imaD-4pqxA:undetectable | 4imaD-4pqxA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtb | MITOGEN-ACTIVATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 3 | ARG A 152GLU A 98ASN A 99 | EDO A 402 (-4.2A)EDO A 402 (-4.4A)EDO A 402 (-3.1A) | 0.77A | 4imaD-4qtbA:undetectable | 4imaD-4qtbA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmo | CPTN TOXIN ([Eubacterium]rectale) |
no annotation | 3 | ARG A 3GLU A 123ASN A 4 | None | 0.88A | 4imaD-4rmoA:undetectable | 4imaD-4rmoA:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | ARG A 73GLU A 118ASN A 71 | None | 0.87A | 4imaD-4ud8A:undetectable | 4imaD-4ud8A:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uft | NUCLEOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap) | 3 | ARG B 204GLU B 252ASN B 256 | None | 0.89A | 4imaD-4uftB:undetectable | 4imaD-4uftB:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 3 | ARG A 234GLU A 274ASN A 230 | None | 0.80A | 4imaD-4w8jA:undetectable | 4imaD-4w8jA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8d | SULFOXIDE SYNTHASEEGTB (Mycolicibacteriumthermoresistibile) |
PF03781(FGE-sulfatase)PF12867(DinB_2) | 3 | ARG A 259GLU A 272ASN A 216 | None | 0.88A | 4imaD-4x8dA:undetectable | 4imaD-4x8dA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgn | 3-HYDROXYACYL-COADEHYDROGENASE (Burkholderiathailandensis) |
PF00106(adh_short) | 3 | ARG A 120GLU A 61ASN A 117 | None | 0.92A | 4imaD-4xgnA:2.8 | 4imaD-4xgnA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xrl | MITOGEN-ACTIVATEDPROTEIN KINASE 1 (Rattusnorvegicus) |
PF00069(Pkinase) | 3 | ARG A 133GLU A 79ASN A 80 | None | 0.71A | 4imaD-4xrlA:undetectable | 4imaD-4xrlA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zm6 | N-ACETYL-BETA-DGLUCOSAMINIDASE (Rhizomucormiehei) |
PF00583(Acetyltransf_1)PF00933(Glyco_hydro_3) | 3 | ARG A 755GLU A 720ASN A 760 | None | 0.92A | 4imaD-4zm6A:11.7 | 4imaD-4zm6A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5an9 | 60S RIBOSOMALPROTEIN L9 (Dictyosteliumdiscoideum) |
PF00347(Ribosomal_L6) | 3 | ARG B 31GLU B 186ASN B 188 | None | 0.84A | 4imaD-5an9B:undetectable | 4imaD-5an9B:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7n | MTA/SAH NUCLEOSIDASE (Aeromonashydrophila) |
PF01048(PNP_UDP_1) | 3 | ARG A 240GLU A 221ASN A 101 | SAH A 301 (-3.9A)SAH A 301 (-2.6A)None | 0.78A | 4imaD-5b7nA:undetectable | 4imaD-5b7nA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci6 | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Arabidopsisthaliana) |
PF00069(Pkinase) | 3 | ARG A 175GLU A 120ASN A 121 | None | 0.73A | 4imaD-5ci6A:undetectable | 4imaD-5ci6A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtu | PRP28 (Chaetomiumthermophilum) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | ARG A 535GLU A 656ASN A 625 | None | 0.85A | 4imaD-5dtuA:undetectable | 4imaD-5dtuA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fur | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 1TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 2 (Homo sapiens) |
PF12157(DUF3591)no annotation | 3 | ARG G 687GLU G 674ASN I 509 | None | 0.75A | 4imaD-5furG:undetectable | 4imaD-5furG:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g47 | SFTSV GC (SFTSphlebovirus) |
PF07245(Phlebovirus_G2) | 3 | ARG A 624GLU A 867ASN A 626 | None | 0.79A | 4imaD-5g47A:undetectable | 4imaD-5g47A:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iy7 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB12 (Homo sapiens) |
PF03604(DNA_RNApol_7kD) | 3 | ARG L 37GLU L 27ASN L 26 | None | 0.90A | 4imaD-5iy7L:undetectable | 4imaD-5iy7L:7.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jdx | PUTATIVE PEPTIDYLCARRIER PROTEIN (Serratia sp.) |
no annotation | 3 | ARG A 76GLU A 58ASN A 63 | None | 0.79A | 4imaD-5jdxA:undetectable | 4imaD-5jdxA:11.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6u | PROTEIN SIDEKICK-1 (Mus musculus) |
PF07679(I-set)PF13927(Ig_3) | 3 | ARG A 336GLU A 353ASN A 334 | None | 0.88A | 4imaD-5k6uA:undetectable | 4imaD-5k6uA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6z | PROTEINSIDEKICK-2,PROTEINSIDEKICK-1 CHIMERA (Mus musculus) |
PF07679(I-set)PF13927(Ig_3) | 3 | ARG A 336GLU A 353ASN A 334 | None | 0.82A | 4imaD-5k6zA:undetectable | 4imaD-5k6zA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltg | AUTOPHAGY-RELATEDPROTEIN 18 (Ogataea angusta) |
no annotation | 3 | ARG A 130GLU A 129ASN A 172 | None | 0.91A | 4imaD-5ltgA:undetectable | 4imaD-5ltgA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlz | DOLICHOLMONOPHOSPHATEMANNOSE SYNTHASE (Pyrococcusfuriosus) |
PF00535(Glycos_transf_2)PF04138(GtrA) | 3 | ARG A 204GLU A 18ASN A 15 | None | 0.90A | 4imaD-5mlzA:4.7 | 4imaD-5mlzA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mm4 | KINESIN-5 (Ustilago maydis) |
no annotation | 3 | ARG K 289GLU K 360ASN K 286 | None | 0.78A | 4imaD-5mm4K:undetectable | 4imaD-5mm4K:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5myu | TYPE VI SECRETIONSYSTEM PROTEIN IMPC (Vibrio cholerae) |
PF05943(VipB) | 3 | ARG A 293GLU A 110ASN A 111 | None | 0.90A | 4imaD-5myuA:undetectable | 4imaD-5myuA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nop | ATTACHMENTGLYCOPROTEIN (Mojianghenipavirus) |
PF00423(HN) | 3 | ARG A 466GLU A 380ASN A 462 | None | 0.87A | 4imaD-5nopA:undetectable | 4imaD-5nopA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5x | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 14GLU A 99ASN A 18 | CL A 501 (-3.3A) CL A 501 (-2.8A)None | 0.74A | 4imaD-5t5xA:undetectable | 4imaD-5t5xA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9j | FLAP ENDONUCLEASEGEN HOMOLOG 1 (Homo sapiens) |
PF00752(XPG_N)PF00867(XPG_I) | 3 | ARG A 59GLU A 37ASN A 55 | None | 0.82A | 4imaD-5t9jA:2.1 | 4imaD-5t9jA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5trv | DENOVO NTF2 (syntheticconstruct) |
PF12680(SnoaL_2) | 3 | ARG A 72GLU A 70ASN A 71 | None | 0.85A | 4imaD-5trvA:undetectable | 4imaD-5trvA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 3 | ARG A 300GLU A 40ASN A 10 | None | 0.72A | 4imaD-5weoA:2.5 | 4imaD-5weoA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2b | SULFOTRANSFERASE (Mus musculus) |
no annotation | 3 | ARG D 240GLU D 55ASN D 221 | None | 0.89A | 4imaD-5x2bD:undetectable | 4imaD-5x2bD:10.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xge | UNCHARACTERIZEDPROTEIN PA0861 (Pseudomonasaeruginosa) |
no annotation | 3 | ARG A 398GLU A 462ASN A 402 | None | 0.77A | 4imaD-5xgeA:6.2 | 4imaD-5xgeA:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xj6 | GLYCEROL-3-PHOSPHATEACYLTRANSFERASE (Aquifexaeolicus) |
no annotation | 3 | ARG A 183GLU A 179ASN A 182 | None | 0.69A | 4imaD-5xj6A:undetectable | 4imaD-5xj6A:10.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eo5 | PPBBE-LIKE 1 D396N (Physcomitrellapatens) |
no annotation | 3 | ARG A 73GLU A 114ASN A 71 | None | 0.80A | 4imaD-6eo5A:undetectable | 4imaD-6eo5A:10.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn0 | - (-) |
no annotation | 3 | ARG A 16GLU A 103ASN A 20 | None | 0.83A | 4imaD-6fn0A:undetectable | 4imaD-6fn0A:undetectable |