SIMILAR PATTERNS OF AMINO ACIDS FOR 4IKK_B_SUZB201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bgp | BARLEY GRAINPEROXIDASE (Hordeum vulgare) |
PF00141(peroxidase) | 4 | SER A 121ALA A 41LEU A 43SER A 117 | NoneHEM A 400 (-3.5A)NoneNone | 0.99A | 4ikkA-1bgpA:undetectable4ikkB-1bgpA:undetectable | 4ikkA-1bgpA:16.884ikkB-1bgpA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlp | LECTIN SCAFETPRECURSOR (Hyacinthoideshispanica) |
PF01453(B_lectin) | 4 | LEU A 62LEU A 68SER A 81THR A 83 | None | 1.01A | 4ikkA-1dlpA:undetectable4ikkB-1dlpA:undetectable | 4ikkA-1dlpA:18.784ikkB-1dlpA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8t | HEMAGGLUTININ-NEURAMINIDASE (Avianavulavirus 1) |
PF00423(HN) | 4 | LEU A 561ALA A 546SER A 529THR A 527 | None | 0.73A | 4ikkA-1e8tA:undetectable4ikkB-1e8tA:undetectable | 4ikkA-1e8tA:15.564ikkB-1e8tA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f80 | HOLO-(ACYL CARRIERPROTEIN) SYNTHASE (Bacillussubtilis) |
PF01648(ACPS) | 4 | LEU A 7ALA A 111SER A 102THR A 104 | NoneNoneNone NA A1255 (-3.8A) | 0.87A | 4ikkA-1f80A:undetectable4ikkB-1f80A:undetectable | 4ikkA-1f80A:24.244ikkB-1f80A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gd3 | CYSTATIN A (Homo sapiens) |
PF00031(Cystatin) | 4 | LEU A 95ALA A 9LEU A 6SER A 7 | None | 1.05A | 4ikkA-1gd3A:undetectable4ikkB-1gd3A:undetectable | 4ikkA-1gd3A:23.084ikkB-1gd3A:23.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gke | TRANSTHYRETIN (Rattusnorvegicus) |
PF00576(Transthyretin) | 4 | LEU A 17ALA A 108LEU A 110THR A 119 | None | 0.37A | 4ikkA-1gkeA:21.24ikkB-1gkeA:20.3 | 4ikkA-1gkeA:83.334ikkB-1gkeA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gke | TRANSTHYRETIN (Rattusnorvegicus) |
PF00576(Transthyretin) | 4 | LYS A 15LEU A 17ALA A 108THR A 119 | None | 0.73A | 4ikkA-1gkeA:21.24ikkB-1gkeA:20.3 | 4ikkA-1gkeA:83.334ikkB-1gkeA:83.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4u | NIDOGEN-1 (Mus musculus) |
PF07474(G2F) | 4 | SER A 430LEU A 623SER A 439THR A 441 | None | 0.84A | 4ikkA-1h4uA:undetectable4ikkB-1h4uA:undetectable | 4ikkA-1h4uA:18.804ikkB-1h4uA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0a | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEDEAMINASE (Pyrococcushorikoshii) |
PF00291(PALP) | 4 | LEU A 94ALA A 90LEU A 96THR A 87 | None | 0.89A | 4ikkA-1j0aA:undetectable4ikkB-1j0aA:undetectable | 4ikkA-1j0aA:19.464ikkB-1j0aA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 577ALA A 78SER A 573THR A 75 | None | 1.00A | 4ikkA-1j1wA:undetectable4ikkB-1j1wA:undetectable | 4ikkA-1j1wA:10.314ikkB-1j1wA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmy | BILE-SALT-ACTIVATEDLIPASE (Homo sapiens) |
PF00135(COesterase) | 4 | LYS A 361LEU A 357ALA A 360THR A 352 | None | 0.87A | 4ikkA-1jmyA:undetectable4ikkB-1jmyA:undetectable | 4ikkA-1jmyA:12.644ikkB-1jmyA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k25 | LOW-AFFINITYPENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 4 | LEU A 585ALA A 291LEU A 293THR A 305 | None | 0.94A | 4ikkA-1k25A:undetectable4ikkB-1k25A:undetectable | 4ikkA-1k25A:10.804ikkB-1k25A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | LEU A 361ALA A 357LEU A 363THR A 354 | None | 0.84A | 4ikkA-1l5jA:undetectable4ikkB-1l5jA:undetectable | 4ikkA-1l5jA:8.334ikkB-1l5jA:8.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9q | ENDOTHELIALNITRIC-OXIDESYNTHASE (Homo sapiens) |
PF02898(NO_synthase) | 4 | SER A 409LEU A 326ALA A 324LEU A 328 | None | 1.04A | 4ikkA-1m9qA:undetectable4ikkB-1m9qA:undetectable | 4ikkA-1m9qA:15.484ikkB-1m9qA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mk7 | TALIN (Gallus gallus) |
PF00373(FERM_M)PF02174(IRS) | 4 | SER B 379ALA B 360SER B 365THR B 367 | None | 0.45A | 4ikkA-1mk7B:undetectable4ikkB-1mk7B:undetectable | 4ikkA-1mk7B:22.494ikkB-1mk7B:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nig | HYPOTHETICAL PROTEINTA1238 (Thermoplasmaacidophilum) |
PF09155(DUF1940) | 4 | SER A 109ALA A 29LEU A 102SER A 105 | None | 0.99A | 4ikkA-1nigA:undetectable4ikkB-1nigA:undetectable | 4ikkA-1nigA:17.094ikkB-1nigA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3w | CYSTEINE DESULFURASE (Escherichiacoli) |
no annotation | 4 | LEU B 344ALA B 341LEU B 339SER B 336 | None | 1.03A | 4ikkA-1p3wB:undetectable4ikkB-1p3wB:undetectable | 4ikkA-1p3wB:15.714ikkB-1p3wB:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3w | CYSTEINE DESULFURASE (Escherichiacoli) |
no annotation | 4 | LEU B 344ALA B 341LEU B 339THR B 102 | None | 1.01A | 4ikkA-1p3wB:undetectable4ikkB-1p3wB:undetectable | 4ikkA-1p3wB:15.714ikkB-1p3wB:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgj | PEROXIDASE N (Arabidopsisthaliana) |
PF00141(peroxidase) | 4 | SER A 109ALA A 34LEU A 36SER A 105 | NoneHEM A1350 (-3.7A)NoneNone | 0.95A | 4ikkA-1qgjA:undetectable4ikkB-1qgjA:undetectable | 4ikkA-1qgjA:20.384ikkB-1qgjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rgw | ZASP PROTEIN (Homo sapiens) |
PF00595(PDZ) | 4 | SER A 4ALA A 51SER A 77THR A 79 | None | 0.96A | 4ikkA-1rgwA:undetectable4ikkB-1rgwA:undetectable | 4ikkA-1rgwA:17.424ikkB-1rgwA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE BETASUBUNIT (Thaueraaromatica) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 4 | LEU B 252ALA B 240LEU B 242SER B 219 | None | 0.95A | 4ikkA-1sb3B:undetectable4ikkB-1sb3B:undetectable | 4ikkA-1sb3B:16.724ikkB-1sb3B:16.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sn2 | TRANSTHYRETIN (Sparus aurata) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17ALA A 108LEU A 110THR A 119 | None | 0.45A | 4ikkA-1sn2A:20.34ikkB-1sn2A:20.8 | 4ikkA-1sn2A:54.624ikkB-1sn2A:54.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 6 | LYS A 15LEU A 17ALA A 108LEU A 110SER A 117THR A 119 | None | 0.47A | 4ikkA-1tfpA:19.64ikkB-1tfpA:19.1 | 4ikkA-1tfpA:73.854ikkB-1tfpA:73.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u6z | EXOPOLYPHOSPHATASE (Escherichiacoli) |
PF02541(Ppx-GppA) | 4 | SER A 148LEU A 124ALA A 122LEU A 297 | SO4 A 701 (-4.2A)NoneNoneNone | 1.04A | 4ikkA-1u6zA:undetectable4ikkB-1u6zA:undetectable | 4ikkA-1u6zA:13.504ikkB-1u6zA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urd | MALTOSE-BINDINGPROTEIN (Alicyclobacillusacidocaldarius) |
PF01547(SBP_bac_1) | 4 | SER A 296ALA A 301LEU A 305THR A 298 | None | 0.96A | 4ikkA-1urdA:undetectable4ikkB-1urdA:undetectable | 4ikkA-1urdA:16.534ikkB-1urdA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uun | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | LEU A 62ALA A 164LEU A 166THR A 176 | None | 0.74A | 4ikkA-1uunA:undetectable4ikkB-1uunA:undetectable | 4ikkA-1uunA:22.834ikkB-1uunA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4a | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 4 | LEU A 359ALA A 355LEU A 361THR A 352 | None | 0.99A | 4ikkA-1v4aA:undetectable4ikkB-1v4aA:undetectable | 4ikkA-1v4aA:13.574ikkB-1v4aA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vch | PHOSPHORIBOSYLTRANSFERASE-RELATEDPROTEIN (Thermusthermophilus) |
PF00156(Pribosyltran) | 4 | LEU A 45ALA A 41LEU A 70THR A 38 | None | 1.00A | 4ikkA-1vchA:undetectable4ikkB-1vchA:undetectable | 4ikkA-1vchA:21.144ikkB-1vchA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7p | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF00588(SpoU_methylase) | 4 | SER A 146LEU A 261ALA A 269THR A 268 | NoneSAM A 301 (-4.1A)NoneNone | 1.02A | 4ikkA-1x7pA:undetectable4ikkB-1x7pA:undetectable | 4ikkA-1x7pA:16.674ikkB-1x7pA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykd | ADENYLATE CYCLASE (Anabaena sp.) |
PF01590(GAF) | 4 | LYS A 200ALA A 101LEU A 180THR A 104 | None | 1.04A | 4ikkA-1ykdA:undetectable4ikkB-1ykdA:undetectable | 4ikkA-1ykdA:15.984ikkB-1ykdA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2af5 | ENGINEERED OUTERSURFACE PROTEIN A(OSPA) WITH THEINSERTED TWOBETA-HAIRPINS (Borreliellaburgdorferi) |
PF00820(Lipoprotein_1) | 4 | SER A 121LEU A 88LEU A 99THR A 115 | None | 0.84A | 4ikkA-2af5A:undetectable4ikkB-2af5A:undetectable | 4ikkA-2af5A:19.394ikkB-2af5A:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2i | RV0130 (Mycobacteriumtuberculosis) |
PF01575(MaoC_dehydratas) | 4 | SER A 110LEU A 91ALA A 143THR A 129 | None | 0.71A | 4ikkA-2c2iA:undetectable4ikkB-2c2iA:undetectable | 4ikkA-2c2iA:23.034ikkB-2c2iA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2csd | TOPOISOMERASE V (Methanopyruskandleri) |
PF13412(HTH_24)PF14520(HHH_5) | 5 | SER A 69LYS A 28LEU A 254LEU A 62SER A 65 | None | 1.34A | 4ikkA-2csdA:undetectable4ikkB-2csdA:undetectable | 4ikkA-2csdA:13.154ikkB-2csdA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ejb | PROBABLE AROMATICACID DECARBOXYLASE (Aquifexaeolicus) |
PF02441(Flavoprotein) | 4 | SER A 91LYS A 40ALA A 39THR A 9 | None | 1.01A | 4ikkA-2ejbA:undetectable4ikkB-2ejbA:undetectable | 4ikkA-2ejbA:20.864ikkB-2ejbA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hr2 | HYPOTHETICAL PROTEIN (Chlorobaculumtepidum) |
PF12968(DUF3856) | 4 | SER A 106ALA A 82LEU A 99SER A 102 | GOL A 159 ( 4.4A)NoneNoneGOL A 159 (-2.8A) | 0.99A | 4ikkA-2hr2A:undetectable4ikkB-2hr2A:undetectable | 4ikkA-2hr2A:24.054ikkB-2hr2A:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6v | GENERAL SECRETIONPATHWAY PROTEIN C (Vibrio cholerae) |
no annotation | 4 | LEU A 267ALA A 263SER A 289THR A 291 | None | 0.95A | 4ikkA-2i6vA:undetectable4ikkB-2i6vA:undetectable | 4ikkA-2i6vA:17.324ikkB-2i6vA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jdx | PROTEIN(L-ARGININE:GLYCINEAMIDINOTRANSFERASE) (Homo sapiens) |
no annotation | 4 | SER A 160LEU A 163SER A 188THR A 161 | None | 0.94A | 4ikkA-2jdxA:undetectable4ikkB-2jdxA:undetectable | 4ikkA-2jdxA:14.624ikkB-2jdxA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jis | CYSTEINE SULFINICACID DECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | LEU A 201ALA A 199LEU A 203SER A 207THR A 205 | None | 1.43A | 4ikkA-2jisA:undetectable4ikkB-2jisA:undetectable | 4ikkA-2jisA:12.974ikkB-2jisA:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nc8 | LIPOPROTEIN LPPM (Mycobacteriumtuberculosis) |
no annotation | 4 | SER A 41ALA A 142SER A 35THR A 33 | None | 1.01A | 4ikkA-2nc8A:undetectable4ikkB-2nc8A:undetectable | 4ikkA-2nc8A:22.044ikkB-2nc8A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfc | HYPOTHETICAL PROTEINRV0098/MT0107 (Mycobacteriumtuberculosis) |
PF10862(FcoT) | 4 | LEU A 141LEU A 54SER A 47THR A 49 | None | 0.85A | 4ikkA-2pfcA:undetectable4ikkB-2pfcA:undetectable | 4ikkA-2pfcA:18.854ikkB-2pfcA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pia | PHTHALATEDIOXYGENASEREDUCTASE (Burkholderiacepacia) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | LEU A 319LEU A 321SER A 245THR A 247 | None | 1.03A | 4ikkA-2piaA:undetectable4ikkB-2piaA:undetectable | 4ikkA-2piaA:18.044ikkB-2piaA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qnw | ACYL CARRIER PROTEIN (Toxoplasmagondii) |
PF00550(PP-binding) | 4 | LYS A 13LEU A 9LEU A 74THR A 69 | NoneNoneNone ZN A 86 ( 4.3A) | 1.06A | 4ikkA-2qnwA:undetectable4ikkB-2qnwA:undetectable | 4ikkA-2qnwA:21.264ikkB-2qnwA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qp2 | UNKNOWN PROTEIN (Photorhabduslaumondii) |
PF01823(MACPF) | 4 | SER A 262ALA A 150SER A 216THR A 218 | None | 0.57A | 4ikkA-2qp2A:undetectable4ikkB-2qp2A:undetectable | 4ikkA-2qp2A:13.134ikkB-2qp2A:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qq6 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Rubrobacterxylanophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | SER A 257LEU A 236LEU A 239THR A 258 | None | 0.97A | 4ikkA-2qq6A:undetectable4ikkB-2qq6A:undetectable | 4ikkA-2qq6A:15.624ikkB-2qq6A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjo | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Paraburkholderiaphytofirmans) |
PF13407(Peripla_BP_4) | 4 | SER A 319LEU A 309ALA A 147LEU A 312 | None | 1.03A | 4ikkA-2rjoA:undetectable4ikkB-2rjoA:undetectable | 4ikkA-2rjoA:18.214ikkB-2rjoA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | ALA A 401LEU A 403SER A 391THR A 393 | None | 1.04A | 4ikkA-2rjtA:undetectable4ikkB-2rjtA:undetectable | 4ikkA-2rjtA:14.324ikkB-2rjtA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8n | LACTOSE PERMEASE (Escherichiacoli) |
PF01306(LacY_symp) | 4 | SER A 396LEU A 222LEU A 225THR A 399 | None | 1.02A | 4ikkA-2v8nA:undetectable4ikkB-2v8nA:undetectable | 4ikkA-2v8nA:14.464ikkB-2v8nA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9u | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | LEU A 62ALA A 164LEU A 166THR A 176 | LEU A 62 ( 0.5A)ALA A 164 ( 0.0A)LEU A 166 ( 0.5A)THR A 176 ( 0.8A) | 0.67A | 4ikkA-2v9uA:3.34ikkB-2v9uA:3.2 | 4ikkA-2v9uA:23.884ikkB-2v9uA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vjt | ALLOPHYCOCYANINALPHA SUBUNITALLOPHYCOCYANIN BETASUBUNIT (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 4 | LEU B 97ALA A 7LEU A 4SER A 2 | None | 1.04A | 4ikkA-2vjtB:undetectable4ikkB-2vjtB:undetectable | 4ikkA-2vjtB:22.784ikkB-2vjtB:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 4 | SER A 455LYS A 489ALA A 490THR A 453 | None | 0.85A | 4ikkA-2vwbA:undetectable4ikkB-2vwbA:undetectable | 4ikkA-2vwbA:11.804ikkB-2vwbA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6d | DYNAMIN FAMILYPROTEIN (Nostocpunctiforme) |
PF00350(Dynamin_N) | 4 | LEU A 49ALA A 38LEU A 51THR A 34 | None | 0.86A | 4ikkA-2w6dA:undetectable4ikkB-2w6dA:undetectable | 4ikkA-2w6dA:12.224ikkB-2w6dA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wba | TRYPANOTHIONEREDUCTASE (Trypanosomabrucei) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 464LYS A 414ALA A 413LEU A 430 | None | 1.03A | 4ikkA-2wbaA:undetectable4ikkB-2wbaA:undetectable | 4ikkA-2wbaA:15.734ikkB-2wbaA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wua | ACETOACETYL COATHIOLASE (Helianthusannuus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | LEU A 77LEU A 163SER A 102THR A 131 | None | 1.00A | 4ikkA-2wuaA:undetectable4ikkB-2wuaA:undetectable | 4ikkA-2wuaA:14.754ikkB-2wuaA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn1 | ALPHA-GALACTOSIDASE (Lactobacillusacidophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | SER A 473LEU A 369ALA A 402LEU A 414 | None | 0.97A | 4ikkA-2xn1A:undetectable4ikkB-2xn1A:undetectable | 4ikkA-2xn1A:11.354ikkB-2xn1A:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y24 | XYLANASE (Dickeyachrysanthemi) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 4 | SER A 377ALA A 351SER A 406THR A 408 | None | 0.75A | 4ikkA-2y24A:undetectable4ikkB-2y24A:undetectable | 4ikkA-2y24A:15.794ikkB-2y24A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2m | PENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 4 | LEU B 585ALA B 291LEU B 293THR B 305 | None | 0.91A | 4ikkA-2z2mB:undetectable4ikkB-2z2mB:undetectable | 4ikkA-2z2mB:17.074ikkB-2z2mB:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 4 | LYS A 549LEU A 544SER A 643THR A 640 | None | 0.88A | 4ikkA-3aibA:undetectable4ikkB-3aibA:undetectable | 4ikkA-3aibA:9.524ikkB-3aibA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b49 | LIN2189 PROTEIN (Listeriainnocua) |
PF06445(GyrI-like) | 4 | SER A 63LYS A 120LEU A 116ALA A 119 | None | 1.03A | 4ikkA-3b49A:undetectable4ikkB-3b49A:undetectable | 4ikkA-3b49A:21.964ikkB-3b49A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bws | PROTEIN LP49 (Leptospirainterrogans) |
PF10282(Lactonase) | 4 | LYS A 76LEU A 78LEU A 86SER A 57 | None | 1.04A | 4ikkA-3bwsA:2.64ikkB-3bwsA:undetectable | 4ikkA-3bwsA:16.974ikkB-3bwsA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1r | FRUCTOSE-1,6-BISPHOSPHATASE CLASS IIGLPX (Escherichiacoli) |
PF03320(FBPase_glpX) | 4 | ALA A 102LEU A 104SER A 281THR A 283 | None | 0.69A | 4ikkA-3d1rA:undetectable4ikkB-3d1rA:undetectable | 4ikkA-3d1rA:16.174ikkB-3d1rA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0l | GUANINE DEAMINASE (Homo sapiens) |
PF01979(Amidohydro_1) | 4 | LEU A 338ALA A 340SER A 334THR A 327 | None | 1.00A | 4ikkA-3e0lA:undetectable4ikkB-3e0lA:undetectable | 4ikkA-3e0lA:15.844ikkB-3e0lA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ea0 | ATPASE, PARA FAMILY (Chlorobaculumtepidum) |
PF13614(AAA_31) | 4 | SER A 212ALA A 223LEU A 220SER A 218 | None | 0.94A | 4ikkA-3ea0A:undetectable4ikkB-3ea0A:undetectable | 4ikkA-3ea0A:21.074ikkB-3ea0A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eex | OUTER SURFACEPROTEIN A (Borreliellaburgdorferi) |
PF00820(Lipoprotein_1) | 4 | SER A 121LEU A 88LEU A 99THR A 115 | None | 0.81A | 4ikkA-3eexA:undetectable4ikkB-3eexA:undetectable | 4ikkA-3eexA:19.754ikkB-3eexA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egj | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Vibrio cholerae) |
PF01979(Amidohydro_1) | 4 | SER A 91LYS A 338LEU A 334ALA A 337 | None | 1.03A | 4ikkA-3egjA:undetectable4ikkB-3egjA:undetectable | 4ikkA-3egjA:16.094ikkB-3egjA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8u | TAPASIN (Homo sapiens) |
PF07654(C1-set) | 4 | ALA B 163LEU B 142SER B 161THR B 231 | NoneNoneNAG B1233 ( 4.6A)None | 0.82A | 4ikkA-3f8uB:2.94ikkB-3f8uB:undetectable | 4ikkA-3f8uB:15.364ikkB-3f8uB:15.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fc8 | TRANSTHYRETIN (Homo sapiens) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17ALA A 108LEU A 110THR A 119 | IFA A3000 (-3.0A)IFA A3000 ( 4.7A)IFA A3000 (-3.1A)IFA A3000 (-4.1A)IFA A3000 ( 4.9A) | 0.90A | 4ikkA-3fc8A:23.34ikkB-3fc8A:22.4 | 4ikkA-3fc8A:100.004ikkB-3fc8A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fet | ELECTRON TRANSFERFLAVOPROTEIN SUBUNITALPHA RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01012(ETF) | 4 | LEU A 100ALA A 71LEU A 19THR A 5 | None | 1.04A | 4ikkA-3fetA:undetectable4ikkB-3fetA:undetectable | 4ikkA-3fetA:22.734ikkB-3fetA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhc | NUCLEAR PORE COMPLEXPROTEIN NUP214 (Homo sapiens) |
PF12894(ANAPC4_WD40) | 5 | LEU A 144ALA A 175LEU A 169SER A 173THR A 188 | None | 1.30A | 4ikkA-3fhcA:1.74ikkB-3fhcA:undetectable | 4ikkA-3fhcA:15.824ikkB-3fhcA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g9w | TALIN-2 (Mus musculus) |
PF00373(FERM_M)PF02174(IRS) | 4 | SER A 382ALA A 363SER A 368THR A 370 | None | 0.67A | 4ikkA-3g9wA:undetectable4ikkB-3g9wA:undetectable | 4ikkA-3g9wA:20.484ikkB-3g9wA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hlz | UNCHARACTERIZEDPROTEIN BT_1490 (Bacteroidesthetaiotaomicron) |
PF12712(DUF3805)PF12713(DUF3806) | 4 | SER A 95LEU A 32SER A 110THR A 112 | None | 0.85A | 4ikkA-3hlzA:undetectable4ikkB-3hlzA:undetectable | 4ikkA-3hlzA:18.394ikkB-3hlzA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hri | HISTIDYL-TRNASYNTHETASE (Trypanosomabrucei) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 4 | ALA A 353LEU A 345SER A 350THR A 352 | None | 1.05A | 4ikkA-3hriA:undetectable4ikkB-3hriA:undetectable | 4ikkA-3hriA:14.454ikkB-3hriA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i1a | SPECTINOMYCINPHOSPHOTRANSFERASE (Legionellapneumophila) |
PF01636(APH) | 4 | SER A 176LYS A 311LEU A 307LEU A 170 | None | 0.92A | 4ikkA-3i1aA:undetectable4ikkB-3i1aA:undetectable | 4ikkA-3i1aA:16.504ikkB-3i1aA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i44 | ALDEHYDEDEHYDROGENASE (Bartonellahenselae) |
PF00171(Aldedh) | 4 | LEU A 173LEU A 146SER A 224THR A 226 | None | 0.85A | 4ikkA-3i44A:undetectable4ikkB-3i44A:undetectable | 4ikkA-3i44A:13.774ikkB-3i44A:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijt | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
no annotation | 4 | SER A 0LEU A 74LEU A 83SER A 103 | None | 0.96A | 4ikkA-3ijtA:undetectable4ikkB-3ijtA:undetectable | 4ikkA-3ijtA:21.954ikkB-3ijtA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivf | TALIN-1 (Mus musculus) |
PF00373(FERM_M)PF02174(IRS)PF09379(FERM_N)PF16511(FERM_f0) | 4 | SER A 379ALA A 360SER A 365THR A 367 | None | 0.71A | 4ikkA-3ivfA:undetectable4ikkB-3ivfA:undetectable | 4ikkA-3ivfA:15.014ikkB-3ivfA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwk | AMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 4 | LEU A 184LEU A 157SER A 235THR A 237 | None | 0.96A | 4ikkA-3iwkA:undetectable4ikkB-3iwkA:undetectable | 4ikkA-3iwkA:13.124ikkB-3iwkA:13.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3iwu | 5-HYDROXYISOURATEHYDROLASE (Danio rerio) |
PF00576(Transthyretin) | 4 | LEU A 14LEU A 107SER A 114THR A 116 | None | 0.65A | 4ikkA-3iwuA:19.44ikkB-3iwuA:19.7 | 4ikkA-3iwuA:32.864ikkB-3iwuA:32.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k96 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Coxiellaburnetii) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 4 | LEU A 324ALA A 198SER A 202THR A 199 | None | 1.01A | 4ikkA-3k96A:undetectable4ikkB-3k96A:undetectable | 4ikkA-3k96A:14.704ikkB-3k96A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq5 | HYPOTHETICALCYTOSOLIC PROTEIN (Coxiellaburnetii) |
PF07515(TraI_2_C) | 4 | SER A 247LEU A 257ALA A 253THR A 250 | None | 1.05A | 4ikkA-3kq5A:undetectable4ikkB-3kq5A:undetectable | 4ikkA-3kq5A:13.454ikkB-3kq5A:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7y | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1108C (Streptococcusmutans) |
PF08282(Hydrolase_3) | 4 | LEU A 134ALA A 106SER A 108THR A 152 | None | 1.00A | 4ikkA-3l7yA:undetectable4ikkB-3l7yA:undetectable | 4ikkA-3l7yA:19.444ikkB-3l7yA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7d | TOPOISOMERASE V (Methanopyruskandleri) |
PF13412(HTH_24) | 5 | SER A 69LYS A 28LEU A 254LEU A 62SER A 65 | None | 1.28A | 4ikkA-3m7dA:undetectable4ikkB-3m7dA:undetectable | 4ikkA-3m7dA:16.994ikkB-3m7dA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mbe | MHC CLASS II H2-IAG7BETA CHAIN (Mus musculus) |
PF00969(MHC_II_beta)PF07654(C1-set) | 4 | LEU B 26ALA B 78LEU B 75THR B 77 | None | 1.02A | 4ikkA-3mbeB:2.64ikkB-3mbeB:2.6 | 4ikkA-3mbeB:17.624ikkB-3mbeB:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mbe | MHC CLASS II H2-IAG7BETA CHAINTCR 21.3 ALPHA CHAIN (Mus musculus) |
PF00969(MHC_II_beta)PF07654(C1-set)PF07686(V-set)PF09291(DUF1968) | 4 | SER C 84LEU B 26ALA B 78LEU B 75 | None | 1.02A | 4ikkA-3mbeC:4.24ikkB-3mbeC:3.6 | 4ikkA-3mbeC:18.314ikkB-3mbeC:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 4 | SER A 200LEU A 55ALA A 117THR A 153 | None | 1.06A | 4ikkA-3mduA:undetectable4ikkB-3mduA:undetectable | 4ikkA-3mduA:12.864ikkB-3mduA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nsj | PERFORIN-1 (Mus musculus) |
PF00168(C2)PF01823(MACPF) | 4 | SER A 233ALA A 106SER A 170THR A 172 | None | 0.68A | 4ikkA-3nsjA:undetectable4ikkB-3nsjA:3.2 | 4ikkA-3nsjA:14.564ikkB-3nsjA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 4 | LYS A 111LEU A 113LEU A 155THR A 148 | SO4 A 5 (-2.8A)NoneNoneSO4 A 369 (-3.7A) | 0.99A | 4ikkA-3nuuA:undetectable4ikkB-3nuuA:undetectable | 4ikkA-3nuuA:18.884ikkB-3nuuA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohn | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher) | 4 | SER A 496LEU A 551LEU A 532THR A 523 | None | 0.88A | 4ikkA-3ohnA:4.34ikkB-3ohnA:4.3 | 4ikkA-3ohnA:11.844ikkB-3ohnA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pei | CYTOSOLAMINOPEPTIDASE (Francisellatularensis) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 4 | LEU A 290ALA A 286LEU A 292THR A 283 | EDO A 491 (-4.2A)NoneNoneNone | 0.97A | 4ikkA-3peiA:undetectable4ikkB-3peiA:undetectable | 4ikkA-3peiA:13.074ikkB-3peiA:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3phf | ENVELOPEGLYCOPROTEIN H (Humangammaherpesvirus4) |
no annotation | 4 | LEU A 351ALA A 104LEU A 348SER A 345 | None | 0.88A | 4ikkA-3phfA:undetectable4ikkB-3phfA:undetectable | 4ikkA-3phfA:11.954ikkB-3phfA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3prx | COBRA VENOM FACTOR (Naja kaouthia) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | LEU B 280LEU B 264SER B 317THR B 319 | None | 0.83A | 4ikkA-3prxB:undetectable4ikkB-3prxB:3.5 | 4ikkA-3prxB:6.134ikkB-3prxB:6.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s3t | NUCLEOTIDE-BINDINGPROTEIN, UNIVERSALSTRESS PROTEIN USPAFAMILY (Lactobacillusplantarum) |
PF00582(Usp) | 4 | LEU A 36ALA A 83LEU A 86THR A 81 | None | 0.94A | 4ikkA-3s3tA:undetectable4ikkB-3s3tA:undetectable | 4ikkA-3s3tA:22.444ikkB-3s3tA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6j | HYDROLASE, HALOACIDDEHALOGENASE-LIKEFAMILY (Pseudomonassyringae groupgenomosp. 3) |
PF13419(HAD_2) | 5 | SER A 121LEU A 231ALA A 228LEU A 226THR A 119 | None | 1.47A | 4ikkA-3s6jA:undetectable4ikkB-3s6jA:undetectable | 4ikkA-3s6jA:19.474ikkB-3s6jA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sag | EXOSOME COMPONENT 10 (Homo sapiens) |
PF00570(HRDC)PF01612(DNA_pol_A_exo1) | 4 | LEU A 396ALA A 392LEU A 398THR A 389 | LEU A 396 ( 0.6A)ALA A 392 ( 0.0A)LEU A 398 ( 0.6A)THR A 389 ( 0.8A) | 0.92A | 4ikkA-3sagA:undetectable4ikkB-3sagA:undetectable | 4ikkA-3sagA:14.594ikkB-3sagA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6s | CERJ (Streptomycestendae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 240ALA A 243LEU A 239THR A 187 | None | 0.90A | 4ikkA-3t6sA:undetectable4ikkB-3t6sA:undetectable | 4ikkA-3t6sA:16.484ikkB-3t6sA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 4 | LEU A 484ALA A 498SER A 695THR A 500 | None | 0.93A | 4ikkA-3ttfA:undetectable4ikkB-3ttfA:undetectable | 4ikkA-3ttfA:10.814ikkB-3ttfA:10.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty1 | HYPOTHETICAL ALDOSE1-EPIMERASE (Klebsiellapneumoniae) |
PF14486(DUF4432) | 4 | SER A 360LYS A 184LEU A 182LEU A 196 | None | 1.01A | 4ikkA-3ty1A:undetectable4ikkB-3ty1A:undetectable | 4ikkA-3ty1A:17.454ikkB-3ty1A:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty1 | HYPOTHETICAL ALDOSE1-EPIMERASE (Klebsiellapneumoniae) |
PF14486(DUF4432) | 4 | SER A 360LYS A 184LEU A 196THR A 215 | None | 0.78A | 4ikkA-3ty1A:undetectable4ikkB-3ty1A:undetectable | 4ikkA-3ty1A:17.454ikkB-3ty1A:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty7 | PUTATIVE ALDEHYDEDEHYDROGENASESAV2122 (Staphylococcusaureus) |
PF00171(Aldedh) | 4 | LEU A 169LEU A 142SER A 220THR A 222 | None | 0.80A | 4ikkA-3ty7A:undetectable4ikkB-3ty7A:undetectable | 4ikkA-3ty7A:14.224ikkB-3ty7A:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk2 | PANTOTHENATESYNTHETASE (Burkholderiathailandensis) |
PF02569(Pantoate_ligase) | 4 | LEU A 268ALA A 266LEU A 273THR A 264 | None | 0.93A | 4ikkA-3uk2A:undetectable4ikkB-3uk2A:undetectable | 4ikkA-3uk2A:18.444ikkB-3uk2A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vot | L-AMINO ACID LIGASE,BL00235 (Bacilluslicheniformis) |
PF13535(ATP-grasp_4) | 4 | LEU A 97ALA A 93LEU A 99THR A 90 | None | 0.93A | 4ikkA-3votA:undetectable4ikkB-3votA:undetectable | 4ikkA-3votA:14.524ikkB-3votA:14.52 |