SIMILAR PATTERNS OF AMINO ACIDS FOR 4IK6_A_LURA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehw NUCLEOSIDE
DIPHOSPHATE KINASE

(Homo sapiens) 		PF00334
(NDK) 		4 LYS A  39
LEU A  41
ALA A  75
VAL A  77
 None
 1.08A 4ik6A-1ehwA:
0.0		 4ik6A-1ehwA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
VAL A 121
 None
 0.84A 4ik6A-1gkeA:
21.2		 4ik6A-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LYS A 333
LEU A 366
ALA A 332
VAL A 422
 None
 1.48A 4ik6A-1j6uA:
0.0		 4ik6A-1j6uA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		4 LYS A  43
LEU A  45
ALA A  79
VAL A  81
 None
 1.03A 4ik6A-1leoA:
0.0		 4ik6A-1leoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7w NUCLEOSIDE
DIPHOSPHATE KINASE

(Pisum sativum) 		PF00334
(NDK) 		4 LYS A  38
LEU A  40
ALA A  74
VAL A  76
 None
 1.08A 4ik6A-1w7wA:
0.0		 4ik6A-1w7wA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		4 LYS A 567
LEU A 590
ALA A 420
VAL A 612
 None
 1.23A 4ik6A-2b8eA:
0.0		 4ik6A-2b8eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk4 CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04127
(DFP) 		4 LYS A 158
LEU A 160
ALA A 186
VAL A 202
 None
 1.16A 4ik6A-2gk4A:
0.0		 4ik6A-2gk4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgd UBIQUITIN-LIKE
DOMAIN-CONTAINING
CTD PHOSPHATASE 1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS A  65
LEU A  61
ALA A  63
VAL A  50
 None
 1.35A 4ik6A-2lgdA:
0.4		 4ik6A-2lgdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvd FERREDOXIN-THIOREDOX
IN REDUCTASE,
VARIABLE CHAIN

(Synechocystis
sp.) 		PF02941
(FeThRed_A) 		4 LYS B  62
LEU B  54
ALA B  63
VAL B  15
 SO4  A 201 (-3.2A)
None
None
None
 1.44A 4ik6A-2pvdB:
undetectable		 4ik6A-2pvdB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		4 LYS I 567
LEU I 590
ALA I 420
VAL I 612
 None
 1.23A 4ik6A-2voyI:
undetectable		 4ik6A-2voyI:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LYS A 367
LEU A 478
ALA A 368
VAL A 426
 None
 1.50A 4ik6A-2wdwA:
undetectable		 4ik6A-2wdwA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.74A 4ik6A-3aqpA:
undetectable		 4ik6A-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 LYS A 102
LEU A  94
ALA A 110
VAL A 325
 None
 1.28A 4ik6A-3bxhA:
undetectable		 4ik6A-3bxhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 LYS A 176
LEU A 102
ALA A 179
VAL A 183
 None
 1.35A 4ik6A-3ct4A:
undetectable		 4ik6A-3ct4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 LYS A 402
LEU A 356
ALA A 405
VAL A 409
 None
 0.87A 4ik6A-3eqaA:
undetectable		 4ik6A-3eqaA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
VAL A 121
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
None
 0.36A 4ik6A-3fc8A:
23.4		 4ik6A-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6e 50S RIBOSOMAL
PROTEIN L11P

(Haloarcula
marismortui) 		PF00298
(Ribosomal_L11) 		4 LYS I 107
LEU I 111
ALA I 104
VAL I 100
 U  01164 ( 4.4A)
G  01163 ( 4.9A)
None
None
 1.44A 4ik6A-3g6eI:
undetectable		 4ik6A-3g6eI:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LYS A 567
LEU A 590
ALA A 420
VAL A 612
 None
 1.43A 4ik6A-3j08A:
undetectable		 4ik6A-3j08A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LYS A 116
LEU A 280
ALA A  92
VAL A  35
 None
 1.11A 4ik6A-3l07A:
undetectable		 4ik6A-3l07A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 LYS A 144
LEU A 204
ALA A 141
VAL A 137
 None
 1.37A 4ik6A-4gr4A:
undetectable		 4ik6A-4gr4A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 LYS A 144
LEU A 204
ALA A 141
VAL A 137
 None
 1.38A 4ik6A-4gr5A:
undetectable		 4ik6A-4gr5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqx KETOL-ACID
REDUCTOISOMERASE

(Slackia exigua) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LYS A 191
LEU A  15
ALA A 161
VAL A 163
 None
 1.03A 4ik6A-4kqxA:
undetectable		 4ik6A-4kqxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9o ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 LYS A  65
LEU A 192
ALA A  21
VAL A  19
 None
 1.48A 4ik6A-4q9oA:
undetectable		 4ik6A-4q9oA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		4 LYS A 347
LEU A 345
ALA A 350
VAL A 354
 None
 1.10A 4ik6A-4xhcA:
undetectable		 4ik6A-4xhcA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis) 		PF01177
(Asp_Glu_race) 		4 LYS A  69
LEU A 226
ALA A  70
VAL A  72
 None
 1.22A 4ik6A-5ijwA:
undetectable		 4ik6A-5ijwA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 4 LYS A 299
LEU A 186
ALA A 300
VAL A  27
 None
 1.25A 4ik6A-5jkqA:
undetectable		 4ik6A-5jkqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsn BCL2 INHIBITOR

(unidentified) 		no annotation 4 LYS B  12
LEU B  96
ALA B  15
VAL B  19
 None
 1.12A 4ik6A-5jsnB:
undetectable		 4ik6A-5jsnB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 LYS A  65
LEU A 192
ALA A  21
VAL A  19
 None
 1.38A 4ik6A-5kh5A:
undetectable		 4ik6A-5kh5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 LYS A 402
LEU A 356
ALA A 405
VAL A 409
 None
 0.93A 4ik6A-6frvA:
undetectable		 4ik6A-6frvA:
22.14