SIMILAR PATTERNS OF AMINO ACIDS FOR 4IJI_F_BEZF501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		4 ALA A  27
SER A  26
LEU A 137
TYR A  20
 None
 1.20A 4ijiF-1a0jA:
undetectable		 4ijiF-1a0jA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 ASN A 142
ALA A 113
SER A 114
TYR A 125
 None
 1.10A 4ijiF-1aqlA:
0.0		 4ijiF-1aqlA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 533
ALA A 552
TYR A 528
ARG A 566
 None
 1.13A 4ijiF-1ciyA:
4.1		 4ijiF-1ciyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE

(Aspergillus
aculeatus) 		PF13472
(Lipase_GDSL_2) 		4 ASN A  37
ALA A  12
ARG A  43
TYR A  48
 None
 0.96A 4ijiF-1dexA:
0.0		 4ijiF-1dexA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ASN A 328
SER A 311
LEU A 315
ARG A 109
 None
 1.22A 4ijiF-1gk2A:
1.5		 4ijiF-1gk2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 ASN A  69
ALA A  67
SER A 234
TYR A 251
 None
 1.02A 4ijiF-1ltdA:
undetectable		 4ijiF-1ltdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 358
ALA A 156
SER A 155
ARG A 392
 None
 1.13A 4ijiF-1ogyA:
0.7		 4ijiF-1ogyA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ALA A 228
SER A 233
LEU A 213
TYR A 361
 None
None
None
DCS  A 401 (-4.5A)
 0.98A 4ijiF-1vftA:
undetectable		 4ijiF-1vftA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ALA A 340
SER A 341
ARG A 315
TYR A 345
 None
 1.21A 4ijiF-1w5tA:
0.2		 4ijiF-1w5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Homo sapiens) 		PF05881
(CNPase) 		4 ALA A 249
LEU A 166
TYR A 378
TYR A 258
 ALA  A 249 ( 0.0A)
LEU  A 166 ( 0.6A)
TYR  A 378 ( 1.3A)
TYR  A 258 ( 1.3A)
 1.16A 4ijiF-1wojA:
undetectable		 4ijiF-1wojA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		4 ASN A 163
LEU A 162
TYR A 152
ARG A 138
 None
 1.14A 4ijiF-1x1sA:
undetectable		 4ijiF-1x1sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3s RAS-RELATED PROTEIN
RAB-18

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 122
ALA A 150
SER A 151
LEU A  24
 GNP  A 300 (-3.2A)
None
GNP  A 300 (-3.4A)
None
 1.19A 4ijiF-1x3sA:
undetectable		 4ijiF-1x3sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		4 ASN A  25
ALA A  27
SER A  28
TYR A  18
 SUG  A1001 (-3.9A)
None
SUG  A1001 (-2.7A)
None
 0.99A 4ijiF-1yniA:
undetectable		 4ijiF-1yniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASN A 771
ALA A 998
SER A 996
TYR A 483
 None
 1.20A 4ijiF-1yq2A:
undetectable		 4ijiF-1yq2A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0f RAB14, MEMBER RAS
ONCOGENE FAMILY

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 124
ALA A 153
SER A 154
LEU A  27
 GDP  A 200 (-3.3A)
None
GDP  A 200 (-3.7A)
None
 1.16A 4ijiF-1z0fA:
undetectable		 4ijiF-1z0fA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 705
ARG A 715
TYR A 716
ARG A 711
 None
 1.21A 4ijiF-1z1wA:
1.3		 4ijiF-1z1wA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 ASN A 324
ALA A 352
SER A 350
ARG A 355
 None
 1.22A 4ijiF-1z7eA:
undetectable		 4ijiF-1z7eA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		4 ASN A 164
ALA A 131
SER A 163
ARG A 161
 None
 1.18A 4ijiF-1zwxA:
undetectable		 4ijiF-1zwxA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASN A 482
ALA A 484
LEU A 475
ARG A 457
 None
 1.10A 4ijiF-2cfzA:
undetectable		 4ijiF-2cfzA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo5 CYSTEINE PROTEINASE
EP-B 2

(Hordeum vulgare) 		PF00112
(Peptidase_C1) 		4 ALA A  42
SER A  47
ARG A  44
TYR A 226
 None
 1.10A 4ijiF-2fo5A:
undetectable		 4ijiF-2fo5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 ASN A  72
ALA A  68
SER A  71
ARG A 114
 None
 1.08A 4ijiF-2fv2A:
undetectable		 4ijiF-2fv2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		4 SER A 122
ARG A  55
TYR A  39
ARG A  57
 None
UNL  A 500 (-3.5A)
None
UNL  A 500 ( 3.4A)
 1.05A 4ijiF-2gfgA:
undetectable		 4ijiF-2gfgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 SER A 447
LEU A 754
ARG A 453
ARG A 792
 None
 1.22A 4ijiF-2h5gA:
undetectable		 4ijiF-2h5gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		4 ALA A 139
SER A 138
ARG A 134
TYR A 129
 None
 1.10A 4ijiF-2i3fA:
undetectable		 4ijiF-2i3fA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il1 RAB12

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 251
ALA A 281
SER A 282
LEU A 154
 GDP  A 401 (-3.2A)
None
GDP  A 401 (-3.5A)
None
 1.15A 4ijiF-2il1A:
undetectable		 4ijiF-2il1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 311
ALA A 144
SER A 143
ARG A 354
 None
 1.04A 4ijiF-2jirA:
undetectable		 4ijiF-2jirA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 320
ALA A 144
SER A 143
ARG A 354
 None
 1.10A 4ijiF-2jirA:
undetectable		 4ijiF-2jirA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 ALA A 151
SER A 111
LEU A 125
TYR A 128
 None
 1.08A 4ijiF-2ml3A:
undetectable		 4ijiF-2ml3A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 4 ASN A 102
ALA A 106
SER A 103
LEU A 110
 None
 1.19A 4ijiF-2nc8A:
undetectable		 4ijiF-2nc8A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 348
ALA A 147
SER A 146
ARG A 382
 None
 1.14A 4ijiF-2nyaA:
undetectable		 4ijiF-2nyaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohg GLUTAMATE RACEMASE

(Streptococcus
pyogenes) 		PF01177
(Asp_Glu_race) 		4 ALA A  40
SER A  37
TYR A  42
ARG A  45
 None
 1.18A 4ijiF-2ohgA:
undetectable		 4ijiF-2ohgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orz NEUROPILIN-1

(Rattus
norvegicus) 		PF00754
(F5_F8_type_C) 		4 ASN A 451
ALA A 449
SER A 450
LEU A 473
 None
 1.14A 4ijiF-2orzA:
undetectable		 4ijiF-2orzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		4 ASN A 342
ALA A 346
SER A 347
ARG A 319
 None
 1.17A 4ijiF-2tbvA:
undetectable		 4ijiF-2tbvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		4 ALA A 122
SER A 152
TYR A 166
TYR A 155
 None
 1.22A 4ijiF-2vc2A:
undetectable		 4ijiF-2vc2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 107
ALA A  47
SER A  39
TYR A 183
 None
 1.05A 4ijiF-2wbaA:
undetectable		 4ijiF-2wbaA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ALA A 355
LEU A 405
TYR A 360
ARG A 357
 None
 1.19A 4ijiF-2xe4A:
undetectable		 4ijiF-2xe4A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ASN A 723
ALA A 735
LEU A 719
TYR A 745
 None
 1.16A 4ijiF-2y3aA:
undetectable		 4ijiF-2y3aA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		4 ASN B 221
ALA B 223
SER B 224
TYR B 251
 None
 1.02A 4ijiF-2zalB:
undetectable		 4ijiF-2zalB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ASN A 295
ALA A 299
SER A 296
TYR A 339
 None
 0.97A 4ijiF-2zzgA:
undetectable		 4ijiF-2zzgA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 ALA A 209
SER A 208
LEU A 231
TYR A 261
 None
 1.17A 4ijiF-3a64A:
undetectable		 4ijiF-3a64A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		4 ASN A 181
ALA A 124
SER A 163
ARG A 128
 None
 1.05A 4ijiF-3bsfA:
undetectable		 4ijiF-3bsfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		4 ASN A 221
ALA A 223
SER A 224
TYR A 251
 NA  A 325 ( 4.1A)
NA  A 325 ( 4.6A)
None
None
 1.04A 4ijiF-3c17A:
undetectable		 4ijiF-3c17A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASN A 433
ALA A 430
SER A 432
TYR A 308
 None
 1.14A 4ijiF-3cghA:
undetectable		 4ijiF-3cghA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		4 ALA A 244
SER A 246
LEU A 232
ARG A 253
 None
 1.21A 4ijiF-3chvA:
undetectable		 4ijiF-3chvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		4 ASN A 205
SER A 204
TYR A  17
ARG A  19
 None
 1.03A 4ijiF-3cueA:
undetectable		 4ijiF-3cueA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		4 ALA A 283
SER A 282
TYR A 288
ARG A 244
 None
 0.86A 4ijiF-3e79A:
undetectable		 4ijiF-3e79A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASN A 244
ALA A 302
SER A 319
ARG A 301
 None
 1.16A 4ijiF-3girA:
undetectable		 4ijiF-3girA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ASN A 258
ALA A 272
TYR A 279
TYR A 234
 None
 1.21A 4ijiF-3j31A:
undetectable		 4ijiF-3j31A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keb PROBABLE THIOL
PEROXIDASE

(Chromobacterium
violaceum) 		no annotation 4 ASN A 145
ALA A 141
LEU A  41
TYR A 121
 None
 1.22A 4ijiF-3kebA:
undetectable		 4ijiF-3kebA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 358
ALA A 156
SER A 155
ARG A 392
 None
None
OCS  A 784 ( 3.2A)
None
 1.18A 4ijiF-3o5aA:
undetectable		 4ijiF-3o5aA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ALA A 353
SER A 354
LEU A  36
TYR A  58
 None
 1.05A 4ijiF-3s4dA:
2.1		 4ijiF-3s4dA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 ALA A1134
LEU A1010
ARG A1142
TYR A1144
 None
 1.12A 4ijiF-3sltA:
undetectable		 4ijiF-3sltA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ALA A  10
SER A  11
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 231 (-2.5A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.90A 4ijiF-3totA:
27.4		 4ijiF-3totA:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 ASN A  11
LEU A 131
TYR A 196
ARG A 195
 ADN  A 353 (-3.7A)
None
None
None
 1.17A 4ijiF-3uboA:
undetectable		 4ijiF-3uboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 ALA A 298
SER A 300
ARG A 405
TYR A 303
 None
 1.10A 4ijiF-3vb9A:
undetectable		 4ijiF-3vb9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 ALA A 747
LEU A 741
TYR A 715
ARG A 749
 None
 1.00A 4ijiF-3wfzA:
undetectable		 4ijiF-3wfzA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		4 ASN A   9
LEU A 129
TYR A 194
ARG A 193
 ADN  A 500 (-3.8A)
None
None
None
 1.12A 4ijiF-4e3aA:
undetectable		 4ijiF-4e3aA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ALA A 123
SER A 122
ARG A 379
TYR A 433
 None
 1.16A 4ijiF-4epaA:
undetectable		 4ijiF-4epaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		4 ALA A 327
SER A 326
ARG A 504
TYR A 452
 None
None
None
EDO  A 617 (-4.8A)
 1.16A 4ijiF-4fwwA:
undetectable		 4ijiF-4fwwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 296
ALA A 294
SER A 295
TYR A 424
 None
 1.07A 4ijiF-4fysA:
undetectable		 4ijiF-4fysA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 196
ALA A 211
SER A 210
ARG A 174
 None
 1.12A 4ijiF-4ggaA:
undetectable		 4ijiF-4ggaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		4 ASN A 497
LEU A 324
TYR A 292
ARG A 425
 None
 1.00A 4ijiF-4gl8A:
undetectable		 4ijiF-4gl8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 ALA A 211
SER A 213
LEU A   7
TYR A 447
 None
 1.18A 4ijiF-4gysA:
undetectable		 4ijiF-4gysA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		4 ALA A 144
LEU A 360
TYR A 148
ARG A  36
 None
None
None
SO4  A 502 (-3.5A)
 1.02A 4ijiF-4hvmA:
undetectable		 4ijiF-4hvmA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		8 ASN A   6
ALA A   8
SER A   9
LEU A  35
ARG A 112
TYR A 113
TYR A 167
ARG A 171
 None
ACT  A 303 ( 3.9A)
ACT  A 302 ( 4.2A)
ACT  A 302 (-3.9A)
None
ACT  A 302 ( 4.5A)
ACT  A 303 (-4.5A)
ACT  A 303 (-4.0A)
 0.66A 4ijiF-4id0A:
34.2		 4ijiF-4id0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 ALA A  84
SER A  87
LEU A 127
ARG A 134
 None
 1.22A 4ijiF-4ig7A:
undetectable		 4ijiF-4ig7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 ASN A 151
ALA A  29
SER A  27
ARG A 102
 None
 1.18A 4ijiF-4ldsA:
undetectable		 4ijiF-4ldsA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01520
(Amidase_3) 		4 ASN A 182
ALA A 184
SER A 186
TYR A 198
 None
 1.16A 4ijiF-4lq6A:
undetectable		 4ijiF-4lq6A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk3 GLUTATHIONE
S-TRANSFERASE

(Cupriavidus
metallidurans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 SER A   9
ARG A 108
TYR A 166
ARG A 170
 GSF  A 304 (-2.4A)
None
None
None
 0.56A 4ijiF-4mk3A:
27.6		 4ijiF-4mk3A:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		4 ALA A 255
SER A 254
LEU A 251
ARG A 256
 None
 1.07A 4ijiF-4q3oA:
undetectable		 4ijiF-4q3oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 ALA A  31
SER A  78
TYR A 149
TYR A 217
 WO4  A 301 (-3.3A)
None
None
None
 1.16A 4ijiF-4rxlA:
undetectable		 4ijiF-4rxlA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ALA A 570
SER A 569
ARG A 665
ARG A 576
 None
None
PO4  A 803 (-3.7A)
PO4  A 803 (-3.8A)
 0.94A 4ijiF-4u1rA:
undetectable		 4ijiF-4u1rA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ASN A  35
ALA A  31
TYR A  25
ARG A  30
 None
 1.14A 4ijiF-4xehA:
undetectable		 4ijiF-4xehA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ASN C 384
ALA C 564
TYR C 569
ARG C 568
 None
 1.00A 4ijiF-4z42C:
undetectable		 4ijiF-4z42C:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 ALA A 318
SER A 315
LEU A 363
ARG A 291
 None
 1.16A 4ijiF-5bq2A:
undetectable		 4ijiF-5bq2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		4 ASN A 342
ALA A  64
SER A  65
ARG A  71
 None
 1.12A 4ijiF-5eqvA:
undetectable		 4ijiF-5eqvA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5r HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF13589
(HATPase_c_3) 		4 ALA A 208
SER A 207
LEU A 116
TYR A 206
 None
 1.22A 4ijiF-5f5rA:
undetectable		 4ijiF-5f5rA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 ASN A 275
ALA A 225
SER A 224
ARG A 214
 None
 1.19A 4ijiF-5fnoA:
undetectable		 4ijiF-5fnoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF01798
(Nop)
PF01269
(Fibrillarin) 		4 ALA A 132
SER A 131
LEU E 131
ARG E 115
 None
 1.18A 4ijiF-5ginA:
undetectable		 4ijiF-5ginA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR

(Acinetobacter
sp. ADP1) 		PF01614
(IclR) 		4 ASN A 107
SER A 133
LEU A 135
ARG A 142
 None
 1.11A 4ijiF-5hpiA:
undetectable		 4ijiF-5hpiA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 ALA A 204
SER A 201
LEU A  74
TYR A 248
 None
 1.14A 4ijiF-5husA:
undetectable		 4ijiF-5husA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 ASN A 349
ALA A 342
TYR A 410
TYR A 365
 None
 1.21A 4ijiF-5inrA:
undetectable		 4ijiF-5inrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ASN B1348
ALA B 982
SER B 983
ARG B1291
 None
 1.13A 4ijiF-5jpnB:
5.9		 4ijiF-5jpnB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 447
SER A 390
LEU A 303
TYR A 279
 None
 1.18A 4ijiF-5kl0A:
undetectable		 4ijiF-5kl0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 ALA A 266
SER A 265
LEU A  11
TYR A 168
 None
 1.18A 4ijiF-5kswA:
undetectable		 4ijiF-5kswA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		4 ALA A 135
LEU A  88
ARG A  94
TYR A 138
 None
 1.22A 4ijiF-5ly3A:
undetectable		 4ijiF-5ly3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		4 ALA A  21
SER A  22
TYR A  82
TYR A  25
 None
None
None
SAH  A 301 (-4.5A)
 1.22A 4ijiF-5mgzA:
undetectable		 4ijiF-5mgzA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ASN A 181
ALA A 185
SER A 182
TYR A  64
 None
 0.75A 4ijiF-5nnyA:
undetectable		 4ijiF-5nnyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 ASN A 162
ALA A 163
SER A 161
ARG A 159
 None
 1.04A 4ijiF-5o25A:
undetectable		 4ijiF-5o25A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 4 SER A  73
ARG A 347
TYR A 320
ARG A  57
 None
None
None
GOL  A 402 ( 4.9A)
 1.13A 4ijiF-5onuA:
undetectable		 4ijiF-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 428
SER A 426
LEU A 388
TYR A 434
 None
 1.13A 4ijiF-5oqpA:
5.4		 4ijiF-5oqpA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 ASN A 231
ALA A 275
TYR A 235
ARG A 288
 None
None
DST  A 401 (-3.4A)
DST  A 401 (-4.3A)
 1.03A 4ijiF-5tu4A:
undetectable		 4ijiF-5tu4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		4 ASN A 128
ALA A 157
SER A 158
LEU A  31
 GDP  A 301 (-3.4A)
None
GDP  A 301 (-3.4A)
None
 1.16A 4ijiF-5ub8A:
undetectable		 4ijiF-5ub8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		4 ALA A 260
LEU A 256
ARG A 524
TYR A 525
 None
None
None
GBF  A1026 (-3.2A)
 1.16A 4ijiF-5v8kA:
undetectable		 4ijiF-5v8kA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 ASN A 289
SER A 361
LEU A 285
ARG A 229
 None
 1.18A 4ijiF-5vc2A:
undetectable		 4ijiF-5vc2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		4 ASN A 265
ALA A 268
SER A 266
ARG A 128
 None
 1.07A 4ijiF-5wtfA:
undetectable		 4ijiF-5wtfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ALA C 804
SER C 803
LEU C 859
ARG C3125
 None
 1.11A 4ijiF-5y3rC:
undetectable		 4ijiF-5y3rC:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ASN C4055
ALA C4057
LEU C4107
ARG C4090
 None
 1.00A 4ijiF-5y3rC:
undetectable		 4ijiF-5y3rC:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 4 ASN A 485
ALA A 484
LEU A 380
TYR A 373
 None
 1.22A 4ijiF-5z96A:
2.6		 4ijiF-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehc OUTER MEMBRANE
PROTEIN U

(Vibrio cholerae) 		no annotation 4 SER A  43
ARG A 317
TYR A 290
ARG A  27
 None
 1.10A 4ijiF-6ehcA:
undetectable		 4ijiF-6ehcA:
undetectable