SIMILAR PATTERNS OF AMINO ACIDS FOR 4IIZ_B_LURB201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1914 | SIGNAL RECOGNITIONPARTICLE 9/14 FUSIONPROTEIN (Mus musculus) |
PF02290(SRP14)PF05486(SRP9-21) | 4 | GLU A2012ALA A2060LEU A2058VAL A2026 | None | 0.89A | 4iizB-1914A:undetectable | 4iizB-1914A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a1s | ORNITHINECARBAMOYLTRANSFERASE (Pyrococcusfuriosus) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | MET A 29LEU A 70THR A 26ALA A 303LEU A 305 | None | 1.43A | 4iizB-1a1sA:undetectable | 4iizB-1a1sA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci3 | PROTEIN (CYTOCHROMEF) (Phormidiumlaminosum) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 4 | LEU M 151ALA M 73LEU M 75VAL M 71 | NoneNoneNoneHEM M 254 (-4.8A) | 0.93A | 4iizB-1ci3M:0.1 | 4iizB-1ci3M:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cja | PROTEIN(ACTIN-FRAGMINKINASE) (Physarumpolycephalum) |
PF09192(Act-Frag_cataly) | 5 | MET A 162GLU A 106ALA A 120LEU A 118VAL A 165 | AMP A 425 (-4.4A)NoneNoneNoneAMP A 425 (-4.0A) | 1.33A | 4iizB-1cjaA:undetectable | 4iizB-1cjaA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cm8 | PHOSPHORYLATED MAPKINASE P38-GAMMA (Homo sapiens) |
PF00069(Pkinase) | 4 | GLU A 297THR A 206LEU A 294VAL A 207 | None | 0.94A | 4iizB-1cm8A:0.5 | 4iizB-1cm8A:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvr | GINGIPAIN R (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 4 | LEU A 415ALA A 380LEU A 382VAL A 394 | None | 0.92A | 4iizB-1cvrA:5.5 | 4iizB-1cvrA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cx1 | ENDOGLUCANASE C (Cellulomonasfimi) |
PF02018(CBM_4_9) | 4 | GLU A 64THR A 150ALA A 152VAL A 7 | None | 0.76A | 4iizB-1cx1A:1.0 | 4iizB-1cx1A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6s | O-ACETYLSERINESULFHYDRYLASE (Salmonellaenterica) |
PF00291(PALP) | 4 | MET A 91LEU A 87THR A 68LEU A 64 | NoneNoneMET A 401 (-3.7A)None | 0.87A | 4iizB-1d6sA:undetectable | 4iizB-1d6sA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF01012(ETF) | 4 | LYS B 158GLU B 151THR B 169ALA B 171 | None | 0.93A | 4iizB-1efpB:undetectable | 4iizB-1efpB:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eq9 | CHYMOTRYPSIN (Solenopsisinvicta) |
PF00089(Trypsin) | 4 | LEU A 155GLU A 157THR A 137VAL A 200 | None | 0.89A | 4iizB-1eq9A:undetectable | 4iizB-1eq9A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fns | VON WILLEBRANDFACTOR (Homo sapiens) |
PF00092(VWA) | 4 | LEU A 518ALA A 618LEU A 620VAL A 646 | None | 0.80A | 4iizB-1fnsA:undetectable | 4iizB-1fnsA:18.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gke | TRANSTHYRETIN (Rattusnorvegicus) |
PF00576(Transthyretin) | 8 | MET A 13LYS A 15LEU A 17GLU A 54THR A 106ALA A 108LEU A 110VAL A 121 | None | 0.81A | 4iizB-1gkeA:20.2 | 4iizB-1gkeA:83.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gmv | UREE (Klebsiellaaerogenes) |
PF02814(UreE_N)PF05194(UreE_C) | 4 | LEU A 4GLU A 63ALA A 40LEU A 42 | None | 0.94A | 4iizB-1gmvA:undetectable | 4iizB-1gmvA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j27 | HYPOTHETICAL PROTEINTT1725 (Thermusthermophilus) |
PF04456(DUF503) | 4 | LEU A 33THR A 70ALA A 74LEU A 78 | None | 0.88A | 4iizB-1j27A:undetectable | 4iizB-1j27A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt9 | DIADENOSINETETRAPHOSPHATEHYDROLASE (Caenorhabditiselegans) |
PF00293(NUDIX) | 4 | LYS A 86ALA A 6LEU A 8VAL A 39 | None | 0.88A | 4iizB-1kt9A:undetectable | 4iizB-1kt9A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktw | IOTA-CARRAGEENASE (Alteromonas sp.ATCC 43554) |
PF12708(Pectate_lyase_3) | 4 | MET A 244LEU A 234THR A 223VAL A 189 | None | 0.84A | 4iizB-1ktwA:undetectable | 4iizB-1ktwA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpo | MALTOPORIN (Escherichiacoli) |
PF02264(LamB) | 4 | LEU A 44THR A 40ALA A 42VAL A 68 | None | 0.94A | 4iizB-1mpoA:undetectable | 4iizB-1mpoA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1od6 | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Thermusthermophilus) |
PF01467(CTP_transf_like) | 4 | THR A 31ALA A 33LEU A 35VAL A 4 | NoneNonePNS A1161 (-3.7A)None | 0.73A | 4iizB-1od6A:undetectable | 4iizB-1od6A:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1otk | PHENYLACETIC ACIDDEGRADATION PROTEINPAAC (Escherichiacoli) |
PF05138(PaaA_PaaC) | 4 | LEU A 69GLU A 63ALA A 57LEU A 54 | None | 0.89A | 4iizB-1otkA:undetectable | 4iizB-1otkA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pq5 | TRYPSIN (Fusariumoxysporum) |
PF00089(Trypsin) | 4 | LYS A 154THR A 134ALA A 136VAL A 200 | None | 0.73A | 4iizB-1pq5A:undetectable | 4iizB-1pq5A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4e | GALACTOKINASE (Pyrococcusfuriosus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 4 | GLU A 139ALA A 135LEU A 133VAL A 112 | MG A 600 ( 4.9A)NoneNoneNone | 0.96A | 4iizB-1s4eA:undetectable | 4iizB-1s4eA:17.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sn2 | TRANSTHYRETIN (Sparus aurata) |
PF00576(Transthyretin) | 6 | LEU A 17GLU A 54THR A 106ALA A 108LEU A 110VAL A 121 | None | 0.58A | 4iizB-1sn2A:20.9 | 4iizB-1sn2A:54.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sn2 | TRANSTHYRETIN (Sparus aurata) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | None | 0.91A | 4iizB-1sn2A:20.9 | 4iizB-1sn2A:54.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 5 | LEU A 17GLU A 54THR A 106ALA A 108LEU A 110 | None | 0.78A | 4iizB-1tfpA:18.9 | 4iizB-1tfpA:73.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 5 | LEU A 17THR A 106ALA A 108LEU A 110VAL A 121 | None | 0.60A | 4iizB-1tfpA:18.9 | 4iizB-1tfpA:73.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | None | 0.98A | 4iizB-1tfpA:18.9 | 4iizB-1tfpA:73.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 4 | MET A 13THR A 106ALA A 108VAL A 121 | None | 0.68A | 4iizB-1tfpA:18.9 | 4iizB-1tfpA:73.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tvz | 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE (Staphylococcusaureus) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | MET A 107ALA A 114LEU A 281VAL A 135 | None | 0.92A | 4iizB-1tvzA:undetectable | 4iizB-1tvzA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4u | HEMOGLOBIN BETACHAIN (Thunnus thynnus) |
PF00042(Globin) | 4 | GLU B 83ALA B 140LEU B 88VAL B 136 | NoneNoneHEM B 147 (-4.9A)None | 0.94A | 4iizB-1v4uB:undetectable | 4iizB-1v4uB:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8h | SULFUR OXIDATIONPROTEIN SOXZ (Thermusthermophilus) |
PF08770(SoxZ) | 4 | LEU A 22THR A 5ALA A 7LEU A 9 | None | 0.90A | 4iizB-1v8hA:3.4 | 4iizB-1v8hA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHARE-EXPORTER (Saccharomycescerevisiae) |
PF03378(CAS_CSE1)PF03810(IBN_N)PF08506(Cse1) | 4 | MET C 284LEU C 269LEU C 272VAL C 280 | None | 0.91A | 4iizB-1wa5C:undetectable | 4iizB-1wa5C:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wde | PROBABLE DIPHTHINESYNTHASE (Aeropyrumpernix) |
PF00590(TP_methylase) | 4 | LEU A 143THR A 169ALA A 171LEU A 173 | None | 0.88A | 4iizB-1wdeA:undetectable | 4iizB-1wdeA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xnj | BIFUNCTIONAL3'-PHOSPHOADENOSINE5'-PHOSPHOSULFATESYNTHETASE 1 (Homo sapiens) |
no annotation | 4 | THR B 204ALA B 160LEU B 162VAL B 158 | ADP B2800 (-4.1A)NoneNoneNone | 0.94A | 4iizB-1xnjB:undetectable | 4iizB-1xnjB:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8p | [PYRUVATEDEHYDROGENASE[LIPOAMIDE]] KINASEISOZYME 3 (Homo sapiens) |
PF02518(HATPase_c)PF10436(BCDHK_Adom3) | 4 | LEU A 281THR A 272LEU A 276VAL A 220 | None | 0.81A | 4iizB-1y8pA:undetectable | 4iizB-1y8pA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysr | SENSOR-TYPEHISTIDINE KINASEPRRB (Mycobacteriumtuberculosis) |
PF02518(HATPase_c) | 4 | LEU A 328ALA A 367LEU A 365VAL A 374 | None | 0.93A | 4iizB-1ysrA:undetectable | 4iizB-1ysrA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2af5 | ENGINEERED OUTERSURFACE PROTEIN A(OSPA) WITH THEINSERTED TWOBETA-HAIRPINS (Borreliellaburgdorferi) |
PF00820(Lipoprotein_1) | 4 | LYS A 279LEU A 281LEU A 269VAL A 273 | None | 0.87A | 4iizB-2af5A:undetectable | 4iizB-2af5A:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bid | PROTEIN (BID) (Homo sapiens) |
PF06393(BID) | 4 | LEU A 191THR A 175LEU A 22VAL A 172 | None | 0.90A | 4iizB-2bidA:undetectable | 4iizB-2bidA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bjr | MFP2B (Ascaris suum) |
PF12150(MFP2b) | 4 | LEU A 121GLU A 124ALA A 129LEU A 131 | None | 0.90A | 4iizB-2bjrA:undetectable | 4iizB-2bjrA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cas | CANINE PARVOVIRUSEMPTY CAPSID (STRAIND) VIRAL PROTEIN 2 (Carnivoreprotoparvovirus1) |
PF00740(Parvo_coat) | 4 | LYS A 52LEU A 54THR A 62VAL A 534 | None | 0.76A | 4iizB-2casA:undetectable | 4iizB-2casA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdq | ASPARTOKINASE (Arabidopsisthaliana) |
PF00696(AA_kinase) | 4 | LEU A 228THR A 213LEU A 235VAL A 212 | None | 0.83A | 4iizB-2cdqA:undetectable | 4iizB-2cdqA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cg8 | DIHYDRONEOPTERINALDOLASE6-HYDROXYMETHYL-7,8-DIHYDROPTERINSYNTHASE (Streptococcuspneumoniae) |
PF01288(HPPK)PF02152(FolB) | 4 | LEU A 34ALA A 32LEU A 4VAL A 30 | None | 0.89A | 4iizB-2cg8A:undetectable | 4iizB-2cg8A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddz | 190AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF04017(DUF366) | 4 | GLU A 156THR A 142LEU A 138VAL A 145 | None | 0.90A | 4iizB-2ddzA:undetectable | 4iizB-2ddzA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2diy | THIOREDOXIN-LIKEPROTEIN 2 (Homo sapiens) |
PF00085(Thioredoxin) | 4 | GLU A 62ALA A 64LEU A 67VAL A 20 | None | 0.92A | 4iizB-2diyA:undetectable | 4iizB-2diyA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drw | D-AMINO ACID AMIDASE (Ochrobactrumanthropi) |
PF00144(Beta-lactamase) | 4 | LEU A 27GLU A 32ALA A 326LEU A 328 | None | 0.96A | 4iizB-2drwA:undetectable | 4iizB-2drwA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5f | HYPOTHETICAL PROTEINPH0510 (Pyrococcushorikoshii) |
PF01380(SIS) | 4 | LEU A 193GLU A 218THR A 237LEU A 241 | None | 0.92A | 4iizB-2e5fA:undetectable | 4iizB-2e5fA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3j | RNA AND EXPORTFACTOR BINDINGPROTEIN 2 (Mus musculus) |
PF00076(RRM_1)PF07078(FYTT) | 4 | LEU A 149THR A 73ALA A 75LEU A 77 | None | 0.83A | 4iizB-2f3jA:undetectable | 4iizB-2f3jA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h4u | THIOESTERASESUPERFAMILY MEMBER 2 (Homo sapiens) |
PF03061(4HBT) | 4 | LYS A 136THR A 116ALA A 114VAL A 106 | None | 0.84A | 4iizB-2h4uA:undetectable | 4iizB-2h4uA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hls | PROTEIN DISULFIDEOXIDOREDUCTASE (Aeropyrumpernix) |
PF13192(Thioredoxin_3) | 4 | GLU A 178THR A 89ALA A 91LEU A 93 | None | 0.92A | 4iizB-2hlsA:undetectable | 4iizB-2hlsA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5c | PLECKSTRIN (Homo sapiens) |
PF00169(PH) | 4 | GLU A 337THR A 331ALA A 329LEU A 327 | None | 0.95A | 4iizB-2i5cA:undetectable | 4iizB-2i5cA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2icf | V-SET ANDIMMUNOGLOBULINDOMAIN-CONTAININGPROTEIN 4 (Homo sapiens) |
PF07686(V-set) | 4 | LYS S 36LEU S 38THR S 97VAL S 107 | None | 0.96A | 4iizB-2icfS:4.1 | 4iizB-2icfS:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ich | PUTATIVE ATTH (Nitrosomonaseuropaea) |
PF07143(CrtC)PF17186(Lipocalin_9) | 4 | LYS A 62LEU A 64THR A 60LEU A 56 | None | 0.88A | 4iizB-2ichA:undetectable | 4iizB-2ichA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq1 | PROTEIN PHOSPHATASE2C KAPPA, PPM1K (Homo sapiens) |
PF00481(PP2C) | 4 | LEU A 201THR A 191ALA A 193LEU A 195 | None | 0.62A | 4iizB-2iq1A:undetectable | 4iizB-2iq1A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0a | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASEMANIC FRINGE (Mus musculus) |
PF02434(Fringe) | 4 | LEU A 156THR A 273LEU A 153VAL A 147 | None | 0.93A | 4iizB-2j0aA:undetectable | 4iizB-2j0aA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l4q | THIOREDOXIN (Mycobacteriumtuberculosis) |
PF00085(Thioredoxin) | 4 | THR A 59ALA A 61LEU A 63VAL A 28 | None | 0.81A | 4iizB-2l4qA:undetectable | 4iizB-2l4qA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l4r | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILY HMEMBER 2 (Homo sapiens) |
PF13426(PAS_9) | 4 | GLU A 91ALA A 89LEU A 87VAL A 122 | None | 0.93A | 4iizB-2l4rA:undetectable | 4iizB-2l4rA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lv3 | THIOREDOXINREDUCTASE 3 (Mus musculus) |
PF00462(Glutaredoxin) | 4 | LEU A 27GLU A 81THR A 84VAL A 92 | None | 0.92A | 4iizB-2lv3A:undetectable | 4iizB-2lv3A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n6j | ZINC METALLOPROTEASEZMP1 (Clostridioidesdifficile) |
PF07737(ATLF) | 4 | LYS A 80LEU A 82THR A 120ALA A 122 | None | 0.80A | 4iizB-2n6jA:undetectable | 4iizB-2n6jA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nx8 | TRNA-SPECIFICADENOSINE DEAMINASE (Streptococcuspyogenes) |
PF14437(MafB19-deam) | 4 | LEU A 144GLU A 141THR A 87VAL A 43 | None | 0.92A | 4iizB-2nx8A:undetectable | 4iizB-2nx8A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyg | YOKD PROTEIN (Bacillussubtilis) |
PF02522(Antibiotic_NAT) | 4 | MET A 237GLU A 232ALA A 255VAL A 171 | None | 0.95A | 4iizB-2nygA:undetectable | 4iizB-2nygA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 4 | LEU A 206ALA A 156LEU A 158VAL A 170 | None | 0.89A | 4iizB-2o3iA:undetectable | 4iizB-2o3iA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obx | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE1 (Mesorhizobiumloti) |
PF00885(DMRL_synthase) | 4 | LEU A 111ALA A 73LEU A 75VAL A 12 | None | 0.78A | 4iizB-2obxA:undetectable | 4iizB-2obxA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ofx | BIFUNCTIONAL3'-PHOSPHOADENOSINE5'-PHOSPHOSULFATESYNTHETASE 1 (Homo sapiens) |
PF01583(APS_kinase) | 4 | THR A 204ALA A 160LEU A 162VAL A 158 | ADP A1300 (-4.0A)NoneNoneNone | 0.95A | 4iizB-2ofxA:undetectable | 4iizB-2ofxA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | LEU A 649THR A 654ALA A 652VAL A 659 | None | 0.94A | 4iizB-2ogvA:undetectable | 4iizB-2ogvA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ohh | TYPE A FLAVOPROTEINFPRA (Methanothermobacterthermautotrophicus) |
PF00258(Flavodoxin_1)PF00753(Lactamase_B) | 4 | LEU A 48ALA A 37LEU A 39VAL A 17 | None | 0.86A | 4iizB-2ohhA:undetectable | 4iizB-2ohhA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ott | T-CELL SURFACEGLYCOPROTEIN CD5 (Homo sapiens) |
PF00530(SRCR) | 4 | LYS X 97THR X 23LEU X 75VAL X 14 | None | 0.92A | 4iizB-2ottX:undetectable | 4iizB-2ottX:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p23 | FIBROBLAST GROWTHFACTOR 19 (Homo sapiens) |
PF00167(FGF) | 4 | GLU A 137THR A 89ALA A 121VAL A 85 | None | 0.90A | 4iizB-2p23A:undetectable | 4iizB-2p23A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | MET A 102LEU A 98ALA A 163LEU A 165 | None | 0.79A | 4iizB-2rdyA:undetectable | 4iizB-2rdyA:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | MET A 102LEU A 98ALA A 163VAL A 236 | None | 0.69A | 4iizB-2rdyA:undetectable | 4iizB-2rdyA:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reo | PUTATIVESULFOTRANSFERASE 1C3 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | LEU A 113THR A 53LEU A 49VAL A 137 | NoneA3P A 401 ( 4.8A)NoneNone | 0.94A | 4iizB-2reoA:undetectable | 4iizB-2reoA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgh | ALPHA-GLYCEROPHOSPHATE OXIDASE (Streptococcussp.) |
PF01266(DAO)PF16901(DAO_C) | 5 | MET A 14LEU A 21ALA A 225LEU A 227VAL A 210 | None | 1.11A | 4iizB-2rghA:undetectable | 4iizB-2rghA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9t | SLIT HOMOLOG 2PROTEIN N-PRODUCT (Homo sapiens) |
PF01462(LRRNT)PF01463(LRRCT)PF13855(LRR_8) | 4 | LEU B 363THR B 415ALA B 391LEU B 367 | None | 0.96A | 4iizB-2v9tB:undetectable | 4iizB-2v9tB:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wda | PUTATIVE SECRETEDLYASE (Streptomycesviolaceoruber) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | LEU A 566ALA A 573LEU A 575VAL A 583 | PEG A1781 (-4.7A)NoneNoneNone | 0.65A | 4iizB-2wdaA:undetectable | 4iizB-2wdaA:10.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wmh | FUCOLECTIN-RELATEDPROTEIN (Streptococcuspneumoniae) |
PF08306(Glyco_hydro_98M)PF08307(Glyco_hydro_98C) | 4 | LEU A 466THR A 539LEU A 543VAL A 579 | None | 0.80A | 4iizB-2wmhA:2.2 | 4iizB-2wmhA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsu | PUTATIVE FIBERPROTEIN (PorcinemastadenovirusB) |
PF00337(Gal-bind_lectin) | 4 | LEU A 561GLU A 681THR A 634LEU A 638 | None | 0.94A | 4iizB-2wsuA:undetectable | 4iizB-2wsuA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvf | PUTATIVENICKEL-RESPONSIVEREGULATOR (Helicobacterpylori) |
PF01402(RHH_1)PF08753(NikR_C) | 4 | LYS A 140LEU A 138ALA A 66LEU A 68 | None | 0.64A | 4iizB-2wvfA:undetectable | 4iizB-2wvfA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 4 | LEU A 722THR A 704ALA A 702LEU A 700 | None | 0.76A | 4iizB-2x05A:3.3 | 4iizB-2x05A:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x30 | PHOSPHORIBOSYLISOMERASE A (Streptomycescoelicolor) |
PF00977(His_biosynth) | 4 | LEU A 232GLU A 47THR A 239ALA A 235 | None | 0.91A | 4iizB-2x30A:undetectable | 4iizB-2x30A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 4 | LEU A 263THR A 267ALA A 244LEU A 242 | None | 0.92A | 4iizB-2xgoA:undetectable | 4iizB-2xgoA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsg | CCMAN5 (Cellulosimicrobiumcellulans) |
PF07971(Glyco_hydro_92) | 4 | MET A 666THR A 665ALA A 663LEU A 67 | None | 0.96A | 4iizB-2xsgA:undetectable | 4iizB-2xsgA:9.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsg | CCMAN5 (Cellulosimicrobiumcellulans) |
PF07971(Glyco_hydro_92) | 4 | MET A 751LEU A 747ALA A 724LEU A 726 | None | 0.83A | 4iizB-2xsgA:undetectable | 4iizB-2xsgA:9.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aay | PUTATIVE THIOSULFATESULFURTRANSFERASE (Mycobacteriumtuberculosis) |
PF00581(Rhodanese) | 4 | LYS A 107THR A 79LEU A 109VAL A 22 | None | 0.86A | 4iizB-3aayA:undetectable | 4iizB-3aayA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | LYS A 528LEU A 526ALA A 482VAL A 558 | None | 0.81A | 4iizB-3aqpA:undetectable | 4iizB-3aqpA:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bqy | PUTATIVE TETR FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 4 | LEU A 36THR A 20ALA A 24LEU A 28 | None | 0.83A | 4iizB-3bqyA:undetectable | 4iizB-3bqyA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bx8 | ENGINEERED HUMANLIPOCALIN 2 (Homo sapiens) |
PF00061(Lipocalin) | 4 | LEU A 144THR A 136LEU A 148VAL A 121 | None | 0.93A | 4iizB-3bx8A:undetectable | 4iizB-3bx8A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh4 | SODIUM/GLUCOSECOTRANSPORTER (Vibrioparahaemolyticus) |
PF00474(SSF) | 4 | MET A 379THR A 378ALA A 374LEU A 370 | None | 0.88A | 4iizB-3dh4A:undetectable | 4iizB-3dh4A:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3duz | MAJOR ENVELOPEGLYCOPROTEIN (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF03273(Baculo_gp64) | 4 | LYS A 49LEU A 47ALA A 227LEU A 229 | None | 0.79A | 4iizB-3duzA:undetectable | 4iizB-3duzA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dxb | THIOREDOXINN-TERMINALLY FUSEDTO PUF60(UHM) (Escherichiacoli;Homo sapiens) |
PF00085(Thioredoxin) | 4 | LYS A 426LEU A 424ALA A 366LEU A 368 | None | 0.68A | 4iizB-3dxbA:undetectable | 4iizB-3dxbA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e6e | ALANINE RACEMASE (Enterococcusfaecalis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | LYS A 132THR A 105ALA A 107VAL A 88 | DCS A 372 ( 4.7A)NoneNoneNone | 0.88A | 4iizB-3e6eA:undetectable | 4iizB-3e6eA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e6q | PUTATIVE5-CARBOXYMETHYL-2-HYDROXYMUCONATEISOMERASE (Pseudomonasaeruginosa) |
PF02962(CHMI) | 4 | LEU A 4ALA A 64LEU A 66VAL A 102 | None | 0.72A | 4iizB-3e6qA:undetectable | 4iizB-3e6qA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb7 | INSECTICIDALDELTA-ENDOTOXINCRY8EA1 (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | GLU A 647THR A 297ALA A 299LEU A 301 | None | 0.83A | 4iizB-3eb7A:undetectable | 4iizB-3eb7A:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | LYS A 402LEU A 356ALA A 405VAL A 409 | None | 0.96A | 4iizB-3eqaA:undetectable | 4iizB-3eqaA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5o | THIOESTERASESUPERFAMILY MEMBER 2 (Homo sapiens) |
PF03061(4HBT) | 4 | LYS A 136THR A 116ALA A 114VAL A 106 | UOC A 149 (-3.1A)NoneNoneNone | 0.82A | 4iizB-3f5oA:undetectable | 4iizB-3f5oA:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fc8 | TRANSTHYRETIN (Homo sapiens) |
PF00576(Transthyretin) | 8 | MET A 13LYS A 15LEU A 17GLU A 54THR A 106ALA A 108LEU A 110VAL A 121 | NoneIFA A3000 (-3.0A)IFA A3000 ( 4.7A)NoneIFA A3000 (-4.9A)IFA A3000 (-3.1A)IFA A3000 (-4.1A)None | 0.65A | 4iizB-3fc8A:22.4 | 4iizB-3fc8A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg2 | PUTATIVE RUBREDOXINREDUCTASE (Rhodopseudomonaspalustris) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 4 | LEU P 102THR P 106ALA P 7LEU P 5 | NoneFAD P 449 (-4.1A)FAD P 449 ( 4.7A)None | 0.86A | 4iizB-3fg2P:undetectable | 4iizB-3fg2P:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwe | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE III (Burkholderiapseudomallei) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 86THR A 150ALA A 148LEU A 146 | None | 0.74A | 4iizB-3gweA:undetectable | 4iizB-3gweA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gz8 | MUTT/NUDIX FAMILYPROTEIN (Shewanellaoneidensis) |
PF00293(NUDIX) | 4 | LEU A 26ALA A 24LEU A 37VAL A 22 | None | 0.96A | 4iizB-3gz8A:undetectable | 4iizB-3gz8A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h39 | TRNA NUCLEOTIDYLTRANSFERASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01743(PolyA_pol)PF12627(PolyA_pol_RNAbd) | 4 | LYS A 81LEU A 79ALA A 88LEU A 90 | None | 0.78A | 4iizB-3h39A:undetectable | 4iizB-3h39A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpd | HYDROXYETHYLTHIAZOLEKINASE (Pyrococcushorikoshii) |
PF02110(HK) | 4 | LEU A 246THR A 29ALA A 33LEU A 37 | None | 0.74A | 4iizB-3hpdA:undetectable | 4iizB-3hpdA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic1 | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Haemophilusinfluenzae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | LYS A 54THR A 125ALA A 127LEU A 129 | None | 0.80A | 4iizB-3ic1A:undetectable | 4iizB-3ic1A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic1 | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Haemophilusinfluenzae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | LYS A 54THR A 125ALA A 127VAL A 61 | None | 0.70A | 4iizB-3ic1A:undetectable | 4iizB-3ic1A:16.48 |