SIMILAR PATTERNS OF AMINO ACIDS FOR 4IIZ_B_LURB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN


(Mus musculus)
PF02290
(SRP14)
PF05486
(SRP9-21)
4 GLU A2012
ALA A2060
LEU A2058
VAL A2026
None
0.89A 4iizB-1914A:
undetectable
4iizB-1914A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE


(Pyrococcus
furiosus)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 MET A  29
LEU A  70
THR A  26
ALA A 303
LEU A 305
None
1.43A 4iizB-1a1sA:
undetectable
4iizB-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci3 PROTEIN (CYTOCHROME
F)


(Phormidium
laminosum)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
4 LEU M 151
ALA M  73
LEU M  75
VAL M  71
None
None
None
HEM  M 254 (-4.8A)
0.93A 4iizB-1ci3M:
0.1
4iizB-1ci3M:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)


(Physarum
polycephalum)
PF09192
(Act-Frag_cataly)
5 MET A 162
GLU A 106
ALA A 120
LEU A 118
VAL A 165
AMP  A 425 (-4.4A)
None
None
None
AMP  A 425 (-4.0A)
1.33A 4iizB-1cjaA:
undetectable
4iizB-1cjaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA


(Homo sapiens)
PF00069
(Pkinase)
4 GLU A 297
THR A 206
LEU A 294
VAL A 207
None
0.94A 4iizB-1cm8A:
0.5
4iizB-1cm8A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis)
PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C)
4 LEU A 415
ALA A 380
LEU A 382
VAL A 394
None
0.92A 4iizB-1cvrA:
5.5
4iizB-1cvrA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cx1 ENDOGLUCANASE C

(Cellulomonas
fimi)
PF02018
(CBM_4_9)
4 GLU A  64
THR A 150
ALA A 152
VAL A   7
None
0.76A 4iizB-1cx1A:
1.0
4iizB-1cx1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE


(Salmonella
enterica)
PF00291
(PALP)
4 MET A  91
LEU A  87
THR A  68
LEU A  64
None
None
MET  A 401 (-3.7A)
None
0.87A 4iizB-1d6sA:
undetectable
4iizB-1d6sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF01012
(ETF)
4 LYS B 158
GLU B 151
THR B 169
ALA B 171
None
0.93A 4iizB-1efpB:
undetectable
4iizB-1efpB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta)
PF00089
(Trypsin)
4 LEU A 155
GLU A 157
THR A 137
VAL A 200
None
0.89A 4iizB-1eq9A:
undetectable
4iizB-1eq9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fns VON WILLEBRAND
FACTOR


(Homo sapiens)
PF00092
(VWA)
4 LEU A 518
ALA A 618
LEU A 620
VAL A 646
None
0.80A 4iizB-1fnsA:
undetectable
4iizB-1fnsA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus)
PF00576
(Transthyretin)
8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
0.81A 4iizB-1gkeA:
20.2
4iizB-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmv UREE

(Klebsiella
aerogenes)
PF02814
(UreE_N)
PF05194
(UreE_C)
4 LEU A   4
GLU A  63
ALA A  40
LEU A  42
None
0.94A 4iizB-1gmvA:
undetectable
4iizB-1gmvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j27 HYPOTHETICAL PROTEIN
TT1725


(Thermus
thermophilus)
PF04456
(DUF503)
4 LEU A  33
THR A  70
ALA A  74
LEU A  78
None
0.88A 4iizB-1j27A:
undetectable
4iizB-1j27A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt9 DIADENOSINE
TETRAPHOSPHATE
HYDROLASE


(Caenorhabditis
elegans)
PF00293
(NUDIX)
4 LYS A  86
ALA A   6
LEU A   8
VAL A  39
None
0.88A 4iizB-1kt9A:
undetectable
4iizB-1kt9A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554)
PF12708
(Pectate_lyase_3)
4 MET A 244
LEU A 234
THR A 223
VAL A 189
None
0.84A 4iizB-1ktwA:
undetectable
4iizB-1ktwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli)
PF02264
(LamB)
4 LEU A  44
THR A  40
ALA A  42
VAL A  68
None
0.94A 4iizB-1mpoA:
undetectable
4iizB-1mpoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Thermus
thermophilus)
PF01467
(CTP_transf_like)
4 THR A  31
ALA A  33
LEU A  35
VAL A   4
None
None
PNS  A1161 (-3.7A)
None
0.73A 4iizB-1od6A:
undetectable
4iizB-1od6A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC


(Escherichia
coli)
PF05138
(PaaA_PaaC)
4 LEU A  69
GLU A  63
ALA A  57
LEU A  54
None
0.89A 4iizB-1otkA:
undetectable
4iizB-1otkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum)
PF00089
(Trypsin)
4 LYS A 154
THR A 134
ALA A 136
VAL A 200
None
0.73A 4iizB-1pq5A:
undetectable
4iizB-1pq5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 GLU A 139
ALA A 135
LEU A 133
VAL A 112
MG  A 600 ( 4.9A)
None
None
None
0.96A 4iizB-1s4eA:
undetectable
4iizB-1s4eA:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata)
PF00576
(Transthyretin)
6 LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
0.58A 4iizB-1sn2A:
20.9
4iizB-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
None
0.91A 4iizB-1sn2A:
20.9
4iizB-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
5 LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
None
0.78A 4iizB-1tfpA:
18.9
4iizB-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
5 LEU A  17
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
0.60A 4iizB-1tfpA:
18.9
4iizB-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
None
0.98A 4iizB-1tfpA:
18.9
4iizB-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
4 MET A  13
THR A 106
ALA A 108
VAL A 121
None
0.68A 4iizB-1tfpA:
18.9
4iizB-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE


(Staphylococcus
aureus)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
4 MET A 107
ALA A 114
LEU A 281
VAL A 135
None
0.92A 4iizB-1tvzA:
undetectable
4iizB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN BETA
CHAIN


(Thunnus thynnus)
PF00042
(Globin)
4 GLU B  83
ALA B 140
LEU B  88
VAL B 136
None
None
HEM  B 147 (-4.9A)
None
0.94A 4iizB-1v4uB:
undetectable
4iizB-1v4uB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8h SULFUR OXIDATION
PROTEIN SOXZ


(Thermus
thermophilus)
PF08770
(SoxZ)
4 LEU A  22
THR A   5
ALA A   7
LEU A   9
None
0.90A 4iizB-1v8hA:
3.4
4iizB-1v8hA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
4 MET C 284
LEU C 269
LEU C 272
VAL C 280
None
0.91A 4iizB-1wa5C:
undetectable
4iizB-1wa5C:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wde PROBABLE DIPHTHINE
SYNTHASE


(Aeropyrum
pernix)
PF00590
(TP_methylase)
4 LEU A 143
THR A 169
ALA A 171
LEU A 173
None
0.88A 4iizB-1wdeA:
undetectable
4iizB-1wdeA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1


(Homo sapiens)
no annotation 4 THR B 204
ALA B 160
LEU B 162
VAL B 158
ADP  B2800 (-4.1A)
None
None
None
0.94A 4iizB-1xnjB:
undetectable
4iizB-1xnjB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
4 LEU A 281
THR A 272
LEU A 276
VAL A 220
None
0.81A 4iizB-1y8pA:
undetectable
4iizB-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB


(Mycobacterium
tuberculosis)
PF02518
(HATPase_c)
4 LEU A 328
ALA A 367
LEU A 365
VAL A 374
None
0.93A 4iizB-1ysrA:
undetectable
4iizB-1ysrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS


(Borreliella
burgdorferi)
PF00820
(Lipoprotein_1)
4 LYS A 279
LEU A 281
LEU A 269
VAL A 273
None
0.87A 4iizB-2af5A:
undetectable
4iizB-2af5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bid PROTEIN (BID)

(Homo sapiens)
PF06393
(BID)
4 LEU A 191
THR A 175
LEU A  22
VAL A 172
None
0.90A 4iizB-2bidA:
undetectable
4iizB-2bidA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum)
PF12150
(MFP2b)
4 LEU A 121
GLU A 124
ALA A 129
LEU A 131
None
0.90A 4iizB-2bjrA:
undetectable
4iizB-2bjrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2


(Carnivore
protoparvovirus
1)
PF00740
(Parvo_coat)
4 LYS A  52
LEU A  54
THR A  62
VAL A 534
None
0.76A 4iizB-2casA:
undetectable
4iizB-2casA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana)
PF00696
(AA_kinase)
4 LEU A 228
THR A 213
LEU A 235
VAL A 212
None
0.83A 4iizB-2cdqA:
undetectable
4iizB-2cdqA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE


(Streptococcus
pneumoniae)
PF01288
(HPPK)
PF02152
(FolB)
4 LEU A  34
ALA A  32
LEU A   4
VAL A  30
None
0.89A 4iizB-2cg8A:
undetectable
4iizB-2cg8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddz 190AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF04017
(DUF366)
4 GLU A 156
THR A 142
LEU A 138
VAL A 145
None
0.90A 4iizB-2ddzA:
undetectable
4iizB-2ddzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diy THIOREDOXIN-LIKE
PROTEIN 2


(Homo sapiens)
PF00085
(Thioredoxin)
4 GLU A  62
ALA A  64
LEU A  67
VAL A  20
None
0.92A 4iizB-2diyA:
undetectable
4iizB-2diyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi)
PF00144
(Beta-lactamase)
4 LEU A  27
GLU A  32
ALA A 326
LEU A 328
None
0.96A 4iizB-2drwA:
undetectable
4iizB-2drwA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510


(Pyrococcus
horikoshii)
PF01380
(SIS)
4 LEU A 193
GLU A 218
THR A 237
LEU A 241
None
0.92A 4iizB-2e5fA:
undetectable
4iizB-2e5fA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2


(Mus musculus)
PF00076
(RRM_1)
PF07078
(FYTT)
4 LEU A 149
THR A  73
ALA A  75
LEU A  77
None
0.83A 4iizB-2f3jA:
undetectable
4iizB-2f3jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2


(Homo sapiens)
PF03061
(4HBT)
4 LYS A 136
THR A 116
ALA A 114
VAL A 106
None
0.84A 4iizB-2h4uA:
undetectable
4iizB-2h4uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE


(Aeropyrum
pernix)
PF13192
(Thioredoxin_3)
4 GLU A 178
THR A  89
ALA A  91
LEU A  93
None
0.92A 4iizB-2hlsA:
undetectable
4iizB-2hlsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5c PLECKSTRIN

(Homo sapiens)
PF00169
(PH)
4 GLU A 337
THR A 331
ALA A 329
LEU A 327
None
0.95A 4iizB-2i5cA:
undetectable
4iizB-2i5cA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icf V-SET AND
IMMUNOGLOBULIN
DOMAIN-CONTAINING
PROTEIN 4


(Homo sapiens)
PF07686
(V-set)
4 LYS S  36
LEU S  38
THR S  97
VAL S 107
None
0.96A 4iizB-2icfS:
4.1
4iizB-2icfS:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea)
PF07143
(CrtC)
PF17186
(Lipocalin_9)
4 LYS A  62
LEU A  64
THR A  60
LEU A  56
None
0.88A 4iizB-2ichA:
undetectable
4iizB-2ichA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K


(Homo sapiens)
PF00481
(PP2C)
4 LEU A 201
THR A 191
ALA A 193
LEU A 195
None
0.62A 4iizB-2iq1A:
undetectable
4iizB-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE


(Mus musculus)
PF02434
(Fringe)
4 LEU A 156
THR A 273
LEU A 153
VAL A 147
None
0.93A 4iizB-2j0aA:
undetectable
4iizB-2j0aA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4q THIOREDOXIN

(Mycobacterium
tuberculosis)
PF00085
(Thioredoxin)
4 THR A  59
ALA A  61
LEU A  63
VAL A  28
None
0.81A 4iizB-2l4qA:
undetectable
4iizB-2l4qA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4r POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2


(Homo sapiens)
PF13426
(PAS_9)
4 GLU A  91
ALA A  89
LEU A  87
VAL A 122
None
0.93A 4iizB-2l4rA:
undetectable
4iizB-2l4rA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv3 THIOREDOXIN
REDUCTASE 3


(Mus musculus)
PF00462
(Glutaredoxin)
4 LEU A  27
GLU A  81
THR A  84
VAL A  92
None
0.92A 4iizB-2lv3A:
undetectable
4iizB-2lv3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1


(Clostridioides
difficile)
PF07737
(ATLF)
4 LYS A  80
LEU A  82
THR A 120
ALA A 122
None
0.80A 4iizB-2n6jA:
undetectable
4iizB-2n6jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE


(Streptococcus
pyogenes)
PF14437
(MafB19-deam)
4 LEU A 144
GLU A 141
THR A  87
VAL A  43
None
0.92A 4iizB-2nx8A:
undetectable
4iizB-2nx8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis)
PF02522
(Antibiotic_NAT)
4 MET A 237
GLU A 232
ALA A 255
VAL A 171
None
0.95A 4iizB-2nygA:
undetectable
4iizB-2nygA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum)
PF06032
(DUF917)
4 LEU A 206
ALA A 156
LEU A 158
VAL A 170
None
0.89A 4iizB-2o3iA:
undetectable
4iizB-2o3iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1


(Mesorhizobium
loti)
PF00885
(DMRL_synthase)
4 LEU A 111
ALA A  73
LEU A  75
VAL A  12
None
0.78A 4iizB-2obxA:
undetectable
4iizB-2obxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1


(Homo sapiens)
PF01583
(APS_kinase)
4 THR A 204
ALA A 160
LEU A 162
VAL A 158
ADP  A1300 (-4.0A)
None
None
None
0.95A 4iizB-2ofxA:
undetectable
4iizB-2ofxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 LEU A 649
THR A 654
ALA A 652
VAL A 659
None
0.94A 4iizB-2ogvA:
undetectable
4iizB-2ogvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA


(Methanothermobacter
thermautotrophicus)
PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B)
4 LEU A  48
ALA A  37
LEU A  39
VAL A  17
None
0.86A 4iizB-2ohhA:
undetectable
4iizB-2ohhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ott T-CELL SURFACE
GLYCOPROTEIN CD5


(Homo sapiens)
PF00530
(SRCR)
4 LYS X  97
THR X  23
LEU X  75
VAL X  14
None
0.92A 4iizB-2ottX:
undetectable
4iizB-2ottX:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p23 FIBROBLAST GROWTH
FACTOR 19


(Homo sapiens)
PF00167
(FGF)
4 GLU A 137
THR A  89
ALA A 121
VAL A  85
None
0.90A 4iizB-2p23A:
undetectable
4iizB-2p23A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 MET A 102
LEU A  98
ALA A 163
LEU A 165
None
0.79A 4iizB-2rdyA:
undetectable
4iizB-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 MET A 102
LEU A  98
ALA A 163
VAL A 236
None
0.69A 4iizB-2rdyA:
undetectable
4iizB-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reo PUTATIVE
SULFOTRANSFERASE 1C3


(Homo sapiens)
PF00685
(Sulfotransfer_1)
4 LEU A 113
THR A  53
LEU A  49
VAL A 137
None
A3P  A 401 ( 4.8A)
None
None
0.94A 4iizB-2reoA:
undetectable
4iizB-2reoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE


(Streptococcus
sp.)
PF01266
(DAO)
PF16901
(DAO_C)
5 MET A  14
LEU A  21
ALA A 225
LEU A 227
VAL A 210
None
1.11A 4iizB-2rghA:
undetectable
4iizB-2rghA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT


(Homo sapiens)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 LEU B 363
THR B 415
ALA B 391
LEU B 367
None
0.96A 4iizB-2v9tB:
undetectable
4iizB-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE


(Streptomyces
violaceoruber)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
4 LEU A 566
ALA A 573
LEU A 575
VAL A 583
PEG  A1781 (-4.7A)
None
None
None
0.65A 4iizB-2wdaA:
undetectable
4iizB-2wdaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN


(Streptococcus
pneumoniae)
PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C)
4 LEU A 466
THR A 539
LEU A 543
VAL A 579
None
0.80A 4iizB-2wmhA:
2.2
4iizB-2wmhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN


(Porcine
mastadenovirus
B)
PF00337
(Gal-bind_lectin)
4 LEU A 561
GLU A 681
THR A 634
LEU A 638
None
0.94A 4iizB-2wsuA:
undetectable
4iizB-2wsuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR


(Helicobacter
pylori)
PF01402
(RHH_1)
PF08753
(NikR_C)
4 LYS A 140
LEU A 138
ALA A  66
LEU A  68
None
0.64A 4iizB-2wvfA:
undetectable
4iizB-2wvfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
4 LEU A 722
THR A 704
ALA A 702
LEU A 700
None
0.76A 4iizB-2x05A:
3.3
4iizB-2x05A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
coelicolor)
PF00977
(His_biosynth)
4 LEU A 232
GLU A  47
THR A 239
ALA A 235
None
0.91A 4iizB-2x30A:
undetectable
4iizB-2x30A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
4 LEU A 263
THR A 267
ALA A 244
LEU A 242
None
0.92A 4iizB-2xgoA:
undetectable
4iizB-2xgoA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans)
PF07971
(Glyco_hydro_92)
4 MET A 666
THR A 665
ALA A 663
LEU A  67
None
0.96A 4iizB-2xsgA:
undetectable
4iizB-2xsgA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans)
PF07971
(Glyco_hydro_92)
4 MET A 751
LEU A 747
ALA A 724
LEU A 726
None
0.83A 4iizB-2xsgA:
undetectable
4iizB-2xsgA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE


(Mycobacterium
tuberculosis)
PF00581
(Rhodanese)
4 LYS A 107
THR A  79
LEU A 109
VAL A  22
None
0.86A 4iizB-3aayA:
undetectable
4iizB-3aayA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 LYS A 528
LEU A 526
ALA A 482
VAL A 558
None
0.81A 4iizB-3aqpA:
undetectable
4iizB-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
4 LEU A  36
THR A  20
ALA A  24
LEU A  28
None
0.83A 4iizB-3bqyA:
undetectable
4iizB-3bqyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx8 ENGINEERED HUMAN
LIPOCALIN 2


(Homo sapiens)
PF00061
(Lipocalin)
4 LEU A 144
THR A 136
LEU A 148
VAL A 121
None
0.93A 4iizB-3bx8A:
undetectable
4iizB-3bx8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
4 MET A 379
THR A 378
ALA A 374
LEU A 370
None
0.88A 4iizB-3dh4A:
undetectable
4iizB-3dh4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duz MAJOR ENVELOPE
GLYCOPROTEIN


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF03273
(Baculo_gp64)
4 LYS A  49
LEU A  47
ALA A 227
LEU A 229
None
0.79A 4iizB-3duzA:
undetectable
4iizB-3duzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)


(Escherichia
coli;
Homo sapiens)
PF00085
(Thioredoxin)
4 LYS A 426
LEU A 424
ALA A 366
LEU A 368
None
0.68A 4iizB-3dxbA:
undetectable
4iizB-3dxbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 LYS A 132
THR A 105
ALA A 107
VAL A  88
DCS  A 372 ( 4.7A)
None
None
None
0.88A 4iizB-3e6eA:
undetectable
4iizB-3e6eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6q PUTATIVE
5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE


(Pseudomonas
aeruginosa)
PF02962
(CHMI)
4 LEU A   4
ALA A  64
LEU A  66
VAL A 102
None
0.72A 4iizB-3e6qA:
undetectable
4iizB-3e6qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 GLU A 647
THR A 297
ALA A 299
LEU A 301
None
0.83A 4iizB-3eb7A:
undetectable
4iizB-3eb7A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 LYS A 402
LEU A 356
ALA A 405
VAL A 409
None
0.96A 4iizB-3eqaA:
undetectable
4iizB-3eqaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5o THIOESTERASE
SUPERFAMILY MEMBER 2


(Homo sapiens)
PF03061
(4HBT)
4 LYS A 136
THR A 116
ALA A 114
VAL A 106
UOC  A 149 (-3.1A)
None
None
None
0.82A 4iizB-3f5oA:
undetectable
4iizB-3f5oA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens)
PF00576
(Transthyretin)
8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.65A 4iizB-3fc8A:
22.4
4iizB-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE


(Rhodopseudomonas
palustris)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
4 LEU P 102
THR P 106
ALA P   7
LEU P   5
None
FAD  P 449 (-4.1A)
FAD  P 449 ( 4.7A)
None
0.86A 4iizB-3fg2P:
undetectable
4iizB-3fg2P:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III


(Burkholderia
pseudomallei)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A  86
THR A 150
ALA A 148
LEU A 146
None
0.74A 4iizB-3gweA:
undetectable
4iizB-3gweA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN


(Shewanella
oneidensis)
PF00293
(NUDIX)
4 LEU A  26
ALA A  24
LEU A  37
VAL A  22
None
0.96A 4iizB-3gz8A:
undetectable
4iizB-3gz8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
4 LYS A  81
LEU A  79
ALA A  88
LEU A  90
None
0.78A 4iizB-3h39A:
undetectable
4iizB-3h39A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE


(Pyrococcus
horikoshii)
PF02110
(HK)
4 LEU A 246
THR A  29
ALA A  33
LEU A  37
None
0.74A 4iizB-3hpdA:
undetectable
4iizB-3hpdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Haemophilus
influenzae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 LYS A  54
THR A 125
ALA A 127
LEU A 129
None
0.80A 4iizB-3ic1A:
undetectable
4iizB-3ic1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Haemophilus
influenzae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 LYS A  54
THR A 125
ALA A 127
VAL A  61
None
0.70A 4iizB-3ic1A:
undetectable
4iizB-3ic1A:
16.48