SIMILAR PATTERNS OF AMINO ACIDS FOR 4IIZ_A_LURA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		3 LYS A  64
LEU A 142
ALA A 134
 None
 0.81A 4iizA-1eepA:
0.0		 4iizA-1eepA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eks MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C

(Escherichia
coli) 		PF01967
(MoaC) 		3 LYS A 147
LEU A 144
ALA A  28
 None
 0.79A 4iizA-1eksA:
undetectable		 4iizA-1eksA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 LYS A 372
LEU A 320
ALA A 371
 None
 0.77A 4iizA-1em2A:
0.0		 4iizA-1em2A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		3 LYS A  19
LEU A  17
ALA A  44
 None
 0.56A 4iizA-1f5jA:
0.4		 4iizA-1f5jA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		3 LYS A  15
LEU A  17
ALA A 108
 None
 0.77A 4iizA-1gkeA:
21.1		 4iizA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II

(Clostridium
pasteurianum) 		PF03459
(TOBE) 		3 LYS A  18
LEU A  16
ALA A  23
 None
 0.71A 4iizA-1gutA:
0.0		 4iizA-1gutA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		3 LYS A  21
LEU A  19
ALA A  46
 None
 0.64A 4iizA-1igoA:
0.0		 4iizA-1igoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE

(Thermosynechococcus
elongatus) 		PF01716
(MSP) 		3 LYS O 178
LEU O 182
ALA O 177
 None
 0.84A 4iizA-1s5lO:
0.0		 4iizA-1s5lO:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sur PAPS REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		3 LYS A 177
LEU A 179
ALA A 170
 None
 0.56A 4iizA-1surA:
undetectable		 4iizA-1surA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442

(Thermotoga
maritima) 		PF01740
(STAS) 		3 LYS A  73
LEU A  69
ALA A  72
 None
 0.85A 4iizA-1t6rA:
undetectable		 4iizA-1t6rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		3 LYS A 164
LEU A 177
ALA A   3
 None
 0.63A 4iizA-1vgjA:
undetectable		 4iizA-1vgjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auw HYPOTHETICAL PROTEIN
NE0471

(Nitrosomonas
europaea) 		PF10387
(DUF2442) 		3 LYS A  82
LEU A  30
ALA A  85
 None
 0.78A 4iizA-2auwA:
undetectable		 4iizA-2auwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 LYS A 567
LEU A 590
ALA A 420
 None
 0.60A 4iizA-2b8eA:
undetectable		 4iizA-2b8eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cup SKELETAL MUSCLE
LIM-PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		3 LYS A  38
LEU A  56
ALA A  37
 None
 0.70A 4iizA-2cupA:
undetectable		 4iizA-2cupA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Thermus
thermophilus) 		PF00106
(adh_short) 		3 LYS A  28
LEU A  24
ALA A  27
 None
 0.77A 4iizA-2ehdA:
undetectable		 4iizA-2ehdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		3 LYS A 119
LEU A 121
ALA A 114
 None
 0.60A 4iizA-2ew9A:
undetectable		 4iizA-2ew9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 LYS A 832
LEU A 658
ALA A 829
 None
 0.74A 4iizA-2hpiA:
undetectable		 4iizA-2hpiA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaa AZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		3 LYS C  41
LEU C  68
ALA C  42
 None
 0.77A 4iizA-2iaaC:
2.4		 4iizA-2iaaC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifu GAMMA-SNAP

(Danio rerio) 		PF14938
(SNAP) 		3 LYS A  54
LEU A  84
ALA A  80
 None
 0.81A 4iizA-2ifuA:
undetectable		 4iizA-2ifuA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		3 LYS A  38
LEU A  62
ALA A  39
 None
 0.82A 4iizA-2iq7A:
undetectable		 4iizA-2iq7A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m08 PPIC-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Nitrosopumilus
maritimus) 		PF13616
(Rotamase_3) 		3 LYS A  25
LEU A  35
ALA A  21
 None
 0.73A 4iizA-2m08A:
undetectable		 4iizA-2m08A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 LYS I 567
LEU I 590
ALA I 420
 None
 0.60A 4iizA-2voyI:
undetectable		 4iizA-2voyI:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 LYS A  79
LEU A  75
ALA A  78
 None
 0.84A 4iizA-2vroA:
undetectable		 4iizA-2vroA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		3 LYS A 101
LEU A 103
ALA A 205
 None
 0.68A 4iizA-2w68A:
undetectable		 4iizA-2w68A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 204
LEU A 481
ALA A 199
 None
 0.85A 4iizA-2xaxA:
undetectable		 4iizA-2xaxA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0u RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		3 LYS A  40
LEU A   5
ALA A  37
 None
 0.82A 4iizA-3a0uA:
undetectable		 4iizA-3a0uA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		3 LYS A 258
LEU A 383
ALA A 261
 None
 0.78A 4iizA-3bmaA:
undetectable		 4iizA-3bmaA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duz MAJOR ENVELOPE
GLYCOPROTEIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF03273
(Baculo_gp64) 		3 LYS A  49
LEU A  47
ALA A 227
 None
 0.59A 4iizA-3duzA:
undetectable		 4iizA-3duzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		3 LYS A 426
LEU A 424
ALA A 366
 None
 0.79A 4iizA-3dxbA:
undetectable		 4iizA-3dxbA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		3 LYS A  15
LEU A  17
ALA A 108
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
 0.28A 4iizA-3fc8A:
23.2		 4iizA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		3 LYS A 242
LEU A 213
ALA A 157
 SO4  A 252 (-3.0A)
None
None
 0.79A 4iizA-3ggdA:
undetectable		 4iizA-3ggdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00072
(Response_reg) 		3 LYS A  13
LEU A  34
ALA A  16
 None
CL  A 140 (-4.2A)
None
 0.84A 4iizA-3h5iA:
undetectable		 4iizA-3h5iA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		3 LYS A 327
LEU A 323
ALA A 326
 TLA  A   2 (-2.8A)
None
None
 0.81A 4iizA-3i5bA:
undetectable		 4iizA-3i5bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		3 LYS A 150
LEU A 156
ALA A 151
 None
 0.84A 4iizA-3ilnA:
undetectable		 4iizA-3ilnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 LYS A  68
LEU A  39
ALA A  65
 None
 0.72A 4iizA-3kbhA:
undetectable		 4iizA-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klt VIMENTIN

(Homo sapiens) 		PF00038
(Filament) 		3 LYS A 313
LEU A 309
ALA A 312
 None
 0.81A 4iizA-3kltA:
undetectable		 4iizA-3kltA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		3 LYS A  87
LEU A  69
ALA A  84
 None
 0.72A 4iizA-3kvoA:
undetectable		 4iizA-3kvoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		3 LYS A 195
LEU A 191
ALA A 194
 None
 0.72A 4iizA-3n0aA:
2.7		 4iizA-3n0aA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		3 LYS A 138
LEU A 140
ALA A 128
 None
 0.64A 4iizA-3okyA:
undetectable		 4iizA-3okyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 LYS A   6
LEU A  27
ALA A  45
 None
 0.81A 4iizA-3ooqA:
undetectable		 4iizA-3ooqA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LYS A 187
LEU A 213
ALA A 172
 None
 0.67A 4iizA-3oryA:
undetectable		 4iizA-3oryA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 LYS A 236
LEU A 232
ALA A 235
 None
 0.80A 4iizA-3ptkA:
undetectable		 4iizA-3ptkA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4n UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		3 LYS A 107
LEU A 154
ALA A 110
 None
 0.70A 4iizA-3q4nA:
undetectable		 4iizA-3q4nA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		3 LYS A  82
LEU A  84
ALA A  74
 None
 0.58A 4iizA-3q54A:
undetectable		 4iizA-3q54A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsj NUDIX HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF00293
(NUDIX) 		3 LYS A   6
LEU A  72
ALA A  46
 None
 0.73A 4iizA-3qsjA:
undetectable		 4iizA-3qsjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrk V-TYPE ATPASE 116
KDA SUBUNIT

(Meiothermus
ruber) 		no annotation 3 LYS A 262
LEU A  49
ALA A 265
 None
 0.81A 4iizA-3rrkA:
undetectable		 4iizA-3rrkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 LYS A 820
LEU A 822
ALA A 817
 None
 0.55A 4iizA-3sfzA:
undetectable		 4iizA-3sfzA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		3 LYS A 231
LEU A 236
ALA A 263
 None
 0.75A 4iizA-3tc8A:
undetectable		 4iizA-3tc8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgd THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 LYS A 143
LEU A 141
ALA A  79
 None
 0.74A 4iizA-3wgdA:
undetectable		 4iizA-3wgdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 3 LYS A 146
LEU A 148
ALA A 201
 None
 0.66A 4iizA-3zphA:
undetectable		 4iizA-3zphA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxi ACCESSORY GENE
REGULATOR PROTEIN C

(Staphylococcus
aureus) 		PF14501
(HATPase_c_5) 		3 LYS A 300
LEU A 296
ALA A 299
 None
 0.81A 4iizA-4bxiA:
undetectable		 4iizA-4bxiA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 670
LEU A 672
ALA A 687
 TPO  A 958 ( 2.8A)
None
None
 0.64A 4iizA-4crsA:
undetectable		 4iizA-4crsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		3 LYS A  34
LEU A  30
ALA A  33
 None
 0.82A 4iizA-4d5rA:
undetectable		 4iizA-4d5rA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LYS A 184
LEU A 192
ALA A 218
 None
 0.73A 4iizA-4dnsA:
undetectable		 4iizA-4dnsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		3 LYS A  68
LEU A 320
ALA A  66
 None
 0.85A 4iizA-4eygA:
undetectable		 4iizA-4eygA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 LYS A 163
LEU A 159
ALA A 195
 None
 0.80A 4iizA-4fmvA:
undetectable		 4iizA-4fmvA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht4 NICKING ENZYME

(Staphylococcus
aureus) 		PF03389
(MobA_MobL) 		3 LYS A  22
LEU A 135
ALA A  19
 None
 0.82A 4iizA-4ht4A:
undetectable		 4iizA-4ht4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		3 LYS A  45
LEU A 321
ALA A  46
 None
 0.81A 4iizA-4i2yA:
undetectable		 4iizA-4i2yA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		3 LYS A 219
LEU A 191
ALA A 220
 None
 0.69A 4iizA-4jejA:
undetectable		 4iizA-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 112
LEU A 108
ALA A 111
 None
 0.64A 4iizA-4l7tA:
undetectable		 4iizA-4l7tA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		3 LYS A 160
LEU A 156
ALA A 159
 None
 0.84A 4iizA-4l9mA:
undetectable		 4iizA-4l9mA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1048
LEU A1027
ALA A1045
 None
 0.83A 4iizA-4lnvA:
5.4		 4iizA-4lnvA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		3 LYS A 426
LEU A 424
ALA A 470
 None
CA  A 702 ( 4.5A)
None
 0.68A 4iizA-4mr0A:
undetectable		 4iizA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		3 LYS A1060
LEU A1015
ALA A1063
 None
 0.84A 4iizA-4n9nA:
undetectable		 4iizA-4n9nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 634
LEU A 636
ALA A 651
 SEP  A 922 ( 2.8A)
None
None
 0.56A 4iizA-4otdA:
undetectable		 4iizA-4otdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		3 LYS A 176
LEU A 178
ALA A 131
 None
 0.60A 4iizA-4oteA:
undetectable		 4iizA-4oteA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 LYS A 247
LEU A 215
ALA A 244
 None
 0.85A 4iizA-4q6rA:
undetectable		 4iizA-4q6rA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 LYS B  36
LEU B  32
ALA B  35
 None
 0.76A 4iizA-4ritB:
undetectable		 4iizA-4ritB:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		3 LYS A 185
LEU A 181
ALA A 184
 None
 0.79A 4iizA-4uarA:
undetectable		 4iizA-4uarA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		3 LYS A  85
LEU A 128
ALA A 151
 None
 0.82A 4iizA-4xfkA:
undetectable		 4iizA-4xfkA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 LYS A 406
LEU A 385
ALA A 405
 None
 0.80A 4iizA-4xz8A:
undetectable		 4iizA-4xz8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		3 LYS A   2
LEU A   9
ALA A 110
 None
 0.65A 4iizA-5a35A:
undetectable		 4iizA-5a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		3 LYS A1181
LEU A 975
ALA A1182
 None
 0.84A 4iizA-5bp3A:
undetectable		 4iizA-5bp3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 290
LEU A 286
ALA A 289
 None
 0.72A 4iizA-5bswA:
undetectable		 4iizA-5bswA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9s RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 LYS B1631
LEU B1627
ALA B1630
 None
 0.67A 4iizA-5c9sB:
undetectable		 4iizA-5c9sB:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez1 PUTATIVE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
HP_0175

(Helicobacter
pylori) 		PF00639
(Rotamase) 		3 LYS A 254
LEU A 251
ALA A 157
 None
 0.62A 4iizA-5ez1A:
undetectable		 4iizA-5ez1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 3 LYS I 704
LEU I 759
ALA I 706
 None
 0.72A 4iizA-5furI:
1.8		 4iizA-5furI:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gox DNA REPAIR PROTEIN
RAD50

(Homo sapiens) 		PF04423
(Rad50_zn_hook) 		3 LYS A 711
LEU A 659
ALA A 708
 None
 0.83A 4iizA-5goxA:
undetectable		 4iizA-5goxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI)
PF00057
(Ldl_recept_a)
PF07502
(MANEC) 		3 LYS A 172
LEU A 241
ALA A 299
 None
 0.74A 4iizA-5h7vA:
undetectable		 4iizA-5h7vA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A  83
LEU A  81
ALA A  27
 None
 0.66A 4iizA-5hqlA:
undetectable		 4iizA-5hqlA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 3 LYS A 127
LEU A 133
ALA A 128
 None
 0.68A 4iizA-5ig8A:
undetectable		 4iizA-5ig8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LYS A 361
LEU A 411
ALA A 358
 None
 0.73A 4iizA-5j6sA:
undetectable		 4iizA-5j6sA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkr DNA POLYMERASE
PROCESSIVITY FACTOR
COMPONENT A20

(Vaccinia virus) 		no annotation 3 LYS D  30
LEU D  16
ALA D  27
 None
 0.77A 4iizA-5jkrD:
undetectable		 4iizA-5jkrD:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 LYS A 276
LEU A 290
ALA A 345
 SO4  A 600 (-3.1A)
None
None
 0.55A 4iizA-5jm7A:
undetectable		 4iizA-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 LYS A 138
LEU A 140
ALA A 128
 None
 0.60A 4iizA-5l5gA:
undetectable		 4iizA-5l5gA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 LYS A 802
LEU A 627
ALA A 799
 None
 0.82A 4iizA-5lewA:
undetectable		 4iizA-5lewA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG

(Homo sapiens) 		PF08202
(MIS13) 		3 LYS D 176
LEU D 139
ALA D 179
 None
 0.84A 4iizA-5lskD:
undetectable		 4iizA-5lskD:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lyn SMALL GLUTAMINE-RICH
TETRATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN 2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 180
LEU A 176
ALA A 179
 None
 0.74A 4iizA-5lynA:
undetectable		 4iizA-5lynA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		3 LYS A  96
LEU A  94
ALA A 142
 None
 0.82A 4iizA-5mifA:
undetectable		 4iizA-5mifA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omb DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Kluyveromyces
lactis) 		no annotation 3 LYS C  44
LEU C  40
ALA C  43
 None
 0.84A 4iizA-5ombC:
undetectable		 4iizA-5ombC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 286
LEU A 284
ALA A 276
 None
 0.84A 4iizA-5suiA:
undetectable		 4iizA-5suiA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 LYS 2 441
LEU 2 438
ALA 2 440
 None
 0.74A 4iizA-5udb2:
undetectable		 4iizA-5udb2:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 LYS B  61
LEU B 126
ALA B  62
 GSH  B 301 ( 3.9A)
None
None
 0.81A 4iizA-5uuoB:
undetectable		 4iizA-5uuoB:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 3 LYS A 222
LEU A 224
ALA A 136
 None
 0.54A 4iizA-5w1jA:
undetectable		 4iizA-5w1jA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwm RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1631
LEU A1627
ALA A1630
 None
 0.68A 4iizA-5wwmA:
undetectable		 4iizA-5wwmA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		3 LYS A 226
LEU A 222
ALA A 225
 None
 0.82A 4iizA-5x49A:
undetectable		 4iizA-5x49A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L2

(Mycolicibacterium
smegmatis) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		3 LYS C 168
LEU C 165
ALA C 173
 None
 0.68A 4iizA-5xymC:
undetectable		 4iizA-5xymC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 3 LYS A 333
LEU A 275
ALA A 335
 None
 0.64A 4iizA-6fheA:
undetectable		 4iizA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 3 LYS A 300
LEU A 298
ALA A 217
 None
 0.49A 4iizA-6fydA:
undetectable		 4iizA-6fydA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A  82
LEU A  80
ALA A  27
 None
 0.60A 4iizA-9rubA:
undetectable		 4iizA-9rubA:
15.01