SIMILAR PATTERNS OF AMINO ACIDS FOR 4IIL_A_RBFA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyo ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		4 PRO A 127
GLN A 123
ILE A 106
MET A 133
 None
 0.86A 4iilA-1dyoA:
undetectable		 4iilA-1dyoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		4 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-1e51A:
2.4		 4iilA-1e51A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PRO A  45
VAL A  46
PRO A 129
GLN A  33
 None
 0.94A 4iilA-1h3jA:
undetectable		 4iilA-1h3jA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 222
PRO A 186
GLN A 354
ILE A 235
 None
 0.72A 4iilA-1i41A:
6.4		 4iilA-1i41A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 PRO A 508
VAL A 507
PRO A 499
ILE A 671
 None
 1.09A 4iilA-1l1lA:
undetectable		 4iilA-1l1lA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw2 THIOREDOXIN

(Alicyclobacillus
acidocaldarius) 		PF00085
(Thioredoxin) 		4 VAL A  22
PRO A  83
GLN A  66
ILE A  69
 None
 0.94A 4iilA-1nw2A:
3.8		 4iilA-1nw2A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		5 PRO A  43
VAL A  42
PRO A 114
GLN A  32
ILE A 119
 None
 1.46A 4iilA-1qu9A:
undetectable		 4iilA-1qu9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4k ARGONAUTE 1

(Drosophila
melanogaster) 		PF02170
(PAZ) 		4 VAL A 305
PRO A 401
GLN A 404
ILE A 337
 None
 1.07A 4iilA-1r4kA:
undetectable		 4iilA-1r4kA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 PRO B  29
ASN B  39
PRO B  38
GLN C  67
GLN B 118
 FAD  B1900 (-3.6A)
None
None
None
FAD  B1900 (-3.2A)
 1.37A 4iilA-1sb3B:
undetectable		 4iilA-1sb3B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		4 VAL A 207
ASN A 158
GLN A 226
ILE A 255
 None
None
GOL  A1202 ( 4.7A)
None
 0.79A 4iilA-1sb7A:
undetectable		 4iilA-1sb7A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		4 PRO A 201
VAL A 202
PRO A  29
GLN A  20
 None
 1.07A 4iilA-1sfsA:
undetectable		 4iilA-1sfsA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		4 PRO A 228
ASN A 279
ILE A 284
MET A 202
 None
 1.06A 4iilA-1sjiA:
2.6		 4iilA-1sjiA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssq SERINE
ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ASN A  36
GLN A 108
GLN A  68
ILE A  73
 None
 1.10A 4iilA-1ssqA:
undetectable		 4iilA-1ssqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiv HIV-1 TRANSACTIVATOR
PROTEIN

(Human
immunodeficiency
virus 1) 		PF00539
(Tat) 		4 PRO A   3
VAL A   4
GLN A  60
ILE A  45
 None
 0.99A 4iilA-1tivA:
undetectable		 4iilA-1tivA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 PRO A  78
VAL A 146
ASN A 176
ILE A 190
 NA  A 289 ( 4.0A)
None
SO4  A 287 (-3.8A)
None
 0.96A 4iilA-1txzA:
undetectable		 4iilA-1txzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A  58
ASN A 160
PRO A 161
ILE A 168
 None
 1.07A 4iilA-1vcwA:
undetectable		 4iilA-1vcwA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 PRO A 535
VAL A 454
ASN A 445
ILE A 434
 None
 1.11A 4iilA-1xhbA:
undetectable		 4iilA-1xhbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2

(Pseudomonas
syringae) 		PF01507
(PAPS_reduct) 		4 PRO A 184
ASN A 168
GLN A  10
ILE A  16
 None
 1.04A 4iilA-1zunA:
2.9		 4iilA-1zunA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 PRO A 217
VAL A 220
PRO A 225
ILE A 306
 None
 1.10A 4iilA-2e3jA:
3.3		 4iilA-2e3jA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		4 VAL A 131
PRO A  20
GLN A  26
ILE A 134
 None
 1.08A 4iilA-2ejaA:
2.4		 4iilA-2ejaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PRO A 295
VAL A 298
PRO A 339
GLN A 274
 None
 1.05A 4iilA-2f43A:
2.7		 4iilA-2f43A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 PRO A 433
ASN A 224
ILE A 449
MET A 368
 None
 1.07A 4iilA-2f5vA:
2.3		 4iilA-2f5vA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inf UROPORPHYRINOGEN
DECARBOXYLASE

(Bacillus
subtilis) 		PF01208
(URO-D) 		4 VAL A 139
PRO A  24
GLN A  30
ILE A 142
 None
 1.01A 4iilA-2infA:
2.2		 4iilA-2infA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR

(Homo sapiens) 		PF11976
(Rad60-SLD) 		4 PRO B  72
ASN B  67
GLN B  64
ILE B  83
 None
 0.97A 4iilA-2io1B:
undetectable		 4iilA-2io1B:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 PRO A 161
VAL A 162
PRO A 195
ILE A 111
 CO  A1432 ( 4.7A)
None
None
None
 0.95A 4iilA-2j3zA:
undetectable		 4iilA-2j3zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 PRO X 350
VAL X 349
PRO X 336
ILE X 341
 None
 1.07A 4iilA-2jfeX:
undetectable		 4iilA-2jfeX:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 VAL B  51
ASN B 155
GLN B  59
MET B 128
 None
HEC  B 250 ( 4.7A)
HEC  B 250 (-4.1A)
None
 1.09A 4iilA-2jxmB:
undetectable		 4iilA-2jxmB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 650
PRO A 416
GLN A 406
ILE A 584
 None
 0.98A 4iilA-2nq5A:
undetectable		 4iilA-2nq5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 VAL A 149
PRO A  32
GLN A  38
ILE A 152
 None
 1.07A 4iilA-2q6zA:
2.5		 4iilA-2q6zA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASN A 130
PRO A 131
GLN A 328
ILE A 119
 None
 1.08A 4iilA-2qz9A:
6.2		 4iilA-2qz9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6u PTERIN-4A-CARBINOLAM
INE DEHYDRATASE

(Toxoplasma
gondii) 		PF01329
(Pterin_4a) 		4 VAL A  74
ASN A  64
ILE A  33
MET A  95
 None
NA  A2104 ( 4.5A)
None
None
 1.06A 4iilA-2v6uA:
undetectable		 4iilA-2v6uA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		4 ASN A 274
GLN A  39
GLN A 280
ILE A  53
 None
 1.03A 4iilA-2x7xA:
18.8		 4iilA-2x7xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-2z1bA:
2.3		 4iilA-2z1bA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 PRO A 204
GLN A 282
GLN A 220
ILE A 214
 None
 1.08A 4iilA-2zm5A:
undetectable		 4iilA-2zm5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 184
VAL A 196
GLN A 443
GLN A 391
 None
None
AMP  A 551 (-4.0A)
None
 1.01A 4iilA-3a9vA:
5.0		 4iilA-3a9vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PRO A 177
ASN A 376
PRO A 375
ILE A  82
 None
 1.02A 4iilA-3ahiA:
2.6		 4iilA-3ahiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 VAL A  93
ASN A 243
ILE A  82
MET A 107
 None
 1.10A 4iilA-3b6vA:
undetectable		 4iilA-3b6vA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 VAL A  76
ASN A 156
GLN A 165
ILE A 282
 None
 1.01A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 VAL A  76
ASN A 156
GLN A 165
MET A 103
 None
 0.92A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 VAL A 139
PRO A  22
GLN A  28
ILE A 142
 None
 1.01A 4iilA-3cyvA:
2.2		 4iilA-3cyvA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 PRO A 124
VAL A 123
ASN A   5
GLN A 248
 None
 1.08A 4iilA-3dbyA:
undetectable		 4iilA-3dbyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 532
ASN A 527
PRO A 528
ILE A 521
 None
 1.10A 4iilA-3e9yA:
4.4		 4iilA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 PRO A 216
VAL A 217
GLN A 190
ILE A 129
 None
 1.02A 4iilA-3gv1A:
2.2		 4iilA-3gv1A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		4 PRO A 209
GLN A 203
ILE A 253
MET A 294
 None
 1.07A 4iilA-3h41A:
undetectable		 4iilA-3h41A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 VAL A 115
PRO A  33
GLN A  48
ILE A  52
 None
 0.97A 4iilA-3hf1A:
undetectable		 4iilA-3hf1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 VAL A  32
ASN A  30
GLN A 312
ILE A 274
 None
 1.03A 4iilA-3ktnA:
3.8		 4iilA-3ktnA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		4 VAL A  91
PRO A 140
ILE A 207
MET A 214
 None
 1.10A 4iilA-3l3bA:
4.5		 4iilA-3l3bA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		4 PRO A 291
VAL A 290
ASN A 270
GLN A 241
 None
None
None
SF4  A 343 ( 4.4A)
 1.02A 4iilA-3lzdA:
4.0		 4iilA-3lzdA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 PRO A  52
VAL A  75
PRO A  68
GLN A  13
 None
 1.04A 4iilA-3m9uA:
undetectable		 4iilA-3m9uA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		4 VAL A 159
ASN A 223
GLN A 120
ILE A 127
 None
 0.91A 4iilA-3n28A:
3.1		 4iilA-3n28A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 PRO B 707
VAL B 706
GLN B 680
ILE B 905
 None
 1.11A 4iilA-3opyB:
2.7		 4iilA-3opyB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 VAL A 237
PRO A  48
ILE A 201
MET A 171
 None
 1.06A 4iilA-3pdiA:
4.6		 4iilA-3pdiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR

(Bacillus
subtilis) 		PF06445
(GyrI-like)
PF13411
(MerR_1) 		4 ASN A 168
PRO A 193
GLN A 115
ILE A 255
 None
None
None
TAC  A7101 (-4.2A)
 1.10A 4iilA-3q5pA:
undetectable		 4iilA-3q5pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 VAL A 306
GLN A 296
ILE A 284
MET A 275
 None
 0.98A 4iilA-3rb9A:
undetectable		 4iilA-3rb9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PRO A 156
ASN A 159
PRO A 163
ILE A 146
 None
 0.90A 4iilA-3tm5A:
undetectable		 4iilA-3tm5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		5 PRO A  43
VAL A  42
PRO A 115
GLN A  32
ILE A 120
 None
 1.37A 4iilA-3vczA:
undetectable		 4iilA-3vczA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PRO A2707
GLN A2765
ILE A2311
MET A2766
 None
 1.10A 4iilA-3vkgA:
undetectable		 4iilA-3vkgA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 VAL A 192
ASN A 232
GLN A  64
ILE A 171
 None
 1.06A 4iilA-3w3eA:
undetectable		 4iilA-3w3eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 VAL A 181
ASN A  52
ILE A  48
MET A 106
 None
 1.10A 4iilA-3wmtA:
undetectable		 4iilA-3wmtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 VAL A 400
PRO A 358
GLN A 228
ILE A 405
 None
 1.06A 4iilA-4c0hA:
3.6		 4iilA-4c0hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		4 VAL A 140
ASN A 136
GLN A 177
ILE A 295
 None
 0.99A 4iilA-4ci0A:
undetectable		 4iilA-4ci0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		4 VAL A 347
GLN A 364
ILE A 358
MET A   1
 None
 1.11A 4iilA-4hb9A:
5.3		 4iilA-4hb9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi) 		no annotation 4 VAL A  10
PRO A  37
GLN A 115
ILE A 282
 None
 1.01A 4iilA-4hcyA:
2.4		 4iilA-4hcyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 VAL A 231
ASN A 227
GLN A 223
ILE A 211
 None
 0.94A 4iilA-4hw8A:
3.1		 4iilA-4hw8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 VAL A 162
GLN A 174
GLN A 206
ILE A 211
 None
 1.02A 4iilA-4i6kA:
undetectable		 4iilA-4i6kA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 VAL A 153
GLN A 244
GLN A 181
ILE A 218
 None
 1.09A 4iilA-4jqsA:
4.3		 4iilA-4jqsA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 PRO A 111
ASN A  87
GLN A  82
ILE A 128
 None
 1.09A 4iilA-4n4pA:
2.6		 4iilA-4n4pA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF04205
(FMN_bind) 		4 PRO C 174
ASN C 182
PRO C 183
ILE D  97
 None
 0.99A 4iilA-4p6vC:
undetectable		 4iilA-4p6vC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 PRO A 125
VAL A 126
ILE A 121
MET A 156
 BMA  A 603 ( 4.2A)
BMA  A 603 ( 4.6A)
None
BMA  A 603 ( 3.8A)
 1.07A 4iilA-4pfyA:
2.4		 4iilA-4pfyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ASN H 273
PRO H 108
GLN H 215
ILE H 224
 None
 1.06A 4iilA-4qslH:
4.0		 4iilA-4qslH:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 VAL A 329
ASN A 325
PRO A 290
MET A 151
 None
 1.11A 4iilA-4ru0A:
8.3		 4iilA-4ru0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLN A 327
ILE A 331
MET A 323
 None
 1.09A 4iilA-4rwfA:
3.6		 4iilA-4rwfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A 160
PRO A 196
GLN A 200
ILE A 207
 None
 1.10A 4iilA-4u2nA:
undetectable		 4iilA-4u2nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 PRO A 204
ASN A 207
GLN A 554
ILE A 549
 None
NAG  A1632 (-1.9A)
None
None
 1.04A 4iilA-4uf7A:
undetectable		 4iilA-4uf7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 PRO A 119
ASN A  95
GLN A  90
ILE A 136
 None
 1.08A 4iilA-4woqA:
undetectable		 4iilA-4woqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 VAL A 625
PRO A 613
GLN A 585
ILE A 581
 None
 1.06A 4iilA-4xhbA:
undetectable		 4iilA-4xhbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 PRO A 233
PRO A 164
GLN A  65
ILE A 230
 None
 1.03A 4iilA-4xuvA:
undetectable		 4iilA-4xuvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 PRO A  50
PRO A 155
ILE A 349
MET A 387
 None
 0.98A 4iilA-4y9lA:
undetectable		 4iilA-4y9lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		5 VAL A  47
ASN A 105
PRO A 106
GLN A 284
ILE A 127
 None
 1.28A 4iilA-4yo7A:
19.1		 4iilA-4yo7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 VAL A1016
GLN A 805
ILE A 795
MET A1010
 None
 1.07A 4iilA-4zlrA:
undetectable		 4iilA-4zlrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afo FIMBRIAE

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 PRO A 283
VAL A 294
ASN A 225
ILE A 229
 None
 1.09A 4iilA-5afoA:
undetectable		 4iilA-5afoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 164
VAL A 163
PRO A 126
ILE A 340
 None
None
None
EDO  A 401 (-4.6A)
 1.06A 4iilA-5cefA:
5.1		 4iilA-5cefA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 481
PRO A 473
GLN A 465
GLN A 429
 None
 1.03A 4iilA-5e7qA:
5.1		 4iilA-5e7qA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 ASN A 950
PRO A 951
GLN A 921
ILE A 927
 None
 1.07A 4iilA-5h42A:
undetectable		 4iilA-5h42A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 PRO A 637
VAL A 664
PRO A 187
GLN A 138
GLN A 183
 None
 1.33A 4iilA-5h7jA:
2.4		 4iilA-5h7jA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PRO A  99
VAL A 101
GLN A 323
ILE A 169
 None
None
None
NAP  A 501 (-4.1A)
 1.05A 4iilA-5ijzA:
5.0		 4iilA-5ijzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE

(Auricularia
auricula-judae) 		PF04261
(Dyp_perox) 		4 ASN A 328
GLN A 172
GLN A 365
ILE A 193
 None
 0.97A 4iilA-5ikgA:
undetectable		 4iilA-5ikgA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 602
ASN A 594
PRO A 595
ILE A 738
 None
 1.11A 4iilA-5kf7A:
undetectable		 4iilA-5kf7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 4 VAL B 289
PRO B 300
GLN A 166
ILE A  21
 None
 1.06A 4iilA-5m22B:
undetectable		 4iilA-5m22B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 PRO A 129
ASN A  26
GLN A 108
ILE A 209
 None
GLC  A 501 (-3.8A)
GLC  A 501 (-3.1A)
None
 1.08A 4iilA-5od2A:
4.1		 4iilA-5od2A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 269
PRO A 105
GLN A 211
ILE A 220
 None
 1.03A 4iilA-5vywA:
2.6		 4iilA-5vywA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 VAL B  57
ASN B  66
PRO B  67
GLN B  73
 None
 1.06A 4iilA-5y3rB:
6.0		 4iilA-5y3rB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 PRO A 195
VAL A 194
GLN A 280
ILE A 275
 None
 0.94A 4iilA-5zqzA:
2.6		 4iilA-5zqzA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 4 VAL C 488
PRO C 220
GLN C 103
MET C 100
 None
 1.04A 4iilA-6ccbC:
undetectable		 4iilA-6ccbC:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 ASN A 368
PRO A 369
GLN A 447
ILE A 478
 None
 0.76A 4iilA-6cipA:
4.1		 4iilA-6cipA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 4 PRO A 273
VAL A 274
GLN A  20
ILE A 269
 None
 0.97A 4iilA-6cj7A:
undetectable		 4iilA-6cj7A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens) 		no annotation 4 PRO A 319
VAL A 318
ASN A 543
GLN A 405
 None
 1.04A 4iilA-6d1wA:
undetectable		 4iilA-6d1wA:
12.72