SIMILAR PATTERNS OF AMINO ACIDS FOR 4IIL_A_RBFA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 TYR A 333
TRP A  49
ALA A 148
GLN A 184
GLY A 335
 None
 1.37A 4iilA-1cpyA:
2.2		 4iilA-1cpyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 ALA A 158
GLN A 240
ILE A 105
GLY A 219
ASP A 252
 None
 1.33A 4iilA-1dlmA:
undetectable		 4iilA-1dlmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		5 SER A  55
GLN A  14
ALA A 126
GLN A  98
TYR A  20
 None
 1.44A 4iilA-1ftpA:
undetectable		 4iilA-1ftpA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 SER A  21
GLN A 706
ALA A 648
ASP A 602
ILE A 640
 None
 1.48A 4iilA-1j1wA:
5.3		 4iilA-1j1wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 SER A 285
TYR A 342
ASP A  96
TYR A 119
GLY A 284
 None
DAN  A 700 (-3.5A)
DAN  A 700 (-3.3A)
DAN  A 700 (-4.2A)
None
 1.11A 4iilA-1ms8A:
undetectable		 4iilA-1ms8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 SER A 526
TYR A 528
ALA A 505
ASP A 658
GLN A 659
 None
 1.44A 4iilA-1pemA:
undetectable		 4iilA-1pemA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		5 SER A 280
TYR A 276
ALA A 233
ILE A 261
GLY A 191
 ZFB  A 450 (-4.7A)
None
None
None
ZFB  A 450 ( 4.1A)
 1.24A 4iilA-1pvjA:
undetectable		 4iilA-1pvjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s24 RUBREDOXIN 2

(Pseudomonas
oleovorans) 		PF00301
(Rubredoxin) 		5 ALA A  45
TYR A  50
ILE A   6
TRP A  38
GLY A  19
 None
 1.41A 4iilA-1s24A:
undetectable		 4iilA-1s24A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		5 TYR A 182
TRP A 210
ALA A 157
GLY A 178
ASP A 107
 None
None
None
None
MES  A 500 (-3.6A)
 1.39A 4iilA-2atmA:
undetectable		 4iilA-2atmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 TYR A 222
ASP A 276
GLN A 293
ILE A 298
GLY A 126
 SO4  A4397 (-4.2A)
SO4  A4396 (-3.5A)
SO4  A4397 ( 4.9A)
None
None
 1.43A 4iilA-2fepA:
18.8		 4iilA-2fepA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 TYR A 598
TYR A 686
ILE A 652
TRP A 578
GLY A 575
 None
 1.48A 4iilA-2g28A:
2.8		 4iilA-2g28A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		5 SER A 135
TYR A 131
ALA A  88
ILE A 116
GLY A  46
 None
 1.21A 4iilA-2jtcA:
undetectable		 4iilA-2jtcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 TYR A 190
GLN A 288
ALA A 264
GLN A 256
GLY A 123
 EPU  A 402 (-4.1A)
EPU  A 402 (-3.1A)
EPU  A 402 (-3.4A)
None
FAD  A 401 (-4.1A)
 1.12A 4iilA-2mbrA:
undetectable		 4iilA-2mbrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 SER B 403
ALA B 322
GLN B 269
ILE B 372
GLY B 404
 None
 1.06A 4iilA-2rhqB:
undetectable		 4iilA-2rhqB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 SER A 169
TYR A 212
ALA A 333
ASP A 233
GLY A 168
 None
SRM  B 503 (-4.4A)
SRM  B 503 (-3.4A)
None
None
 1.15A 4iilA-2v4jA:
undetectable		 4iilA-2v4jA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 SER A  79
ALA A  37
ASP A  33
ILE A 297
GLY A  78
 PP6  A 327 (-3.4A)
None
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.2A)
None
 1.44A 4iilA-2wedA:
undetectable		 4iilA-2wedA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 SER A 169
TYR A 212
ALA A 333
ASP A 233
GLY A 168
 None
SRM  B 503 (-4.6A)
SRM  B 503 (-3.6A)
None
None
 1.17A 4iilA-2xsjA:
undetectable		 4iilA-2xsjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 SER A 911
TYR A 913
ALA A 851
GLY A 910
ASP A 181
 None
 1.43A 4iilA-3ecqA:
undetectable		 4iilA-3ecqA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 SER A  79
TYR A 104
GLN A 176
ASP A 133
GLN A 141
 None
None
GOL  A 764 (-3.1A)
None
None
 1.33A 4iilA-3eqnA:
undetectable		 4iilA-3eqnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 ALA A 245
ASP A 187
ILE A 253
GLY A 236
ASP A 212
 None
SAH  A 346 ( 4.5A)
SAH  A 346 (-4.9A)
None
SAH  A 346 (-3.0A)
 1.49A 4iilA-3lstA:
2.9		 4iilA-3lstA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 SER A 167
TYR A 210
ALA A 315
ASP A 231
GLY A 166
 None
SRM  A 580 (-4.5A)
SRM  A 580 (-3.3A)
None
None
 1.20A 4iilA-3mm5A:
undetectable		 4iilA-3mm5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 TYR A 222
ASP A 276
GLN A 293
ILE A 298
GLY A 126
 None
 1.40A 4iilA-3oqnA:
18.5		 4iilA-3oqnA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		5 SER A 169
TYR A 212
ALA A 333
ASP A 233
GLY A 168
 None
SRM  A 582 (-4.6A)
SRM  A 582 (-3.4A)
None
None
 1.19A 4iilA-3or2A:
undetectable		 4iilA-3or2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 GLN A 114
ALA A 160
ILE A 165
GLY A  65
ASP A  11
 None
None
AMP  A 263 (-4.6A)
None
FE  A 264 (-3.0A)
 1.07A 4iilA-3qfoA:
undetectable		 4iilA-3qfoA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		5 SER A 198
TYR A 233
GLN A 270
ASP A 221
ASP A 218
 None
None
None
MG  A 503 ( 4.7A)
MG  A 502 (-1.9A)
 1.43A 4iilA-3tdwA:
undetectable		 4iilA-3tdwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		5 SER A 253
TYR A 251
ALA A 212
ASP A 208
GLY A 254
 None
None
None
PLP  A 397 (-2.9A)
None
 1.42A 4iilA-3tqxA:
7.7		 4iilA-3tqxA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 5 ALA C1107
GLN C1111
ILE C1131
GLY C1179
ASP C1181
 None
 1.27A 4iilA-3ud2C:
undetectable		 4iilA-3ud2C:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 TYR A 527
ALA A 512
TYR A 427
ILE A 477
GLY A 400
 None
 1.31A 4iilA-3welA:
undetectable		 4iilA-3welA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 384
ASP A 168
GLN A 164
ILE A 211
GLY A 202
 None
 1.37A 4iilA-4apbA:
undetectable		 4iilA-4apbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		5 TYR A  98
ALA A 105
TYR A  73
ILE A 419
GLY A  16
 None
 1.50A 4iilA-4b3kA:
undetectable		 4iilA-4b3kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 134
ALA A 322
ILE A  22
GLY A 263
ASP A 193
 None
None
None
None
MG  A 401 ( 2.7A)
 1.49A 4iilA-4h2hA:
4.1		 4iilA-4h2hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 SER A 212
TYR A 214
ASP A 154
TRP A 607
GLY A 604
 None
 1.00A 4iilA-4hvtA:
3.4		 4iilA-4hvtA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 SER A 241
ALA A 373
GLN A  23
TYR A 401
ILE A 135
 None
 1.45A 4iilA-4l87A:
undetectable		 4iilA-4l87A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 SER A 355
ASP A 290
GLN A 292
ILE A 294
GLY A 314
 None
 1.19A 4iilA-4p72A:
undetectable		 4iilA-4p72A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		5 SER A  47
ALA A  56
GLN A 135
GLY A  46
ASP A 250
 None
None
SR1  A 401 (-3.5A)
None
SR1  A 401 (-2.7A)
 1.41A 4iilA-4ry8A:
19.4		 4iilA-4ry8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		5 SER A  17
ALA A  79
ILE A  54
GLY A  16
ASP A  34
 None
None
NAD  A 400 (-3.8A)
None
NAD  A 400 (-2.7A)
 1.42A 4iilA-4twrA:
6.3		 4iilA-4twrA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		5 SER A 206
TRP A 279
ALA A 128
ASP A 249
GLY A  41
 None
 1.15A 4iilA-4y7dA:
2.9		 4iilA-4y7dA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 SER A 200
ALA A 280
GLN A  54
TYR A 276
GLY A 237
 None
 1.24A 4iilA-4zgzA:
2.2		 4iilA-4zgzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 TRP A 258
ALA A 272
ASP A 233
ILE A 158
GLY A 308
 None
 1.42A 4iilA-5d8wA:
undetectable		 4iilA-5d8wA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 SER A1005
GLN A 921
ILE A 601
GLY A1007
ASP A 608
 G1P  A1201 (-2.5A)
None
None
None
None
 0.96A 4iilA-5h42A:
undetectable		 4iilA-5h42A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens) 		PF13895
(Ig_2) 		5 ALA D 176
ASP D 123
GLN D 121
ILE D 158
GLY D 153
 None
 1.34A 4iilA-5knmD:
undetectable		 4iilA-5knmD:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 TYR A 150
ALA A 116
TYR A 275
ILE A 315
GLY A 323
 None
 1.43A 4iilA-5nv3A:
3.1		 4iilA-5nv3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A 349
TYR A 352
ASP A 379
GLN A 375
GLY A 273
 None
None
None
None
PG5  A 501 (-4.2A)
 1.33A 4iilA-5w4xA:
undetectable		 4iilA-5w4xA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 SER C 115
ALA C 174
TYR C 178
ILE C 574
GLY C 114
 None
 1.31A 4iilA-5x6xC:
5.0		 4iilA-5x6xC:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 5 SER A 225
TYR A 158
ILE A 139
GLY A 247
ASP A 249
 None
 1.43A 4iilA-6c2hA:
undetectable		 4iilA-6c2hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyo ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		4 PRO A 127
GLN A 123
ILE A 106
MET A 133
 None
 0.86A 4iilA-1dyoA:
undetectable		 4iilA-1dyoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		4 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-1e51A:
2.4		 4iilA-1e51A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PRO A  45
VAL A  46
PRO A 129
GLN A  33
 None
 0.94A 4iilA-1h3jA:
undetectable		 4iilA-1h3jA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 222
PRO A 186
GLN A 354
ILE A 235
 None
 0.72A 4iilA-1i41A:
6.4		 4iilA-1i41A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 PRO A 508
VAL A 507
PRO A 499
ILE A 671
 None
 1.09A 4iilA-1l1lA:
undetectable		 4iilA-1l1lA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw2 THIOREDOXIN

(Alicyclobacillus
acidocaldarius) 		PF00085
(Thioredoxin) 		4 VAL A  22
PRO A  83
GLN A  66
ILE A  69
 None
 0.94A 4iilA-1nw2A:
3.8		 4iilA-1nw2A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		5 PRO A  43
VAL A  42
PRO A 114
GLN A  32
ILE A 119
 None
 1.46A 4iilA-1qu9A:
undetectable		 4iilA-1qu9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4k ARGONAUTE 1

(Drosophila
melanogaster) 		PF02170
(PAZ) 		4 VAL A 305
PRO A 401
GLN A 404
ILE A 337
 None
 1.07A 4iilA-1r4kA:
undetectable		 4iilA-1r4kA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 PRO B  29
ASN B  39
PRO B  38
GLN C  67
GLN B 118
 FAD  B1900 (-3.6A)
None
None
None
FAD  B1900 (-3.2A)
 1.37A 4iilA-1sb3B:
undetectable		 4iilA-1sb3B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		4 VAL A 207
ASN A 158
GLN A 226
ILE A 255
 None
None
GOL  A1202 ( 4.7A)
None
 0.79A 4iilA-1sb7A:
undetectable		 4iilA-1sb7A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		4 PRO A 201
VAL A 202
PRO A  29
GLN A  20
 None
 1.07A 4iilA-1sfsA:
undetectable		 4iilA-1sfsA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		4 PRO A 228
ASN A 279
ILE A 284
MET A 202
 None
 1.06A 4iilA-1sjiA:
2.6		 4iilA-1sjiA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssq SERINE
ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ASN A  36
GLN A 108
GLN A  68
ILE A  73
 None
 1.10A 4iilA-1ssqA:
undetectable		 4iilA-1ssqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiv HIV-1 TRANSACTIVATOR
PROTEIN

(Human
immunodeficiency
virus 1) 		PF00539
(Tat) 		4 PRO A   3
VAL A   4
GLN A  60
ILE A  45
 None
 0.99A 4iilA-1tivA:
undetectable		 4iilA-1tivA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 PRO A  78
VAL A 146
ASN A 176
ILE A 190
 NA  A 289 ( 4.0A)
None
SO4  A 287 (-3.8A)
None
 0.96A 4iilA-1txzA:
undetectable		 4iilA-1txzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A  58
ASN A 160
PRO A 161
ILE A 168
 None
 1.07A 4iilA-1vcwA:
undetectable		 4iilA-1vcwA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 PRO A 535
VAL A 454
ASN A 445
ILE A 434
 None
 1.11A 4iilA-1xhbA:
undetectable		 4iilA-1xhbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2

(Pseudomonas
syringae) 		PF01507
(PAPS_reduct) 		4 PRO A 184
ASN A 168
GLN A  10
ILE A  16
 None
 1.04A 4iilA-1zunA:
2.9		 4iilA-1zunA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 PRO A 217
VAL A 220
PRO A 225
ILE A 306
 None
 1.10A 4iilA-2e3jA:
3.3		 4iilA-2e3jA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		4 VAL A 131
PRO A  20
GLN A  26
ILE A 134
 None
 1.08A 4iilA-2ejaA:
2.4		 4iilA-2ejaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PRO A 295
VAL A 298
PRO A 339
GLN A 274
 None
 1.05A 4iilA-2f43A:
2.7		 4iilA-2f43A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 PRO A 433
ASN A 224
ILE A 449
MET A 368
 None
 1.07A 4iilA-2f5vA:
2.3		 4iilA-2f5vA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inf UROPORPHYRINOGEN
DECARBOXYLASE

(Bacillus
subtilis) 		PF01208
(URO-D) 		4 VAL A 139
PRO A  24
GLN A  30
ILE A 142
 None
 1.01A 4iilA-2infA:
2.2		 4iilA-2infA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR

(Homo sapiens) 		PF11976
(Rad60-SLD) 		4 PRO B  72
ASN B  67
GLN B  64
ILE B  83
 None
 0.97A 4iilA-2io1B:
undetectable		 4iilA-2io1B:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 PRO A 161
VAL A 162
PRO A 195
ILE A 111
 CO  A1432 ( 4.7A)
None
None
None
 0.95A 4iilA-2j3zA:
undetectable		 4iilA-2j3zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 PRO X 350
VAL X 349
PRO X 336
ILE X 341
 None
 1.07A 4iilA-2jfeX:
undetectable		 4iilA-2jfeX:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 VAL B  51
ASN B 155
GLN B  59
MET B 128
 None
HEC  B 250 ( 4.7A)
HEC  B 250 (-4.1A)
None
 1.09A 4iilA-2jxmB:
undetectable		 4iilA-2jxmB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 650
PRO A 416
GLN A 406
ILE A 584
 None
 0.98A 4iilA-2nq5A:
undetectable		 4iilA-2nq5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 VAL A 149
PRO A  32
GLN A  38
ILE A 152
 None
 1.07A 4iilA-2q6zA:
2.5		 4iilA-2q6zA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASN A 130
PRO A 131
GLN A 328
ILE A 119
 None
 1.08A 4iilA-2qz9A:
6.2		 4iilA-2qz9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6u PTERIN-4A-CARBINOLAM
INE DEHYDRATASE

(Toxoplasma
gondii) 		PF01329
(Pterin_4a) 		4 VAL A  74
ASN A  64
ILE A  33
MET A  95
 None
NA  A2104 ( 4.5A)
None
None
 1.06A 4iilA-2v6uA:
undetectable		 4iilA-2v6uA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		4 ASN A 274
GLN A  39
GLN A 280
ILE A  53
 None
 1.03A 4iilA-2x7xA:
18.8		 4iilA-2x7xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-2z1bA:
2.3		 4iilA-2z1bA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 PRO A 204
GLN A 282
GLN A 220
ILE A 214
 None
 1.08A 4iilA-2zm5A:
undetectable		 4iilA-2zm5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 184
VAL A 196
GLN A 443
GLN A 391
 None
None
AMP  A 551 (-4.0A)
None
 1.01A 4iilA-3a9vA:
5.0		 4iilA-3a9vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PRO A 177
ASN A 376
PRO A 375
ILE A  82
 None
 1.02A 4iilA-3ahiA:
2.6		 4iilA-3ahiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 VAL A  93
ASN A 243
ILE A  82
MET A 107
 None
 1.10A 4iilA-3b6vA:
undetectable		 4iilA-3b6vA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 VAL A  76
ASN A 156
GLN A 165
ILE A 282
 None
 1.01A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 VAL A  76
ASN A 156
GLN A 165
MET A 103
 None
 0.92A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 VAL A 139
PRO A  22
GLN A  28
ILE A 142
 None
 1.01A 4iilA-3cyvA:
2.2		 4iilA-3cyvA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 PRO A 124
VAL A 123
ASN A   5
GLN A 248
 None
 1.08A 4iilA-3dbyA:
undetectable		 4iilA-3dbyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 532
ASN A 527
PRO A 528
ILE A 521
 None
 1.10A 4iilA-3e9yA:
4.4		 4iilA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 PRO A 216
VAL A 217
GLN A 190
ILE A 129
 None
 1.02A 4iilA-3gv1A:
2.2		 4iilA-3gv1A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		4 PRO A 209
GLN A 203
ILE A 253
MET A 294
 None
 1.07A 4iilA-3h41A:
undetectable		 4iilA-3h41A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 VAL A 115
PRO A  33
GLN A  48
ILE A  52
 None
 0.97A 4iilA-3hf1A:
undetectable		 4iilA-3hf1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 VAL A  32
ASN A  30
GLN A 312
ILE A 274
 None
 1.03A 4iilA-3ktnA:
3.8		 4iilA-3ktnA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		4 VAL A  91
PRO A 140
ILE A 207
MET A 214
 None
 1.10A 4iilA-3l3bA:
4.5		 4iilA-3l3bA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		4 PRO A 291
VAL A 290
ASN A 270
GLN A 241
 None
None
None
SF4  A 343 ( 4.4A)
 1.02A 4iilA-3lzdA:
4.0		 4iilA-3lzdA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 PRO A  52
VAL A  75
PRO A  68
GLN A  13
 None
 1.04A 4iilA-3m9uA:
undetectable		 4iilA-3m9uA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		4 VAL A 159
ASN A 223
GLN A 120
ILE A 127
 None
 0.91A 4iilA-3n28A:
3.1		 4iilA-3n28A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 PRO B 707
VAL B 706
GLN B 680
ILE B 905
 None
 1.11A 4iilA-3opyB:
2.7		 4iilA-3opyB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 VAL A 237
PRO A  48
ILE A 201
MET A 171
 None
 1.06A 4iilA-3pdiA:
4.6		 4iilA-3pdiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR

(Bacillus
subtilis) 		PF06445
(GyrI-like)
PF13411
(MerR_1) 		4 ASN A 168
PRO A 193
GLN A 115
ILE A 255
 None
None
None
TAC  A7101 (-4.2A)
 1.10A 4iilA-3q5pA:
undetectable		 4iilA-3q5pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 VAL A 306
GLN A 296
ILE A 284
MET A 275
 None
 0.98A 4iilA-3rb9A:
undetectable		 4iilA-3rb9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PRO A 156
ASN A 159
PRO A 163
ILE A 146
 None
 0.90A 4iilA-3tm5A:
undetectable		 4iilA-3tm5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		5 PRO A  43
VAL A  42
PRO A 115
GLN A  32
ILE A 120
 None
 1.37A 4iilA-3vczA:
undetectable		 4iilA-3vczA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PRO A2707
GLN A2765
ILE A2311
MET A2766
 None
 1.10A 4iilA-3vkgA:
undetectable		 4iilA-3vkgA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 VAL A 192
ASN A 232
GLN A  64
ILE A 171
 None
 1.06A 4iilA-3w3eA:
undetectable		 4iilA-3w3eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 VAL A 181
ASN A  52
ILE A  48
MET A 106
 None
 1.10A 4iilA-3wmtA:
undetectable		 4iilA-3wmtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 VAL A 400
PRO A 358
GLN A 228
ILE A 405
 None
 1.06A 4iilA-4c0hA:
3.6		 4iilA-4c0hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		4 VAL A 140
ASN A 136
GLN A 177
ILE A 295
 None
 0.99A 4iilA-4ci0A:
undetectable		 4iilA-4ci0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		4 VAL A 347
GLN A 364
ILE A 358
MET A   1
 None
 1.11A 4iilA-4hb9A:
5.3		 4iilA-4hb9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi) 		no annotation 4 VAL A  10
PRO A  37
GLN A 115
ILE A 282
 None
 1.01A 4iilA-4hcyA:
2.4		 4iilA-4hcyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 VAL A 231
ASN A 227
GLN A 223
ILE A 211
 None
 0.94A 4iilA-4hw8A:
3.1		 4iilA-4hw8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 VAL A 162
GLN A 174
GLN A 206
ILE A 211
 None
 1.02A 4iilA-4i6kA:
undetectable		 4iilA-4i6kA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 VAL A 153
GLN A 244
GLN A 181
ILE A 218
 None
 1.09A 4iilA-4jqsA:
4.3		 4iilA-4jqsA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 PRO A 111
ASN A  87
GLN A  82
ILE A 128
 None
 1.09A 4iilA-4n4pA:
2.6		 4iilA-4n4pA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF04205
(FMN_bind) 		4 PRO C 174
ASN C 182
PRO C 183
ILE D  97
 None
 0.99A 4iilA-4p6vC:
undetectable		 4iilA-4p6vC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 PRO A 125
VAL A 126
ILE A 121
MET A 156
 BMA  A 603 ( 4.2A)
BMA  A 603 ( 4.6A)
None
BMA  A 603 ( 3.8A)
 1.07A 4iilA-4pfyA:
2.4		 4iilA-4pfyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ASN H 273
PRO H 108
GLN H 215
ILE H 224
 None
 1.06A 4iilA-4qslH:
4.0		 4iilA-4qslH:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 VAL A 329
ASN A 325
PRO A 290
MET A 151
 None
 1.11A 4iilA-4ru0A:
8.3		 4iilA-4ru0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLN A 327
ILE A 331
MET A 323
 None
 1.09A 4iilA-4rwfA:
3.6		 4iilA-4rwfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A 160
PRO A 196
GLN A 200
ILE A 207
 None
 1.10A 4iilA-4u2nA:
undetectable		 4iilA-4u2nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 PRO A 204
ASN A 207
GLN A 554
ILE A 549
 None
NAG  A1632 (-1.9A)
None
None
 1.04A 4iilA-4uf7A:
undetectable		 4iilA-4uf7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 PRO A 119
ASN A  95
GLN A  90
ILE A 136
 None
 1.08A 4iilA-4woqA:
undetectable		 4iilA-4woqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 VAL A 625
PRO A 613
GLN A 585
ILE A 581
 None
 1.06A 4iilA-4xhbA:
undetectable		 4iilA-4xhbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 PRO A 233
PRO A 164
GLN A  65
ILE A 230
 None
 1.03A 4iilA-4xuvA:
undetectable		 4iilA-4xuvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 PRO A  50
PRO A 155
ILE A 349
MET A 387
 None
 0.98A 4iilA-4y9lA:
undetectable		 4iilA-4y9lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		5 VAL A  47
ASN A 105
PRO A 106
GLN A 284
ILE A 127
 None
 1.28A 4iilA-4yo7A:
19.1		 4iilA-4yo7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 VAL A1016
GLN A 805
ILE A 795
MET A1010
 None
 1.07A 4iilA-4zlrA:
undetectable		 4iilA-4zlrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afo FIMBRIAE

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 PRO A 283
VAL A 294
ASN A 225
ILE A 229
 None
 1.09A 4iilA-5afoA:
undetectable		 4iilA-5afoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 164
VAL A 163
PRO A 126
ILE A 340
 None
None
None
EDO  A 401 (-4.6A)
 1.06A 4iilA-5cefA:
5.1		 4iilA-5cefA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 481
PRO A 473
GLN A 465
GLN A 429
 None
 1.03A 4iilA-5e7qA:
5.1		 4iilA-5e7qA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 ASN A 950
PRO A 951
GLN A 921
ILE A 927
 None
 1.07A 4iilA-5h42A:
undetectable		 4iilA-5h42A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 PRO A 637
VAL A 664
PRO A 187
GLN A 138
GLN A 183
 None
 1.33A 4iilA-5h7jA:
2.4		 4iilA-5h7jA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PRO A  99
VAL A 101
GLN A 323
ILE A 169
 None
None
None
NAP  A 501 (-4.1A)
 1.05A 4iilA-5ijzA:
5.0		 4iilA-5ijzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE

(Auricularia
auricula-judae) 		PF04261
(Dyp_perox) 		4 ASN A 328
GLN A 172
GLN A 365
ILE A 193
 None
 0.97A 4iilA-5ikgA:
undetectable		 4iilA-5ikgA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 602
ASN A 594
PRO A 595
ILE A 738
 None
 1.11A 4iilA-5kf7A:
undetectable		 4iilA-5kf7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 4 VAL B 289
PRO B 300
GLN A 166
ILE A  21
 None
 1.06A 4iilA-5m22B:
undetectable		 4iilA-5m22B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 PRO A 129
ASN A  26
GLN A 108
ILE A 209
 None
GLC  A 501 (-3.8A)
GLC  A 501 (-3.1A)
None
 1.08A 4iilA-5od2A:
4.1		 4iilA-5od2A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 269
PRO A 105
GLN A 211
ILE A 220
 None
 1.03A 4iilA-5vywA:
2.6		 4iilA-5vywA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 VAL B  57
ASN B  66
PRO B  67
GLN B  73
 None
 1.06A 4iilA-5y3rB:
6.0		 4iilA-5y3rB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 PRO A 195
VAL A 194
GLN A 280
ILE A 275
 None
 0.94A 4iilA-5zqzA:
2.6		 4iilA-5zqzA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 4 VAL C 488
PRO C 220
GLN C 103
MET C 100
 None
 1.04A 4iilA-6ccbC:
undetectable		 4iilA-6ccbC:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 ASN A 368
PRO A 369
GLN A 447
ILE A 478
 None
 0.76A 4iilA-6cipA:
4.1		 4iilA-6cipA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 4 PRO A 273
VAL A 274
GLN A  20
ILE A 269
 None
 0.97A 4iilA-6cj7A:
undetectable		 4iilA-6cj7A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens) 		no annotation 4 PRO A 319
VAL A 318
ASN A 543
GLN A 405
 None
 1.04A 4iilA-6d1wA:
undetectable		 4iilA-6d1wA:
12.72