SIMILAR PATTERNS OF AMINO ACIDS FOR 4II8_A_010A210_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		4 GLU B 175
ASP B 170
GLN B 176
ASN B 172
 None
 1.23A 4ii8A-1abrB:
undetectable		 4ii8A-1abrB:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b9o PROTEIN
(ALPHA-LACTALBUMIN)

(Homo sapiens) 		PF00062
(Lys) 		4 GLN A  54
TRP A  60
ILE A  95
TRP A 104
 None
 0.51A 4ii8A-1b9oA:
19.4		 4ii8A-1b9oA:
37.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		4 GLU A 112
GLN A   3
TRP A  43
ILE A 105
 None
 1.24A 4ii8A-1bgfA:
undetectable		 4ii8A-1bgfA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1di4 LYSOZYME C

(Homo sapiens) 		PF00062
(Lys) 		6 GLU A  35
ASP A  53
GLN A  58
ASN A  60
TRP A  64
TRP A 109
 None
 0.62A 4ii8A-1di4A:
25.1		 4ii8A-1di4A:
60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		4 ASP A 313
GLN A 319
ASN A 317
ILE A  71
 None
 1.23A 4ii8A-1f1uA:
undetectable		 4ii8A-1f1uA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gd6 LYSOZYME

(Bombyx mori) 		PF00062
(Lys) 		7 GLU A  32
ASP A  49
GLN A  54
ASN A  56
TRP A  60
ILE A  93
TRP A 102
 None
 0.27A 4ii8A-1gd6A:
20.1		 4ii8A-1gd6A:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLU A 341
ASP A 452
GLN A 338
ILE A  86
 None
 1.15A 4ii8A-1gz7A:
undetectable		 4ii8A-1gz7A:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfy ALPHA-LACTALBUMIN

(Capra hircus) 		PF00062
(Lys) 		4 GLN A  54
TRP A  60
ILE A  95
TRP A 104
 None
 0.34A 4ii8A-1hfyA:
19.5		 4ii8A-1hfyA:
41.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		4 GLN A  54
TRP A  60
ILE A  95
TRP A 104
 None
 0.41A 4ii8A-1hmlA:
19.8		 4ii8A-1hmlA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiz LYSOZYME

(Antheraea
mylitta) 		PF00062
(Lys) 		7 GLU A  32
ASP A  50
GLN A  55
ASN A  57
TRP A  61
ILE A  94
TRP A 103
 None
 0.39A 4ii8A-1iizA:
19.5		 4ii8A-1iizA:
39.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ivm LYSOZYME M

(Mus musculus) 		PF00062
(Lys) 		4 ASP A  53
GLN A  58
ASN A  60
TRP A 109
 None
 0.95A 4ii8A-1ivmA:
18.7		 4ii8A-1ivmA:
56.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ivm LYSOZYME M

(Mus musculus) 		PF00062
(Lys) 		4 GLU A  35
ASP A  53
GLN A  58
ASN A  60
 None
 1.12A 4ii8A-1ivmA:
18.7		 4ii8A-1ivmA:
56.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jug LYSOZYME

(Tachyglossus
aculeatus) 		PF00062
(Lys) 		7 GLU A  35
ASP A  52
GLN A  57
ASN A  59
TRP A  63
ILE A  98
TRP A 108
 None
 0.28A 4ii8A-1jugA:
23.1		 4ii8A-1jugA:
52.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lmo LYSOZYME

(Oncorhynchus
mykiss) 		PF00062
(Lys) 		6 GLU A  35
ASP A  52
GLN A  57
ASN A  59
TRP A  63
TRP A 108
 None
NAG  A 131 ( 4.5A)
None
NAG  A 131 (-4.1A)
NAG  A 131 ( 4.1A)
NAG  A 131 (-3.7A)
 0.26A 4ii8A-1lmoA:
26.1		 4ii8A-1lmoA:
60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		4 ASP A 111
GLN A  26
ASN A 112
ILE A   8
 TTP  A 501 (-3.2A)
TTP  A 501 (-4.0A)
None
None
 1.17A 4ii8A-1mp3A:
undetectable		 4ii8A-1mp3A:
15.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nf5 ALPHA-LACTALBUMIN

(Mus musculus) 		PF00062
(Lys) 		4 GLN A  54
TRP A  60
ILE A  95
TRP A 104
 None
 0.41A 4ii8A-1nf5A:
21.1		 4ii8A-1nf5A:
34.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ode CHORISMATE MUTASE

(Thermus
thermophilus) 		PF07736
(CM_1) 		4 GLU A  40
ASN A  95
TRP A  94
ILE A  36
 None
 1.18A 4ii8A-1odeA:
undetectable		 4ii8A-1odeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLU A 410
ASP A 317
ILE A 455
TRP A 413
 None
None
None
FAD  A1561 ( 4.1A)
 1.19A 4ii8A-1w1kA:
undetectable		 4ii8A-1w1kA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		4 GLU A 485
ASP A 529
ASN A 531
ILE A 535
 None
 1.08A 4ii8A-1xhkA:
undetectable		 4ii8A-1xhkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 GLN A 207
ASN A 206
TRP A 205
ILE A 144
 None
 1.22A 4ii8A-1z72A:
undetectable		 4ii8A-1z72A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 GLU A  86
ASP A  79
GLN A  83
ILE A 116
 None
 1.10A 4ii8A-2csuA:
undetectable		 4ii8A-2csuA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 GLU A 199
ASP A 142
ASN A 244
ILE A 170
 None
 1.22A 4ii8A-2d1cA:
undetectable		 4ii8A-2d1cA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eql HORSE MILK LYSOZYME

(Equus caballus) 		PF00062
(Lys) 		6 GLU A  35
ASP A  53
GLN A  58
ASN A  60
TRP A  64
TRP A 108
 None
 0.39A 4ii8A-2eqlA:
22.7		 4ii8A-2eqlA:
49.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLN B 780
ASN B 781
ILE B 786
TRP B 783
 None
 1.20A 4ii8A-2fffB:
undetectable		 4ii8A-2fffB:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gv0 LYSOZYME C

(Pelodiscus
sinensis) 		PF00062
(Lys) 		7 GLU A  36
ASP A  54
GLN A  59
ASN A  61
TRP A  65
ILE A 100
TRP A 110
 None
 0.28A 4ii8A-2gv0A:
25.7		 4ii8A-2gv0A:
68.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLU A  47
ASN A  44
TRP A  43
ILE A 180
 None
 1.27A 4ii8A-2h2qA:
undetectable		 4ii8A-2h2qA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h5z LYSOZYME 1

(Musca domestica) 		PF00062
(Lys) 		7 GLU A  32
ASP A  50
GLN A  55
ASN A  57
TRP A  61
ILE A  96
TRP A 105
 None
 0.29A 4ii8A-2h5zA:
19.9		 4ii8A-2h5zA:
39.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 GLU A 376
ASP A 378
ASN A 382
ILE A 432
 None
 1.11A 4ii8A-2hj0A:
undetectable		 4ii8A-2hj0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		4 GLN A 151
ASN A 152
TRP A 153
ILE A  95
 None
 1.17A 4ii8A-2hsjA:
undetectable		 4ii8A-2hsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 ASP A  56
GLN A 424
ASN A  59
TRP A  61
 None
ACT  A1447 ( 4.8A)
None
None
 0.94A 4ii8A-2j7cA:
undetectable		 4ii8A-2j7cA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0h DNA PACKAGING
PROTEIN GP17

(Escherichia
virus T4) 		PF03237
(Terminase_6) 		4 GLU A 208
ASP A 201
GLN A 205
ILE A 226
 None
 1.13A 4ii8A-2o0hA:
undetectable		 4ii8A-2o0hA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLU A 498
ASP A 499
ASN A 502
ILE A 492
 None
 1.21A 4ii8A-2o1wA:
undetectable		 4ii8A-2o1wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLU A 121
ASN A 141
ILE A 143
TRP A 142
 None
 1.13A 4ii8A-2p8uA:
undetectable		 4ii8A-2p8uA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk2 CYCLIN-T1, PROTEIN
TAT

(Homo sapiens;
Equine
infectious
anemia virus) 		PF00134
(Cyclin_N) 		4 ASP A  47
GLN A  50
ASN A  43
ILE A  63
 ASP  A  47 ( 0.6A)
GLN  A  50 ( 0.6A)
ASN  A  43 ( 0.6A)
ILE  A  63 ( 0.7A)
 1.23A 4ii8A-2pk2A:
undetectable		 4ii8A-2pk2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 GLU B  54
ASP B  51
ASN B  48
ILE B  62
 None
 1.17A 4ii8A-2q2eB:
undetectable		 4ii8A-2q2eB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ASP A 145
GLN A  42
ASN A 147
ILE A 125
 GOL  A1240 (-2.7A)
None
GOL  A1240 (-2.9A)
None
 1.11A 4ii8A-2v0sA:
undetectable		 4ii8A-2v0sA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		4 ASP B 613
GLN B 609
ILE B 747
TRP B 606
 None
 1.17A 4ii8A-2w2dB:
undetectable		 4ii8A-2w2dB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLU A 452
ASP A 474
GLN A 477
TRP A 479
 None
 1.22A 4ii8A-2w8qA:
undetectable		 4ii8A-2w8qA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASP A  99
GLN A 102
ASN A  25
ILE A 125
 None
 1.24A 4ii8A-2x0qA:
undetectable		 4ii8A-2x0qA:
12.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2e LYSOZYME C, MILK
ISOZYME

(Canis lupus) 		PF00062
(Lys) 		6 GLU A  35
ASP A  53
GLN A  58
ASN A  60
TRP A  64
TRP A 108
 None
 0.45A 4ii8A-2z2eA:
23.0		 4ii8A-2z2eA:
50.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2f LYSOZYME C-2

(Bos taurus) 		PF00062
(Lys) 		7 GLU A  35
ASP A  53
GLN A  58
ASN A  60
TRP A  64
ILE A  99
TRP A 108
 None
 0.28A 4ii8A-2z2fA:
25.7		 4ii8A-2z2fA:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5b UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 GLU B  47
ASP B  49
TRP B 150
ILE B 149
 None
 1.16A 4ii8A-2z5bB:
undetectable		 4ii8A-2z5bB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 GLU A 124
GLN A 162
TRP A 269
ILE A 165
 None
 1.28A 4ii8A-2zufA:
undetectable		 4ii8A-2zufA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 GLU A 558
ASP A 545
ASN A 567
ILE A 601
 None
GOL  A 901 (-2.8A)
GOL  A 901 (-3.3A)
None
 0.82A 4ii8A-3a21A:
undetectable		 4ii8A-3a21A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 361
ASP A 233
ASN A 235
ILE A 177
 None
MG  A 501 (-2.9A)
MG  A 501 ( 4.3A)
None
 1.27A 4ii8A-3bjsA:
undetectable		 4ii8A-3bjsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		4 ASP A 207
GLN A 203
ASN A 208
ILE A 272
 None
 1.17A 4ii8A-3bkxA:
undetectable		 4ii8A-3bkxA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cb7 LYS-RICH LYSOZYME 2

(Musca domestica) 		PF00062
(Lys) 		6 GLU A  36
ASP A  54
GLN A  59
ASN A  61
TRP A  65
TRP A 109
 GLU  A  36 (-0.6A)
ASP  A  54 (-0.5A)
GLN  A  59 (-0.6A)
ASN  A  61 (-0.6A)
TRP  A  65 (-0.5A)
TRP  A 109 ( 0.5A)
 0.32A 4ii8A-3cb7A:
19.0		 4ii8A-3cb7A:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASN A 459
TRP A 456
ILE A 301
TRP A 460
 None
 1.22A 4ii8A-3cghA:
undetectable		 4ii8A-3cghA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeh PUTATIVE LIGHT AND
REDOX SENSING
HISTIDINE KINASE

(Haloarcula
marismortui) 		PF08447
(PAS_3) 		4 ASP A  58
ASN A  61
ILE A  63
TRP A  45
 None
 1.20A 4ii8A-3eehA:
undetectable		 4ii8A-3eehA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 327
ASP A 199
ASN A 201
ILE A  55
 None
MG  A 382 ( 4.3A)
MG  A 382 (-3.1A)
None
 1.11A 4ii8A-3fcpA:
undetectable		 4ii8A-3fcpA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 GLU A 762
ASP A 830
GLN A 832
ILE A 181
 None
 1.16A 4ii8A-3fqdA:
undetectable		 4ii8A-3fqdA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 GLU A 302
ASP A 299
GLN A 303
ILE A  40
 None
 1.23A 4ii8A-3gohA:
undetectable		 4ii8A-3gohA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		4 GLU A 179
ASP A 218
ASN A 227
ILE A 225
 None
 1.13A 4ii8A-3h7kA:
undetectable		 4ii8A-3h7kA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgz SINGLE-STRANDED
DNA-BINDING PROTEIN

(Bartonella
henselae) 		PF00436
(SSB) 		4 GLU A  69
GLN A  70
ASN A  63
ILE A  59
 None
 0.90A 4ii8A-3pgzA:
undetectable		 4ii8A-3pgzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 4 GLU A  43
ASP A 212
ASN A 371
ILE A 205
 None
 1.22A 4ii8A-3slrA:
undetectable		 4ii8A-3slrA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 ASP A 185
GLN A 213
ASN A 188
ILE A 192
 None
 0.91A 4ii8A-3wquA:
undetectable		 4ii8A-3wquA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 ASP A 185
GLN A 213
ASN A 188
ILE A 192
 None
 0.89A 4ii8A-3wt0A:
undetectable		 4ii8A-3wt0A:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zvq LYSOZYME C
LYSOZYME C

(Gallus gallus;
Gallus gallus) 		PF00062
(Lys)
PF00062
(Lys) 		7 GLU A  35
ASP A  52
GLN A  57
ASN A  59
TRP A  63
ILE B  98
TRP B 108
 None
 0.24A 4ii8A-3zvqA:
10.6		 4ii8A-3zvqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 GLU A 575
ASN A 592
TRP A 593
ILE A 572
 None
 0.95A 4ii8A-4aeeA:
undetectable		 4ii8A-4aeeA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9n AGGLUTININ

(Rhizoctonia
solani) 		PF14200
(RicinB_lectin_2) 		4 GLU A 121
ASP A  22
ASN A  44
TRP A  24
 NGA  A 201 (-3.4A)
NGA  A 201 (-2.8A)
NGA  A 201 (-3.2A)
NGA  A 201 ( 4.1A)
 1.22A 4ii8A-4g9nA:
undetectable		 4ii8A-4g9nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 ASP A  63
GLN A 445
ASN A  66
TRP A  68
 None
 1.08A 4ii8A-4gxpA:
undetectable		 4ii8A-4gxpA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum PROTEIN B

(Escherichia
coli) 		PF00041
(fn3) 		4 GLU B  38
ASP B  67
ASN B  88
ILE B  70
 None
 1.08A 4ii8A-4humB:
undetectable		 4ii8A-4humB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 GLU A  43
ASP A  50
GLN A  46
ILE A 127
 None
None
None
6NA  A 301 (-4.8A)
 1.26A 4ii8A-4kvsA:
undetectable		 4ii8A-4kvsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 ASP A 233
GLN A 276
ASN A 235
ILE A 237
 None
 1.16A 4ii8A-4lg8A:
undetectable		 4ii8A-4lg8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lss ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLU G 466
ASN G 280
ILE G 277
TRP G 353
 None
None
NAG  G 502 ( 4.6A)
None
 1.20A 4ii8A-4lssG:
undetectable		 4ii8A-4lssG:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASP A  60
GLN A  57
ILE A 112
TRP A 357
 None
 1.27A 4ii8A-4pdxA:
undetectable		 4ii8A-4pdxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 GLU A  82
ASN A 120
ILE A 122
TRP A 118
 None
 1.23A 4ii8A-4qtsA:
undetectable		 4ii8A-4qtsA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN

(Parabacteroides
merdae) 		PF13432
(TPR_16) 		4 GLU A 147
GLN A 148
ASN A 142
ILE A 138
 None
 1.17A 4ii8A-4r7sA:
undetectable		 4ii8A-4r7sA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wg1 LYSOZYME C

(Gallus gallus) 		PF00062
(Lys) 		7 GLU A  35
ASP A  52
GLN A  57
ASN A  59
TRP A  63
ILE A  98
TRP A 108
 None
None
None
None
None
CL  A 201 ( 4.9A)
CL  A 201 ( 4.3A)
 0.25A 4ii8A-4wg1A:
28.5		 4ii8A-4wg1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 GLU A 307
ASP A 304
ILE A 298
TRP A 303
 None
 1.08A 4ii8A-4xf5A:
undetectable		 4ii8A-4xf5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 ASP A 127
GLN A 107
ASN A 105
ILE A 446
 None
 1.22A 4ii8A-4xprA:
undetectable		 4ii8A-4xprA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans;
Roseobacter
denitrificans) 		PF00115
(COX1)
PF00034
(Cytochrom_C) 		4 GLU B  58
ASP A 185
ILE B  68
TRP B  57
 None
 1.18A 4ii8A-4xydB:
undetectable		 4ii8A-4xydB:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yf2 SPERM ACROSOME
MEMBRANE-ASSOCIATED
PROTEIN 3

(Mus musculus) 		PF00062
(Lys) 		4 GLN A  57
TRP A  63
ILE A  97
TRP A 107
 None
 0.37A 4ii8A-4yf2A:
24.2		 4ii8A-4yf2A:
50.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		4 GLU A 212
GLN A 215
ASN A 219
ILE A 200
 None
 1.10A 4ii8A-4ynvA:
undetectable		 4ii8A-4ynvA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 305
GLN A 304
ASN A 320
ILE A 327
 None
 0.88A 4ii8A-4zktA:
undetectable		 4ii8A-4zktA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 ASP A 120
ASN A 118
ILE A 133
TRP A 124
 NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
None
None
 1.26A 4ii8A-5a3cA:
undetectable		 4ii8A-5a3cA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 GLU A 538
ASP A 289
GLN A 262
ILE A 285
 None
 1.07A 4ii8A-5aeeA:
undetectable		 4ii8A-5aeeA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 GLU A 179
ASP A 230
ILE A 219
TRP A 180
 None
TRS  A 409 (-3.3A)
None
None
 1.07A 4ii8A-5c0pA:
undetectable		 4ii8A-5c0pA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		4 GLU A 351
GLN A 348
ASN A 344
ILE A 313
 None
 1.20A 4ii8A-5eqjA:
undetectable		 4ii8A-5eqjA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		4 GLN A 287
ASN A 512
TRP A 513
ILE A 505
 None
 1.03A 4ii8A-5fifA:
undetectable		 4ii8A-5fifA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		4 ASP A  61
GLN A 431
ASN A  64
TRP A  66
 None
 1.00A 4ii8A-5gnxA:
undetectable		 4ii8A-5gnxA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 4 GLU B 298
GLN B 336
ASN B 338
ILE B 313
 None
 1.24A 4ii8A-5hzgB:
undetectable		 4ii8A-5hzgB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ASP A  54
GLN A 422
ASN A  57
TRP A  59
 None
 0.91A 4ii8A-5idiA:
undetectable		 4ii8A-5idiA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 GLU A 366
ASP A 362
ILE A 406
TRP A 365
 None
 1.19A 4ii8A-5ikpA:
undetectable		 4ii8A-5ikpA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		4 ASP A 200
GLN A 233
ASN A 197
ILE A 170
 None
 1.14A 4ii8A-5j72A:
undetectable		 4ii8A-5j72A:
9.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jen LYSOZYME C

(Gallus gallus) 		PF00062
(Lys) 		7 GLU B  35
ASP B  52
GLN B  57
ASN B  59
TRP B  63
ILE B  98
TRP B 108
 NA  A 401 ( 4.2A)
NA  A 401 (-3.1A)
None
None
None
None
None
 0.42A 4ii8A-5jenB:
26.7		 4ii8A-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		4 GLU A  74
ASP A  96
ASN A 115
ILE A 103
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
None
 1.27A 4ii8A-5jq9A:
undetectable		 4ii8A-5jq9A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 4 GLU B 257
ASP B 276
GLN B 306
ILE B 303
 None
 1.22A 4ii8A-5m22B:
undetectable		 4ii8A-5m22B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A  22
GLN A  21
ASN A 145
ILE A  32
 None
 1.05A 4ii8A-5mzsA:
undetectable		 4ii8A-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 4 GLU B 556
ASP B 547
ASN B 551
ILE B 599
 None
 1.17A 4ii8A-5oarB:
undetectable		 4ii8A-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 GLU A 504
ASP A 505
ASN A 409
ILE A 499
 None
 1.19A 4ii8A-5txeA:
undetectable		 4ii8A-5txeA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 GLU A  36
ASN A 276
ILE A  43
TRP A  40
 None
 1.17A 4ii8A-5umeA:
undetectable		 4ii8A-5umeA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v8g LYSOZYME ISOFORM I

(Anas
platyrhynchos) 		no annotation 7 GLU A  35
ASP A  52
GLN A  57
ASN A  59
TRP A  63
ILE A  98
TRP A 108
 None
 0.30A 4ii8A-5v8gA:
27.0		 4ii8A-5v8gA:
84.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 4 GLU A 189
ASP A 146
ASN A 150
TRP A 153
 None
 1.05A 4ii8A-5vlgA:
undetectable		 4ii8A-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 ASP A 115
GLN A 436
ASN A 112
ILE A 515
 None
 1.27A 4ii8A-5w0sA:
undetectable		 4ii8A-5w0sA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi4 DYNEIN LIGHT CHAIN
TCTEX-TYPE 1,RHO
GUANINE NUCLEOTIDE
EXCHANGE FACTOR 2

(Mus musculus) 		no annotation 4 GLN A  49
ASN A  45
TRP A  42
ILE A  29
 None
None
SO4  A 201 (-4.0A)
None
 1.25A 4ii8A-5wi4A:
undetectable		 4ii8A-5wi4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 GLU A 119
ASP A 106
GLN A 110
ILE A 126
 None
 0.91A 4ii8A-5ydgA:
undetectable		 4ii8A-5ydgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6asx DNA-DIRECTED RNA
POLYMERASE SUBUNIT
OMEGA

(Escherichia
coli) 		no annotation 4 GLU K  68
ASP K  65
ASN K  61
ILE K  59
 None
 0.94A 4ii8A-6asxK:
undetectable		 4ii8A-6asxK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 GLU A 564
ASP A 709
ASN A 708
ILE A 649
 None
 0.99A 4ii8A-6byiA:
undetectable		 4ii8A-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 GLU L 535
ASP L 529
ASN L 531
ILE L   5
 None
 1.25A 4ii8A-6ehsL:
undetectable		 4ii8A-6ehsL:
undetectable