SIMILAR PATTERNS OF AMINO ACIDS FOR 4IG1_A_ACTA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA

(Homo sapiens) 		PF00042
(Globin) 		4 SER A 107
LYS A 104
LEU A 134
ASP A 131
 None
 1.03A 4ig1A-1ch4A:
undetectable		 4ig1A-1ch4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 SER A  87
LYS A  10
ARG A  14
LEU A  82
 None
 1.39A 4ig1A-1dgmA:
0.4		 4ig1A-1dgmA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 SER A 159
ARG A 106
LEU A 156
ASP A 155
 None
 1.07A 4ig1A-1dgpA:
0.0		 4ig1A-1dgpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g84 IMMUNOGLOBULIN E

(Homo sapiens) 		PF07654
(C1-set) 		4 LYS A  78
ARG A  84
LEU A  75
ASP A  52
 None
 1.35A 4ig1A-1g84A:
0.0		 4ig1A-1g84A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		4 SER A 211
LYS A 212
ARG A 215
LEU A 301
 None
 1.13A 4ig1A-1musA:
0.5		 4ig1A-1musA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 SER A  33
LYS A   2
LEU A  63
ASP A  62
 None
 1.44A 4ig1A-1obbA:
0.0		 4ig1A-1obbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		4 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.14A 4ig1A-1p9bA:
0.0		 4ig1A-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 4 SER A 264
LYS A 265
LEU A 231
ASP A 235
 None
 1.43A 4ig1A-1pgvA:
0.0		 4ig1A-1pgvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A 256
ARG A 253
LEU A 257
ASP A 254
 None
 1.40A 4ig1A-1q5nA:
0.0		 4ig1A-1q5nA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.42A 4ig1A-1qpwA:
undetectable		 4ig1A-1qpwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A 255
ARG A 252
LEU A 256
ASP A 253
 None
 1.39A 4ig1A-1re5A:
0.0		 4ig1A-1re5A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN

(Equus asinus) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.31A 4ig1A-1s0hA:
undetectable		 4ig1A-1s0hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LYS A 168
ARG A 171
LEU A 153
ASP A 155
 None
None
None
CIT  A 250 (-4.1A)
 1.41A 4ig1A-1xjtA:
undetectable		 4ig1A-1xjtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 SER A 181
LYS A 180
LEU A 186
ASP A 187
 None
 1.25A 4ig1A-2e80A:
undetectable		 4ig1A-2e80A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		4 SER A 100
LYS A 101
LEU A  13
ASP A  12
 None
 1.33A 4ig1A-2espA:
undetectable		 4ig1A-2espA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljx PROTEIN E6

(Alphapapillomavirus
9) 		PF00518
(E6) 		4 SER A  71
ARG A  48
LEU A  50
ASP A  49
 None
 1.42A 4ig1A-2ljxA:
undetectable		 4ig1A-2ljxA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		4 SER A  60
ARG A  65
LEU A  63
ASP A  64
 None
 1.10A 4ig1A-2m5tA:
undetectable		 4ig1A-2m5tA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 4 SER A  80
ARG A  51
LEU A  82
ASP A  52
 None
None
None
CA  A 203 ( 2.6A)
 1.04A 4ig1A-2ml2A:
undetectable		 4ig1A-2ml2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 SER A 223
LYS A 222
LEU A 201
ASP A 202
 None
 1.42A 4ig1A-2qe8A:
undetectable		 4ig1A-2qe8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 SER A  46
LYS A  45
LEU A  48
ASP A  51
 None
 1.25A 4ig1A-2r0vA:
undetectable		 4ig1A-2r0vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 SER A 347
LYS A 344
ARG A 343
LEU A  86
 None
 1.17A 4ig1A-2v6jA:
undetectable		 4ig1A-2v6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 SER A 569
ARG A 515
LEU A 566
ASP A 565
 None
 1.48A 4ig1A-2vz9A:
undetectable		 4ig1A-2vz9A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 LYS A 164
ARG A  39
LEU A 169
ASP A 167
 None
 1.22A 4ig1A-2x77A:
undetectable		 4ig1A-2x77A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 SER A 226
ARG A 112
LEU A 106
ASP A 107
 None
 1.40A 4ig1A-2z6vA:
undetectable		 4ig1A-2z6vA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 SER A 502
LYS A 433
LEU A 461
ASP A 460
 None
None
None
CA  A 540 (-3.0A)
 1.26A 4ig1A-3afgA:
undetectable		 4ig1A-3afgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.31A 4ig1A-3at6A:
undetectable		 4ig1A-3at6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		4 SER A   6
LYS A   4
LEU A   8
ASP A   9
 None
 1.39A 4ig1A-3c1lA:
undetectable		 4ig1A-3c1lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		4 SER A  54
ARG A  55
LEU A 108
ASP A 111
 None
 1.41A 4ig1A-3cljA:
undetectable		 4ig1A-3cljA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.33A 4ig1A-3d1aA:
undetectable		 4ig1A-3d1aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 SER A 322
LYS A 317
LEU A 310
ASP A 311
 None
 1.34A 4ig1A-3gd9A:
undetectable		 4ig1A-3gd9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER A 473
ARG A 170
LEU A 470
ASP A 471
 None
 1.47A 4ig1A-3hhsA:
undetectable		 4ig1A-3hhsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 SER A 856
ARG A 844
LEU A 805
ASP A 806
 None
 1.47A 4ig1A-3iu6A:
undetectable		 4ig1A-3iu6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 SER A 169
LYS A 168
ARG A 149
LEU A 152
 None
 1.43A 4ig1A-3j3iA:
undetectable		 4ig1A-3j3iA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		4 SER A 512
ARG A 401
LEU A 488
ASP A 486
 None
None
EDO  A 815 (-4.5A)
ME8  A 801 ( 2.6A)
 1.32A 4ig1A-3kflA:
undetectable		 4ig1A-3kflA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		4 SER A   3
ARG A   5
LEU A   6
ASP A  25
 None
 1.46A 4ig1A-3kr9A:
undetectable		 4ig1A-3kr9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 SER B 155
ARG B 130
LEU B 132
ASP B 131
 None
 1.44A 4ig1A-3lcvB:
undetectable		 4ig1A-3lcvB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		4 SER A  41
LYS A  42
LEU A  17
ASP A  18
 None
 1.17A 4ig1A-3mtiA:
undetectable		 4ig1A-3mtiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 SER A1745
ARG A1748
LEU A1757
ASP A1759
 None
 1.50A 4ig1A-3pg7A:
undetectable		 4ig1A-3pg7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 SER A 121
LYS A 118
ARG A 120
LEU A 193
 None
 1.46A 4ig1A-3sm3A:
undetectable		 4ig1A-3sm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 SER A 103
LYS A 100
LEU A 130
ASP A 127
 HEM  A 202 ( 4.7A)
None
None
None
 1.44A 4ig1A-4esaA:
undetectable		 4ig1A-4esaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 SER A 325
ARG A 328
LEU A 327
ASP A 330
 None
 1.39A 4ig1A-4go4A:
undetectable		 4ig1A-4go4A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 SER A  46
LYS A  45
LEU A  48
ASP A  49
 None
 1.42A 4ig1A-4jccA:
undetectable		 4ig1A-4jccA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 SER A 295
LYS A 280
ARG A 293
LEU A 213
 None
 1.28A 4ig1A-4l6uA:
undetectable		 4ig1A-4l6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 SER A 574
LYS A 575
ARG A 566
LEU A 491
 None
 1.48A 4ig1A-4pw5A:
undetectable		 4ig1A-4pw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urs DIGUANYLATE CYCLASE

(Thermotoga
maritima) 		PF00990
(GGDEF) 		4 SER A 150
LYS A 147
ARG A 165
LEU A  96
 SER  A 150 ( 0.0A)
LYS  A 147 ( 0.0A)
ARG  A 165 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.29A 4ig1A-4ursA:
undetectable		 4ig1A-4ursA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 SER A  27
LYS A  28
ARG A  29
LEU A 181
ASP A 182
 ACT  A 406 (-2.6A)
None
None
ACT  A 406 (-4.4A)
ACT  A 406 ( 2.5A)
 0.72A 4ig1A-4xdtA:
55.2		 4ig1A-4xdtA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 SER A 499
ARG A 467
LEU A 457
ASP A 496
 None
GOL  A 706 (-3.7A)
None
None
 1.45A 4ig1A-4z0vA:
undetectable		 4ig1A-4z0vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		4 SER A  88
LYS A  89
LEU A  83
ASP A  84
 None
None
None
SO4  A 401 ( 4.2A)
 1.43A 4ig1A-5dmnA:
undetectable		 4ig1A-5dmnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 SER A 542
ARG A 506
LEU A 546
ASP A 539
 None
 1.46A 4ig1A-5e26A:
undetectable		 4ig1A-5e26A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 4 SER A 128
ARG A  75
LEU A 125
ASP A 124
 None
 1.08A 4ig1A-5in8A:
undetectable		 4ig1A-5in8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwy EPIDIDYMAL SECRETORY
PROTEIN E1

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 SER C  63
LYS C 103
LEU C 138
ASP C  31
 None
 1.32A 4ig1A-5kwyC:
undetectable		 4ig1A-5kwyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 4 SER A1566
LYS A1567
LEU A1537
ASP A1544
 None
 1.16A 4ig1A-5nnlA:
undetectable		 4ig1A-5nnlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		4 LYS A 242
ARG A 245
LEU A 248
ASP A 249
 None
 1.49A 4ig1A-5nnpA:
undetectable		 4ig1A-5nnpA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 SER A 206
ARG A 180
LEU A 217
ASP A 216
 None
None
None
MG  A1002 ( 3.8A)
 1.44A 4ig1A-5wu3A:
undetectable		 4ig1A-5wu3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 SER A 460
LYS A 459
LEU A 467
ASP A 463
 None
 1.39A 4ig1A-5xxiA:
undetectable		 4ig1A-5xxiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 SER A2225
LYS A2226
ARG A2227
ASP A2274
 None
 1.50A 4ig1A-5y2aA:
undetectable		 4ig1A-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN

(Marburg
marburgvirus) 		no annotation 4 SER A 104
LYS A 103
ARG A 156
LEU A 106
 None
None
NAG  A 302 ( 4.4A)
None
 1.33A 4ig1A-6bp2A:
undetectable		 4ig1A-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 SER F 199
LYS F 197
ARG F 196
LEU F  89
 None
 1.30A 4ig1A-6f0kF:
undetectable		 4ig1A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae) 		no annotation 4 SER G  90
LYS G  91
LEU G 102
ASP G 106
 None
 1.45A 4ig1A-6f42G:
undetectable		 4ig1A-6f42G:
undetectable