SIMILAR PATTERNS OF AMINO ACIDS FOR 4IFX_A_ACTA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA

(Homo sapiens) 		PF00042
(Globin) 		4 SER A 107
LYS A 104
LEU A 134
ASP A 131
 None
 1.02A 4ifxA-1ch4A:
undetectable		 4ifxA-1ch4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 SER A  87
LYS A  10
ARG A  14
LEU A  82
 None
 1.35A 4ifxA-1dgmA:
0.0		 4ifxA-1dgmA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 SER A 159
ARG A 106
LEU A 156
ASP A 155
 None
 1.05A 4ifxA-1dgpA:
0.0		 4ifxA-1dgpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g84 IMMUNOGLOBULIN E

(Homo sapiens) 		PF07654
(C1-set) 		4 LYS A  78
ARG A  84
LEU A  75
ASP A  52
 None
 1.31A 4ifxA-1g84A:
0.1		 4ifxA-1g84A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 SER A  33
LYS A   2
LEU A  63
ASP A  62
 None
 1.44A 4ifxA-1obbA:
0.0		 4ifxA-1obbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		4 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.15A 4ifxA-1p9bA:
0.0		 4ifxA-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 4 SER A 264
LYS A 265
LEU A 231
ASP A 235
 None
 1.41A 4ifxA-1pgvA:
0.0		 4ifxA-1pgvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.45A 4ifxA-1qpwA:
undetectable		 4ifxA-1qpwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A 255
ARG A 252
LEU A 256
ASP A 253
 None
 1.41A 4ifxA-1re5A:
0.0		 4ifxA-1re5A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN

(Equus asinus) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.34A 4ifxA-1s0hA:
undetectable		 4ifxA-1s0hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 SER A 215
LYS A 216
LEU A 212
ASP A 178
 None
 1.49A 4ifxA-1vl4A:
undetectable		 4ifxA-1vl4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LYS A 168
ARG A 171
LEU A 153
ASP A 155
 None
None
None
CIT  A 250 (-4.1A)
 1.45A 4ifxA-1xjtA:
0.0		 4ifxA-1xjtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 SER A 181
LYS A 180
LEU A 186
ASP A 187
 None
 1.24A 4ifxA-2e80A:
undetectable		 4ifxA-2e80A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		4 SER A 100
LYS A 101
LEU A  13
ASP A  12
 None
 1.32A 4ifxA-2espA:
undetectable		 4ifxA-2espA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljx PROTEIN E6

(Alphapapillomavirus
9) 		PF00518
(E6) 		4 SER A  71
ARG A  48
LEU A  50
ASP A  49
 None
 1.49A 4ifxA-2ljxA:
undetectable		 4ifxA-2ljxA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		4 SER A  60
ARG A  65
LEU A  63
ASP A  64
 None
 1.12A 4ifxA-2m5tA:
undetectable		 4ifxA-2m5tA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 4 SER A  80
ARG A  51
LEU A  82
ASP A  52
 None
None
None
CA  A 203 ( 2.6A)
 1.07A 4ifxA-2ml2A:
undetectable		 4ifxA-2ml2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 SER A 223
LYS A 222
LEU A 201
ASP A 202
 None
 1.43A 4ifxA-2qe8A:
undetectable		 4ifxA-2qe8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 SER A  46
LYS A  45
LEU A  48
ASP A  51
 None
 1.25A 4ifxA-2r0vA:
undetectable		 4ifxA-2r0vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 SER A 347
LYS A 344
ARG A 343
LEU A  86
 None
 1.22A 4ifxA-2v6jA:
undetectable		 4ifxA-2v6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 LYS A 164
ARG A  39
LEU A 169
ASP A 167
 None
 1.23A 4ifxA-2x77A:
undetectable		 4ifxA-2x77A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 SER A 226
ARG A 112
LEU A 106
ASP A 107
 None
 1.44A 4ifxA-2z6vA:
undetectable		 4ifxA-2z6vA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 SER A 502
LYS A 433
LEU A 461
ASP A 460
 None
None
None
CA  A 540 (-3.0A)
 1.26A 4ifxA-3afgA:
undetectable		 4ifxA-3afgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.35A 4ifxA-3at6A:
undetectable		 4ifxA-3at6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 SER A   1
LYS A   2
ARG A   3
LEU A   8
 None
 1.46A 4ifxA-3b4tA:
0.9		 4ifxA-3b4tA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		4 SER A   6
LYS A   4
LEU A   8
ASP A   9
 None
 1.38A 4ifxA-3c1lA:
undetectable		 4ifxA-3c1lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		4 SER A  54
ARG A  55
LEU A 108
ASP A 111
 None
 1.45A 4ifxA-3cljA:
undetectable		 4ifxA-3cljA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		4 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.37A 4ifxA-3d1aA:
undetectable		 4ifxA-3d1aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 SER A 322
LYS A 317
LEU A 310
ASP A 311
 None
 1.33A 4ifxA-3gd9A:
undetectable		 4ifxA-3gd9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER A 473
ARG A 170
LEU A 470
ASP A 471
 None
 1.48A 4ifxA-3hhsA:
undetectable		 4ifxA-3hhsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 SER A 856
ARG A 844
LEU A 805
ASP A 806
 None
 1.43A 4ifxA-3iu6A:
undetectable		 4ifxA-3iu6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 SER A 169
LYS A 168
ARG A 149
LEU A 152
 None
 1.45A 4ifxA-3j3iA:
undetectable		 4ifxA-3j3iA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		4 SER A   3
ARG A   5
LEU A   6
ASP A  25
 None
 1.45A 4ifxA-3kr9A:
0.3		 4ifxA-3kr9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 SER B 155
ARG B 130
LEU B 132
ASP B 131
 None
 1.46A 4ifxA-3lcvB:
undetectable		 4ifxA-3lcvB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		4 SER A  41
LYS A  42
LEU A  17
ASP A  18
 None
 1.20A 4ifxA-3mtiA:
undetectable		 4ifxA-3mtiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 SER A1745
ARG A1748
LEU A1757
ASP A1759
 None
 1.49A 4ifxA-3pg7A:
undetectable		 4ifxA-3pg7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 SER A 121
LYS A 118
ARG A 120
LEU A 193
 None
 1.45A 4ifxA-3sm3A:
undetectable		 4ifxA-3sm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 4 SER A 270
LYS A 271
LEU A  89
ASP A  88
 None
 1.34A 4ifxA-3wnbA:
undetectable		 4ifxA-3wnbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 SER A 103
LYS A 100
LEU A 130
ASP A 127
 HEM  A 202 ( 4.7A)
None
None
None
 1.47A 4ifxA-4esaA:
undetectable		 4ifxA-4esaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 SER A 325
ARG A 328
LEU A 327
ASP A 330
 None
 1.43A 4ifxA-4go4A:
undetectable		 4ifxA-4go4A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 SER A  46
LYS A  45
LEU A  48
ASP A  49
 None
 1.42A 4ifxA-4jccA:
undetectable		 4ifxA-4jccA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 SER A 295
LYS A 280
ARG A 293
LEU A 213
 None
 1.27A 4ifxA-4l6uA:
0.5		 4ifxA-4l6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 SER A 574
LYS A 575
ARG A 566
LEU A 491
 None
 1.46A 4ifxA-4pw5A:
undetectable		 4ifxA-4pw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urs DIGUANYLATE CYCLASE

(Thermotoga
maritima) 		PF00990
(GGDEF) 		4 SER A 150
LYS A 147
ARG A 165
LEU A  96
 SER  A 150 ( 0.0A)
LYS  A 147 ( 0.0A)
ARG  A 165 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.31A 4ifxA-4ursA:
1.2		 4ifxA-4ursA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 SER A  27
LYS A  28
ARG A  29
LEU A 181
ASP A 182
 ACT  A 406 (-2.6A)
None
None
ACT  A 406 (-4.4A)
ACT  A 406 ( 2.5A)
 0.77A 4ifxA-4xdtA:
55.4		 4ifxA-4xdtA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 SER A 499
ARG A 467
LEU A 457
ASP A 496
 None
GOL  A 706 (-3.7A)
None
None
 1.47A 4ifxA-4z0vA:
0.3		 4ifxA-4z0vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		4 SER A  88
LYS A  89
LEU A  83
ASP A  84
 None
None
None
SO4  A 401 ( 4.2A)
 1.43A 4ifxA-5dmnA:
undetectable		 4ifxA-5dmnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 SER A 542
ARG A 506
LEU A 546
ASP A 539
 None
 1.42A 4ifxA-5e26A:
1.3		 4ifxA-5e26A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans) 		PF16960
(HpuA) 		4 SER A 280
LYS A 267
LEU A 162
ASP A 160
 None
 1.45A 4ifxA-5ee4A:
undetectable		 4ifxA-5ee4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Solanum
habrochaites) 		PF01255
(Prenyltransf) 		4 SER A 239
LYS A 240
LEU A 260
ASP A 206
 None
 1.48A 4ifxA-5hxtA:
undetectable		 4ifxA-5hxtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 4 SER A 128
ARG A  75
LEU A 125
ASP A 124
 None
 1.05A 4ifxA-5in8A:
undetectable		 4ifxA-5in8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwy EPIDIDYMAL SECRETORY
PROTEIN E1

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 SER C  63
LYS C 103
LEU C 138
ASP C  31
 None
 1.31A 4ifxA-5kwyC:
undetectable		 4ifxA-5kwyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 4 SER A1566
LYS A1567
LEU A1537
ASP A1544
 None
 1.17A 4ifxA-5nnlA:
undetectable		 4ifxA-5nnlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 SER A 243
ARG A 140
LEU A 337
ASP A 139
 None
 1.36A 4ifxA-5sujA:
undetectable		 4ifxA-5sujA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 SER A 206
ARG A 180
LEU A 217
ASP A 216
 None
None
None
MG  A1002 ( 3.8A)
 1.43A 4ifxA-5wu3A:
1.9		 4ifxA-5wu3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 SER A 460
LYS A 459
LEU A 467
ASP A 463
 None
 1.37A 4ifxA-5xxiA:
undetectable		 4ifxA-5xxiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN

(Marburg
marburgvirus) 		no annotation 4 SER A 104
LYS A 103
ARG A 156
LEU A 106
 None
None
NAG  A 302 ( 4.4A)
None
 1.30A 4ifxA-6bp2A:
undetectable		 4ifxA-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 SER F 199
LYS F 197
ARG F 196
LEU F  89
 None
 1.34A 4ifxA-6f0kF:
undetectable		 4ifxA-6f0kF:
undetectable