SIMILAR PATTERNS OF AMINO ACIDS FOR 4IFG_A_1E8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 274
VAL A 281
ALA A 293
LYS A 295
LEU A 325
LEU A 393
LEU A 407
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
None
 0.71A 4ifgA-2h8hA:
25.3		 4ifgA-2h8hA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  60
VAL A  67
ALA A  80
LYS A  82
LEU A 115
LEU A 127
 None
 0.29A 4ifgA-2hakA:
21.4		 4ifgA-2hakA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  56
VAL A  63
ALA A  76
LEU A 110
LEU A 122
LEU A 177
 None
 0.47A 4ifgA-2hw6A:
22.6		 4ifgA-2hw6A:
30.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 345
VAL A 352
ALA A 367
LYS A 369
LEU A 401
LEU A 412
GLY A 419
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
None
 0.74A 4ifgA-2ozoA:
23.5		 4ifgA-2ozoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 783
LEU A 794
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
 0.40A 4ifgA-2r4bA:
23.9		 4ifgA-2r4bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  83
VAL A  90
ALA A 103
LEU A 139
GLY A 159
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
 0.49A 4ifgA-2v55A:
22.4		 4ifgA-2v55A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  78
VAL A  85
ALA A  98
LEU A 134
LEU A 146
GLY A 154
LEU A 202
 BI8  A1417 ( 3.9A)
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
None
None
None
BI8  A1417 (-4.8A)
 0.64A 4ifgA-2vd5A:
23.4		 4ifgA-2vd5A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 GLY A 491
VAL A 498
ALA A 509
LEU A 559
LEU A 603
LEU A 656
ILE A 686
 5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
None
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.2A)
 0.54A 4ifgA-2vuwA:
14.4		 4ifgA-2vuwA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  53
VAL A  60
ALA A  73
LEU A 104
LEU A 116
GLY A 124
GLU A 125
LEU A 171
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
None
None
None
DKI  A1338 (-4.9A)
 0.79A 4ifgA-2w4oA:
34.1		 4ifgA-2w4oA:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  13
VAL B  20
LYS B  35
LEU B  74
LEU B  91
LEU B 147
LEU B 161
 None
 0.95A 4ifgA-2w9fB:
24.3		 4ifgA-2w9fB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 425
ALA A 445
LEU A 475
LEU A 487
GLY A 495
GLU A 496
LEU A 542
 None
 0.58A 4ifgA-2wntA:
25.3		 4ifgA-2wntA:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 113
VAL A 120
ALA A 133
LYS A 135
LEU A 166
LEU A 178
GLY A 186
 16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 ( 4.3A)
None
None
16X  A1374 (-4.0A)
 0.85A 4ifgA-2x4fA:
25.3		 4ifgA-2x4fA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 120
ALA A 133
LYS A 135
LEU A 166
LEU A 178
GLY A 186
ILE A 246
 16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 ( 4.3A)
None
None
16X  A1374 (-4.0A)
16X  A1374 (-4.1A)
 0.71A 4ifgA-2x4fA:
25.3		 4ifgA-2x4fA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  69
VAL A  76
ALA A  92
LEU A 127
LEU A 139
GLY A 147
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.53A 4ifgA-2z7rA:
17.8		 4ifgA-2z7rA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 127
LEU A 139
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
None
 0.46A 4ifgA-2z7rA:
17.8		 4ifgA-2z7rA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  98
VAL A 105
ALA A 121
LEU A 158
LEU A 170
GLY A 178
GLU A 179
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
 0.71A 4ifgA-3a62A:
21.4		 4ifgA-3a62A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 488
VAL A 495
ALA A 515
LYS A 517
LEU A 550
GLY A 570
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.85A 4ifgA-3b2tA:
21.2		 4ifgA-3b2tA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  20
VAL A  27
ALA A  40
LEU A  79
LEU A  91
GLY A  99
GLU A 100
ILE A 160
 4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
PGO  A 501 ( 4.6A)
None
None
4RB  A 401 (-3.8A)
4RB  A 401 (-3.5A)
 0.46A 4ifgA-3bqrA:
25.0		 4ifgA-3bqrA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A  87
LEU A 105
 None
 0.50A 4ifgA-3coiA:
20.8		 4ifgA-3coiA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  24
VAL A  31
ALA A  44
LYS A  46
LEU A  90
GLY A  98
LEU A 153
 ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
 0.50A 4ifgA-3dakA:
23.9		 4ifgA-3dakA:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 GLY A  14
VAL A  21
ALA A  34
GLY A  89
GLU A  90
LEU A 136
ILE A 149
LEU A 153
 None
 0.80A 4ifgA-3dfaA:
34.6		 4ifgA-3dfaA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 GLY A  14
VAL A  21
ALA A  34
LEU A  69
GLY A  89
GLU A  90
LEU A 136
ILE A 149
 None
 0.72A 4ifgA-3dfaA:
34.6		 4ifgA-3dfaA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 GLY A  14
VAL A  21
LYS A  36
GLY A  89
GLU A  90
LEU A 136
ILE A 149
LEU A 153
 None
 1.17A 4ifgA-3dfaA:
34.6		 4ifgA-3dfaA:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  45
VAL A  52
ALA A  65
LEU A 106
LEU A 118
LEU A 174
ILE A 185
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.66A 4ifgA-3f2aA:
22.9		 4ifgA-3f2aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
LEU A  88
LEU A 100
GLY A 108
ILE A 168
 DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 ( 4.2A)
 0.56A 4ifgA-3f3zA:
29.5		 4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 100
GLY A 108
ILE A 168
 DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 ( 4.9A)
DRK  A   1 ( 4.2A)
 0.64A 4ifgA-3f3zA:
29.5		 4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LEU A  88
LEU A 100
GLY A 108
GLU A 109
LEU A 155
ILE A 168
 DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.6A)
DRK  A   1 ( 4.2A)
 0.53A 4ifgA-3f3zA:
29.5		 4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
LEU A 100
GLY A 108
LEU A 155
ILE A 168
 DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-4.6A)
DRK  A   1 ( 4.2A)
 0.58A 4ifgA-3f3zA:
29.5		 4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLY A  63
VAL A  70
ALA A  83
LYS A  85
LEU A 118
LEU A 130
GLY A 138
 None
 0.63A 4ifgA-3fe3A:
23.9		 4ifgA-3fe3A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 489
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.80A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 432
VAL A 439
LYS A 457
LEU A 489
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.73A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 105
VAL A 112
ALA A 125
LEU A 162
GLY A 182
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.0A)
None
GMG  A   1 ( 4.9A)
 0.84A 4ifgA-3hdnA:
24.7		 4ifgA-3hdnA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 VAL A  24
ALA A  37
LEU A  75
LEU A  87
GLY A  95
LEU A 182
 ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
None
None
None
ANP  A 329 (-4.4A)
 0.48A 4ifgA-3hkoA:
22.6		 4ifgA-3hkoA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 834
VAL A 841
ALA A 859
LEU A 894
GLY A 915
LEU A1029
 None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
None
None
None
 0.46A 4ifgA-3hngA:
16.9		 4ifgA-3hngA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  60
VAL A  67
ALA A  80
LEU A 115
LEU A 127
GLY A 135
GLU A 136
LEU A 182
 None
 0.53A 4ifgA-3iecA:
23.6		 4ifgA-3iecA:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  83
VAL A  90
ALA A 103
GLY A 158
GLU A 159
LEU A 205
ILE A 218
 ANP  A 610 (-3.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
None
None
None
ANP  A 610 ( 4.4A)
 0.41A 4ifgA-3igoA:
29.2		 4ifgA-3igoA:
59.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLY A 158
LEU A 205
ILE A 218
 ANP  A 610 (-3.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
None
None
ANP  A 610 ( 4.4A)
 0.62A 4ifgA-3igoA:
29.2		 4ifgA-3igoA:
59.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
VAL A 704
LYS A 723
LEU A 755
LEU A 766
GLY A 774
LEU A 822
 ANP  A   1 (-3.7A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
None
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
 0.73A 4ifgA-3kexA:
24.3		 4ifgA-3kexA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  69
VAL A  76
ALA A  89
LYS A  91
LEU A 124
LEU A 136
GLU A 145
LEU A 191
 ANP  A 522 (-3.5A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
None
ANP  A 522 (-2.8A)
ANP  A 522 (-4.7A)
 0.64A 4ifgA-3lijA:
27.4		 4ifgA-3lijA:
59.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 VAL A  76
ALA A  89
LYS A  91
LEU A 124
LEU A 136
GLY A 144
GLU A 145
LEU A 191
 ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
None
None
ANP  A 522 (-2.8A)
ANP  A 522 (-4.7A)
 0.53A 4ifgA-3lijA:
27.4		 4ifgA-3lijA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  40
VAL A  47
ALA A  60
LEU A  96
LEU A 108
GLY A 116
GLU A 117
LEU A 165
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
None
None
None
 0.55A 4ifgA-3lm5A:
26.1		 4ifgA-3lm5A:
23.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		9 GLY A  41
VAL A  48
ALA A  61
MET A  95
LEU A  97
GLY A 117
LEU A 164
ILE A 177
LEU A 181
 DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
DXR  A 299 (-3.2A)
None
None
None
DXR  A 299 ( 3.6A)
None
 0.41A 4ifgA-3ma6A:
31.1		 4ifgA-3ma6A:
90.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 MET A  95
LEU A  97
GLY A 117
GLU A 118
LEU A 164
ILE A 177
LEU A 181
 DXR  A 299 (-3.2A)
None
None
None
None
DXR  A 299 ( 3.6A)
None
 0.58A 4ifgA-3ma6A:
31.1		 4ifgA-3ma6A:
90.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  89
VAL A  96
ALA A 109
LEU A 145
GLY A 165
GLU A 166
LEU A 212
 JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
None
 0.68A 4ifgA-3nuuA:
25.0		 4ifgA-3nuuA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  89
VAL A  96
ALA A 109
LYS A 111
LEU A 145
GLY A 165
LEU A 212
 JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
None
 0.79A 4ifgA-3nuuA:
25.0		 4ifgA-3nuuA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
LEU A 249
LEU A 261
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.49A 4ifgA-3nyoA:
22.5		 4ifgA-3nyoA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  64
VAL A  71
ALA A  84
LEU A 130
LEU A 142
GLY A 150
GLU A 151
LEU A 197
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.1A)
ANP  A1634 (-4.4A)
 0.42A 4ifgA-3q5iA:
26.2		 4ifgA-3q5iA:
50.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
LEU A 139
LEU A 151
GLY A 159
LEU A 207
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
None
NM7  A 416 ( 4.2A)
 0.66A 4ifgA-3qfvA:
23.3		 4ifgA-3qfvA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 139
LEU A 151
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
None
 0.52A 4ifgA-3qfvA:
23.3		 4ifgA-3qfvA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
MET A 112
LEU A 114
LEU A 126
GLY A 134
GLU A 135
LEU A 181
ILE A 194
LEU A 198
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
None
None
BK5  A 701 ( 3.5A)
BK5  A 701 ( 4.9A)
 0.32A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  58
VAL A  65
LYS A  80
LEU A 114
LEU A 126
GLU A 178
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 ( 3.5A)
 1.23A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 485
VAL A 492
ALA A 512
LEU A 547
GLY A 567
LEU A 630
 07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
None
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.46A 4ifgA-3tt0A:
21.9		 4ifgA-3tt0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 362
VAL A 369
ALA A 382
LEU A 419
GLY A 439
LEU A 486
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.43A 4ifgA-3txoA:
20.8		 4ifgA-3txoA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 841
VAL A 848
ALA A 866
LEU A 901
GLY A 922
LEU A1035
 4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.49A 4ifgA-3vidA:
19.4		 4ifgA-3vidA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  84
VAL A  91
ALA A 104
LYS A 106
LEU A 140
LEU A 152
LEU A 207
 VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
None
VX6  A 500 (-4.6A)
 0.80A 4ifgA-4af3A:
21.7		 4ifgA-4af3A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  84
VAL A  91
LYS A 106
LEU A 140
LEU A 152
GLY A 160
LEU A 207
 VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.3A)
None
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.96A 4ifgA-4af3A:
21.7		 4ifgA-4af3A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  91
ALA A 104
LYS A 106
LEU A 140
LEU A 152
GLU A 161
LEU A 207
 VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
None
VX6  A 500 ( 4.6A)
VX6  A 500 (-4.6A)
 0.74A 4ifgA-4af3A:
21.7		 4ifgA-4af3A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  91
LYS A 106
LEU A 140
LEU A 152
GLY A 160
GLU A 161
LEU A 207
 VX6  A 500 ( 4.8A)
VX6  A 500 (-3.3A)
None
None
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.6A)
VX6  A 500 (-4.6A)
 0.83A 4ifgA-4af3A:
21.7		 4ifgA-4af3A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
ALA A 104
LEU A 140
LEU A 152
GLY A 160
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
None
None
EDO  A1420 ( 4.8A)
 0.55A 4ifgA-4aw2A:
23.3		 4ifgA-4aw2A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 GLY A 247
VAL A 254
ALA A 267
LEU A 304
GLY A 324
GLU A 325
LEU A 371
 None
 0.48A 4ifgA-4c0tA:
23.7		 4ifgA-4c0tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 VAL A  30
ALA A  43
LEU A  79
GLY A  99
GLU A 100
LEU A 146
 None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
 0.52A 4ifgA-4cfhA:
21.0		 4ifgA-4cfhA:
29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
LEU A  81
LEU A  93
GLY A 101
GLU A 102
LEU A 148
 ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
None
None
None
ATP  A 401 (-3.7A)
ATP  A 401 (-4.6A)
 0.73A 4ifgA-4fg8A:
32.4		 4ifgA-4fg8A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
LEU A 515
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.5A)
None
 0.54A 4ifgA-4fl3A:
23.8		 4ifgA-4fl3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 GLY A 133
VAL A 140
ALA A 156
LYS A 158
LEU A 192
LEU A 259
LEU A 273
 None
 0.74A 4ifgA-4hzsA:
23.6		 4ifgA-4hzsA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 LYS A 335
LEU A 365
LEU A 377
GLY A 385
LEU A 436
ILE A 446
LEU A 450
 None
 0.67A 4ifgA-4l68A:
15.0		 4ifgA-4l68A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  76
LEU A  93
LEU A 164
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
 0.61A 4ifgA-4m69A:
19.0		 4ifgA-4m69A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  79
VAL A  86
ALA A  99
LEU A 132
LEU A 144
LEU A 199
ILE A 212
 STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.58A 4ifgA-4mvfA:
24.2		 4ifgA-4mvfA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 GLY A  25
VAL A  32
ALA A  45
LEU A  81
GLY A 101
GLU A 102
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
None
STU  A 601 ( 3.8A)
STU  A 601 (-4.0A)
STU  A 601 (-4.2A)
 0.65A 4ifgA-4rewA:
25.8		 4ifgA-4rewA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 133
LEU A 145
GLU A 154
ILE A 214
 None
 0.63A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
GLU A 154
ILE A 214
LEU A 218
 None
 0.65A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 GLY A  77
VAL A  84
LYS A  99
LEU A 133
LEU A 145
GLY A 153
GLU A 154
LEU A 200
ILE A 214
 None
 0.70A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 GLY A  77
VAL A  84
LYS A  99
LEU A 145
GLY A 153
GLU A 154
LEU A 200
ILE A 214
LEU A 218
 None
 0.70A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 193
VAL A 200
ALA A 213
LEU A 249
LEU A 261
GLY A 269
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
None
None
SGV  A 601 (-4.9A)
 0.62A 4ifgA-4tnbA:
21.3		 4ifgA-4tnbA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 151
VAL A 158
ALA A 169
LEU A 206
LEU A 218
GLY A 226
LEU A 275
 None
 0.63A 4ifgA-4uy9A:
24.4		 4ifgA-4uy9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 131
VAL A 138
ALA A 149
LEU A 186
LEU A 198
GLY A 206
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
None
AGS  A1438 (-4.7A)
 0.56A 4ifgA-4uyaA:
23.0		 4ifgA-4uyaA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 250
LEU A 262
GLY A 270
LEU A 321
 None
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.60A 4ifgA-4wboA:
22.7		 4ifgA-4wboA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 194
VAL A 201
ALA A 214
LEU A 250
LEU A 262
GLY A 270
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
None
None
 0.47A 4ifgA-4yhjA:
21.3		 4ifgA-4yhjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 166
VAL A 173
ALA A 186
LEU A 224
LEU A 236
LEU A 294
 4E1  A 505 (-3.5A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
None
None
 0.39A 4ifgA-4yljA:
21.6		 4ifgA-4yljA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  82
LEU A  94
LEU A 149
 None
 0.53A 4ifgA-4ynzA:
26.9		 4ifgA-4ynzA:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A  89
LEU A  91
LEU A 103
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 (-4.5A)
 0.70A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  35
VAL A  42
ALA A  55
MET A  89
LEU A  91
LEU A 103
LEU A 158
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
 0.65A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 VAL A  42
ALA A  55
LYS A  57
MET A  89
LEU A  91
LEU A 103
GLY A 111
GLU A 112
ILE A 171
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.5A)
 0.75A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 VAL A  42
ALA A  55
MET A  89
LEU A  91
LEU A 103
GLY A 111
GLU A 112
LEU A 158
ILE A 171
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
 0.63A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 485
VAL A 492
ALA A 512
LYS A 514
LEU A 547
GLY A 567
LEU A 630
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.59A 4ifgA-5a46A:
21.9		 4ifgA-5a46A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
LEU A  78
LEU A  90
GLY A  98
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.68A 4ifgA-5ci7A:
22.6		 4ifgA-5ci7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
GLY A 156
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
 0.46A 4ifgA-5dbxA:
23.2		 4ifgA-5dbxA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  63
VAL A  70
ALA A  83
LEU A 118
LEU A 130
GLY A 138
GLU A 139
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
None
 0.70A 4ifgA-5es1A:
24.1		 4ifgA-5es1A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLY A  63
VAL A  70
ALA A  83
LYS A  85
LEU A 118
LEU A 130
GLU A 182
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
5RC  A4000 (-4.0A)
 0.80A 4ifgA-5es1A:
24.1		 4ifgA-5es1A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.41A 4ifgA-5eykA:
25.3		 4ifgA-5eykA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		8 GLY A 541
VAL A 548
ALA A 561
LEU A 597
GLY A 617
GLU A 618
LEU A 664
ILE A 674
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
None
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
 0.68A 4ifgA-5ezrA:
22.7		 4ifgA-5ezrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 790
LEU A 802
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
PP1  A2012 (-4.6A)
 0.61A 4ifgA-5fm2A:
21.4		 4ifgA-5fm2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 GLY A  23
VAL A  30
ALA A  43
LEU A  79
GLY A  99
GLU A 100
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.0A)
STU  A 601 (-3.4A)
STU  A 601 (-4.5A)
 0.63A 4ifgA-5isoA:
25.6		 4ifgA-5isoA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 397
VAL A 404
ALA A 417
LEU A 451
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.58A 4ifgA-5jznA:
26.3		 4ifgA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 GLY A 359
VAL A 366
ALA A 379
LEU A 415
LEU A 427
GLY A 435
LEU A 482
 ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
None
None
None
ANP  A 801 (-4.8A)
 0.78A 4ifgA-5nclA:
23.8		 4ifgA-5nclA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 GLY A 359
VAL A 366
ALA A 379
LYS A 381
LEU A 427
GLY A 435
LEU A 482
 ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 (-2.6A)
None
None
ANP  A 801 (-4.8A)
 0.79A 4ifgA-5nclA:
23.8		 4ifgA-5nclA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 GLY A  45
VAL A  52
ALA A  65
LEU A 106
LEU A 118
LEU A 174
ILE A 185
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
 0.60A 4ifgA-5turA:
23.0		 4ifgA-5turA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 8 GLY A  18
VAL A  25
ALA A  38
LEU A  72
GLY A  92
GLU A  93
LEU A 139
ILE A 149
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
None
None
7LV  A 401 ( 4.7A)
7LV  A 401 (-4.9A)
7LV  A 401 (-3.6A)
 0.38A 4ifgA-5tvtA:
24.4		 4ifgA-5tvtA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  99
VAL A 106
ALA A 119
LEU A 155
GLY A 175
LEU A 221
 None
 0.44A 4ifgA-5u7qA:
23.0		 4ifgA-5u7qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 7 GLY A  76
VAL A  83
ALA A  95
LYS A  97
LEU A 127
LEU A 139
LEU A 206
 ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
None
ANP  A1000 (-4.5A)
 0.63A 4ifgA-5xd6A:
20.6		 4ifgA-5xd6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 7 GLY A  76
VAL A  83
LYS A  97
LEU A 127
LEU A 139
GLY A 147
LEU A 206
 ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
None
None
ANP  A1000 (-4.5A)
 0.51A 4ifgA-5xd6A:
20.6		 4ifgA-5xd6A:
11.26