SIMILAR PATTERNS OF AMINO ACIDS FOR 4ID5_A_T27A601
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1axd | GLUTATHIONES-TRANSFERASE I (Zea mays) |
PF00043(GST_C)PF02798(GST_N) | 5 | PRO A 55LEU A 5VAL A 206VAL A 9TYR A 28 | None | 1.47A | 4id5A-1axdA:0.0 | 4id5A-1axdA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1doi | 2FE-2S FERREDOXIN (Haloarculamarismortui) |
PF00111(Fer2) | 5 | PRO A 60VAL A 3TYR A 115TYR A 5PRO A 106 | K A 204 ( 4.6A)NoneNoneNoneNone | 1.25A | 4id5A-1doiA:undetectable | 4id5A-1doiA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kol | FORMALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 249VAL A 255VAL A 212TYR A 190PRO A 253 | None | 1.08A | 4id5A-1kolA:0.0 | 4id5A-1kolA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmy | SIMILAR TOTHYMIDYLATE KINASE(DTMP KINASE) (Homo sapiens) |
PF02223(Thymidylate_kin) | 5 | PRO A 127LEU A 210LYS A 118VAL A 103PRO A 120 | None | 1.30A | 4id5A-1nmyA:undetectable | 4id5A-1nmyA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 5 | LEU B 311VAL B 186VAL B 226PRO B 193PRO B 306 | NoneNonePLP B 400 ( 4.5A)NoneNone | 1.47A | 4id5A-1wdwB:0.5 | 4id5A-1wdwB:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wic | HYPOTHETICAL PROTEINRIKEN CDNA6030424E15 (Mus musculus) |
PF00635(Motile_Sperm) | 5 | LEU A 131VAL A 82VAL A 55TYR A 63PHE A 29 | None | 1.43A | 4id5A-1wicA:0.0 | 4id5A-1wicA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wpx | CARBOXYPEPTIDASE YINHIBITOR (Saccharomycescerevisiae) |
PF01161(PBP) | 5 | PRO B 532LEU B 708VAL B 524TYR B 515TYR B 668 | None | 1.36A | 4id5A-1wpxB:1.2 | 4id5A-1wpxB:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xea | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Vibrio cholerae) |
PF01408(GFO_IDH_MocA) | 5 | LEU A 86VAL A 67VAL A 59TYR A 56PRO A 89 | None | 1.38A | 4id5A-1xeaA:0.0 | 4id5A-1xeaA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | PRO A 243VAL A 154TYR A 151PRO A 81PHE A 383 | None | 1.43A | 4id5A-1z8lA:0.8 | 4id5A-1z8lA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9l | VESICLE-ASSOCIATEDMEMBRANEPROTEIN-ASSOCIATEDPROTEIN A (Rattusnorvegicus) |
PF00635(Motile_Sperm) | 5 | LEU A 119VAL A 71VAL A 44TYR A 52PHE A 18 | None | 1.39A | 4id5A-1z9lA:undetectable | 4id5A-1z9lA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5i | CYTOKINE RECEPTORCOMMON GAMMA CHAIN (Homo sapiens) |
PF00041(fn3)PF09240(IL6Ra-bind) | 5 | LEU C 140VAL C 165TYR C 197TYR C 167PHE C 186 | None | 1.46A | 4id5A-2b5iC:undetectable | 4id5A-2b5iC:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2erj | CYTOKINE RECEPTORCOMMON GAMMA CHAIN (Homo sapiens) |
PF00041(fn3)PF09240(IL6Ra-bind) | 5 | LEU C 140VAL C 165TYR C 197TYR C 167PHE C 186 | None | 1.38A | 4id5A-2erjC:undetectable | 4id5A-2erjC:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5u | VIRION PROTEIN UL25 (Humanalphaherpesvirus1) |
PF01499(Herpes_UL25) | 5 | PRO A 574LEU A 406VAL A 416PRO A 145TYR A 562 | None | 1.31A | 4id5A-2f5uA:undetectable | 4id5A-2f5uA:20.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 8 | LEU A 100LYS A 103VAL A 106TYR A 181TYR A 188PRO A 225PRO A 236TYR A 318 | PC0 A 999 ( 3.9A)NonePC0 A 999 ( 4.8A)PC0 A 999 (-3.9A)PC0 A 999 (-4.1A)NonePC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.81A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 8 | LEU A 100LYS A 103VAL A 106TYR A 188PRO A 225PHE A 227PRO A 236TYR A 318 | PC0 A 999 ( 3.9A)NonePC0 A 999 ( 4.8A)PC0 A 999 (-4.1A)NonePC0 A 999 (-4.7A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.91A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 8 | LEU A 100VAL A 106VAL A 179TYR A 181TYR A 188PRO A 225PRO A 236TYR A 318 | PC0 A 999 ( 3.9A)PC0 A 999 ( 4.8A)PC0 A 999 (-4.4A)PC0 A 999 (-3.9A)PC0 A 999 (-4.1A)NonePC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.76A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 8 | LEU A 100VAL A 106VAL A 179TYR A 188PRO A 225PHE A 227PRO A 236TYR A 318 | PC0 A 999 ( 3.9A)PC0 A 999 ( 4.8A)PC0 A 999 (-4.4A)PC0 A 999 (-4.1A)NonePC0 A 999 (-4.7A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.87A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 9 | PRO A 95LEU A 100LYS A 103VAL A 106PRO A 225PHE A 227TRP A 229PRO A 236TYR A 318 | PC0 A 999 ( 4.9A)PC0 A 999 ( 3.9A)NonePC0 A 999 ( 4.8A)NonePC0 A 999 (-4.7A)PC0 A 999 ( 4.2A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.75A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 9 | PRO A 95LEU A 100LYS A 103VAL A 106TYR A 181PRO A 225TRP A 229PRO A 236TYR A 318 | PC0 A 999 ( 4.9A)PC0 A 999 ( 3.9A)NonePC0 A 999 ( 4.8A)PC0 A 999 (-3.9A)NonePC0 A 999 ( 4.2A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.84A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 9 | PRO A 95LEU A 100VAL A 106VAL A 179PRO A 225PHE A 227TRP A 229PRO A 236TYR A 318 | PC0 A 999 ( 4.9A)PC0 A 999 ( 3.9A)PC0 A 999 ( 4.8A)PC0 A 999 (-4.4A)NonePC0 A 999 (-4.7A)PC0 A 999 ( 4.2A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.71A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 9 | PRO A 95LEU A 100VAL A 106VAL A 179TYR A 181PRO A 225TRP A 229PRO A 236TYR A 318 | PC0 A 999 ( 4.9A)PC0 A 999 ( 3.9A)PC0 A 999 ( 4.8A)PC0 A 999 (-4.4A)PC0 A 999 (-3.9A)NonePC0 A 999 ( 4.2A)PC0 A 999 ( 4.3A)PC0 A 999 (-4.3A) | 0.80A | 4id5A-2hnzA:36.1 | 4id5A-2hnzA:98.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o4c | ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE (Pseudomonasaeruginosa) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C)PF11890(DUF3410) | 5 | LEU A 42TYR A 274TYR A 271PHE A 15PRO A 10 | None | 1.22A | 4id5A-2o4cA:undetectable | 4id5A-2o4cA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4b | SIGMA-E FACTORREGULATORY PROTEINRSEB (Escherichiacoli) |
PF03888(MucB_RseB)PF17188(MucB_RseB_C) | 5 | LEU A 31VAL A 170TYR A 156PRO A 112PRO A 167 | None | 1.22A | 4id5A-2p4bA:undetectable | 4id5A-2p4bA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ze4 | PHOSPHOLIPASE D (Streptomycesantibioticus) |
PF13091(PLDc_2) | 5 | PRO A 124LEU A 164VAL A 274PRO A 462PRO A 347 | None | 1.49A | 4id5A-2ze4A:undetectable | 4id5A-2ze4A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | PRO A 233VAL A 144TYR A 141PRO A 71PHE A 373 | None | 1.34A | 4id5A-3fedA:undetectable | 4id5A-3fedA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3frn | FLAGELLAR PROTEINFLGA (Thermotogamaritima) |
PF13144(ChapFlgA) | 5 | LEU A 56VAL A 148VAL A 139PRO A 119TYR A 58 | None | 1.49A | 4id5A-3frnA:undetectable | 4id5A-3frnA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2e | GLYCOCYAMINE KINASEALPHA CHAIN (Namalycastissp. ST01) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | PRO A 120LEU A 122VAL A 248VAL A 302TYR A 290 | None | 1.16A | 4id5A-3l2eA:3.8 | 4id5A-3l2eA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7g | XAA-PRO DIPEPTIDASE (Alteromonas sp.) |
PF00557(Peptidase_M24) | 5 | PRO A 54LEU A 340LYS A 160TYR A 153TYR A 252 | None | 1.18A | 4id5A-3l7gA:undetectable | 4id5A-3l7gA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3a | PROTEIN NRDI (Escherichiacoli) |
PF07972(Flavodoxin_NdrI) | 5 | LEU C 66VAL C 46VAL C 78TYR C 42PRO C 59 | None | 1.40A | 4id5A-3n3aC:undetectable | 4id5A-3n3aC:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bp8 | OLIGOPEPTIDASE B (Trypanosomabrucei) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | PRO A 638LEU A 640VAL A 590VAL A 569PRO A 656 | None | 1.45A | 4id5A-4bp8A:0.8 | 4id5A-4bp8A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by6 | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF04054(Not1) | 5 | VAL A1802VAL A1798TYR A1792PHE A1788TYR A1839 | None | 1.50A | 4id5A-4by6A:undetectable | 4id5A-4by6A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 250VAL A 256VAL A 213TYR A 191PRO A 254 | None | 1.12A | 4id5A-4jlwA:undetectable | 4id5A-4jlwA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfu | GLYCOSIDE HYDROLASEFAMILY 5 (Bacteroidesvulgatus) |
PF12904(Collagen_bind_2)PF13204(DUF4038) | 5 | LEU A 366VAL A 473TYR A 401TYR A 472PRO A 481 | None | 1.31A | 4id5A-4qfuA:undetectable | 4id5A-4qfuA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5k | ASPARTATEAMINOTRANSFERASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF00155(Aminotran_1_2) | 5 | LEU A 134TYR A 137TYR A 139PRO A 174PRO A 121 | None | 1.14A | 4id5A-4w5kA:0.8 | 4id5A-4w5kA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wcj | POLYSACCHARIDEDEACETYLASE (Ammonifexdegensii) |
PF01522(Polysacc_deac_1) | 5 | LEU A 242VAL A 89VAL A 40TYR A 97TYR A 219 | None | 1.31A | 4id5A-4wcjA:undetectable | 4id5A-4wcjA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5agq | BROMODOMAIN ADJACENTTO ZINC FINGERDOMAIN PROTEIN 2A (Homo sapiens) |
PF01429(MBD) | 5 | VAL A 566TYR A 553PHE A 585TRP A 551PRO A 564 | None | 1.48A | 4id5A-5agqA:undetectable | 4id5A-5agqA:11.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 5 | LYS B 103VAL B 106VAL B 179TYR B 181TYR B 188 | None | 0.73A | 4id5A-5c24B:9.5 | 4id5A-5c24B:96.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evl | BETA-LACTAMASE (Chromobacteriumviolaceum) |
PF00144(Beta-lactamase) | 5 | LEU A 110VAL A 101TYR A 136PRO A 141PRO A 145 | None | 1.32A | 4id5A-5evlA:0.4 | 4id5A-5evlA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey5 | LBCA-B (syntheticconstruct) |
PF00291(PALP) | 5 | LEU B 313VAL B 188VAL B 228PRO B 195PRO B 308 | NoneNonePLP B 501 ( 4.6A)NoneNone | 1.46A | 4id5A-5ey5B:undetectable | 4id5A-5ey5B:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i32 | AQUAPORIN TIP2-1 (Arabidopsisthaliana) |
PF00230(MIP) | 5 | PRO A 84LEU A 109VAL A 206PHE A 211TRP A 218 | None | 1.32A | 4id5A-5i32A:undetectable | 4id5A-5i32A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfm | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | VAL A 214VAL A 239TYR A 237PHE A 153TYR A 45 | None | 1.24A | 4id5A-5xfmA:undetectable | 4id5A-5xfmA:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhw | PUTATIVE6-DEOXY-D-MANNOHEPTOSE PATHWAY PROTEIN (Yersiniapseudotuberculosis) |
no annotation | 5 | PRO A 25LEU A 35VAL A 75PHE A 77TYR A 36 | None | 1.45A | 4id5A-5xhwA:0.9 | 4id5A-5xhwA:8.35 |