SIMILAR PATTERNS OF AMINO ACIDS FOR 4IAQ_A_2GMA2001_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dju | AROMATICAMINOTRANSFERASE (Pyrococcushorikoshii) |
PF00155(Aminotran_1_2) | 4 | ILE A 215THR A 225VAL A 176SER A 217 | None | 1.12A | 4iaqA-1djuA:undetectable | 4iaqA-1djuA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ece | ENDOCELLULASE E1 (Acidothermuscellulolyticus) |
PF00150(Cellulase) | 4 | ILE A 111THR A 60VAL A 96ASP A 45 | None | 1.04A | 4iaqA-1eceA:undetectable | 4iaqA-1eceA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnf | FIBRONECTIN (Homo sapiens) |
PF00041(fn3) | 4 | ILE A1172THR A1169VAL A1194SER A1225 | None | 1.05A | 4iaqA-1fnfA:undetectable | 4iaqA-1fnfA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlg | LIPASE, GASTRIC (Homo sapiens) |
PF00561(Abhydrolase_1) | 4 | TRP A 275ILE A 161SER A 164ASP A 331 | None | 1.10A | 4iaqA-1hlgA:undetectable | 4iaqA-1hlgA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1miq | PLASMEPSIN (Plasmodiumvivax) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312ASP A 316 | None | 0.99A | 4iaqA-1miqA:undetectable | 4iaqA-1miqA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1miq | PLASMEPSIN (Plasmodiumvivax) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312SER A 261 | None | 0.99A | 4iaqA-1miqA:undetectable | 4iaqA-1miqA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n1c | TORA SPECIFICCHAPERONE (Shewanellamassilia) |
PF02613(Nitrate_red_del) | 4 | ILE A 171THR A 175VAL A 163ASP A 134 | None | 1.02A | 4iaqA-1n1cA:2.8 | 4iaqA-1n1cA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbu | PROBABLEDIHYDRONEOPTERINALDOLASE (Mycobacteriumtuberculosis) |
PF02152(FolB) | 4 | ILE B 5THR B 51VAL B 95ASP B 82 | None | 1.08A | 4iaqA-1nbuB:undetectable | 4iaqA-1nbuB:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o0x | METHIONINEAMINOPEPTIDASE (Thermotogamaritima) |
PF00557(Peptidase_M24) | 4 | ILE A 168VAL A 218SER A 211ASP A 222 | None | 1.16A | 4iaqA-1o0xA:0.5 | 4iaqA-1o0xA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1osn | THYMIDINE KINASE (Humanalphaherpesvirus3) |
PF00693(Herpes_TK) | 4 | TRP A 53ILE A 65THR A 86ASP A 18 | BVP A 500 (-4.6A)BVP A 500 ( 4.2A)NoneNone | 1.11A | 4iaqA-1osnA:1.0 | 4iaqA-1osnA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5r | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 4 | ILE H 3THR H 1VAL H 121ASP H 124 | None | 0.86A | 4iaqA-1q5rH:0.5 | 4iaqA-1q5rH:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs8 | PLASMEPSIN (Plasmodiumvivax) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312SER A 261 | None | 1.02A | 4iaqA-1qs8A:undetectable | 4iaqA-1qs8A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzm | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 4 | ILE A 83THR A 81VAL A 162ASP A 269 | None | 1.12A | 4iaqA-1rzmA:0.0 | 4iaqA-1rzmA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vko | INOSITOL-3-PHOSPHATESYNTHASE (Caenorhabditiselegans) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 4 | ILE A 466THR A 492VAL A 308ASP A 311 | None | 1.17A | 4iaqA-1vkoA:0.3 | 4iaqA-1vkoA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vtk | THYMIDINE KINASE (Humanalphaherpesvirus1) |
PF00693(Herpes_TK) | 4 | ILE A 143THR A 350VAL A 138ASP A 363 | None | 1.13A | 4iaqA-1vtkA:2.6 | 4iaqA-1vtkA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aml | SIS DOMAIN PROTEIN (Listeriamonocytogenes) |
PF01380(SIS) | 4 | ILE A 218THR A 216VAL A 278ASP A 301 | None | 1.17A | 4iaqA-2amlA:undetectable | 4iaqA-2amlA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bju | PLASMEPSIN II (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312ASP A 316 | None | 0.97A | 4iaqA-2bjuA:undetectable | 4iaqA-2bjuA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bju | PLASMEPSIN II (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312SER A 261 | None | 1.01A | 4iaqA-2bjuA:undetectable | 4iaqA-2bjuA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1z | UDP-GLUCOSEFLAVONOID 3-OGLYCOSYLTRANSFERASE (Vitis vinifera) |
PF00201(UDPGT) | 4 | THR A 230VAL A 382SER A 221ASP A 186 | None | 0.96A | 4iaqA-2c1zA:undetectable | 4iaqA-2c1zA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dvu | THERMOPHILICREVERSIBLEGAMMA-RESORCYLATEDECARBOXYLASE (Rhizobium sp.MTP-10005) |
PF04909(Amidohydro_2) | 4 | ILE A 293THR A 286SER A 297ASP A 93 | None | 1.01A | 4iaqA-2dvuA:undetectable | 4iaqA-2dvuA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gaf | POLY(A) POLYMERASECATALYTIC SUBUNIT (Vaccinia virus) |
PF03296(Pox_polyA_pol)PF12629(Pox_polyA_pol_C)PF12630(Pox_polyA_pol_N) | 4 | ILE D 229THR D 225VAL D 242ASP D 202 | None | 1.16A | 4iaqA-2gafD:2.5 | 4iaqA-2gafD:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gou | OXIDOREDUCTASE,FMN-BINDING (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 4 | ILE A 249THR A 253SER A 283ASP A 276 | None | 1.13A | 4iaqA-2gouA:undetectable | 4iaqA-2gouA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 4 | THR A 775VAL A 827SER A 705ASP A 834 | None | 1.16A | 4iaqA-2hg4A:undetectable | 4iaqA-2hg4A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqa | CALPAIN 8 (Homo sapiens) |
PF00648(Peptidase_C2) | 4 | TRP A 106ILE A 111THR A 115ASP A 206 | None | 1.10A | 4iaqA-2nqaA:undetectable | 4iaqA-2nqaA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okx | RHAMNOSIDASE B (Bacillus sp.GL1) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | TRP A 684ILE A 687THR A 766ASP A 616 | None | 1.13A | 4iaqA-2okxA:2.6 | 4iaqA-2okxA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5o | PHENYLPYRUVATEDECARBOXYLASE (Azospirillumbrasilense) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | THR A 236VAL A 533SER A 281ASP A 382 | None | 1.12A | 4iaqA-2q5oA:undetectable | 4iaqA-2q5oA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgy | ENOLASE FROM THEENVIRONMENTAL GENOMESHOTGUN SEQUENCINGOF THE SARGASSO SEA (-) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 36THR A 19VAL A 361SER A 304 | None | 1.11A | 4iaqA-2qgyA:undetectable | 4iaqA-2qgyA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v1l | HYPOTHETICAL PROTEIN (Vibrio cholerae) |
PF10980(DUF2787) | 4 | TRP A 72ILE A 74THR A 9VAL A 42 | None | 1.08A | 4iaqA-2v1lA:undetectable | 4iaqA-2v1lA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsu | P-HYDROXYCINNAMOYLCOA HYDRATASE/LYASE (Pseudomonasfluorescens) |
PF00378(ECH_1) | 4 | TRP C 8ILE C 23THR C 60ASP C 51 | None | 1.15A | 4iaqA-2vsuC:undetectable | 4iaqA-2vsuC:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzo | REGULATOR OFNONSENSE TRANSCRIPTS1 (Homo sapiens) |
PF04851(ResIII)PF13086(AAA_11)PF13087(AAA_12) | 4 | ILE A 329THR A 325VAL A 405ASP A 369 | None | 1.17A | 4iaqA-2xzoA:2.4 | 4iaqA-2xzoA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 94THR A 92VAL A 42ASP A 28 | None | 1.17A | 4iaqA-2y7jA:2.7 | 4iaqA-2y7jA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ag7 | PUTATIVEUNCHARACTERIZEDPROTEIN F9E10.5 (Arabidopsisthaliana) |
no annotation | 4 | TRP A 583ILE A 581THR A 577SER A 564 | None | 0.91A | 4iaqA-3ag7A:undetectable | 4iaqA-3ag7A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE SMALLSUBUNIT (Hydrogenovibriomarinus) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 4 | ILE B 78THR B 13VAL B 81ASP B 52 | None | 1.15A | 4iaqA-3ayxB:undetectable | 4iaqA-3ayxB:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn1 | PEROSAMINESYNTHETASE (Caulobactervibrioides) |
PF01041(DegT_DnrJ_EryC1) | 4 | ILE A 137THR A 280VAL A 162ASP A 248 | None | 1.10A | 4iaqA-3bn1A:undetectable | 4iaqA-3bn1A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cir | FUMARATE REDUCTASEIRON-SULFUR SUBUNIT (Escherichiacoli) |
PF13085(Fer2_3)PF13183(Fer4_8) | 4 | TRP B 202ILE B 224THR B 174SER B 211 | NoneF3S B 245 ( 4.5A)NoneNone | 1.10A | 4iaqA-3cirB:undetectable | 4iaqA-3cirB:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cyj | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Rubrobacterxylanophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 35THR A 33VAL A 100SER A 55 | None | 0.95A | 4iaqA-3cyjA:undetectable | 4iaqA-3cyjA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d5t | MALATE DEHYDROGENASE (Burkholderiapseudomallei) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ILE A 267THR A 154VAL A 295ASP A 195 | None | 1.14A | 4iaqA-3d5tA:undetectable | 4iaqA-3d5tA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da0 | CLEAVED CHIMERICRECEPTOR BINDINGPROTEIN FROMBACTERIOPHAGESTP901-1 AND P2 (Lactococcusphage TP901-1;Lactococcusvirus P2) |
PF08931(Caudo_bapla_RBP) | 4 | ILE A 88THR A 80VAL A 122ASP A 135 | None | 1.17A | 4iaqA-3da0A:undetectable | 4iaqA-3da0A:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4f | AMINOGLYCOSIDEN3-ACETYLTRANSFERASE (Bacillusanthracis) |
PF02522(Antibiotic_NAT) | 4 | TRP A 260ILE A 253VAL A 223ASP A 218 | None | 1.10A | 4iaqA-3e4fA:undetectable | 4iaqA-3e4fA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6t | ASPARTATEAMINOTRANSFERASE (Lactobacillusacidophilus) |
PF00155(Aminotran_1_2) | 4 | ILE A 388THR A 142VAL A 54ASP A 98 | None | 1.02A | 4iaqA-3f6tA:undetectable | 4iaqA-3f6tA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4g | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D (Homo sapiens) |
PF00233(PDEase_I) | 4 | ILE A 502THR A 499VAL A 373ASP A 322 | D71 A 901 (-4.1A)D71 A 901 (-3.6A)NoneNone | 1.06A | 4iaqA-3g4gA:undetectable | 4iaqA-3g4gA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kom | TRANSKETOLASE (Francisellatularensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ILE A 446VAL A 459SER A 449ASP A 381 | None | 1.10A | 4iaqA-3komA:undetectable | 4iaqA-3komA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8a | PUTATIVEAMINOTRANSFERASE,PROBABLEBETA-CYSTATHIONASE (Streptococcusmutans) |
PF00155(Aminotran_1_2) | 4 | ILE A 381VAL A 348SER A 383ASP A 38 | None | 1.14A | 4iaqA-3l8aA:undetectable | 4iaqA-3l8aA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3luf | TWO-COMPONENT SYSTEMRESPONSEREGULATOR/GGDEFDOMAIN PROTEIN (Aeromonassalmonicida) |
PF00072(Response_reg) | 4 | ILE A 77THR A 79VAL A 67ASP A 58 | None | 1.09A | 4iaqA-3lufA:undetectable | 4iaqA-3lufA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzv | DECAPRENYLDIPHOSPHATE SYNTHASE (Rhodobactercapsulatus) |
PF00348(polyprenyl_synt) | 4 | ILE A 85THR A 81VAL A 150ASP A 210 | None | 1.14A | 4iaqA-3mzvA:2.6 | 4iaqA-3mzvA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o57 | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
PF00233(PDEase_I) | 4 | ILE A 410THR A 407VAL A 281ASP A 230 | ZG2 A 506 (-4.4A)ZG2 A 506 (-4.3A)NoneNone | 1.09A | 4iaqA-3o57A:undetectable | 4iaqA-3o57A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppc | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Candidaalbicans) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 4 | ILE A 654VAL A 643SER A 656ASP A 598 | None | 1.07A | 4iaqA-3ppcA:undetectable | 4iaqA-3ppcA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5t | FERRIC VIBRIOBACTINABC TRANSPORTER,PERIPLASMIC FERRICVIBRIOBACTIN-BINDINGPROTEIN (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 4 | ILE A 132VAL A 119SER A 43ASP A 116 | None | 1.14A | 4iaqA-3r5tA:undetectable | 4iaqA-3r5tA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rn2 | INTERFERON-INDUCIBLEPROTEIN AIM2 (Homo sapiens) |
PF02760(HIN) | 4 | ILE A 334THR A 301VAL A 264ASP A 286 | None | 1.13A | 4iaqA-3rn2A:undetectable | 4iaqA-3rn2A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5n | 4-HYDROXY-2-OXOGLUTARATE ALDOLASE,MITOCHONDRIAL (Homo sapiens) |
PF00701(DHDPS) | 4 | ILE A 151THR A 155VAL A 180ASP A 197 | None | 0.89A | 4iaqA-3s5nA:undetectable | 4iaqA-3s5nA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqz | PUTATIVEHYDROXYMETHYLGLUTARYL-COA SYNTHASE (Streptococcusmutans) |
PF00195(Chal_sti_synt_N)PF08540(HMG_CoA_synt_C) | 4 | ILE A 62VAL A 162SER A 58ASP A 72 | None | 0.91A | 4iaqA-3sqzA:undetectable | 4iaqA-3sqzA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t1w | FOUR-DOMAINFIBRONECTIN FRAGMENT (Homo sapiens) |
PF00041(fn3) | 4 | ILE A1203THR A1200VAL A1225SER A1256 | None | 1.12A | 4iaqA-3t1wA:undetectable | 4iaqA-3t1wA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tkt | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | ILE A 16THR A 415VAL A 44ASP A 338 | None | 0.97A | 4iaqA-3tktA:undetectable | 4iaqA-3tktA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vmn | DEXTRANASE (Streptococcusmutans) |
PF13199(Glyco_hydro_66) | 4 | ILE A 450THR A 484VAL A 434SER A 445 | None | 1.14A | 4iaqA-3vmnA:undetectable | 4iaqA-3vmnA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnb | PROTEIN TRANSLATIONELONGATION FACTOR 1A (Methanosarcinamazei) |
no annotation | 4 | ILE A 253THR A 205VAL A 189SER A 199 | None | 1.10A | 4iaqA-3wnbA:undetectable | 4iaqA-3wnbA:25.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zef | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | TRP B1335ILE B1440VAL B1361ASP B1313 | None | 1.17A | 4iaqA-3zefB:undetectable | 4iaqA-3zefB:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1r | MANNOSYL-6-PHOSPHATASE (Bacteroidesthetaiotaomicron) |
PF03372(Exo_endo_phos) | 4 | ILE A 194THR A 196VAL A 308ASP A 225 | None | 0.74A | 4iaqA-4c1rA:undetectable | 4iaqA-4c1rA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzh | AMIDOHYDROLASE (Xanthomonascampestris) |
PF01979(Amidohydro_1) | 4 | ILE A 312THR A 351VAL A 135ASP A 379 | None | 0.97A | 4iaqA-4dzhA:undetectable | 4iaqA-4dzhA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ehc | PE-PGRS FAMILYPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 4 | ILE A 130THR A 132VAL A 115ASP A 189 | NoneNoneNone ZN A 301 (-2.0A) | 1.11A | 4iaqA-4ehcA:undetectable | 4iaqA-4ehcA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fix | UDP-GALACTOFURANOSYLTRANSFERASE GLFT2 (Mycobacteriumtuberculosis) |
PF13641(Glyco_tranf_2_3) | 4 | ILE A 259THR A 349VAL A 176ASP A 199 | None | 1.15A | 4iaqA-4fixA:2.1 | 4iaqA-4fixA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gni | PUTATIVE HEAT SHOCKPROTEIN (Chaetomiumthermophilum) |
PF00012(HSP70) | 4 | ILE A 231THR A 220SER A 185ASP A 204 | None | 1.08A | 4iaqA-4gniA:undetectable | 4iaqA-4gniA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq1 | NUP37 (Schizosaccharomycespombe) |
PF00400(WD40) | 4 | ILE A 158VAL A 146SER A 75ASP A 214 | None | 1.16A | 4iaqA-4gq1A:undetectable | 4iaqA-4gq1A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmb | CYSTEINE SYNTHASE (Microcystisaeruginosa) |
PF00291(PALP) | 4 | ILE A 156THR A 161VAL A 54ASP A 6 | None | 1.05A | 4iaqA-4lmbA:undetectable | 4iaqA-4lmbA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4neg | TRYPTOPHAN SYNTHASEBETA CHAIN (Bacillusanthracis) |
PF00291(PALP) | 4 | ILE A 212THR A 60VAL A 205SER A 380 | None | 1.06A | 4iaqA-4negA:undetectable | 4iaqA-4negA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okd | ISOAMYLASE (Chlamydomonasreinhardtii) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | TRP A 440THR A 383VAL A 200SER A 394 | None | 1.11A | 4iaqA-4okdA:undetectable | 4iaqA-4okdA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pd4 | CYTOCHROME B (Saccharomycescerevisiae) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 4 | THR C 148VAL C 264SER C 170ASP C 255 | None | 1.11A | 4iaqA-4pd4C:4.5 | 4iaqA-4pd4C:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | ILE A 661THR A 657VAL B 728SER A 509 | None | 1.17A | 4iaqA-4qiwA:3.8 | 4iaqA-4qiwA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qme | AMINOPEPTIDASE N (Neisseriameningitidis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 4 | ILE A 18THR A 21VAL A 50SER A 180 | None | 1.10A | 4iaqA-4qmeA:2.7 | 4iaqA-4qmeA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Pisum sativum) |
PF00223(PsaA_PsaB) | 4 | ILE A 743THR A 746VAL A 735SER A 610 | CLA A1126 (-3.9A)CL0 A9011 (-3.4A)NoneCL0 A9011 ( 4.3A) | 1.14A | 4iaqA-4rkuA:2.8 | 4iaqA-4rkuA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 4 | TRP P 108THR P 134VAL P 66SER P 126 | None | 1.03A | 4iaqA-4s2tP:undetectable | 4iaqA-4s2tP:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8u | LINKER L2 (Glossoscolexpaulistus) |
PF00057(Ldl_recept_a)PF16915(Eryth_link_C) | 4 | ILE N 158VAL N 217SER N 160ASP N 203 | None | 1.13A | 4iaqA-4u8uN:undetectable | 4iaqA-4u8uN:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wat | PFRH5 (Plasmodiumfalciparum) |
no annotation | 4 | ILE A 157VAL A 174SER A 153ASP A 218 | None | 1.08A | 4iaqA-4watA:5.3 | 4iaqA-4watA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wlh | KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | ILE A 229THR A 239VAL A 190SER A 231 | None | 1.04A | 4iaqA-4wlhA:undetectable | 4iaqA-4wlhA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wp0 | KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | ILE A 229THR A 239VAL A 190SER A 231 | None | 0.90A | 4iaqA-4wp0A:undetectable | 4iaqA-4wp0A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9x | DEGVDOMAIN-CONTAININGPROTEIN MW1315 (Staphylococcusaureus) |
PF02645(DegV) | 4 | ILE A 263THR A 260VAL A 158SER A 119 | OLA A 301 ( 3.7A)NoneNoneOLA A 301 ( 3.3A) | 1.12A | 4iaqA-4x9xA:undetectable | 4iaqA-4x9xA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeb | FIBRONECTIN LEUCINERICH TRANSMEMBRANEPROTEIN 3 (Mus musculus) |
PF13855(LRR_8) | 4 | ILE B 190VAL B 205SER B 194ASP B 184 | None | 1.09A | 4iaqA-4yebB:undetectable | 4iaqA-4yebB:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypg | INTERFERON ALPHA-2 (Homo sapiens) |
PF00143(Interferon) | 4 | TRP C 76THR C 14VAL C 142SER C 152 | None | 1.09A | 4iaqA-4ypgC:undetectable | 4iaqA-4ypgC:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312ASP A 316 | None | 0.91A | 4iaqA-5bwyA:undetectable | 4iaqA-5bwyA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312SER A 261 | None | 0.96A | 4iaqA-5bwyA:undetectable | 4iaqA-5bwyA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey2 | GTP-SENSINGTRANSCRIPTIONALPLEIOTROPICREPRESSOR CODY (Bacillus cereus) |
PF06018(CodY)PF08222(HTH_CodY) | 4 | ILE A 113THR A 125VAL A 91SER A 78 | None | 0.99A | 4iaqA-5ey2A:undetectable | 4iaqA-5ey2A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7v | LMO0181 PROTEIN (Listeriamonocytogenes) |
PF01547(SBP_bac_1) | 4 | ILE A 211THR A 219VAL A 203SER A 407 | None | 1.03A | 4iaqA-5f7vA:undetectable | 4iaqA-5f7vA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fft | PULMONARYSURFACTANT-ASSOCIATED PROTEIN A (Rattusnorvegicus) |
PF00059(Lectin_C) | 4 | ILE A 131THR A 130VAL A 144ASP A 182 | None | 1.12A | 4iaqA-5fftA:undetectable | 4iaqA-5fftA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsl | 778AA LONGHYPOTHETICALBETA-GALACTOSIDASE (Pyrococcushorikoshii) |
PF02449(Glyco_hydro_42) | 4 | ILE A 95THR A 177VAL A 21ASP A 9 | None | 0.90A | 4iaqA-5gslA:undetectable | 4iaqA-5gslA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i70 | PLASMEPSIN IV (Plasmodiumfalciparum) |
no annotation | 4 | TRP B 193ILE B 195VAL B 312SER B 261 | None | 1.07A | 4iaqA-5i70B:undetectable | 4iaqA-5i70B:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5igq | E3 UBIQUITIN-PROTEINLIGASE RFWD2 (Homo sapiens) |
PF00400(WD40) | 4 | ILE A 473VAL A 495SER A 426ASP A 535 | None | 1.06A | 4iaqA-5igqA:undetectable | 4iaqA-5igqA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jod | PROPLASMEPSIN IV (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | TRP A 193ILE A 195VAL A 312SER A 261 | None | 0.95A | 4iaqA-5jodA:undetectable | 4iaqA-5jodA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kci | UNCHARACTERIZEDPROTEIN YPL067C (Saccharomycescerevisiae) |
PF12239(DUF3605) | 4 | ILE A 190THR A 186VAL A 106ASP A 93 | None | 1.13A | 4iaqA-5kciA:undetectable | 4iaqA-5kciA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l56 | PLEXIN-A1 (Mus musculus) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 4 | ILE A 484THR A 433SER A 452ASP A 527 | None | 1.14A | 4iaqA-5l56A:undetectable | 4iaqA-5l56A:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 4 | ILE A 251THR A 254VAL A 144ASP A 166 | None | 1.16A | 4iaqA-5l94A:undetectable | 4iaqA-5l94A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohj | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
no annotation | 4 | ILE A 582THR A 579VAL A 453ASP A 402 | 9VE A 801 (-4.1A)9VE A 801 (-4.1A)NoneNone | 1.05A | 4iaqA-5ohjA:undetectable | 4iaqA-5ohjA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v12 | HERCYNYLCYSTEINESULFOXIDE LYASE (Neurosporacrassa) |
no annotation | 4 | ILE C 268THR C 112VAL C 262ASP C 237 | None | 1.08A | 4iaqA-5v12C:undetectable | 4iaqA-5v12C:12.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v54 | 5-HYDROXYTRYPTAMINERECEPTOR 1B,OB-1FUSED 5-HT1BRECEPTOR,5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens;Spodopterafrugiperda) |
no annotation | 6 | TRP A 125ILE A 130THR A 134VAL A 200SER A 212ASP A 352 | None89F A1201 (-4.3A)89F A1201 (-4.2A)None89F A1201 ( 3.8A)None | 0.85A | 4iaqA-5v54A:39.9 | 4iaqA-5v54A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 4 | ILE A 694VAL A 714SER A 696ASP A 626 | None | 1.06A | 4iaqA-5wblA:2.9 | 4iaqA-5wblA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbf | HARMONINUNCONVENTIONALMYOSIN-VIIB (Homo sapiens) |
PF00373(FERM_M)PF00595(PDZ)PF00784(MyTH4) | 4 | ILE A2038THR A2006VAL A2025ASP B 547 | None | 1.03A | 4iaqA-5xbfA:undetectable | 4iaqA-5xbfA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | UNCHARACTERIZEDPROTEIN (Trichomonasvaginalis) |
PF00366(Ribosomal_S17)PF16205(Ribosomal_S17_N) | 4 | ILE L 105THR L 103VAL L 137ASP L 119 | None U 2 238 ( 2.8A)NoneNone | 1.13A | 4iaqA-5xyiL:undetectable | 4iaqA-5xyiL:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yid | PLASMEPSIN II (Plasmodiumfalciparum) |
no annotation | 4 | TRP A 195ILE A 197VAL A 314SER A 263 | None | 0.93A | 4iaqA-5yidA:undetectable | 4iaqA-5yidA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywp | JEV E PROTEIN (Japaneseencephalitisvirus) |
no annotation | 4 | ILE A 33THR A 40VAL A 24ASP A 28 | None | 1.12A | 4iaqA-5ywpA:undetectable | 4iaqA-5ywpA:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqh | 5-HYDROXYTRYPTAMINERECEPTOR 2C,SOLUBLECYTOCHROME B562 (Escherichiacoli;Homo sapiens) |
no annotation | 4 | TRP A 130THR A 139VAL A 208SER A 219 | NoneE2J A1201 (-4.3A)NoneE2J A1201 (-3.2A) | 0.90A | 4iaqA-6bqhA:32.0 | 4iaqA-6bqhA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Cyanidioschyzonmerolae) |
no annotation | 4 | ILE A 733THR A 736VAL A 725SER A 600 | CLA A1126 ( 3.8A)CLA A1011 (-3.1A)NoneCLA A1011 ( 4.3A) | 1.09A | 4iaqA-6fosA:2.9 | 4iaqA-6fosA:11.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6g79 | 5-HYDROXYTRYPTAMINERECEPTOR 1B (Homo sapiens) |
no annotation | 4 | TRP S 125ILE S 130THR S 134SER S 212 | NoneEP5 S 401 (-4.2A)EP5 S 401 (-3.8A)EP5 S 401 (-3.3A) | 0.72A | 4iaqA-6g79S:34.2 | 4iaqA-6g79S:95.18 |