SIMILAR PATTERNS OF AMINO ACIDS FOR 4I90_A_ACTA500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1z TNSA ENDONUCLEASE

(Escherichia
coli) 		PF08721
(Tn7_Tnp_TnsA_C)
PF08722
(Tn7_Tnp_TnsA_N) 		3 LYS A 183
ARG A 233
TRP A 178
 None
 0.95A 4i90A-1f1zA:
0.1		 4i90A-1f1zA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 LYS A 274
ARG A 271
TRP A 267
 None
 1.09A 4i90A-1gqjA:
4.9		 4i90A-1gqjA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdp OCT-2 POU
HOMEODOMAIN

(Homo sapiens) 		PF00046
(Homeobox) 		3 LYS A  55
ARG A  52
TRP A  48
 None
 1.42A 4i90A-1hdpA:
undetectable		 4i90A-1hdpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		3 LYS B 192
ARG B 162
TRP B 188
 None
 1.46A 4i90A-1i1qB:
0.0		 4i90A-1i1qB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		3 LYS B 195
ARG B 165
TRP B 191
 None
 0.74A 4i90A-1i7qB:
0.0		 4i90A-1i7qB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n10 POLLEN ALLERGEN PHL
P 1

(Phleum pratense) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		3 LYS A1221
ARG A1213
TRP A1187
 None
 0.83A 4i90A-1n10A:
undetectable		 4i90A-1n10A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2d PURINE TRANS
DEOXYRIBOSYLASE

(Lactobacillus
helveticus) 		PF05014
(Nuc_deoxyrib_tr) 		3 LYS A  57
ARG A  63
TRP A  67
 None
 1.33A 4i90A-1s2dA:
undetectable		 4i90A-1s2dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LYS A 401
ARG A 404
TRP A 392
 None
 1.23A 4i90A-1tezA:
0.0		 4i90A-1tezA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5d SRC
KINASE-ASSOCIATED
PHOSPHOPROTEIN OF 55
KDA

(Homo sapiens) 		PF00169
(PH) 		3 LYS A 173
ARG A 169
TRP A 128
 None
 1.10A 4i90A-1u5dA:
undetectable		 4i90A-1u5dA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5g SRC-ASSOCIATED
ADAPTOR PROTEIN

(Mus musculus) 		PF00169
(PH) 		3 LYS A 182
ARG A 178
TRP A 137
 None
 1.49A 4i90A-1u5gA:
undetectable		 4i90A-1u5gA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5h NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		3 LYS A  64
ARG A  59
TRP A 108
 None
 1.31A 4i90A-1x5hA:
undetectable		 4i90A-1x5hA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A 576
ARG A 569
TRP A 594
 None
 1.06A 4i90A-1zcjA:
1.8		 4i90A-1zcjA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cue PAIRED BOX PROTEIN
PAX6

(Homo sapiens) 		PF00046
(Homeobox) 		3 LYS A  61
ARG A  58
TRP A  54
 None
 0.95A 4i90A-2cueA:
undetectable		 4i90A-2cueA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2da5 ZINC FINGERS AND
HOMEOBOXES PROTEIN 3

(Homo sapiens) 		PF00046
(Homeobox) 		3 LYS A  61
ARG A  58
TRP A  54
 None
 1.36A 4i90A-2da5A:
undetectable		 4i90A-2da5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		3 LYS A 106
ARG A 248
TRP A 145
 AKG  A 897 (-4.2A)
AKG  A 897 (-2.8A)
AKG  A 897 (-4.0A)
 0.89A 4i90A-2fctA:
undetectable		 4i90A-2fctA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		3 LYS X 221
ARG X 213
TRP X 187
 None
 1.19A 4i90A-2hczX:
undetectable		 4i90A-2hczX:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kso EPHRIN TYPE-A
RECEPTOR 2
PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens;
Homo sapiens) 		PF00536
(SAM_1)
PF00536
(SAM_1) 		3 LYS A  62
ARG A  63
TRP B  50
 None
 1.47A 4i90A-2ksoA:
undetectable		 4i90A-2ksoA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9r HOMEOBOX PROTEIN
NKX-3.1

(Homo sapiens) 		PF00046
(Homeobox) 		3 LYS A  58
ARG A  55
TRP A  51
 None
 1.34A 4i90A-2l9rA:
undetectable		 4i90A-2l9rA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwv XISI PROTEIN-LIKE

(Trichormus
variabilis) 		PF08869
(XisI) 		3 LYS A  57
ARG A  55
TRP A  50
 None
 1.50A 4i90A-2nwvA:
undetectable		 4i90A-2nwvA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 LYS A  80
ARG A  37
TRP A  50
 None
 1.22A 4i90A-2nykA:
undetectable		 4i90A-2nykA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Bacillus
thuringiensis) 		PF00388
(PI-PLC-X) 		3 LYS A 115
ARG A 163
TRP A 178
 None
 0.69A 4i90A-2or2A:
42.9		 4i90A-2or2A:
41.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A 576
ARG A 569
TRP A 594
 None
 1.17A 4i90A-2x58A:
0.8		 4i90A-2x58A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		3 LYS A 438
ARG A 437
TRP A 484
 None
 1.41A 4i90A-3be8A:
undetectable		 4i90A-3be8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		3 LYS A 474
ARG A 473
TRP A 520
 None
 1.30A 4i90A-3biwA:
1.0		 4i90A-3biwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf5 MAJOR VAULT PROTEIN

(Mus musculus) 		PF01505
(Vault) 		3 LYS A 188
ARG A 190
TRP A 196
 None
 1.18A 4i90A-3gf5A:
undetectable		 4i90A-3gf5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.) 		PF05721
(PhyH) 		3 LYS A 108
ARG A 253
TRP A 150
 AKG  A 321 (-2.4A)
AKG  A 321 (-3.4A)
None
 1.43A 4i90A-3gjbA:
undetectable		 4i90A-3gjbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 LYS A 381
ARG A 385
TRP A 129
 None
 1.46A 4i90A-3j3iA:
undetectable		 4i90A-3j3iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 LYS A 954
ARG A 963
TRP A 929
 None
 1.30A 4i90A-3l4kA:
undetectable		 4i90A-3l4kA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 LYS A 417
ARG A 430
TRP A 206
 None
 1.42A 4i90A-3loyA:
undetectable		 4i90A-3loyA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		3 LYS A 107
ARG A 111
TRP A  79
 None
 1.14A 4i90A-3na8A:
1.4		 4i90A-3na8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05721
(PhyH) 		3 LYS A 145
ARG A 257
TRP A 174
 AKG  A 481 (-4.1A)
AKG  A 481 (-2.7A)
AKG  A 481 (-4.2A)
 1.33A 4i90A-3obzA:
undetectable		 4i90A-3obzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz6 HPCH/HPAI ALDOLASE

(Desulfitobacterium
hafniense) 		PF03328
(HpcH_HpaI) 		3 LYS A   0
ARG A 137
TRP A 133
 None
 1.44A 4i90A-3qz6A:
2.3		 4i90A-3qz6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 219
ARG A 220
TRP A 205
 None
 1.47A 4i90A-3sszA:
undetectable		 4i90A-3sszA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 381
ARG A 398
TRP A 361
 None
 1.48A 4i90A-3vnsA:
undetectable		 4i90A-3vnsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		3 LYS A 387
ARG A 390
TRP A 291
 None
 1.27A 4i90A-3wonA:
undetectable		 4i90A-3wonA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 LYS A 551
ARG A 410
TRP A 482
 None
 1.19A 4i90A-3zxlA:
undetectable		 4i90A-3zxlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 LYS A 954
ARG A 963
TRP A 929
 None
 1.27A 4i90A-4gfhA:
undetectable		 4i90A-4gfhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 LYS A 704
ARG A 669
TRP A 671
 None
 1.40A 4i90A-4hsuA:
undetectable		 4i90A-4hsuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iej DNA
METHYLTRANSFERASE
1-ASSOCIATED PROTEIN
1

(Homo sapiens) 		PF16282
(SANT_DAMP1_like) 		3 LYS A 184
ARG A 186
TRP A 152
 None
 1.05A 4i90A-4iejA:
undetectable		 4i90A-4iejA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1v MOB KINASE ACTIVATOR
1A
NS5A DOMAIN II
PEPTIDE

(Homo sapiens;
Hepacivirus C) 		PF03637
(Mob1_phocein)
PF12941
(HCV_NS5a_C) 		3 LYS E 308
ARG A 154
TRP A 121
 None
 1.35A 4i90A-4j1vE:
undetectable		 4i90A-4j1vE:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 LYS A 103
ARG A  60
TRP A  73
 None
 0.99A 4i90A-4jo8A:
undetectable		 4i90A-4jo8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		3 LYS A 150
ARG A 149
TRP A 553
 None
 1.19A 4i90A-4nj5A:
undetectable		 4i90A-4nj5A:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		3 LYS A 113
ARG A 166
TRP A 185
 INS  A 402 (-3.9A)
INS  A 402 (-2.6A)
INS  A 402 ( 4.9A)
 0.28A 4i90A-4rv3A:
54.5		 4i90A-4rv3A:
99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		3 LYS A1095
ARG A1098
TRP A1007
 None
 1.32A 4i90A-4rwaA:
undetectable		 4i90A-4rwaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		3 LYS A 302
ARG A 301
TRP A  39
 None
 1.01A 4i90A-4ur8A:
1.3		 4i90A-4ur8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		3 LYS A 211
ARG A 257
TRP A 262
 None
 1.37A 4i90A-4x9eA:
undetectable		 4i90A-4x9eA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8t POLYHEDRIN

(Cypovirus 4) 		PF17515
(CPV_Polyhedrin) 		3 LYS A 162
ARG A 168
TRP A 126
 None
 1.36A 4i90A-5a8tA:
undetectable		 4i90A-5a8tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9a POLYHEDRIN

(Simulium
ubiquitum
cypovirus) 		PF17515
(CPV_Polyhedrin) 		3 LYS A 152
ARG A 158
TRP A 116
 None
 1.25A 4i90A-5a9aA:
undetectable		 4i90A-5a9aA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9c POLYHEDRIN

(Cypovirus 4) 		PF17515
(CPV_Polyhedrin) 		3 LYS A 162
ARG A 168
TRP A 126
 None
 1.40A 4i90A-5a9cA:
undetectable		 4i90A-5a9cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		3 LYS B 212
ARG B 212
TRP B 208
 None
 1.08A 4i90A-5b48B:
1.4		 4i90A-5b48B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg0 HOMEOBOX PROTEIN
HOX-B13

(Homo sapiens) 		PF00046
(Homeobox) 		3 LYS B 270
ARG B 267
TRP B 263
 None
 1.46A 4i90A-5eg0B:
undetectable		 4i90A-5eg0B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epa SNOK

(Streptomyces
nogalater) 		PF05721
(PhyH) 		3 LYS A 110
ARG A 221
TRP A 139
 AKG  A 301 (-4.2A)
AKG  A 301 (-2.7A)
AKG  A 301 (-4.3A)
 1.24A 4i90A-5epaA:
undetectable		 4i90A-5epaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5equ SNON,SNON

(Streptomyces
nogalater) 		PF05721
(PhyH) 		3 LYS A 116
ARG A 224
TRP A 148
 AKG  A 301 ( 4.2A)
AKG  A 301 (-2.7A)
AKG  A 301 (-3.9A)
 1.14A 4i90A-5equA:
undetectable		 4i90A-5equA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		3 LYS A 107
ARG A 112
TRP A 378
 None
SO4  A 601 (-2.8A)
None
 1.16A 4i90A-5f8pA:
undetectable		 4i90A-5f8pA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 LYS A 175
ARG A 238
TRP A 206
 None
 1.33A 4i90A-5gjaA:
undetectable		 4i90A-5gjaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		3 LYS A 446
ARG A 444
TRP A 417
 None
 1.44A 4i90A-5msxA:
undetectable		 4i90A-5msxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 LYS A 498
ARG A 498
TRP A  23
 None
 1.33A 4i90A-5u30A:
undetectable		 4i90A-5u30A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 3 LYS A  17
ARG A  92
TRP A 191
 None
 1.48A 4i90A-5wp6A:
undetectable		 4i90A-5wp6A:
undetectable