SIMILAR PATTERNS OF AMINO ACIDS FOR 4I41_A_MIXA501_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aug | PYROGLUTAMYLPEPTIDASE-1 (Bacillusamyloliquefaciens) |
PF01470(Peptidase_C15) | 5 | ILE A 207THR A 209ASP A 206THR A 115ILE A 122 | None | 1.35A | 4i41A-1augA:undetectable | 4i41A-1augA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdj | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 5 | THR A1122VAL A1150ASP A1193ILE A1191GLU A1187 | NoneNoneNoneNone2FP A5001 (-4.3A) | 1.30A | 4i41A-1fdjA:undetectable | 4i41A-1fdjA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdw | 17-BETA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) |
PF00106(adh_short) | 5 | ILE A 7THR A 8THR A 190VAL A 188ILE A 14 | None | 1.36A | 4i41A-1fdwA:undetectable | 4i41A-1fdwA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gcw | PROTEIN (HEMOGLOBIN) (Mustelusgriseus) |
PF00042(Globin) | 5 | ILE B 100THR B 97ILE B 11GLU B 7GLU B 6 | NoneHEM B 136 ( 4.6A)NoneNoneNone | 1.26A | 4i41A-1gcwB:undetectable | 4i41A-1gcwB:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jpu | GLYCEROLDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00465(Fe-ADH) | 5 | ILE A 45THR A 240VAL A 236ILE A 159GLU A 233 | None | 0.92A | 4i41A-1jpuA:undetectable | 4i41A-1jpuA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqg | FORMATEDEHYDROGENASE,NITRATE-INDUCIBLE,IRON-SULFUR SUBUNIT (Escherichiacoli) |
PF09163(Form-deh_trans)PF12800(Fer4_4)PF13247(Fer4_11) | 5 | ILE B 8ASP B 7VAL B 167ASP B 127ILE B 125 | None | 1.36A | 4i41A-1kqgB:undetectable | 4i41A-1kqgB:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 5 | LYS D 74ASP D 75THR D 241VAL D 239GLU D 114 | NoneNoneNoneNone FE D 801 ( 2.7A) | 1.33A | 4i41A-1mhzD:undetectable | 4i41A-1mhzD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mr2 | ADPR PYROPHOSPHATASE (Mycobacteriumtuberculosis) |
PF00293(NUDIX) | 5 | ILE A 164VAL A 122ILE A 168GLU A 120ARG A 64 | NoneNoneNoneNoneA12 A 301 (-2.5A) | 1.37A | 4i41A-1mr2A:undetectable | 4i41A-1mr2A:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s6j | CALCIUM-DEPENDENTPROTEIN KINASE SK5 (Glycine max) |
PF13499(EF-hand_7) | 5 | ILE A 40THR A 41LYS A 30ASP A 33ASP A 77 | NoneNoneNone CA A 88 (-3.0A) CA A 89 (-4.3A) | 1.36A | 4i41A-1s6jA:undetectable | 4i41A-1s6jA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tzs | CATHEPSIN E (Homo sapiens) |
PF00026(Asp) | 5 | ILE A 234THR A 235VAL A 164ASP A 319ILE A 322 | None | 1.29A | 4i41A-1tzsA:undetectable | 4i41A-1tzsA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpv | UPF0230 PROTEINTM1468 (Thermotogamaritima) |
PF02645(DegV) | 5 | ILE A 125VAL A 272ASP A 12ILE A 268ARG A 42 | NoneNoneNonePLM A 501 ( 4.5A)None | 1.15A | 4i41A-1vpvA:undetectable | 4i41A-1vpvA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzc | MANNOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE (Pyrococcushorikoshii) |
PF08282(Hydrolase_3) | 5 | ILE A 235THR A 12THR A 58VAL A 56ILE A 26 | None MG A 300 ( 4.9A)NoneNoneNone | 1.39A | 4i41A-1wzcA:undetectable | 4i41A-1wzcA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrs | D-LYSINE5,6-AMINOMUTASEALPHA SUBUNIT (Acetoanaerobiumsticklandii) |
PF09043(Lys-AminoMut_A) | 5 | ILE A 30THR A 26THR A 295GLU A 321GLU A 331 | None | 1.39A | 4i41A-1xrsA:undetectable | 4i41A-1xrsA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xx7 | OXETANOCIN-LIKEPROTEIN (Pyrococcusfuriosus) |
PF13023(HD_3) | 5 | ILE A 40THR A 41VAL A 30ASP A 124GLU A 71 | NoneNoneNone NI A 201 ( 2.6A)None | 1.26A | 4i41A-1xx7A:undetectable | 4i41A-1xx7A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ycg | NITRIC OXIDEREDUCTASE (Moorellathermoacetica) |
PF00258(Flavodoxin_1)PF00753(Lactamase_B) | 5 | THR A 155VAL A 157ASP A 44ILE A 42GLU A 159 | None | 1.34A | 4i41A-1ycgA:undetectable | 4i41A-1ycgA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxx | 6-PHOSPHOFRUCTOKINASE (Lactobacillusdelbrueckii) |
PF00365(PFK) | 5 | ILE A 137ASP A 260THR A 145ILE A 126GLU A 222 | None | 1.34A | 4i41A-1zxxA:undetectable | 4i41A-1zxxA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | THR A 53THR A 139ASP A 48ASP A 71GLU A 94 | NoneNoneSAI A1300 ( 4.9A)SAI A1300 (-2.9A)SAI A1300 (-3.0A) | 1.23A | 4i41A-2avnA:undetectable | 4i41A-2avnA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 5 | ILE A 330THR A1419ASP A 752ILE A 754GLU A 757 | None | 1.27A | 4i41A-2b39A:undetectable | 4i41A-2b39A:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbn | RIBONUCLEASE Z (Escherichiacoli) |
PF12706(Lactamase_B_2) | 5 | ILE A 62ASP A 38THR A 269VAL A 230ILE A 209 | None | 1.40A | 4i41A-2cbnA:undetectable | 4i41A-2cbnA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2een | HYPOTHETICAL PROTEINPH1819 (Pyrococcushorikoshii) |
PF01928(CYTH) | 5 | THR A 138VAL A 140ASP A 72ILE A 146GLU A 145 | None | 1.34A | 4i41A-2eenA:undetectable | 4i41A-2eenA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glx | 1,5-ANHYDRO-D-FRUCTOSE REDUCTASE (Ensiferadhaerens) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ASP A 181THR A 239VAL A 153ASP A 176ILE A 177 | NoneNoneNoneACT A1502 ( 3.9A)None | 1.29A | 4i41A-2glxA:undetectable | 4i41A-2glxA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hd3 | ETHANOLAMINEUTILIZATION PROTEINEUTN (Escherichiacoli) |
PF03319(EutN_CcmL) | 5 | ILE A 47VAL A 74ASP A 45ASP A 22ILE A 44 | None | 1.32A | 4i41A-2hd3A:undetectable | 4i41A-2hd3A:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9e | TRIOSEPHOSPHATEISOMERASE (Tenebriomolitor) |
PF00121(TIM) | 5 | ILE A 123VAL A 142ILE A 126GLU A 128GLU A 132 | None | 1.31A | 4i41A-2i9eA:undetectable | 4i41A-2i9eA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibp | CITRATE SYNTHASE (Pyrobaculumaerophilum) |
PF00285(Citrate_synt) | 5 | THR A 34VAL A 291ASP A 38ILE A 39GLU A 42 | None | 1.41A | 4i41A-2ibpA:1.8 | 4i41A-2ibpA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2im9 | HYPOTHETICAL PROTEIN (Legionellapneumophila) |
PF07313(DUF1460) | 5 | ILE A 289ASP A 288ASP A 163ILE A 162GLU A 236 | None | 1.21A | 4i41A-2im9A:undetectable | 4i41A-2im9A:21.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2iwi | SERINE/THREONINE-PROTEIN KINASE PIM-2 (Homo sapiens) |
PF00069(Pkinase) | 9 | ILE A 129THR A 130ASP A 166THR A 200VAL A 202ASP A 230ASP A 235ILE A 236GLU A 243 | None | 0.86A | 4i41A-2iwiA:36.6 | 4i41A-2iwiA:55.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2iwi | SERINE/THREONINE-PROTEIN KINASE PIM-2 (Homo sapiens) |
PF00069(Pkinase) | 9 | ILE A 129THR A 130ASP A 166VAL A 202ASP A 230ASP A 235ILE A 236GLU A 239GLU A 243 | None | 0.85A | 4i41A-2iwiA:36.6 | 4i41A-2iwiA:55.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2iwi | SERINE/THREONINE-PROTEIN KINASE PIM-2 (Homo sapiens) |
PF00069(Pkinase) | 8 | ILE A 129THR A 130LYS A 165ASP A 166ASP A 230ASP A 235ILE A 236GLU A 239 | None | 0.80A | 4i41A-2iwiA:36.6 | 4i41A-2iwiA:55.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8v | PHOSPHOADENOSINEPHOSPHOSULFATEREDUCTASE (Escherichiacoli) |
PF01507(PAPS_reduct) | 5 | ILE A 190THR A 189VAL A 169ILE A 183GLU A 29 | None | 1.33A | 4i41A-2o8vA:undetectable | 4i41A-2o8vA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfk | 6-PHOSPHOFRUCTOKINASE ISOZYME I (Escherichiacoli) |
PF00365(PFK) | 5 | ILE A 137ASP A 260THR A 145ILE A 126GLU A 222 | None | 1.32A | 4i41A-2pfkA:undetectable | 4i41A-2pfkA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q49 | PROBABLEN-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Arabidopsisthaliana) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 321VAL A 240ILE A 186GLU A 184ARG A 318 | None | 1.10A | 4i41A-2q49A:undetectable | 4i41A-2q49A:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uwb | CELLULASE (Tropaeolummajus) |
PF00722(Glyco_hydro_16)PF06955(XET_C) | 5 | ILE A 95THR A 263ASP A 93ILE A 116ARG A 171 | None | 1.29A | 4i41A-2uwbA:undetectable | 4i41A-2uwbA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | THR A 967ASP A 770ASP A 787ILE A 798GLU A 797 | None | 1.29A | 4i41A-2yocA:undetectable | 4i41A-2yocA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1j | CELL CYCLECHECKPOINT PROTEINRAD1 (Homo sapiens) |
PF02144(Rad1) | 5 | ILE C 30THR C 29VAL C 241GLU C 211ARG C 258 | None | 1.36A | 4i41A-3a1jC:undetectable | 4i41A-3a1jC:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF01336(tRNA_anti-codon)PF08489(DUF1743) | 5 | THR A 48ASP A 115VAL A 258ILE A 253GLU A 256 | None | 1.32A | 4i41A-3au7A:undetectable | 4i41A-3au7A:21.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dls | PASDOMAIN-CONTAININGSERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A1094LYS A1130ASP A1131THR A1165GLU A1205 | None | 0.88A | 4i41A-3dlsA:31.4 | 4i41A-3dlsA:31.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3f2a | PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
PF00069(Pkinase) | 12 | ILE A 133THR A 134LYS A 169ASP A 170THR A 204VAL A 206ASP A 234ASP A 239ILE A 240GLU A 243GLU A 247ARG A 256 | None | 0.59A | 4i41A-3f2aA:44.5 | 4i41A-3f2aA:95.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4s | 50S RIBOSOMALPROTEIN L6P (Haloarculamarismortui) |
PF00347(Ribosomal_L6) | 5 | ILE E 118THR E 122VAL E 166ILE E 148GLU E 149 | None | 1.31A | 4i41A-3g4sE:undetectable | 4i41A-3g4sE:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g77 | CYTOSINE DEAMINASE (Escherichiacoli) |
PF07969(Amidohydro_3) | 5 | ILE A 218ASP A 216THR A 228VAL A 194GLU A 191 | None | 1.26A | 4i41A-3g77A:undetectable | 4i41A-3g77A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8d | BIOTIN CARBOXYLASE (Escherichiacoli) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 315THR A 304VAL A 328ILE A 323GLU A 326 | None | 1.42A | 4i41A-3g8dA:undetectable | 4i41A-3g8dA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j26 | CAPSID PROTEIN V20 (Mimivirus-dependentvirus Sputnik) |
no annotation | 5 | ILE A 257THR A 256THR A 191VAL A 189ASP A 96 | None | 1.39A | 4i41A-3j26A:undetectable | 4i41A-3j26A:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j70 | MONOCLONAL ANTIBODY17B LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | ILE A 69THR A 70THR A 107VAL A 109ARG A 66 | None | 1.26A | 4i41A-3j70A:undetectable | 4i41A-3j70A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ILE A 854THR A 845ASP A 856ASP A 39GLU A 45 | None | 1.39A | 4i41A-3j9dA:undetectable | 4i41A-3j9dA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksd | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE1 (Staphylococcusaureus) |
no annotation | 5 | THR Q 176THR Q 129VAL Q 220ILE Q 217GLU Q 223 | None | 1.33A | 4i41A-3ksdQ:2.5 | 4i41A-3ksdQ:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4i | PHOSPHOHYDROLASE(MUTT/NUDIX FAMILYPROTEIN) (Bacillus cereus) |
PF00293(NUDIX)PF12535(Nudix_N) | 5 | ILE A 129VAL A 108ASP A 70ILE A 71GLU A 116 | NoneNoneNoneNoneGD3 A 301 (-3.1A) | 1.41A | 4i41A-3q4iA:undetectable | 4i41A-3q4iA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpf | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF06824(Glyco_hydro_125) | 5 | ILE A 329THR A 325ASP A 299ILE A 363GLU A 417 | NoneNoneNoneNoneEDO A 433 ( 4.4A) | 1.36A | 4i41A-3qpfA:undetectable | 4i41A-3qpfA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgk | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ILE A 61THR A 128VAL A 99ILE A 17GLU A 39 | None | 1.16A | 4i41A-3wgkA:undetectable | 4i41A-3wgkA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ypi | TRIOSEPHOSPHATEISOMERASE (Saccharomycescerevisiae) |
PF00121(TIM) | 5 | ILE A 124VAL A 143ILE A 127GLU A 129GLU A 133 | None | 1.39A | 4i41A-3ypiA:undetectable | 4i41A-3ypiA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyy | IRON-SULFUR CLUSTERBINDING PROTEIN (Carboxydothermushydrogenoformans) |
PF00111(Fer2)PF14574(DUF4445) | 5 | ILE X 507THR X 471VAL X 472ILE X 461GLU X 426 | None | 1.19A | 4i41A-3zyyX:undetectable | 4i41A-3zyyX:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | ILE A 137ASP A 260THR A 145ILE A 126GLU A 222 | None | 1.30A | 4i41A-4a3sA:undetectable | 4i41A-4a3sA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cj0 | ENDOGLUCANASE D (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 5 | ILE A 241ASP A 246ASP A 243ILE A 234GLU A 233 | None CA A1577 (-3.0A) CA A1577 (-3.3A)NoneNone | 1.19A | 4i41A-4cj0A:undetectable | 4i41A-4cj0A:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ex9 | ALNA (Streptomycessp. CM020) |
PF04227(Indigoidine_A) | 5 | ILE A 110THR A 109THR A 288ASP A 142ILE A 126 | NoneNoneNone5RP A 402 (-3.0A)None | 1.34A | 4i41A-4ex9A:undetectable | 4i41A-4ex9A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0b | THIOL TRANSFERASE (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 5 | ILE A 172VAL A 216ASP A 180ILE A 210GLU A 211 | None | 1.38A | 4i41A-4f0bA:undetectable | 4i41A-4f0bA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzi | PROSTAGLANDIN FSYNTHASE (Trypanosomacruzi) |
PF00248(Aldo_ket_red) | 5 | THR A 186VAL A 247ASP A 224ILE A 221GLU A 243 | None | 1.30A | 4i41A-4fziA:undetectable | 4i41A-4fziA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 5 | ILE A 98THR A 222VAL A 226ASP A 190ILE A 189 | None | 1.35A | 4i41A-4g4iA:undetectable | 4i41A-4g4iA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hne | PHOSPHATIDYLINOSITOL4-KINASE TYPE2-ALPHA (Homo sapiens) |
PF00454(PI3_PI4_kinase) | 5 | ILE A 304ASP A 301VAL A 342ASP A 200ILE A 207 | ILE A 304 ( 0.6A)ASP A 301 ( 0.6A)VAL A 342 ( 0.5A)ASP A 200 ( 0.6A)ILE A 207 ( 0.6A) | 1.36A | 4i41A-4hneA:6.5 | 4i41A-4hneA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4i | 6-PHOSPHOFRUCTOKINASE (Geobacillusstearothermophilus) |
PF00365(PFK) | 5 | ILE A 137ASP A 260THR A 145ILE A 126GLU A 222 | None | 1.30A | 4i41A-4i4iA:undetectable | 4i41A-4i4iA:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5c | LOOP DESIGNEDANKYRIN REPEATPROTEIN NRAN1_G06_C (Escherichiacoli) |
PF12796(Ank_2) | 5 | ILE A 142VAL A 63ILE A 109GLU A 64GLU A 61 | None | 1.30A | 4i41A-4k5cA:undetectable | 4i41A-4k5cA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7a | UNCHARACTERIZEDPROTEIN (Bacteroidescaccae) |
PF15890(Peptidase_Mx1) | 5 | ILE A 189VAL A 243ASP A 256ILE A 255GLU A 241 | None | 1.40A | 4i41A-4l7aA:undetectable | 4i41A-4l7aA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfn | GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNITAGALACTOSE-6-PHOSPHATE ISOMERASE SUBUNITB (Lactobacillusrhamnosus) |
PF02502(LacAB_rpiB) | 5 | ILE B 81ASP B 76VAL A 41ASP B 142ILE B 141 | None | 1.35A | 4i41A-4lfnB:undetectable | 4i41A-4lfnB:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE OPERONREGULATORY PROTEIN (Escherichiacoli) |
PF00989(PAS) | 5 | ILE C 16LYS C 129THR C 170VAL C 167ASP C 133 | None | 1.01A | 4i41A-4lryC:undetectable | 4i41A-4lryC:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw0 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Chitinophagapinensis) |
PF00561(Abhydrolase_1) | 5 | ILE A 65VAL A 270ASP A 50ILE A 53GLU A 267 | None | 1.35A | 4i41A-4pw0A:undetectable | 4i41A-4pw0A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 5 | ASP A 768VAL A 940ASP A 923ILE A 926ARG A 142 | None | 1.37A | 4i41A-4q73A:0.2 | 4i41A-4q73A:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhg | SIMILAR TOUNIPROT|P29295SACCHAROMYCESCEREVISIAE YPL204WHRR25 ([Candida]glabrata) |
PF00069(Pkinase) | 5 | ILE A 129ASP A 195ASP A 194ILE A 125GLU A 189 | None | 1.32A | 4i41A-4xhgA:21.4 | 4i41A-4xhgA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymx | ABC-TYPE AMINO ACIDTRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Caldanaerobactersubterraneus) |
PF00497(SBP_bac_3) | 5 | ILE A 104THR A 43ASP A 66THR A 195ARG A 113 | NoneNoneNoneNoneARG A 301 (-2.9A) | 1.38A | 4i41A-4ymxA:undetectable | 4i41A-4ymxA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zwn | MONOGLYCERIDE LIPASE (Saccharomycescerevisiae) |
PF12146(Hydrolase_4) | 5 | ILE A 253THR A 252THR A 288VAL A 291ILE A 283 | None | 1.22A | 4i41A-4zwnA:undetectable | 4i41A-4zwnA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 5 | THR A 504ASP A 522ASP A 519GLU A 512GLU A 515 | None | 1.40A | 4i41A-5a22A:undetectable | 4i41A-5a22A:8.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6d | DNA POLYMERASESLIDING CLAMP (Thermococcusgammatolerans) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | ILE A 101THR A 102ILE A 5GLU A 62GLU A 64 | None | 1.30A | 4i41A-5a6dA:undetectable | 4i41A-5a6dA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aqa | OFF7_DB04V3 (syntheticconstruct) |
PF00023(Ank)PF12796(Ank_2)PF13354(Beta-lactamase2) | 5 | ILE A 161VAL A 96ILE A 128GLU A 97GLU A 94 | None | 1.33A | 4i41A-5aqaA:undetectable | 4i41A-5aqaA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwe | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 5 | ASP A 132THR A 243VAL A 239ASP A 135GLU A 236 | None | 1.19A | 4i41A-5cweA:undetectable | 4i41A-5cweA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dj4 | SESTRIN-2 (Homo sapiens) |
PF04636(PA26) | 5 | THR A 476THR A 202VAL A 199ILE A 195GLU A 358 | None | 1.30A | 4i41A-5dj4A:undetectable | 4i41A-5dj4A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eut | PHOSPHATIDYLINOSITOL4-KINASE TYPE2-ALPHA,ENDOLYSIN,PHOSPHATIDYLINOSITOL4-KINASE TYPE2-ALPHA (Escherichiavirus T4;Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00959(Phage_lysozyme) | 5 | ILE A 304ASP A 301VAL A 342ASP A 200ILE A 207 | None | 1.36A | 4i41A-5eutA:6.5 | 4i41A-5eutA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwm | HEAT SHOCK PROTEINHSP 90 BETA (Homo sapiens) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | ILE A 123VAL A 360ASP A 49ILE A 126GLU A 42 | NoneNoneNoneNoneATP A1691 (-4.0A) | 1.38A | 4i41A-5fwmA:undetectable | 4i41A-5fwmA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h76 | DARPIN,IMMUNOGLOBULIN G-BINDING PROTEINA (Staphylococcusaureus;syntheticconstruct) |
PF02216(B)PF12796(Ank_2) | 5 | ILE A 128VAL A 63ILE A 95GLU A 64GLU A 61 | None | 1.37A | 4i41A-5h76A:undetectable | 4i41A-5h76A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 5 | ILE A 432THR A 480VAL A 489ILE A 179GLU A 493 | None | 1.43A | 4i41A-5i6zA:undetectable | 4i41A-5i6zA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihr | PROBABLEBETA-GALACTOSIDASE A (Aspergillusniger) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | ILE A 296THR A 417VAL A 429ASP A 331GLU A 490 | None | 1.41A | 4i41A-5ihrA:undetectable | 4i41A-5ihrA:14.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j9g | GLYCERALDEHYDE-3-PDEHYDROGENASE (Lactobacillusacidophilus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | THR A 248THR A 134VAL A 225ILE A 222GLU A 228 | None | 1.34A | 4i41A-5j9gA:2.5 | 4i41A-5j9gA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8x | TETRAHYDROMETHANOPTERINS-METHYLTRANSFERASESUBUNIT A (Methanocaldococcusjannaschii) |
PF04208(MtrA) | 5 | ILE A 149THR A 146VAL A 19ASP A 43ILE A 42 | None | 1.40A | 4i41A-5l8xA:undetectable | 4i41A-5l8xA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc8 | ARACHIDONATE15-LIPOXYGENASE (Pseudomonasaeruginosa) |
PF00305(Lipoxygenase) | 5 | ILE A 113THR A 109THR A 567ILE A 608GLU A 373 | ZPE A 703 ( 4.6A)ZPE A 703 ( 4.4A)NoneZPE A 703 ( 4.9A)ZPE A 703 (-4.1A) | 1.16A | 4i41A-5lc8A:undetectable | 4i41A-5lc8A:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfd | ALLANTOIN RACEMASE (Pseudomonasfluorescens) |
no annotation | 5 | ILE A 18THR A 17THR A 114GLU A 45GLU A 49 | None | 1.37A | 4i41A-5lfdA:undetectable | 4i41A-5lfdA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mak | R7 (syntheticconstruct) |
no annotation | 5 | ILE A 161VAL A 96ILE A 128GLU A 97GLU A 94 | None | 1.20A | 4i41A-5makA:undetectable | 4i41A-5makA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mak | R7 (syntheticconstruct) |
no annotation | 5 | ILE A 298VAL A 233ILE A 265GLU A 234GLU A 231 | None | 1.28A | 4i41A-5makA:undetectable | 4i41A-5makA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mbm | DARPIN 8H6 (syntheticconstruct) |
no annotation | 5 | ILE C 160VAL C 95ILE C 127GLU C 96GLU C 93 | None | 1.33A | 4i41A-5mbmC:undetectable | 4i41A-5mbmC:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg3 | PROTEIN TRANSLOCASESUBUNIT SECDPROTEIN TRANSLOCASESUBUNIT SECF (Escherichiacoli) |
PF02355(SecD_SecF)PF07549(Sec_GG)PF13721(SecD-TM1) | 5 | ILE D 575THR D 572ASP F 51GLU F 132GLU F 59 | None | 1.37A | 4i41A-5mg3D:undetectable | 4i41A-5mg3D:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msw | THIOESTER REDUCTASEDOMAIN-CONTAININGPROTEIN (Segniliparusrugosus) |
PF00501(AMP-binding)PF00550(PP-binding) | 5 | ILE A 77THR A 232ASP A 208GLU A 215ARG A 85 | None | 1.16A | 4i41A-5mswA:undetectable | 4i41A-5mswA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol6 | NUCLEIC ACIDBINDING, OB-FOLD,TRNA/HELICASE-TYPE,DNA-DIRECTED DNAPOLYMERASE (Nostocpunctiforme) |
no annotation | 5 | THR A 48VAL A 20ASP A 17ILE A 18ARG A 92 | None | 1.23A | 4i41A-5ol6A:undetectable | 4i41A-5ol6A:20.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tur | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
no annotation | 11 | ILE A 133THR A 134LYS A 169ASP A 170THR A 204VAL A 206ASP A 234ASP A 239ILE A 240GLU A 247ARG A 256 | None | 0.43A | 4i41A-5turA:44.2 | 4i41A-5turA:70.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tur | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
no annotation | 5 | LYS A 169THR A 204VAL A 206GLU A 243GLU A 247 | None | 0.94A | 4i41A-5turA:44.2 | 4i41A-5turA:70.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v54 | 5-HYDROXYTRYPTAMINERECEPTOR 1B,OB-1FUSED 5-HT1BRECEPTOR,5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens;Spodopterafrugiperda) |
no annotation | 5 | ILE A 319THR A 315THR A 73VAL A 74ILE A 88 | None | 1.21A | 4i41A-5v54A:2.7 | 4i41A-5v54A:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf3 | CAPSID VERTEXPROTEIN GP24 (Escherichiavirus T4) |
PF07068(Gp23) | 5 | ILE a 210ASP a 213THR a 220VAL a 221ILE a 340 | None | 1.22A | 4i41A-5vf3a:undetectable | 4i41A-5vf3a:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x18 | CASEIN KINASE IHOMOLOG 1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | ILE A 189ASP A 257ASP A 256ILE A 185GLU A 251 | None | 1.28A | 4i41A-5x18A:22.9 | 4i41A-5x18A:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S4 (Trichomonasvaginalis) |
PF00900(Ribosomal_S4e)PF01479(S4)PF08071(RS4NT)PF16121(40S_S4_C) | 5 | ILE E 228THR E 220VAL E 208ASP E 179ILE E 195 | None A 2 601 ( 4.5A)NoneNoneNone | 1.36A | 4i41A-5xyiE:undetectable | 4i41A-5xyiE:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yly | NITRATE REDUCTASE (Ulva prolifera) |
no annotation | 5 | ILE A 679VAL A 647ILE A 697GLU A 655ARG A 659 | NoneNoneNoneNoneFAD A1001 (-3.8A) | 1.10A | 4i41A-5ylyA:undetectable | 4i41A-5ylyA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c9k | DARP14 - SUBUNIT AWITH DARPIN (syntheticconstruct) |
no annotation | 5 | ILE A 278VAL A 213ILE A 245GLU A 214GLU A 211 | None | 1.35A | 4i41A-6c9kA:undetectable | 4i41A-6c9kA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chj | DIACYLGLYCEROLO-ACYLTRANSFERASE (Marinobacterhydrocarbonoclasticus) |
no annotation | 5 | ILE A 235THR A 236VAL A 401ASP A 404ILE A 426 | None | 1.25A | 4i41A-6chjA:undetectable | 4i41A-6chjA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5e | DD_D12_10_47 (syntheticconstruct) |
no annotation | 5 | ILE A 161VAL A 96ILE A 128GLU A 97GLU A 94 | None | 1.33A | 4i41A-6f5eA:undetectable | 4i41A-6f5eA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm7 | BETA-LACTAMASE (Aeromonasenteropelogenes) |
no annotation | 5 | THR A 68THR A 316VAL A 210ASP A 217ARG A 169 | None | 1.39A | 4i41A-6fm7A:undetectable | 4i41A-6fm7A:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g45 | PUTATIVE MAJORCAPSID PROTEIN (Cafeteriavirus-dependentmavirus) |
no annotation | 5 | ASP A 433VAL A 327ASP A 360ILE A 444GLU A 292 | None | 1.40A | 4i41A-6g45A:undetectable | 4i41A-6g45A:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gii | CYTOCHROME P450 (Tepidiphilusthermophilus) |
no annotation | 5 | ASP A 200THR A 318VAL A 314ASP A 203GLU A 311 | None | 1.17A | 4i41A-6giiA:undetectable | 4i41A-6giiA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6req | PROTEIN(METHYLMALONYL-COAMUTASE) (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase) | 5 | ILE B 70ASP B 68ASP B 248GLU B 330ARG B 296 | None | 1.22A | 4i41A-6reqB:undetectable | 4i41A-6reqB:21.16 |