SIMILAR PATTERNS OF AMINO ACIDS FOR 4I41_A_MIXA500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 LEU A  68
LEU A   5
GLN A  22
GLU A  10
 None
 1.11A 4i41A-1a2zA:
undetectable		 4i41A-1a2zA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)

(Saccharomyces
cerevisiae) 		PF01088
(Peptidase_C12) 		4 LEU A  39
LEU A 229
GLN A 204
GLU A 179
 None
 1.21A 4i41A-1cmxA:
undetectable		 4i41A-1cmxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		4 LEU B  33
LEU B 135
GLN B 111
GLU B 116
 None
 0.82A 4i41A-1d2zB:
undetectable		 4i41A-1d2zB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 LEU A 207
LEU A  91
GLN A 198
GLU A 201
 None
 1.21A 4i41A-1e25A:
0.0		 4i41A-1e25A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		4 LEU E1218
LEU A  43
GLN E1212
GLU A  57
 None
None
MG  E2001 (-4.1A)
None
 1.24A 4i41A-1f51E:
undetectable		 4i41A-1f51E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 LEU A 255
LEU A 212
GLN A 496
GLU A 169
 None
 1.14A 4i41A-1iwpA:
0.0		 4i41A-1iwpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 LEU A   8
LEU A  14
GLN A  26
GLU A  30
 None
 1.11A 4i41A-1ixkA:
0.0		 4i41A-1ixkA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 LEU A  73
LEU A  10
GLN A 256
GLU A  79
 None
 1.19A 4i41A-1k72A:
0.0		 4i41A-1k72A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		4 LEU A  92
LEU A   9
GLN A   4
GLU A 119
 None
UPG  A 334 (-4.2A)
None
None
 1.21A 4i41A-1ll2A:
0.0		 4i41A-1ll2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 168
LEU A 212
GLN A 161
GLU B  49
 None
None
None
SO4  A1302 ( 4.9A)
 1.06A 4i41A-1mu2A:
undetectable		 4i41A-1mu2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 LEU A 457
LEU A 462
GLN A 166
GLU A 161
 None
 1.27A 4i41A-1ndfA:
undetectable		 4i41A-1ndfA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 153
LEU A 198
GLN A 139
GLU A 335
 None
 1.26A 4i41A-1qf7A:
1.1		 4i41A-1qf7A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 352
LEU A 182
GLN A 336
GLU A 357
 LEU  A 352 ( 0.6A)
LEU  A 182 ( 0.6A)
GLN  A 336 ( 0.6A)
GLU  A 357 ( 0.6A)
 1.21A 4i41A-1tedA:
undetectable		 4i41A-1tedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 LEU A 365
LEU A  82
GLN A 466
GLU A 286
 None
 1.23A 4i41A-1u8vA:
undetectable		 4i41A-1u8vA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 LEU A 148
LEU A  98
GLN A 142
GLU A 210
 None
 1.25A 4i41A-1v5cA:
undetectable		 4i41A-1v5cA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 118
LEU A  90
GLN A  78
GLU A 123
 None
 1.26A 4i41A-1xeuA:
undetectable		 4i41A-1xeuA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 153
LEU A 198
GLN A 139
GLU E 335
 None
 1.27A 4i41A-1ye9A:
1.5		 4i41A-1ye9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 LEU A 115
LEU A 106
GLN A 125
GLU A 150
 None
 1.19A 4i41A-1yx1A:
undetectable		 4i41A-1yx1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		4 LEU A 110
LEU A 105
GLN A 218
GLU A 123
 None
None
TYR  A 888 (-3.3A)
None
 1.15A 4i41A-2amcA:
undetectable		 4i41A-2amcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 LEU A  20
LEU A 277
GLN A  46
GLU A  14
 None
 1.11A 4i41A-2bb6A:
undetectable		 4i41A-2bb6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brf BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Homo sapiens) 		no annotation 4 LEU A  31
LEU A  10
GLN A  50
GLU A  84
 None
 1.10A 4i41A-2brfA:
undetectable		 4i41A-2brfA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		4 LEU A 351
LEU A 375
GLN A 347
GLU A 341
 None
 1.27A 4i41A-2c0lA:
undetectable		 4i41A-2c0lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db1 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Mus musculus) 		PF00076
(RRM_1) 		4 LEU A  15
LEU A  71
GLN A  28
GLU A  60
 None
 1.12A 4i41A-2db1A:
undetectable		 4i41A-2db1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 503
LEU A 528
GLN A 498
GLU A 467
 None
None
UNL  A1004 ( 4.2A)
None
 1.24A 4i41A-2h88A:
undetectable		 4i41A-2h88A:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  38
LEU A 116
GLN A 123
GLU A 167
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.7A)
 0.75A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfy HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Homo sapiens) 		no annotation 4 LEU A  15
LEU A  71
GLN A  28
GLU A  60
 None
 1.04A 4i41A-2kfyA:
undetectable		 4i41A-2kfyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 LEU A  28
LEU A 192
GLN A 113
GLU A  44
 None
 1.22A 4i41A-2p17A:
undetectable		 4i41A-2p17A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2

(Homo sapiens) 		PF03031
(NIF) 		4 LEU A 216
LEU A 150
GLN A 234
GLU A 110
 None
 1.08A 4i41A-2q5eA:
undetectable		 4i41A-2q5eA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A 178
LEU A 139
GLN A  91
GLU A 120
 None
 0.97A 4i41A-2wnwA:
1.4		 4i41A-2wnwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 LEU A  74
LEU A  10
GLN A 258
GLU A  80
 None
 1.15A 4i41A-2xfgA:
undetectable		 4i41A-2xfgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 LEU A 109
LEU A 164
GLN A 185
GLU A 117
 None
 1.18A 4i41A-3b8oA:
undetectable		 4i41A-3b8oA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmb REGULATOR OF
NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 LEU A  75
LEU A 119
GLN A 127
GLU A 125
 None
 1.14A 4i41A-3bmbA:
undetectable		 4i41A-3bmbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		4 LEU A 163
LEU A 182
GLN A 212
GLU A 196
 None
 1.24A 4i41A-3bwsA:
undetectable		 4i41A-3bwsA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A 378
LEU A 372
GLN A 162
GLU A 392
 None
 1.22A 4i41A-3e0lA:
undetectable		 4i41A-3e0lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 LEU A  17
LEU A  45
GLN A 257
GLU A  36
 None
None
PO4  A 329 (-3.7A)
None
 1.09A 4i41A-3e59A:
undetectable		 4i41A-3e59A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  44
LEU A 120
GLN A 127
GLU A 171
 985  A   1 (-4.1A)
985  A   1 (-4.3A)
None
None
 0.49A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hw2 PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY M MEMBER 2

(Homo sapiens) 		PF00169
(PH) 		4 LEU B 800
LEU B 852
GLN B 867
GLU B 861
 None
 1.09A 4i41A-3hw2B:
undetectable		 4i41A-3hw2B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 LEU A 315
LEU A 259
GLN A 321
GLU A 254
 None
 1.26A 4i41A-3i5bA:
undetectable		 4i41A-3i5bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 LEU A 410
LEU A 396
GLN A 368
GLU A 432
 None
 1.17A 4i41A-3j0aA:
undetectable		 4i41A-3j0aA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		4 LEU A  82
LEU A 304
GLN A 166
GLU A 122
 None
 0.89A 4i41A-3k8vA:
undetectable		 4i41A-3k8vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 338
LEU A 402
GLN A 310
GLU A 315
 None
 1.12A 4i41A-3mzsA:
undetectable		 4i41A-3mzsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		4 LEU A 116
LEU A 371
GLN A 110
GLU A 362
 None
None
None
HEM  A 406 ( 4.6A)
 1.24A 4i41A-3nc3A:
undetectable		 4i41A-3nc3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nj2 DUF269-CONTAINING
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF03270
(DUF269) 		4 LEU A 147
LEU A  60
GLN A  33
GLU A  25
 None
 1.04A 4i41A-3nj2A:
undetectable		 4i41A-3nj2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		4 LEU A 192
LEU A 166
GLN A 154
GLU A 340
 None
 1.02A 4i41A-3q5eA:
undetectable		 4i41A-3q5eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 LEU A  64
LEU A  43
GLN A  67
GLU A  93
 None
 1.23A 4i41A-3r4rA:
undetectable		 4i41A-3r4rA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 LEU A  92
LEU A   9
GLN A   4
GLU A 119
 None
UDP  A 264 (-4.1A)
None
None
 1.24A 4i41A-3rmvA:
undetectable		 4i41A-3rmvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqz METALLOPHOSPHOESTERA
SE

(Sphaerobacter
thermophilus) 		PF12850
(Metallophos_2) 		4 LEU A  95
LEU A 101
GLN A  89
GLU A  47
 None
 1.27A 4i41A-3rqzA:
undetectable		 4i41A-3rqzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		4 LEU A 110
LEU A 105
GLN A 218
GLU A 123
 None
None
DAH  A 351 (-2.8A)
None
 1.14A 4i41A-3tehA:
1.2		 4i41A-3tehA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 169
LEU A 138
GLN A 164
GLU A   9
 None
 1.16A 4i41A-3txxA:
undetectable		 4i41A-3txxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 368
LEU A 417
GLN A 365
GLU A 244
 None
 1.24A 4i41A-3uowA:
undetectable		 4i41A-3uowA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LEU A 253
LEU A 185
GLN A 249
GLU A 180
 None
 0.99A 4i41A-3uxjA:
undetectable		 4i41A-3uxjA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A 510
LEU A 437
GLN A 125
GLU A 655
 None
 1.25A 4i41A-3v8xA:
undetectable		 4i41A-3v8xA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		4 LEU B  56
LEU B  24
GLN B  68
GLU B  71
 None
 0.68A 4i41A-3w6jB:
undetectable		 4i41A-3w6jB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6k SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		4 LEU B  56
LEU B  24
GLN B  68
GLU B  71
 None
 0.70A 4i41A-3w6kB:
undetectable		 4i41A-3w6kB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 LEU A 172
LEU A 178
GLN A  76
GLU A 182
 None
 1.24A 4i41A-3wviA:
undetectable		 4i41A-3wviA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmd PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		4 LEU A 131
LEU A 140
GLN A  31
GLU A  23
 None
 1.24A 4i41A-3zmdA:
undetectable		 4i41A-3zmdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuv DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF13857
(Ank_5) 		4 LEU B  57
LEU B  51
GLN B  26
GLU B  61
 None
 1.23A 4i41A-3zuvB:
undetectable		 4i41A-3zuvB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		4 LEU A 147
LEU A 201
GLN A 166
GLU A 174
 None
 1.22A 4i41A-4a39A:
undetectable		 4i41A-4a39A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		4 LEU A 350
LEU A 320
GLN A 308
GLU A 355
 None
 1.21A 4i41A-4fcgA:
undetectable		 4i41A-4fcgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjp HAX3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		4 LEU A 287
LEU A 307
GLN A 326
GLU A 292
 None
 1.16A 4i41A-4gjpA:
undetectable		 4i41A-4gjpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 LEU A 207
LEU A 226
GLN A 173
GLU A 178
 None
 1.22A 4i41A-4hykA:
undetectable		 4i41A-4hykA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 448
LEU A 521
GLN A 475
GLU A 453
 None
 1.27A 4i41A-4i7iA:
undetectable		 4i41A-4i7iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 LEU A1136
LEU A1133
GLN A1049
GLU A1076
 None
 0.82A 4i41A-4igiA:
undetectable		 4i41A-4igiA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  69
LEU A 133
GLN A  80
GLU A 123
 None
 1.27A 4i41A-4jj6A:
undetectable		 4i41A-4jj6A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 LEU A 159
LEU A 170
GLN A 328
GLU A 144
 None
 1.13A 4i41A-4k22A:
undetectable		 4i41A-4k22A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhv PROTEIN C-ETS-2

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 LEU A 142
LEU A 159
GLN A 137
GLU A 108
 None
 1.21A 4i41A-4mhvA:
undetectable		 4i41A-4mhvA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A  79
LEU A  88
GLN A  83
GLU A 249
 None
 1.13A 4i41A-4mnaA:
undetectable		 4i41A-4mnaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 295
LEU A 394
GLN A 404
GLU A 461
 None
 1.16A 4i41A-4mz0A:
undetectable		 4i41A-4mz0A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A4479
LEU A4578
GLN A4588
GLU A4651
 None
 1.06A 4i41A-4opeA:
undetectable		 4i41A-4opeA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LEU A 235
LEU A 254
GLN A  46
GLU A  83
 None
 1.11A 4i41A-4pfrA:
undetectable		 4i41A-4pfrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 LEU A  94
LEU A  11
GLN A   6
GLU A 121
 None
 1.27A 4i41A-4uegA:
undetectable		 4i41A-4uegA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xng UNCHARACTERIZED
PROTEIN MG218.1

(Mycoplasma
genitalium) 		no annotation 4 LEU A  89
LEU A  95
GLN A 183
GLU A 132
 None
 1.27A 4i41A-4xngA:
undetectable		 4i41A-4xngA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 LEU A 333
LEU A 327
GLN A 274
GLU A 449
 None
 1.03A 4i41A-4zzyA:
undetectable		 4i41A-4zzyA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU E  46
LEU E 106
GLN E 113
GLU E  80
 None
 1.19A 4i41A-5brrE:
undetectable		 4i41A-5brrE:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		4 LEU A 439
LEU A 465
GLN A 433
GLU A 427
 None
 1.15A 4i41A-5c6gA:
undetectable		 4i41A-5c6gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A 546
LEU A 527
GLN A 322
GLU A 331
 None
 1.26A 4i41A-5cslA:
1.7		 4i41A-5cslA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cv1 P GRANULE
ABNORMALITY PROTEIN
1

(Caenorhabditis
elegans) 		no annotation 4 LEU A 352
LEU A 391
GLN A 358
GLU A 320
 None
 1.24A 4i41A-5cv1A:
undetectable		 4i41A-5cv1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF04104
(DNA_primase_lrg)
PF08996
(zf-DNA_Pol) 		4 LEU B 108
LEU C1451
GLN B 247
GLU B  43
 None
 1.00A 4i41A-5exrB:
undetectable		 4i41A-5exrB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 LEU A 201
LEU A 225
GLN A 293
GLU A 298
 None
 1.00A 4i41A-5fubA:
undetectable		 4i41A-5fubA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA

(Homo sapiens) 		no annotation 4 LEU B 175
LEU B 154
GLN B 179
GLU B 169
 None
 1.27A 4i41A-5gpyB:
undetectable		 4i41A-5gpyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LEU A 475
LEU A 495
GLN A 444
GLU A 522
 None
 1.14A 4i41A-5h2vA:
undetectable		 4i41A-5h2vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 LEU B  37
LEU B  92
GLN B 164
GLU B 161
 None
 1.20A 4i41A-5hbtB:
1.5		 4i41A-5hbtB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy6 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Spodoptera
frugiperda) 		PF01287
(eIF-5a) 		4 LEU A 102
LEU A 122
GLN A  92
GLU A  89
 None
 1.19A 4i41A-5hy6A:
undetectable		 4i41A-5hy6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  14
LEU A  54
GLN A  26
GLU A  33
 None
 1.22A 4i41A-5ijzA:
undetectable		 4i41A-5ijzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 LEU A 347
LEU A 306
GLN A 340
GLU A 195
 None
 0.88A 4i41A-5irmA:
undetectable		 4i41A-5irmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 4 LEU A1152
LEU A1159
GLN A1235
GLU A1310
 None
 1.10A 4i41A-5j1iA:
undetectable		 4i41A-5j1iA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		4 LEU A  59
LEU A 130
GLN A  70
GLU A  89
 None
 1.11A 4i41A-5keuA:
undetectable		 4i41A-5keuA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		4 LEU B 488
LEU B 494
GLN B 169
GLU B 271
 None
 1.21A 4i41A-5lw7B:
undetectable		 4i41A-5lw7B:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU A 287
LEU A 221
GLN A 295
GLU A 291
 None
 1.28A 4i41A-5m2nA:
undetectable		 4i41A-5m2nA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		4 LEU A  87
LEU A  62
GLN A 157
GLU A 122
 None
 1.06A 4i41A-5m42A:
undetectable		 4i41A-5m42A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6
26S PROTEASOME
REGULATORY SUBUNIT
RPN7
26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF01398
(JAB)
PF01399
(PCI)
PF10602
(RPN7)
PF13012
(MitMem_reg) 		4 LEU Q 419
LEU U 261
GLN R 406
GLU Q 414
 None
 1.17A 4i41A-5mpdQ:
undetectable		 4i41A-5mpdQ:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LEU A1023
LEU A 996
GLN A1016
GLU A1052
 None
 1.18A 4i41A-5nvrA:
undetectable		 4i41A-5nvrA:
14.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 LEU A  44
LEU A 120
GLN A 127
GLU A 171
 None
7LK  A 401 (-4.0A)
None
None
 0.56A 4i41A-5turA:
44.2		 4i41A-5turA:
70.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 LEU A 308
LEU A 416
GLN A 437
GLU A 347
 None
 1.18A 4i41A-5u2gA:
undetectable		 4i41A-5u2gA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		4 LEU A 114
LEU A 358
GLN A 108
GLU A 349
 None
None
None
HEM  A 401 ( 4.7A)
 1.16A 4i41A-5vwsA:
undetectable		 4i41A-5vwsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU M 154
LEU M 148
GLN M 175
GLU N 160
 None
 1.27A 4i41A-5wwlM:
undetectable		 4i41A-5wwlM:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 4 LEU A 331
LEU A 325
GLN A 341
GLU A 197
 None
 1.26A 4i41A-5wxiA:
undetectable		 4i41A-5wxiA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 LEU A 304
LEU A 351
GLN A 314
GLU A 378
 None
 1.07A 4i41A-5xgsA:
undetectable		 4i41A-5xgsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 LEU A 619
LEU A 604
GLN A 634
GLU A 629
 None
 1.26A 4i41A-5xpgA:
2.5		 4i41A-5xpgA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 4 LEU A 860
LEU A 964
GLN A 996
GLU A 844
 None
 1.12A 4i41A-6bhvA:
undetectable		 4i41A-6bhvA:
13.60