SIMILAR PATTERNS OF AMINO ACIDS FOR 4I00_A_ZMRA509_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | LEU A 263ARG A 265ILE A 36ASN A 419 | None | 1.32A | 4i00A-1ciyA:undetectable | 4i00A-1ciyA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp9 | PENICILLIN G AMIDASE (Providenciarettgeri) |
PF01804(Penicil_amidase) | 4 | LEU B 18TRP B 65ILE B 44ASN B 535 | None | 1.44A | 4i00A-1cp9B:undetectable | 4i00A-1cp9B:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dy6 | CARBAPENEM-HYDROLYSING BETA-LACTAMASESME-1 (Serratiamarcescens) |
PF13354(Beta-lactamase2) | 4 | LEU A 142ARG A 83ILE A 155ASN A 158 | None | 1.39A | 4i00A-1dy6A:undetectable | 4i00A-1dy6A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fyh | INTERFERON GAMMA (Homo sapiens) |
PF00714(IFN-gamma) | 4 | LEU A 33ARG A 42ILE A 244ASN A 78 | None | 0.92A | 4i00A-1fyhA:undetectable | 4i00A-1fyhA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fyh | INTERFERON GAMMA (Homo sapiens) |
PF00714(IFN-gamma) | 4 | LEU A 233ARG A 242ILE A 44ASN A 278 | None | 1.20A | 4i00A-1fyhA:undetectable | 4i00A-1fyhA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g1a | DTDP-D-GLUCOSE4,6-DEHYDRATASE (Salmonellaenterica) |
PF16363(GDP_Man_Dehyd) | 4 | LEU A 320ARG A 241TRP A 317ILE A 258 | None | 1.43A | 4i00A-1g1aA:undetectable | 4i00A-1g1aA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqj | ALPHA-D-GLUCURONIDASE (Cellvibriojaponicus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 4 | ARG A 165TRP A 179ILE A 207ASN A 197 | None | 1.25A | 4i00A-1gqjA:undetectable | 4i00A-1gqjA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ks8 | ENDO-B-1,4-GLUCANASE (Nasutitermestakasagoensis) |
PF00759(Glyco_hydro_9) | 4 | LEU A 222TRP A 221ILE A 77ASN A 168 | None | 1.40A | 4i00A-1ks8A:undetectable | 4i00A-1ks8A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | LEU A 488TRP A 651ILE A 617ASN A 845 | None | 1.41A | 4i00A-1l5jA:undetectable | 4i00A-1l5jA:16.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | LEU A 488TRP A 651ILE A 617ASN A 847 | None | 1.33A | 4i00A-1l5jA:undetectable | 4i00A-1l5jA:16.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m4x | PBCV-1 VIRUS CAPSID (ParameciumbursariaChlorella virus1) |
PF04451(Capsid_NCLDV)PF16903(Capsid_N) | 4 | LEU A 414TRP A 264ILE A 318ASN A 376 | None | 1.49A | 4i00A-1m4xA:undetectable | 4i00A-1m4xA:19.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nmb | N9 NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU N 134ARG N 156TRP N 178ILE N 222ASN N 294 | None | 0.88A | 4i00A-1nmbN:62.7 | 4i00A-1nmbN:40.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7d | LYSOSOMALALPHA-MANNOSIDASE (Bos taurus) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C) | 4 | LEU D 865ARG E 901ILE A 169ASN A 158 | None | 1.34A | 4i00A-1o7dD:undetectable | 4i00A-1o7dD:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1paq | TRANSLATIONINITIATION FACTOREIF-2B EPSILONSUBUNIT (Saccharomycescerevisiae) |
PF02020(W2) | 4 | LEU A 567ARG A 624ILE A 667ASN A 616 | None | 0.98A | 4i00A-1paqA:undetectable | 4i00A-1paqA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1paq | TRANSLATIONINITIATION FACTOREIF-2B EPSILONSUBUNIT (Saccharomycescerevisiae) |
PF02020(W2) | 4 | LEU A 692TRP A 696ILE A 673ASN A 637 | None | 1.47A | 4i00A-1paqA:undetectable | 4i00A-1paqA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxz | MAJOR POLLENALLERGEN JUN A 1 (Juniperus ashei) |
PF00544(Pec_lyase_C) | 4 | ARG A 18TRP A 69ILE A 117ASN A 190 | None | 1.33A | 4i00A-1pxzA:undetectable | 4i00A-1pxzA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzo | AGGLUTININ (Ricinuscommunis) |
PF00652(Ricin_B_lectin) | 4 | LEU B2161TRP B2173ILE B2181ASN B2226 | None | 1.49A | 4i00A-1rzoB:undetectable | 4i00A-1rzoB:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5j | DNA POLYMERASE I (Sulfolobussolfataricus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | LEU A 329ARG A 325ILE A 253ASN A 272 | None | 1.30A | 4i00A-1s5jA:undetectable | 4i00A-1s5jA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlf | LAC REPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 4 | LEU A 90ARG A 86ILE A 123ASN A 157 | None | 1.46A | 4i00A-1tlfA:undetectable | 4i00A-1tlfA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tua | HYPOTHETICAL PROTEINAPE0754 (Aeropyrumpernix) |
PF00013(KH_1) | 4 | LEU A 82ARG A 31ILE A 69ASN A 131 | None | 1.20A | 4i00A-1tuaA:undetectable | 4i00A-1tuaA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | ARG A 340TRP A 741ILE A 796ASN A 799 | None | 1.32A | 4i00A-1ut9A:undetectable | 4i00A-1ut9A:19.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v0z | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 140ARG A 162TRP A 185ILE A 229ASN A 301 | None | 0.87A | 4i00A-1v0zA:63.7 | 4i00A-1v0zA:50.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vcj | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 5 | LEU A 132ARG A 154TRP A 177ILE A 221ASN A 294 | NoneIBA A 1 (-4.1A)NoneIBA A 1 ( 4.3A)IBA A 1 ( 3.9A) | 0.95A | 4i00A-1vcjA:52.3 | 4i00A-1vcjA:34.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wt9 | ANTICOAGULANTPROTEIN-B (Deinagkistrodonacutus) |
PF00059(Lectin_C) | 4 | LEU B 39TRP B 65ILE B 63ASN B 103 | None | 1.48A | 4i00A-1wt9B:undetectable | 4i00A-1wt9B:15.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xog | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 135ARG A 157TRP A 180ILE A 224ASN A 296 | NoneABW A1000 (-4.2A)NoneABW A1000 ( 4.7A)ABW A1000 ( 4.0A) | 0.96A | 4i00A-1xogA:62.9 | 4i00A-1xogA:47.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yts | YERSINIA PROTEINTYROSINE PHOSPHATASE (Yersiniaenterocolitica) |
PF00102(Y_phosphatase) | 4 | LEU A 204ARG A 437ILE A 249ASN A 424 | None | 1.28A | 4i00A-1ytsA:undetectable | 4i00A-1ytsA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ckh | SENTRIN-SPECIFICPROTEASE 1 (Homo sapiens) |
PF02902(Peptidase_C48) | 4 | LEU A 643ARG A 632ILE A 637ASN A 476 | None | 1.08A | 4i00A-2ckhA:undetectable | 4i00A-2ckhA:18.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2htv | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | LEU A 134ARG A 156TRP A 178ILE A 222 | None | 0.63A | 4i00A-2htvA:62.7 | 4i00A-2htvA:46.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2htv | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | LEU A 134TRP A 178ILE A 222ASN A 294 | None | 1.08A | 4i00A-2htvA:62.7 | 4i00A-2htvA:46.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hy5 | DSRHPUTATIVESULFURTRANSFERASEDSRE (Allochromatiumvinosum) |
PF02635(DrsE)PF04077(DsrH) | 4 | ARG A 63TRP A 64ILE A 7ASN C 408 | None | 1.25A | 4i00A-2hy5A:undetectable | 4i00A-2hy5A:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jar | 5'(3')-DEOXYRIBONUCLEOTIDASE (Mus musculus) |
PF06941(NT5C) | 4 | LEU A 143TRP A 160ILE A 151ASN A 170 | None | 1.43A | 4i00A-2jarA:undetectable | 4i00A-2jarA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jau | 5'(3')-DEOXYRIBONUCLEOTIDASE (Homo sapiens) |
PF06941(NT5C) | 4 | LEU A 172TRP A 189ILE A 180ASN A 199 | None | 1.41A | 4i00A-2jauA:undetectable | 4i00A-2jauA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xal | INOSITOL-PENTAKISPHOSPHATE 2-KINASE (Arabidopsisthaliana) |
PF06090(Ins_P5_2-kin) | 4 | LEU A 144ARG A 40ILE A 93ASN A 72 | NoneADP A 600 (-3.7A)NoneNone | 1.46A | 4i00A-2xalA:undetectable | 4i00A-2xalA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xc8 | GENE 22 PRODUCT (Bacillus phageSPP1) |
no annotation | 4 | LEU A 31TRP A 73ILE A 17ASN A 6 | None | 1.42A | 4i00A-2xc8A:undetectable | 4i00A-2xc8A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afo | NADH KINASE POS5 (Saccharomycescerevisiae) |
PF01513(NAD_kinase) | 4 | LEU A 202ARG A 204ILE A 277ASN A 395 | MPD A2001 ( 4.8A)MPD A2001 (-3.4A)NoneNone | 1.34A | 4i00A-3afoA:undetectable | 4i00A-3afoA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 4 | LEU A 195TRP A 131ILE A 463ASN A 439 | None | 1.40A | 4i00A-3ayxA:undetectable | 4i00A-3ayxA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3buz | IOTA TOXIN COMPONENTIA (Clostridiumperfringens) |
PF03496(ADPrib_exo_Tox) | 4 | LEU A 304TRP A 326ILE A 331ASN A 335 | NoneNoneNoneTAD A 500 (-2.8A) | 1.35A | 4i00A-3buzA:undetectable | 4i00A-3buzA:21.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ckz | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | LEU A 134ARG A 156TRP A 178ILE A 222 | NoneZMR A 469 (-3.4A)NoneNone | 0.71A | 4i00A-3ckzA:64.4 | 4i00A-3ckzA:46.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ckz | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | LEU A 134TRP A 178ILE A 222ASN A 294 | NoneNoneNoneZMR A 469 (-3.9A) | 0.95A | 4i00A-3ckzA:64.4 | 4i00A-3ckzA:46.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fww | BIFUNCTIONAL PROTEINGLMU (Yersinia pestis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 4 | LEU A 186TRP A 183ILE A 126ASN A 169 | None | 1.41A | 4i00A-3fwwA:undetectable | 4i00A-3fwwA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8y | SUSD/RAGB-ASSOCIATEDESTERASE-LIKEPROTEIN (Bacteroidesvulgatus) |
PF12715(Abhydrolase_7) | 4 | LEU A 257ARG A 307ILE A 310ASN A 318 | NoneNoneEDO A 9 (-4.6A)None | 1.29A | 4i00A-3g8yA:undetectable | 4i00A-3g8yA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 4 | LEU A 262ARG A 247ILE A 239ASN A 193 | None | 1.41A | 4i00A-3kswA:undetectable | 4i00A-3kswA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ltw | ARYLAMINEN-ACETYLTRANSFERASENAT (Mycobacteriummarinum) |
PF00797(Acetyltransf_2) | 4 | LEU A 41ARG A 66ILE A 36ASN A 74 | None | 1.00A | 4i00A-3ltwA:undetectable | 4i00A-3ltwA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0k | ALDO/KETO REDUCTASE (Brucellaabortus) |
PF00248(Aldo_ket_red) | 4 | LEU A 165TRP A 140ILE A 155ASN A 31 | None | 1.49A | 4i00A-3o0kA:undetectable | 4i00A-3o0kA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of7 | REGULATOR OFCHROMOSOMECONDENSATION (Saccharomycescerevisiae) |
PF00415(RCC1)PF13540(RCC1_2) | 4 | LEU A 428ARG A 72TRP A 51ASN A 450 | None | 1.35A | 4i00A-3of7A:7.2 | 4i00A-3of7A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | LEU A 84ARG A 66ILE A 97ASN A 137 | NoneNoneNoneCOA A2598 (-3.3A) | 1.47A | 4i00A-3owcA:undetectable | 4i00A-3owcA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdy | PLECTIN (Homo sapiens) |
PF00435(Spectrin) | 4 | LEU A 555TRP A 558ILE A 592ASN A 633 | None | 1.42A | 4i00A-3pdyA:undetectable | 4i00A-3pdyA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qnm | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 4 | LEU A 10TRP A 15ILE A 100ASN A 70 | None | 1.49A | 4i00A-3qnmA:undetectable | 4i00A-3qnmA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 4 | LEU L 194TRP L 130ILE L 470ASN L 446 | None | 1.45A | 4i00A-3rgwL:undetectable | 4i00A-3rgwL:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t24 | PORIN (Pseudomonasaeruginosa) |
PF03573(OprD) | 4 | LEU A 125ARG A 13ILE A 58ASN A 161 | None | 1.45A | 4i00A-3t24A:undetectable | 4i00A-3t24A:21.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneLNV A 901 (-4.0A)NoneNoneLNV A 901 (-4.0A) | 0.91A | 4i00A-3ti8A:65.2 | 4i00A-3ti8A:45.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tia | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneLNV A 801 (-4.0A)NoneNoneLNV A 801 (-4.0A) | 0.87A | 4i00A-3tiaA:65.4 | 4i00A-3tiaA:45.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umv | DEOXYRIBODIPYRIMIDINE PHOTO-LYASE (Oryza sativa) |
PF00875(DNA_photolyase) | 4 | LEU A 482TRP A 241ILE A 426ASN A 421 | NoneEDO A 701 (-4.6A)NoneFAD A 801 (-3.0A) | 1.05A | 4i00A-3umvA:undetectable | 4i00A-3umvA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | LEU A1867ARG A1872ILE A1879ASN A1857 | None | 1.10A | 4i00A-3vkgA:undetectable | 4i00A-3vkgA:7.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wg6 | CONJUGATEDPOLYKETONE REDUCTASEC1 (Candidaparapsilosis) |
PF00248(Aldo_ket_red) | 4 | LEU A 171TRP A 142ILE A 157ASN A 14 | None | 1.33A | 4i00A-3wg6A:undetectable | 4i00A-3wg6A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 4 | LEU A 108ARG A 106ILE A 242ASN A 150 | None | 1.47A | 4i00A-3wiqA:undetectable | 4i00A-3wiqA:18.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4b7j | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | LEU A 134ARG A 156TRP A 179ASN A 295 | NoneNoneNoneG39 A1470 ( 3.7A) | 0.95A | 4i00A-4b7jA:64.0 | 4i00A-4b7jA:40.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | LEU A 345TRP A 503ILE A 456ASN A 335 | None | 1.02A | 4i00A-4c7vA:undetectable | 4i00A-4c7vA:19.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4cpn | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 5 | LEU A 131ARG A 153TRP A 176ILE A 220ASN A 293 | NoneZMR A 700 (-4.2A)NoneNoneZMR A 700 ( 3.9A) | 0.97A | 4i00A-4cpnA:53.0 | 4i00A-4cpnA:30.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkj | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Mycoplasmapenetrans) |
PF00145(DNA_methylase) | 4 | LEU A 318ARG A 228ILE A 291ASN A 303 | None | 1.37A | 4i00A-4dkjA:undetectable | 4i00A-4dkjA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl2 | INTERFERON-INDUCEDHELICASE CDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 4 | LEU A 809ARG A 806ILE A 814ASN A 364 | None | 1.37A | 4i00A-4gl2A:undetectable | 4i00A-4gl2A:17.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h53 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneNoneNoneNoneSLB A 512 ( 4.2A) | 0.86A | 4i00A-4h53A:65.5 | 4i00A-4h53A:53.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4he4 | YELLOW FLUORESCENTPROTEIN (Phialidium sp.SL-2003) |
PF01353(GFP) | 4 | LEU A 207TRP A 57ILE A 29ASN A 119 | NoneNoneNoneCRO A 65 ( 4.0A) | 1.40A | 4i00A-4he4A:undetectable | 4i00A-4he4A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hym | TOPOISOMERASE IV,SUBUNIT B (Francisellatularensis) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 4 | LEU A 231TRP A 254ILE A 290ASN A 297 | None | 1.50A | 4i00A-4hymA:undetectable | 4i00A-4hymA:23.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzz | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneNoneNoneG39 A 509 ( 4.1A)G39 A 509 ( 4.4A) | 0.19A | 4i00A-4hzzA:75.2 | 4i00A-4hzzA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2b | NTD BIOSYNTHESISOPERON PROTEIN NTDA (Bacillussubtilis) |
PF01041(DegT_DnrJ_EryC1) | 4 | LEU A 415ARG A 317TRP A 348ASN A 149 | None | 1.25A | 4i00A-4k2bA:undetectable | 4i00A-4k2bA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lss | ENVELOPEGLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 4 | LEU G 416TRP G 338ILE G 452ASN G 478 | None | 1.48A | 4i00A-4lssG:undetectable | 4i00A-4lssG:21.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mju | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneNoneNone27S A 501 ( 4.6A)27S A 501 (-3.6A) | 1.04A | 4i00A-4mjuA:62.9 | 4i00A-4mjuA:46.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 4 | LEU A 12ARG A 24ILE A 6ASN A 70 | None | 1.37A | 4i00A-4mptA:undetectable | 4i00A-4mptA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6r | ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 4 | ARG A 441TRP A 435ILE A 282ASN A 149 | NoneNoneNO3 A 502 (-4.8A)None | 1.32A | 4i00A-4o6rA:undetectable | 4i00A-4o6rA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o87 | N-TAGGED NUCLEASE (Millerozymaacaciae) |
no annotation | 4 | LEU A 164TRP A 68ILE A 47ASN A 123 | NoneNoneNoneSO4 A 513 (-4.6A) | 1.19A | 4i00A-4o87A:undetectable | 4i00A-4o87A:22.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qn3 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 52ARG A 74TRP A 97ILE A 141ASN A 213 | None | 0.88A | 4i00A-4qn3A:63.7 | 4i00A-4qn3A:47.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 4 | ARG A 452TRP A 456ILE A 457ASN A 71 | None | 1.33A | 4i00A-4ud8A:undetectable | 4i00A-4ud8A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | LEU A 263ARG A 265ILE A 36ASN A 418 | None | 1.39A | 4i00A-4w8jA:undetectable | 4i00A-4w8jA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 4 | LEU A1181TRP A1178ILE A1162ASN A1087 | None | 1.47A | 4i00A-4xqkA:undetectable | 4i00A-4xqkA:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y7s | SURFACE ANTIGENPROTEIN 2 (Candidaalbicans) |
PF05730(CFEM) | 4 | LEU A 138ARG A 111ILE A 55ASN A 49 | None | 1.46A | 4i00A-4y7sA:undetectable | 4i00A-4y7sA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yc7 | FORMIN-LIKE PROTEIN2 (Homo sapiens) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 4 | LEU B 284ARG B 299ILE B 324ASN B 374 | None | 1.20A | 4i00A-4yc7B:undetectable | 4i00A-4yc7B:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | LEU A 455ARG A 457ILE A 695ASN A 692 | None | 1.26A | 4i00A-4yzwA:undetectable | 4i00A-4yzwA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bpt | MGC81278 PROTEIN (Xenopus laevis) |
PF12894(ANAPC4_WD40)PF12896(ANAPC4) | 4 | LEU A 199ARG A 200ILE A 17ASN A 730 | None | 1.49A | 4i00A-5bptA:undetectable | 4i00A-5bptA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncl | SERINE/THREONINE-PROTEIN KINASE CBK1 (Saccharomycescerevisiae) |
no annotation | 4 | ARG A 656TRP A 594ILE A 463ASN A 480 | NoneNoneNoneANP A 801 (-3.8A) | 1.49A | 4i00A-5nclA:undetectable | 4i00A-5nclA:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o60 | 50S RIBOSOMALPROTEIN L10 (Mycolicibacteriumsmegmatis) |
PF00466(Ribosomal_L10) | 4 | LEU I 36ARG I 40ILE I 79ASN I 54 | A A1202 ( 4.9A) G A1201 ( 3.5A)None G A1225 ( 3.2A) | 1.25A | 4i00A-5o60I:undetectable | 4i00A-5o60I:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocs | PUTATIVENADH-DEPENTDENTFLAVINOXIDOREDUCTASE (Cupriavidusmetallidurans) |
PF00724(Oxidored_FMN) | 4 | ARG A 231TRP A 229ILE A 10ASN A 17 | FMN A 401 (-2.8A)NoneNoneNone | 1.47A | 4i00A-5ocsA:undetectable | 4i00A-5ocsA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tt1 | PUTATIVE SHORT-CHAINALCOHOLDEHYDROGENASE (Burkholderiamultivorans) |
PF00106(adh_short) | 4 | ARG A 31TRP A 33ILE A 11ASN A 90 | None | 1.49A | 4i00A-5tt1A:undetectable | 4i00A-5tt1A:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkw | ADENYLOSUCCINATELYASE (Candidaalbicans) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | LEU A 173TRP A 172ILE A 266ASN A 354 | None | 1.33A | 4i00A-5vkwA:undetectable | 4i00A-5vkwA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wru | PROBABLE INORGANICPYROPHOSPHATASE (Plasmodiumfalciparum) |
no annotation | 4 | LEU A 269ARG A 273ILE A 229ASN A 361 | None | 1.37A | 4i00A-5wruA:undetectable | 4i00A-5wruA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 4 | LEU A 143TRP A 118ILE A 119ASN A 94 | None | 1.46A | 4i00A-5wugA:undetectable | 4i00A-5wugA:10.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 4 | LEU C 773TRP C 776ILE C 792ASN C 869 | None | 1.30A | 4i00A-5y3rC:undetectable | 4i00A-5y3rC:6.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASELARGE SUBUNIT (Methylobacillussp. KY4400) |
no annotation | 4 | LEU C 400ARG C 401ILE C 322ASN C 197 | None | 1.02A | 4i00A-5y6qC:undetectable | 4i00A-5y6qC:11.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7y | ARYL HYDROCARBONRECEPTOR NUCLEARTRANSLOCATORARYL HYDROCARBONRECEPTOR REPRESSOR (Bos taurus;Homo sapiens) |
PF00010(HLH)PF00989(PAS)PF14598(PAS_11) | 4 | LEU A 248TRP A 177ILE B 458ASN B 461 | None | 1.14A | 4i00A-5y7yA:undetectable | 4i00A-5y7yA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ax6 | PROCOLLAGEN LYSYLHYDROXYLASE ANDGLYCOSYLTRANSFERASE (Acanthamoebapolyphagamimivirus) |
no annotation | 4 | LEU A 778TRP A 782ILE A 835ASN A 838 | NoneNoneNoneIOD A 907 ( 4.7A) | 1.40A | 4i00A-6ax6A:undetectable | 4i00A-6ax6A:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6br6 | NEURAMINIDASE (Influenza Avirus) |
no annotation | 5 | LEU A 134ARG A 156TRP A 178ILE A 222ASN A 294 | NoneNoneNoneE3M A 511 ( 4.3A)E3M A 511 ( 3.1A) | 0.88A | 4i00A-6br6A:65.7 | 4i00A-6br6A:12.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ejj | WLAC PROTEIN (Campylobacterjejuni) |
no annotation | 4 | LEU A 21TRP A 350ILE A 114ASN A 106 | None | 1.49A | 4i00A-6ejjA:undetectable | 4i00A-6ejjA:11.08 |