SIMILAR PATTERNS OF AMINO ACIDS FOR 4HZ2_A_BEZA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4hz2	GLUTATHIONE S-TRANSFERASE DOMAIN (Xanthobacter autotrophicus)	PF00043 (GST_C) PF13417 (GST_N_3)	6	MET A 6 SER A 9 ARG A 109 TYR A 110 TRP A 114 TYR A 164	GSH A 301 (-3.6A) BEZ A 302 (-3.1A) BEZ A 302 ( 4.3A) UNL A 303 ( 4.0A) BEZ A 302 (-3.5A) BEZ A 302 (-4.4A)	0.01A	4hz2A-4hz2A: 39.1	4hz2A-4hz2A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ojz	PUTATIVE ALGINATE LYASE (Saccharophagus degradans)	PF05426 (Alginate_lyase) PF07940 (Hepar_II_III)	4	SER A 301 ARG A 392 TYR A 424 TYR A 372	EDO A 805 (-2.7A) None None None	1.44A	4hz2A-4ojzA: 0.9	4hz2A-4ojzA: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pmu	ENDO-1,4-BETA-XYLANA SE A (Xanthomonas citri)	PF00331 (Glyco_hydro_10)	4	SER A 240 ARG A 313 TYR A 238 TRP A 234	None	1.24A	4hz2A-4pmuA: 0.0	4hz2A-4pmuA: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4s3j	CORTICAL-LYTIC ENZYME (Bacillus cereus)	PF00704 (Glyco_hydro_18) PF01476 (LysM)	4	MET A 318 SER A 405 TYR A 134 TYR A 109	None	1.35A	4hz2A-4s3jA: 0.0	4hz2A-4s3jA: 18.43

[["4HZ2_A_BEZA302_0","4hz2","Xanthobacter autotrophicus","GLUTATHIONE S-TRANSFERASE DOMAIN","PF00043(GST_C);PF13417(GST_N_3)",6,"MET A   6;SER A   9;ARG A 109;TYR A 110;TRP A 114;TYR A 164","GSH A 301 (-3.6A);BEZ A 302 (-3.1A);BEZ A 302 ( 4.3A);UNL A 303 ( 4.0A);BEZ A 302 (-3.5A);BEZ A 302 (-4.4A)","0.01A","4hz2A-4hz2A:39.1","4hz2A-4hz2A:100.00"],["4HZ2_A_BEZA302_0","4ojz","Saccharophagus degradans","PUTATIVE ALGINATE LYASE","PF05426(Alginate_lyase);PF07940(Hepar_II_III)",4,"SER A 301;ARG A 392;TYR A 424;TYR A 372","EDO A 805 (-2.7A);None;None;None","1.44A","4hz2A-4ojzA:0.9","4hz2A-4ojzA:16.74"],["4HZ2_A_BEZA302_0","4pmu","Xanthomonas citri","ENDO-1,4-BETA-XYLANASE A","PF00331(Glyco_hydro_10)",4,"SER A 240;ARG A 313;TYR A 238;TRP A 234","None","1.24A","4hz2A-4pmuA:0.0","4hz2A-4pmuA:21.11"],["4HZ2_A_BEZA302_0","4s3j","Bacillus cereus","CORTICAL-LYTIC ENZYME","PF00704(Glyco_hydro_18);PF01476(LysM)",4,"MET A 318;SER A 405;TYR A 134;TYR A 109","None","1.35A","4hz2A-4s3jA:0.0","4hz2A-4s3jA:18.43"]]