SIMILAR PATTERNS OF AMINO ACIDS FOR 4HYT_A_OBNA1104_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  10
ILE A  33
VAL A 124
 None
CA  A 401 (-3.0A)
None
None
 1.41A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 (-2.7A)
None
None
 1.32A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		4 ASP A 314
ASN A 248
ILE A 318
VAL A 289
 MAV  A 402 ( 4.7A)
None
None
None
 1.42A 4hytA-1hv6A:
undetectable		 4hytA-1hv6A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmr DIHYDROLIPOYL
SUCCINYLTRANSFERASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		4 PRO A   8
ASP A   9
ILE A   5
VAL A  19
 None
 1.31A 4hytA-1pmrA:
undetectable		 4hytA-1pmrA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 337
ASN A 313
ILE A 232
VAL A 281
 None
 1.34A 4hytA-1qpgA:
0.0		 4hytA-1qpgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A  91
ASN A 217
ILE A 219
VAL A  99
 None
 1.23A 4hytA-1r3nA:
0.0		 4hytA-1r3nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO E 346
ASP E 345
ILE E 340
VAL E 162
 None
None
None
SO4  E 474 (-4.1A)
 1.28A 4hytA-1skyE:
0.0		 4hytA-1skyE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PRO A 370
ASP A 369
ILE A 172
VAL A 169
 None
 1.43A 4hytA-1sy7A:
2.3		 4hytA-1sy7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzj FIBRILLIN-1

(Homo sapiens) 		PF00683
(TB)
PF07645
(EGF_CA) 		4 ASP A1537
ASN A1551
ILE A1553
VAL A1645
 None
 1.18A 4hytA-1uzjA:
undetectable		 4hytA-1uzjA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 PRO A 158
ASP A 157
ILE A 182
VAL A 220
 None
 1.29A 4hytA-1vm7A:
0.0		 4hytA-1vm7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		4 PRO A  99
ASP A 103
ILE A  62
VAL A 142
 None
 1.30A 4hytA-1wnhA:
0.0		 4hytA-1wnhA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 PRO A 259
ASP A 230
ILE A  62
VAL A 236
 None
 1.28A 4hytA-1xdpA:
0.0		 4hytA-1xdpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		4 PRO A 207
ASP A 205
ILE A 167
VAL A 174
 None
 1.38A 4hytA-1xfjA:
undetectable		 4hytA-1xfjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.20A 4hytA-1zcjA:
3.5		 4hytA-1zcjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 PRO A 170
ASP A 103
ILE A 175
VAL A 226
 None
 1.40A 4hytA-2bhmA:
undetectable		 4hytA-2bhmA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		4 PRO A  86
ASP A  85
ILE A 178
VAL A 263
 None
 1.15A 4hytA-2bjqA:
undetectable		 4hytA-2bjqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		4 PRO B  99
ASP B 103
ILE B  62
VAL B 142
 None
None
MPD  B 303 ( 4.8A)
None
 1.35A 4hytA-2bo9B:
undetectable		 4hytA-2bo9B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d28 TYPE II SECRETION
ATPASE XPSE

(Xanthomonas
campestris) 		PF05157
(T2SSE_N) 		4 PRO C 113
ASP C 112
ILE C  10
VAL C  49
 None
 1.35A 4hytA-2d28C:
undetectable		 4hytA-2d28C:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyy V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 PRO A 165
ASP A 163
ASN A 171
ILE A 182
 None
 1.42A 4hytA-2eyyA:
undetectable		 4hytA-2eyyA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 PRO A  64
ASP A  19
ILE A  66
VAL A 314
 None
 1.36A 4hytA-2gopA:
undetectable		 4hytA-2gopA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 110
ASP A 109
ILE A 146
VAL A 163
 None
None
None
MHO  A 162 ( 3.4A)
 1.45A 4hytA-2iqfA:
undetectable		 4hytA-2iqfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 246
 None
CA  A 316 (-2.2A)
None
None
 1.32A 4hytA-2masA:
5.0		 4hytA-2masA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 PRO A 292
ASP A 291
ILE A 260
VAL A 271
 None
 1.10A 4hytA-2osyA:
undetectable		 4hytA-2osyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D 339
ASP D 338
ILE D 333
VAL D 155
 None
 1.31A 4hytA-2qe7D:
undetectable		 4hytA-2qe7D:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B 200 (-3.6A)
None
GNP  B 200 (-3.9A)
 1.39A 4hytA-2qtvB:
2.8		 4hytA-2qtvB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5t NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.24A 4hytA-2v5tA:
undetectable		 4hytA-2v5tA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 PRO A 123
ASP A 122
ILE A 136
VAL A 321
 None
 1.08A 4hytA-2vwbA:
undetectable		 4hytA-2vwbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wim NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.25A 4hytA-2wimA:
undetectable		 4hytA-2wimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.23A 4hytA-2x58A:
1.1		 4hytA-2x58A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 PRO A 368
ASP A 367
ILE A 699
VAL A 671
 None
 1.35A 4hytA-2xsgA:
undetectable		 4hytA-2xsgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.22A 4hytA-2xy1A:
undetectable		 4hytA-2xy1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 PRO A 169
ASP A 170
ASN A 168
VAL A 414
 None
 1.39A 4hytA-2zwsA:
undetectable		 4hytA-2zwsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 PRO A 279
ASP A 180
ASN A 280
VAL A 285
 None
 1.42A 4hytA-3b9gA:
2.3		 4hytA-3b9gA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 PRO A 444
ASP A 443
ILE A 474
VAL A 502
 None
 1.02A 4hytA-3d3kA:
undetectable		 4hytA-3d3kA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PRO X 374
ASP X 375
ILE X  54
VAL X   5
 C8E  X 455 (-3.9A)
C8E  X 455 (-4.2A)
C8E  X 455 (-4.0A)
C8E  X 455 ( 4.8A)
 1.43A 4hytA-3dwoX:
undetectable		 4hytA-3dwoX:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 PRO A 365
ASP A 394
ILE A  53
VAL A  79
 None
 1.32A 4hytA-3e4eA:
undetectable		 4hytA-3e4eA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PRO A 429
ASP A 356
ILE A 407
VAL A 311
 None
 1.21A 4hytA-3fjoA:
undetectable		 4hytA-3fjoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 PRO A 119
ASP A 112
ILE A 143
VAL A 168
 None
 1.38A 4hytA-3fzgA:
2.9		 4hytA-3fzgA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		4 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 None
 1.45A 4hytA-3g4eA:
undetectable		 4hytA-3g4eA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  10
ILE A  33
VAL A 122
 None
CA  A 501 (-3.0A)
None
None
 1.34A 4hytA-3g5iA:
5.0		 4hytA-3g5iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 323
ASP A 322
ILE A 128
VAL A 292
 None
 1.05A 4hytA-3hpfA:
undetectable		 4hytA-3hpfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 PRO A 287
ASN A 299
ILE A  26
VAL A 111
 None
 1.39A 4hytA-3iu0A:
undetectable		 4hytA-3iu0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 PRO A 330
ASP A 297
ILE A 303
VAL A  80
 None
 1.19A 4hytA-3kjxA:
2.2		 4hytA-3kjxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASP A  46
ASN A  45
ILE A 127
VAL A 219
 None
 1.25A 4hytA-3o7qA:
undetectable		 4hytA-3o7qA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 PRO A 452
ASP A 379
ILE A 430
VAL A 334
 None
 1.32A 4hytA-3qfsA:
2.1		 4hytA-3qfsA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		4 PRO A  83
ASP A  82
ILE A   9
VAL A 206
 None
 1.31A 4hytA-3qvlA:
undetectable		 4hytA-3qvlA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 PRO A 169
ASN A 144
ILE A 236
VAL A 233
 None
 1.34A 4hytA-3rr6A:
undetectable		 4hytA-3rr6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 PRO A  70
ASN A  71
ILE A  64
VAL A 385
 None
 1.17A 4hytA-3t02A:
undetectable		 4hytA-3t02A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PRO A 154
ASN A 153
ILE A 172
VAL A 188
 None
 1.41A 4hytA-3vtfA:
4.2		 4hytA-3vtfA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 PRO A  72
ASP A 182
ILE A  64
VAL A 192
 None
 1.20A 4hytA-3wfzA:
undetectable		 4hytA-3wfzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus;
Thermus virus
P23-45) 		PF00562
(RNA_pol_Rpb2_6)
no annotation 		4 PRO B  17
ASP A 738
ILE A 745
VAL A 825
 None
 1.30A 4hytA-3woeB:
undetectable		 4hytA-3woeB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D 350
ASP D 349
ILE D 344
VAL D 161
 None
None
None
ADP  D1476 (-4.4A)
 1.14A 4hytA-4b2qD:
undetectable		 4hytA-4b2qD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B1190 (-3.6A)
None
GNP  B1190 (-3.9A)
 1.39A 4hytA-4bziB:
2.5		 4hytA-4bziB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 ASP A 154
ASN A 356
ILE A 352
VAL A 285
 None
 1.42A 4hytA-4c3yA:
undetectable		 4hytA-4c3yA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PRO A 272
ASP A 270
ILE A 287
VAL A 243
 None
 1.28A 4hytA-4dvjA:
2.7		 4hytA-4dvjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 ASO  A 304 (-4.4A)
None
None
None
 1.40A 4hytA-4gn8A:
undetectable		 4hytA-4gn8A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 PRO A 427
ASP A 426
ASN A 398
VAL A 408
 None
 1.24A 4hytA-4haqA:
undetectable		 4hytA-4haqA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 PRO A  82
ASP A  81
ILE A  48
VAL A 176
 None
 1.42A 4hytA-4i0nA:
undetectable		 4hytA-4i0nA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)

(Treponema
pallidum) 		PF02608
(Bmp) 		4 PRO A  83
ASP A 105
ILE A 164
VAL A 286
 RBF  A 401 ( 3.7A)
RBF  A 401 (-3.2A)
RBF  A 401 ( 4.7A)
None
 1.43A 4hytA-4iilA:
2.1		 4hytA-4iilA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A  85
ASP A  84
ILE A 148
VAL A 292
 None
None
NAI  A 401 (-4.2A)
None
 1.10A 4hytA-4ilkA:
3.9		 4hytA-4ilkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 PRO A  30
ASP A  29
ILE A  59
VAL A 145
 None
None
None
PGE  A 302 ( 4.7A)
 1.28A 4hytA-4jejA:
undetectable		 4hytA-4jejA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 PRO A 143
ASP A 142
ASN A  36
VAL A 151
 None
 1.28A 4hytA-4jr7A:
undetectable		 4hytA-4jr7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PRO A 152
ASP A 146
ILE A 666
VAL A 571
 None
 0.98A 4hytA-4lnvA:
undetectable		 4hytA-4lnvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 PRO A  29
ASN A  28
ILE A  26
VAL A 210
 None
 1.44A 4hytA-4lsbA:
undetectable		 4hytA-4lsbA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 ASP A 502
ASN A 530
ILE A 532
VAL A 600
 None
 1.42A 4hytA-4n3sA:
2.8		 4hytA-4n3sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 ASP B  24
ASN B  23
ILE B 194
VAL B 216
 None
 1.25A 4hytA-4o6dB:
undetectable		 4hytA-4o6dB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 ASP A 349
ASN A 350
ILE A  85
VAL A 322
 None
 1.27A 4hytA-4obsA:
undetectable		 4hytA-4obsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 PRO A 229
ASP A 234
ILE A 362
VAL A 377
 None
 0.98A 4hytA-4oc8A:
undetectable		 4hytA-4oc8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4l ATP SYNTHASE SUBUNIT
BETA 1

(Burkholderia
thailandensis) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO A 353
ASP A 352
ILE A 347
VAL A 170
 None
 1.28A 4hytA-4q4lA:
undetectable		 4hytA-4q4lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax CARD
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1

(Thermus
aquaticus;
Thermus
thermophilus) 		PF02559
(CarD_CdnL_TRCF)
PF04563
(RNA_pol_Rpb2_1) 		4 PRO A 369
ASP A 111
ILE A 108
VAL B  38
 None
 1.42A 4hytA-4xaxA:
undetectable		 4hytA-4xaxA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 PRO A 903
ASP A 902
ILE A1081
VAL A 881
 None
 1.15A 4hytA-4xqkA:
2.5		 4hytA-4xqkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 4 PRO A  62
ASP A  61
ILE A  93
VAL A  35
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.3A)
None
 1.37A 4hytA-5bw4A:
2.1		 4hytA-5bw4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 PRO A 110
ASP A 109
ILE A 131
VAL A 159
 None
 1.39A 4hytA-5d6nA:
undetectable		 4hytA-5d6nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		4 PRO A 298
ASP A 299
ILE A 229
VAL A 308
 PLP  A1001 (-4.3A)
PLP  A1001 (-3.2A)
None
None
 0.97A 4hytA-5d86A:
3.6		 4hytA-5d86A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 PRO A  43
ASN A  44
ILE A  91
VAL A  19
 None
 1.36A 4hytA-5firA:
3.2		 4hytA-5firA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A 381
ASN A 355
ILE A 352
VAL A 385
 None
 1.35A 4hytA-5fjiA:
4.9		 4hytA-5fjiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A1145
ASN A1144
ILE A1086
VAL A1136
 None
 0.99A 4hytA-5fkuA:
undetectable		 4hytA-5fkuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 ASP A 175
ASN A 177
ILE A 182
VAL A 129
 None
 1.25A 4hytA-5if3A:
4.0		 4hytA-5if3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		4 PRO A 123
ASP A 122
ILE A 136
VAL A 321
 None
 1.16A 4hytA-5jmvA:
undetectable		 4hytA-5jmvA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 PRO A  58
ASN A  48
ILE A  28
VAL A 267
 None
 1.38A 4hytA-5jowA:
undetectable		 4hytA-5jowA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PRO B 555
ASP B 594
ILE B 557
VAL B 565
 None
 1.41A 4hytA-5ldrB:
undetectable		 4hytA-5ldrB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwe C-C CHEMOKINE
RECEPTOR TYPE 9

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASP A  94
ASN A 313
ILE A 137
VAL A 262
 None
None
None
OLA  A 402 ( 4.0A)
 1.26A 4hytA-5lweA:
2.2		 4hytA-5lweA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 PRO D  62
ASP D  61
ILE D  40
VAL D  98
 None
 1.01A 4hytA-5n03D:
undetectable		 4hytA-5n03D:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 4 PRO A 117
ASP A 562
ILE A  78
VAL A 234
 None
 1.23A 4hytA-5nf2A:
undetectable		 4hytA-5nf2A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A  88
ASN A 301
ILE A 131
VAL A 251
 None
 1.25A 4hytA-5t1aA:
undetectable		 4hytA-5t1aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 PRO B 186
ASP B 185
ILE B 256
VAL B 147
 MGD  B 504 (-4.4A)
MGD  B 504 (-3.1A)
None
None
 1.25A 4hytA-5t5iB:
3.2		 4hytA-5t5iB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 ( 2.2A)
None
None
 1.26A 4hytA-5tsqA:
4.7		 4hytA-5tsqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 ASP A  76
ASN A 293
ILE A 119
VAL A 243
 None
 1.33A 4hytA-5uiwA:
undetectable		 4hytA-5uiwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 PRO A 222
ASP A 246
ILE A 262
VAL A 265
 None
 1.34A 4hytA-5umhA:
3.0		 4hytA-5umhA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 4 ASP A 333
ASN A 146
ILE A 132
VAL A 241
 None
 1.43A 4hytA-5v8cA:
undetectable		 4hytA-5v8cA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		4 ASP A 351
ASN A 347
ILE A 485
VAL A 388
 None
None
None
GB0  A1001 ( 4.7A)
 1.43A 4hytA-5v8kA:
undetectable		 4hytA-5v8kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4

(Homo sapiens) 		no annotation 4 PRO B 106
ASN B 153
ILE B 160
VAL B 133
 None
 1.30A 4hytA-5vgzB:
3.4		 4hytA-5vgzB:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 ASP C 335
ASN C 344
ILE C 286
VAL C 330
 None
 1.20A 4hytA-5x6xC:
undetectable		 4hytA-5x6xC:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 PRO A 382
ASP A 381
ILE A 378
VAL A 332
 None
EPE  A 504 (-3.8A)
None
None
 1.43A 4hytA-5xj1A:
2.7		 4hytA-5xj1A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 PRO A 768
ASP A 771
ASN A 777
VAL A 832
 None
 1.39A 4hytA-5xqoA:
undetectable		 4hytA-5xqoA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 4 PRO A 346
ASP A 376
ILE A 370
VAL A 430
 None
 1.41A 4hytA-5xt3A:
2.6		 4hytA-5xt3A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 PRO A 298
ASN A 276
ILE A 230
VAL A 250
 PLP  A 401 (-4.3A)
None
PLP  A 401 (-4.8A)
None
 1.33A 4hytA-5z5cA:
3.7		 4hytA-5z5cA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 PRO A 582
ASN A 583
ILE A 625
VAL A 621
 None
 1.40A 4hytA-6au1A:
undetectable		 4hytA-6au1A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 PRO A  48
ASP A  54
ILE A  95
VAL A  61
 None
 1.24A 4hytA-6c2hA:
2.3		 4hytA-6c2hA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 PRO A 219
ASP A 424
ASN A 423
VAL A 491
 None
 1.44A 4hytA-6cddA:
undetectable		 4hytA-6cddA:
6.74