SIMILAR PATTERNS OF AMINO ACIDS FOR 4HYT_A_OBNA1104_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		5 GLU A 161
LEU A 152
THR A 107
ILE A 108
ARG A 175
 None
None
ARC  A1000 (-3.7A)
None
None
 1.16A 4hytA-1brrA:
3.1		 4hytA-1brrA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eun KDPG ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 GLU A 120
LEU A 129
PHE A 158
PHE A 134
ILE A 112
 None
 1.21A 4hytA-1eunA:
undetectable		 4hytA-1eunA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
PF08720
(Hema_stalk) 		5 LEU A   7
GLY B  44
ALA B  41
PHE B 156
PHE B 152
 None
 1.21A 4hytA-1flcA:
0.0		 4hytA-1flcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 GLU A 151
PHE B 428
PHE B 431
LEU A 185
ARG B 350
 None
 1.13A 4hytA-1gxsA:
undetectable		 4hytA-1gxsA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he7 HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07679
(I-set) 		5 GLY A 357
ALA A 376
PHE A 317
LEU A 322
ILE A 301
 None
 1.21A 4hytA-1he7A:
undetectable		 4hytA-1he7A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		5 LEU A 128
GLU A 163
GLY A 131
LEU A 103
ILE A  97
 None
 1.20A 4hytA-1ij9A:
undetectable		 4hytA-1ij9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 LEU A  66
GLU A 180
GLY A  61
ALA A  93
ILE A 149
 None
 1.14A 4hytA-1o9gA:
undetectable		 4hytA-1o9gA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 GLU A 150
GLY A  31
LEU A 158
ILE A  77
ARG A 157
 None
 1.03A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 GLU A 178
GLU A 150
GLY A  31
LEU A 158
ARG A 157
 None
 0.98A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLU A1068
LEU A1291
GLY A1180
ALA A1182
LEU A1343
 None
 1.13A 4hytA-1p0cA:
5.1		 4hytA-1p0cA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLU A 206
GLY A 190
PHE A  52
LEU A  39
ILE A  56
 None
 1.16A 4hytA-1pieA:
undetectable		 4hytA-1pieA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		5 LEU A 138
GLY A  61
PHE A  64
LEU A 127
ILE A  86
 None
 1.13A 4hytA-1r4vA:
undetectable		 4hytA-1r4vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 685
GLY A 608
ALA A 619
LEU A 668
ILE A 663
 None
 1.21A 4hytA-1ry2A:
4.3		 4hytA-1ry2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 GLY A 198
ALA A 332
PHE A 236
LEU A 274
THR A 215
 None
 1.16A 4hytA-1sb8A:
3.5		 4hytA-1sb8A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 LEU A 111
GLU A 124
GLY A  70
ALA A  74
PHE A 162
 None
 1.17A 4hytA-1tf1A:
undetectable		 4hytA-1tf1A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLN A  79
LEU A  35
GLU A  76
ILE A 136
ARG A 122
 None
 0.98A 4hytA-1uznA:
4.2		 4hytA-1uznA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 GLN A 200
GLU A 158
GLY A 139
ALA A 141
ILE A 174
 None
NAD  A1002 (-3.6A)
None
None
None
 1.21A 4hytA-1vrqA:
1.9		 4hytA-1vrqA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		5 LEU A 119
GLU A  89
GLY A  80
ALA A  77
LEU A  10
 None
 1.08A 4hytA-1wloA:
undetectable		 4hytA-1wloA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 575
GLY A 635
ALA A 469
PHE A 456
ARG A 439
 None
 1.16A 4hytA-1zjkA:
undetectable		 4hytA-1zjkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 LEU A 283
GLU A 229
GLY A 293
PHE A 222
ILE A 240
 None
 1.22A 4hytA-2c07A:
undetectable		 4hytA-2c07A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 LEU A 224
GLU A 180
GLY A 233
PHE A 173
ILE A 191
 None
 1.16A 4hytA-2et6A:
3.9		 4hytA-2et6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 GLN A 201
GLU A 159
GLY A 140
ALA A 142
ILE A 175
 None
NAD  A 999 (-3.4A)
None
None
None
 1.15A 4hytA-2gahA:
undetectable		 4hytA-2gahA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 GLN A 298
GLY A 293
ALA A 289
PHE A  83
LEU A  63
 None
 1.21A 4hytA-2i4cA:
undetectable		 4hytA-2i4cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		5 LEU A  26
ALA A  88
PHE A  73
PHE A  69
LEU A  33
 None
 1.03A 4hytA-2l08A:
undetectable		 4hytA-2l08A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		5 LEU A  77
GLU A  93
GLY A  85
PHE A 146
ILE A 130
 None
 1.21A 4hytA-2owzA:
undetectable		 4hytA-2owzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.17A 4hytA-2p2vA:
undetectable		 4hytA-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLU B 599
PHE B 637
PHE B 585
ILE B 641
ARG A 359
 None
 1.16A 4hytA-2pjrB:
undetectable		 4hytA-2pjrB:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  29
GLY A 120
LEU A 423
THR A 129
ILE A 128
 None
 1.15A 4hytA-2pokA:
undetectable		 4hytA-2pokA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pww UNCHARACTERIZED
PROTEIN

(Bacillus
clausii) 		PF08868
(YugN) 		5 GLU A  88
GLY A  49
PHE A  51
PHE A  94
LEU A  78
 None
 1.18A 4hytA-2pwwA:
undetectable		 4hytA-2pwwA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 GLU A  61
PHE A  41
LEU A  44
ILE A  32
ARG A  68
 None
 1.21A 4hytA-2qxyA:
3.8		 4hytA-2qxyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.18A 4hytA-2r6r1:
5.9		 4hytA-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLU A 158
GLU A 108
GLY A 278
LEU A 155
ILE A 324
 None
 1.03A 4hytA-2rghA:
undetectable		 4hytA-2rghA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 142
LEU A 215
THR A 224
ILE A 227
ARG A 214
 None
None
None
HEM  A1400 (-3.6A)
None
 1.12A 4hytA-2xkrA:
undetectable		 4hytA-2xkrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 GLU A 161
GLY A 261
ALA A 237
ILE A 316
ARG A 168
 None
 1.18A 4hytA-2xr1A:
undetectable		 4hytA-2xr1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 GLY A 453
ALA A 402
PHE A 418
PHE A 432
LEU A 408
 None
 1.21A 4hytA-2zuxA:
undetectable		 4hytA-2zuxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		5 LEU A 240
GLU A 174
GLY A 250
ALA A 252
PHE A 167
 None
 1.01A 4hytA-3ai2A:
4.9		 4hytA-3ai2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 198
GLY A 142
ALA A 256
LEU A 171
ILE A 233
 None
 1.07A 4hytA-3cwcA:
undetectable		 4hytA-3cwcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 241
GLY A 243
ALA A 210
THR A 220
ILE A 219
 None
 1.19A 4hytA-3d1jA:
4.3		 4hytA-3d1jA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 349
GLY A 353
PHE A  45
ILE A 271
ARG A 217
 None
 1.14A 4hytA-3d6bA:
undetectable		 4hytA-3d6bA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 LEU A 227
GLU A 173
GLY A 237
PHE A 166
LEU A 120
 None
 0.93A 4hytA-3edmA:
undetectable		 4hytA-3edmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		5 GLY A 269
ALA A 265
LEU A 150
THR A 182
ILE A 192
 None
 1.22A 4hytA-3ekmA:
undetectable		 4hytA-3ekmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		5 LEU A 226
GLU A 172
GLY A 236
PHE A 165
LEU A 118
 None
 1.10A 4hytA-3ezlA:
4.3		 4hytA-3ezlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4k PUTATIVE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF13649
(Methyltransf_25) 		5 GLU A 203
GLY A  27
ALA A 123
PHE A  63
THR A  57
 None
 0.75A 4hytA-3f4kA:
undetectable		 4hytA-3f4kA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 GLU A 122
GLY A 324
ALA A  64
LEU A 112
ILE A 315
 None
 1.21A 4hytA-3fgqA:
undetectable		 4hytA-3fgqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 LEU A 407
GLY A  44
ALA A  41
PHE A  22
LEU A  32
 None
 1.16A 4hytA-3i4jA:
undetectable		 4hytA-3i4jA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLU A  57
GLY A 138
ALA A  79
THR A  82
ARG A  97
 None
 1.21A 4hytA-3il7A:
undetectable		 4hytA-3il7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 142
GLY A 160
ALA A 272
THR A  82
ARG A  97
 None
 1.12A 4hytA-3il7A:
undetectable		 4hytA-3il7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 GLN B 130
LEU B 486
GLY B 172
THR B 482
ARG B 183
 None
 1.18A 4hytA-3jruB:
undetectable		 4hytA-3jruB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 GLU A 364
PHE A 374
LEU A 371
ILE A 429
ARG A 370
 None
 1.19A 4hytA-3jwjA:
2.9		 4hytA-3jwjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 614
GLU A 604
LEU A 551
THR A 530
ILE A 533
 None
 1.19A 4hytA-3k1jA:
undetectable		 4hytA-3k1jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k20 OXIDOREDUCTASE

(Corynebacterium
diphtheriae) 		PF03358
(FMN_red) 		5 GLU A  37
GLY A 170
ALA A 168
LEU A   4
ILE A  24
 None
 1.19A 4hytA-3k20A:
2.5		 4hytA-3k20A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		5 GLU A  16
GLY A  46
ALA A  48
THR A  41
ILE A  40
 None
 1.06A 4hytA-3klqA:
undetectable		 4hytA-3klqA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY B1170
ALA A  54
LEU B1546
THR B1011
ARG B1547
 None
 1.11A 4hytA-3myrB:
undetectable		 4hytA-3myrB:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLN A 111
GLU A 312
PHE A 786
LEU A 793
ARG A 880
 OBN  A   1 (-3.8A)
None
None
None
OBN  A   1 (-3.7A)
 0.99A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
 1.01A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
 0.86A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans;
Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 643
GLU B  76
GLU A 645
ALA A 530
ILE A 572
 None
 1.17A 4hytA-3n6rA:
undetectable		 4hytA-3n6rA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		5 GLU A  74
ALA A  43
PHE A  35
PHE A  31
LEU A  24
 None
 1.15A 4hytA-3ne9A:
undetectable		 4hytA-3ne9A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 LEU B  72
GLY B  56
PHE B  58
LEU B  65
ILE B  49
 None
 1.02A 4hytA-3nvnB:
undetectable		 4hytA-3nvnB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 GLU A 171
GLY A 201
ALA A 203
THR A  88
ILE A  91
 None
 1.15A 4hytA-3of3A:
undetectable		 4hytA-3of3A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A 228
GLU A 174
GLY A 238
ALA A 240
PHE A 167
 None
 1.19A 4hytA-3pk0A:
5.0		 4hytA-3pk0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		5 LEU A 330
GLY A 311
ALA A 313
PHE A 132
ILE A 115
 None
 1.06A 4hytA-3qufA:
undetectable		 4hytA-3qufA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 GLU G  16
GLY G  51
ALA G  88
LEU G  11
THR G  56
 None
 1.12A 4hytA-4adsG:
undetectable		 4hytA-4adsG:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52

(Arabidopsis
thaliana) 		no annotation 5 GLN A  88
GLU A  86
GLY A 118
LEU A  67
ILE A 122
 None
 1.16A 4hytA-4c6sA:
3.5		 4hytA-4c6sA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		5 GLY A 423
ALA A 372
PHE A 388
PHE A 402
LEU A 378
 None
 1.19A 4hytA-4cagA:
undetectable		 4hytA-4cagA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 512
GLY A 276
ALA A 274
PHE A 272
ILE A 294
 None
None
None
None
1GA  A 603 (-4.1A)
 1.10A 4hytA-4di5A:
undetectable		 4hytA-4di5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 GLN H 374
GLU H 373
ALA H 307
LEU H 358
ILE H 332
 None
 1.20A 4hytA-4l0oH:
2.3		 4hytA-4l0oH:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 GLY A 242
ALA A 240
PHE A 249
LEU A 270
ILE A 259
 None
 1.12A 4hytA-4l5iA:
2.3		 4hytA-4l5iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU A1096
GLY A1089
PHE A1080
LEU A1049
THR A1073
 None
 1.18A 4hytA-4lnvA:
undetectable		 4hytA-4lnvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maq PUTATIVE
FUMARYLPYRUVATE
HYDROLASE

(Burkholderia
cenocepacia) 		PF01557
(FAA_hydrolase) 		5 LEU A  83
GLY A 217
ALA A 222
PHE A 224
PHE A 226
 None
 1.03A 4hytA-4maqA:
undetectable		 4hytA-4maqA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 200
GLU A 207
GLY A 215
PHE A  63
LEU A 158
 None
 1.20A 4hytA-4rshA:
undetectable		 4hytA-4rshA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		5 LEU B 296
GLU B 240
GLY B 261
ILE B 300
ARG B 284
 None
 1.17A 4hytA-4v0nB:
undetectable		 4hytA-4v0nB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 LEU A 382
GLU A 337
ALA A 415
PHE A 412
LEU A 372
 None
 1.14A 4hytA-4xguA:
undetectable		 4hytA-4xguA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLU A2421
GLY A2562
ALA A2675
LEU A2338
THR A2565
 None
 1.19A 4hytA-4z37A:
undetectable		 4hytA-4z37A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.19A 4hytA-4zpjA:
undetectable		 4hytA-4zpjA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 ALA A 330
PHE A 793
LEU A 800
THR A 804
ARG A 887
 None
 0.97A 4hytA-5aw4A:
53.2		 4hytA-5aw4A:
87.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE A 793
LEU A 800
THR A 804
ILE A 807
ARG A 887
 None
 0.75A 4hytA-5aw4A:
53.2		 4hytA-5aw4A:
87.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 142
GLU A  57
ALA A 282
THR A  82
ILE A  81
 None
 1.01A 4hytA-5bqsA:
undetectable		 4hytA-5bqsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 GLU A 467
ALA A 446
PHE A 541
LEU A 533
ILE A 500
 None
 1.10A 4hytA-5c16A:
undetectable		 4hytA-5c16A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLN A 109
GLY A  94
ALA A  18
LEU A  77
ILE A  84
 NA  A 405 (-3.9A)
None
None
None
None
 1.16A 4hytA-5cnxA:
undetectable		 4hytA-5cnxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 GLU A 310
LEU A 318
GLU A 299
ALA A 258
ILE A 280
 PEG  A1386 (-4.8A)
None
None
None
None
 1.21A 4hytA-5fipA:
undetectable		 4hytA-5fipA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 LEU A 444
GLU A 462
ALA A 384
PHE A 377
THR A 440
 None
 1.05A 4hytA-5gppA:
undetectable		 4hytA-5gppA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		5 LEU A 212
GLY A  55
ALA A 105
ILE A 223
ARG A  96
 None
 1.22A 4hytA-5hftA:
undetectable		 4hytA-5hftA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CDII IMMUNITY
PROTEIN

(Escherichia
coli) 		no annotation 5 LEU I 115
ALA I  35
PHE I  23
PHE I   6
ARG I  20
 None
 1.13A 4hytA-5hkqI:
undetectable		 4hytA-5hkqI:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLU A  98
ALA A  88
PHE A  75
LEU A 151
ILE A 139
 None
 1.19A 4hytA-5hy7A:
undetectable		 4hytA-5hy7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 GLU A 334
LEU A 347
LEU A 703
THR A 629
ARG A 656
 None
 1.11A 4hytA-5im3A:
undetectable		 4hytA-5im3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		5 GLN A 417
GLY A 477
ALA A 123
PHE A  40
THR A  66
 None
 1.21A 4hytA-5j55A:
undetectable		 4hytA-5j55A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 LEU A 108
GLY A 304
ALA A 308
PHE A 288
LEU A 120
 None
 1.10A 4hytA-5jhoA:
undetectable		 4hytA-5jhoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln1 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		5 GLU A  68
GLY A  75
PHE A  37
ILE A  10
ARG A  41
 None
 1.10A 4hytA-5ln1A:
4.1		 4hytA-5ln1A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 LEU A   8
GLU A 138
GLY A  36
PHE A 129
ILE A 102
 None
 1.17A 4hytA-5o25A:
3.5		 4hytA-5o25A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLN A  87
LEU A  43
GLU A  84
ILE A 144
ARG A 130
 None
 0.95A 4hytA-5ovkA:
3.4		 4hytA-5ovkA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 GLN A1510
GLY A1530
PHE A1500
THR A1547
ILE A1548
 None
 1.15A 4hytA-5u1sA:
5.1		 4hytA-5u1sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 GLU A 296
ALA A 311
LEU A 258
THR A 342
ILE A 318
 None
 1.13A 4hytA-5u3fA:
undetectable		 4hytA-5u3fA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 GLU A 519
LEU A 312
GLU A 477
THR A 327
ILE A 330
 None
 1.00A 4hytA-5uj1A:
undetectable		 4hytA-5uj1A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 876
LEU A 869
THR A 832
ILE A 833
ARG A 783
 None
 1.14A 4hytA-5ur2A:
3.0		 4hytA-5ur2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 6 LEU A 149
GLU A 140
GLY A 105
PHE A  33
LEU A  47
ARG A  49
 None
 1.45A 4hytA-5ux2A:
2.3		 4hytA-5ux2A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 183
GLY A  79
ALA A  35
LEU A  57
ILE A  31
 None
 1.18A 4hytA-5xwbA:
undetectable		 4hytA-5xwbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU i 311
GLY i 339
ALA i 343
PHE i 371
LEU i 359
 None
None
G  21267 ( 3.2A)
None
None
 1.21A 4hytA-6faii:
undetectable		 4hytA-6faii:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii) 		no annotation 5 GLN C   3
LEU C   9
GLY C  90
PHE C  86
ILE C  84
 None
 1.14A 4hytA-6feaC:
undetectable		 4hytA-6feaC:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 746
GLY A 751
LEU A 802
ILE A 759
ARG A 801
 None
 0.95A 4hytA-6fnwA:
undetectable		 4hytA-6fnwA:
6.66