SIMILAR PATTERNS OF AMINO ACIDS FOR 4HYT_A_OBNA1104

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		5 GLU A 161
LEU A 152
THR A 107
ILE A 108
ARG A 175
 None
None
ARC  A1000 (-3.7A)
None
None
 1.16A 4hytA-1brrA:
3.1		 4hytA-1brrA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eun KDPG ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 GLU A 120
LEU A 129
PHE A 158
PHE A 134
ILE A 112
 None
 1.21A 4hytA-1eunA:
undetectable		 4hytA-1eunA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
PF08720
(Hema_stalk) 		5 LEU A   7
GLY B  44
ALA B  41
PHE B 156
PHE B 152
 None
 1.21A 4hytA-1flcA:
0.0		 4hytA-1flcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 GLU A 151
PHE B 428
PHE B 431
LEU A 185
ARG B 350
 None
 1.13A 4hytA-1gxsA:
undetectable		 4hytA-1gxsA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he7 HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07679
(I-set) 		5 GLY A 357
ALA A 376
PHE A 317
LEU A 322
ILE A 301
 None
 1.21A 4hytA-1he7A:
undetectable		 4hytA-1he7A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		5 LEU A 128
GLU A 163
GLY A 131
LEU A 103
ILE A  97
 None
 1.20A 4hytA-1ij9A:
undetectable		 4hytA-1ij9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 LEU A  66
GLU A 180
GLY A  61
ALA A  93
ILE A 149
 None
 1.14A 4hytA-1o9gA:
undetectable		 4hytA-1o9gA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 GLU A 150
GLY A  31
LEU A 158
ILE A  77
ARG A 157
 None
 1.03A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 GLU A 178
GLU A 150
GLY A  31
LEU A 158
ARG A 157
 None
 0.98A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLU A1068
LEU A1291
GLY A1180
ALA A1182
LEU A1343
 None
 1.13A 4hytA-1p0cA:
5.1		 4hytA-1p0cA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLU A 206
GLY A 190
PHE A  52
LEU A  39
ILE A  56
 None
 1.16A 4hytA-1pieA:
undetectable		 4hytA-1pieA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		5 LEU A 138
GLY A  61
PHE A  64
LEU A 127
ILE A  86
 None
 1.13A 4hytA-1r4vA:
undetectable		 4hytA-1r4vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 685
GLY A 608
ALA A 619
LEU A 668
ILE A 663
 None
 1.21A 4hytA-1ry2A:
4.3		 4hytA-1ry2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 GLY A 198
ALA A 332
PHE A 236
LEU A 274
THR A 215
 None
 1.16A 4hytA-1sb8A:
3.5		 4hytA-1sb8A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 LEU A 111
GLU A 124
GLY A  70
ALA A  74
PHE A 162
 None
 1.17A 4hytA-1tf1A:
undetectable		 4hytA-1tf1A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLN A  79
LEU A  35
GLU A  76
ILE A 136
ARG A 122
 None
 0.98A 4hytA-1uznA:
4.2		 4hytA-1uznA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 GLN A 200
GLU A 158
GLY A 139
ALA A 141
ILE A 174
 None
NAD  A1002 (-3.6A)
None
None
None
 1.21A 4hytA-1vrqA:
1.9		 4hytA-1vrqA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		5 LEU A 119
GLU A  89
GLY A  80
ALA A  77
LEU A  10
 None
 1.08A 4hytA-1wloA:
undetectable		 4hytA-1wloA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 575
GLY A 635
ALA A 469
PHE A 456
ARG A 439
 None
 1.16A 4hytA-1zjkA:
undetectable		 4hytA-1zjkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 LEU A 283
GLU A 229
GLY A 293
PHE A 222
ILE A 240
 None
 1.22A 4hytA-2c07A:
undetectable		 4hytA-2c07A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 LEU A 224
GLU A 180
GLY A 233
PHE A 173
ILE A 191
 None
 1.16A 4hytA-2et6A:
3.9		 4hytA-2et6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 GLN A 201
GLU A 159
GLY A 140
ALA A 142
ILE A 175
 None
NAD  A 999 (-3.4A)
None
None
None
 1.15A 4hytA-2gahA:
undetectable		 4hytA-2gahA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 GLN A 298
GLY A 293
ALA A 289
PHE A  83
LEU A  63
 None
 1.21A 4hytA-2i4cA:
undetectable		 4hytA-2i4cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		5 LEU A  26
ALA A  88
PHE A  73
PHE A  69
LEU A  33
 None
 1.03A 4hytA-2l08A:
undetectable		 4hytA-2l08A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		5 LEU A  77
GLU A  93
GLY A  85
PHE A 146
ILE A 130
 None
 1.21A 4hytA-2owzA:
undetectable		 4hytA-2owzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 LEU A 225
GLU A 172
GLY A 167
ALA A  22
LEU A 211
 None
 1.17A 4hytA-2p2vA:
undetectable		 4hytA-2p2vA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLU B 599
PHE B 637
PHE B 585
ILE B 641
ARG A 359
 None
 1.16A 4hytA-2pjrB:
undetectable		 4hytA-2pjrB:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  29
GLY A 120
LEU A 423
THR A 129
ILE A 128
 None
 1.15A 4hytA-2pokA:
undetectable		 4hytA-2pokA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pww UNCHARACTERIZED
PROTEIN

(Bacillus
clausii) 		PF08868
(YugN) 		5 GLU A  88
GLY A  49
PHE A  51
PHE A  94
LEU A  78
 None
 1.18A 4hytA-2pwwA:
undetectable		 4hytA-2pwwA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 GLU A  61
PHE A  41
LEU A  44
ILE A  32
ARG A  68
 None
 1.21A 4hytA-2qxyA:
3.8		 4hytA-2qxyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.18A 4hytA-2r6r1:
5.9		 4hytA-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLU A 158
GLU A 108
GLY A 278
LEU A 155
ILE A 324
 None
 1.03A 4hytA-2rghA:
undetectable		 4hytA-2rghA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 142
LEU A 215
THR A 224
ILE A 227
ARG A 214
 None
None
None
HEM  A1400 (-3.6A)
None
 1.12A 4hytA-2xkrA:
undetectable		 4hytA-2xkrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 GLU A 161
GLY A 261
ALA A 237
ILE A 316
ARG A 168
 None
 1.18A 4hytA-2xr1A:
undetectable		 4hytA-2xr1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 GLY A 453
ALA A 402
PHE A 418
PHE A 432
LEU A 408
 None
 1.21A 4hytA-2zuxA:
undetectable		 4hytA-2zuxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		5 LEU A 240
GLU A 174
GLY A 250
ALA A 252
PHE A 167
 None
 1.01A 4hytA-3ai2A:
4.9		 4hytA-3ai2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 198
GLY A 142
ALA A 256
LEU A 171
ILE A 233
 None
 1.07A 4hytA-3cwcA:
undetectable		 4hytA-3cwcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 241
GLY A 243
ALA A 210
THR A 220
ILE A 219
 None
 1.19A 4hytA-3d1jA:
4.3		 4hytA-3d1jA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 349
GLY A 353
PHE A  45
ILE A 271
ARG A 217
 None
 1.14A 4hytA-3d6bA:
undetectable		 4hytA-3d6bA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 LEU A 227
GLU A 173
GLY A 237
PHE A 166
LEU A 120
 None
 0.93A 4hytA-3edmA:
undetectable		 4hytA-3edmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		5 GLY A 269
ALA A 265
LEU A 150
THR A 182
ILE A 192
 None
 1.22A 4hytA-3ekmA:
undetectable		 4hytA-3ekmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		5 LEU A 226
GLU A 172
GLY A 236
PHE A 165
LEU A 118
 None
 1.10A 4hytA-3ezlA:
4.3		 4hytA-3ezlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4k PUTATIVE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF13649
(Methyltransf_25) 		5 GLU A 203
GLY A  27
ALA A 123
PHE A  63
THR A  57
 None
 0.75A 4hytA-3f4kA:
undetectable		 4hytA-3f4kA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 GLU A 122
GLY A 324
ALA A  64
LEU A 112
ILE A 315
 None
 1.21A 4hytA-3fgqA:
undetectable		 4hytA-3fgqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 LEU A 407
GLY A  44
ALA A  41
PHE A  22
LEU A  32
 None
 1.16A 4hytA-3i4jA:
undetectable		 4hytA-3i4jA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLU A  57
GLY A 138
ALA A  79
THR A  82
ARG A  97
 None
 1.21A 4hytA-3il7A:
undetectable		 4hytA-3il7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 142
GLY A 160
ALA A 272
THR A  82
ARG A  97
 None
 1.12A 4hytA-3il7A:
undetectable		 4hytA-3il7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 GLN B 130
LEU B 486
GLY B 172
THR B 482
ARG B 183
 None
 1.18A 4hytA-3jruB:
undetectable		 4hytA-3jruB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 GLU A 364
PHE A 374
LEU A 371
ILE A 429
ARG A 370
 None
 1.19A 4hytA-3jwjA:
2.9		 4hytA-3jwjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 614
GLU A 604
LEU A 551
THR A 530
ILE A 533
 None
 1.19A 4hytA-3k1jA:
undetectable		 4hytA-3k1jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k20 OXIDOREDUCTASE

(Corynebacterium
diphtheriae) 		PF03358
(FMN_red) 		5 GLU A  37
GLY A 170
ALA A 168
LEU A   4
ILE A  24
 None
 1.19A 4hytA-3k20A:
2.5		 4hytA-3k20A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		5 GLU A  16
GLY A  46
ALA A  48
THR A  41
ILE A  40
 None
 1.06A 4hytA-3klqA:
undetectable		 4hytA-3klqA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY B1170
ALA A  54
LEU B1546
THR B1011
ARG B1547
 None
 1.11A 4hytA-3myrB:
undetectable		 4hytA-3myrB:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLN A 111
GLU A 312
PHE A 786
LEU A 793
ARG A 880
 OBN  A   1 (-3.8A)
None
None
None
OBN  A   1 (-3.7A)
 0.99A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
 1.01A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
 0.86A 4hytA-3n23A:
58.3		 4hytA-3n23A:
97.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans;
Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 643
GLU B  76
GLU A 645
ALA A 530
ILE A 572
 None
 1.17A 4hytA-3n6rA:
undetectable		 4hytA-3n6rA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		5 GLU A  74
ALA A  43
PHE A  35
PHE A  31
LEU A  24
 None
 1.15A 4hytA-3ne9A:
undetectable		 4hytA-3ne9A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 LEU B  72
GLY B  56
PHE B  58
LEU B  65
ILE B  49
 None
 1.02A 4hytA-3nvnB:
undetectable		 4hytA-3nvnB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 GLU A 171
GLY A 201
ALA A 203
THR A  88
ILE A  91
 None
 1.15A 4hytA-3of3A:
undetectable		 4hytA-3of3A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A 228
GLU A 174
GLY A 238
ALA A 240
PHE A 167
 None
 1.19A 4hytA-3pk0A:
5.0		 4hytA-3pk0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		5 LEU A 330
GLY A 311
ALA A 313
PHE A 132
ILE A 115
 None
 1.06A 4hytA-3qufA:
undetectable		 4hytA-3qufA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 GLU G  16
GLY G  51
ALA G  88
LEU G  11
THR G  56
 None
 1.12A 4hytA-4adsG:
undetectable		 4hytA-4adsG:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52

(Arabidopsis
thaliana) 		no annotation 5 GLN A  88
GLU A  86
GLY A 118
LEU A  67
ILE A 122
 None
 1.16A 4hytA-4c6sA:
3.5		 4hytA-4c6sA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		5 GLY A 423
ALA A 372
PHE A 388
PHE A 402
LEU A 378
 None
 1.19A 4hytA-4cagA:
undetectable		 4hytA-4cagA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 512
GLY A 276
ALA A 274
PHE A 272
ILE A 294
 None
None
None
None
1GA  A 603 (-4.1A)
 1.10A 4hytA-4di5A:
undetectable		 4hytA-4di5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 GLN H 374
GLU H 373
ALA H 307
LEU H 358
ILE H 332
 None
 1.20A 4hytA-4l0oH:
2.3		 4hytA-4l0oH:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 GLY A 242
ALA A 240
PHE A 249
LEU A 270
ILE A 259
 None
 1.12A 4hytA-4l5iA:
2.3		 4hytA-4l5iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU A1096
GLY A1089
PHE A1080
LEU A1049
THR A1073
 None
 1.18A 4hytA-4lnvA:
undetectable		 4hytA-4lnvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maq PUTATIVE
FUMARYLPYRUVATE
HYDROLASE

(Burkholderia
cenocepacia) 		PF01557
(FAA_hydrolase) 		5 LEU A  83
GLY A 217
ALA A 222
PHE A 224
PHE A 226
 None
 1.03A 4hytA-4maqA:
undetectable		 4hytA-4maqA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 200
GLU A 207
GLY A 215
PHE A  63
LEU A 158
 None
 1.20A 4hytA-4rshA:
undetectable		 4hytA-4rshA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		5 LEU B 296
GLU B 240
GLY B 261
ILE B 300
ARG B 284
 None
 1.17A 4hytA-4v0nB:
undetectable		 4hytA-4v0nB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 LEU A 382
GLU A 337
ALA A 415
PHE A 412
LEU A 372
 None
 1.14A 4hytA-4xguA:
undetectable		 4hytA-4xguA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLU A2421
GLY A2562
ALA A2675
LEU A2338
THR A2565
 None
 1.19A 4hytA-4z37A:
undetectable		 4hytA-4z37A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.19A 4hytA-4zpjA:
undetectable		 4hytA-4zpjA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 ALA A 330
PHE A 793
LEU A 800
THR A 804
ARG A 887
 None
 0.97A 4hytA-5aw4A:
53.2		 4hytA-5aw4A:
87.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE A 793
LEU A 800
THR A 804
ILE A 807
ARG A 887
 None
 0.75A 4hytA-5aw4A:
53.2		 4hytA-5aw4A:
87.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 142
GLU A  57
ALA A 282
THR A  82
ILE A  81
 None
 1.01A 4hytA-5bqsA:
undetectable		 4hytA-5bqsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 GLU A 467
ALA A 446
PHE A 541
LEU A 533
ILE A 500
 None
 1.10A 4hytA-5c16A:
undetectable		 4hytA-5c16A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLN A 109
GLY A  94
ALA A  18
LEU A  77
ILE A  84
 NA  A 405 (-3.9A)
None
None
None
None
 1.16A 4hytA-5cnxA:
undetectable		 4hytA-5cnxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 GLU A 310
LEU A 318
GLU A 299
ALA A 258
ILE A 280
 PEG  A1386 (-4.8A)
None
None
None
None
 1.21A 4hytA-5fipA:
undetectable		 4hytA-5fipA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 LEU A 444
GLU A 462
ALA A 384
PHE A 377
THR A 440
 None
 1.05A 4hytA-5gppA:
undetectable		 4hytA-5gppA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		5 LEU A 212
GLY A  55
ALA A 105
ILE A 223
ARG A  96
 None
 1.22A 4hytA-5hftA:
undetectable		 4hytA-5hftA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CDII IMMUNITY
PROTEIN

(Escherichia
coli) 		no annotation 5 LEU I 115
ALA I  35
PHE I  23
PHE I   6
ARG I  20
 None
 1.13A 4hytA-5hkqI:
undetectable		 4hytA-5hkqI:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLU A  98
ALA A  88
PHE A  75
LEU A 151
ILE A 139
 None
 1.19A 4hytA-5hy7A:
undetectable		 4hytA-5hy7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 GLU A 334
LEU A 347
LEU A 703
THR A 629
ARG A 656
 None
 1.11A 4hytA-5im3A:
undetectable		 4hytA-5im3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		5 GLN A 417
GLY A 477
ALA A 123
PHE A  40
THR A  66
 None
 1.21A 4hytA-5j55A:
undetectable		 4hytA-5j55A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 LEU A 108
GLY A 304
ALA A 308
PHE A 288
LEU A 120
 None
 1.10A 4hytA-5jhoA:
undetectable		 4hytA-5jhoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln1 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		5 GLU A  68
GLY A  75
PHE A  37
ILE A  10
ARG A  41
 None
 1.10A 4hytA-5ln1A:
4.1		 4hytA-5ln1A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 LEU A   8
GLU A 138
GLY A  36
PHE A 129
ILE A 102
 None
 1.17A 4hytA-5o25A:
3.5		 4hytA-5o25A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLN A  87
LEU A  43
GLU A  84
ILE A 144
ARG A 130
 None
 0.95A 4hytA-5ovkA:
3.4		 4hytA-5ovkA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 GLN A1510
GLY A1530
PHE A1500
THR A1547
ILE A1548
 None
 1.15A 4hytA-5u1sA:
5.1		 4hytA-5u1sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 GLU A 296
ALA A 311
LEU A 258
THR A 342
ILE A 318
 None
 1.13A 4hytA-5u3fA:
undetectable		 4hytA-5u3fA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 GLU A 519
LEU A 312
GLU A 477
THR A 327
ILE A 330
 None
 1.00A 4hytA-5uj1A:
undetectable		 4hytA-5uj1A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 876
LEU A 869
THR A 832
ILE A 833
ARG A 783
 None
 1.14A 4hytA-5ur2A:
3.0		 4hytA-5ur2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 6 LEU A 149
GLU A 140
GLY A 105
PHE A  33
LEU A  47
ARG A  49
 None
 1.45A 4hytA-5ux2A:
2.3		 4hytA-5ux2A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 183
GLY A  79
ALA A  35
LEU A  57
ILE A  31
 None
 1.18A 4hytA-5xwbA:
undetectable		 4hytA-5xwbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU i 311
GLY i 339
ALA i 343
PHE i 371
LEU i 359
 None
None
G  21267 ( 3.2A)
None
None
 1.21A 4hytA-6faii:
undetectable		 4hytA-6faii:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii) 		no annotation 5 GLN C   3
LEU C   9
GLY C  90
PHE C  86
ILE C  84
 None
 1.14A 4hytA-6feaC:
undetectable		 4hytA-6feaC:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 746
GLY A 751
LEU A 802
ILE A 759
ARG A 801
 None
 0.95A 4hytA-6fnwA:
undetectable		 4hytA-6fnwA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  10
ILE A  33
VAL A 124
 None
CA  A 401 (-3.0A)
None
None
 1.41A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 (-2.7A)
None
None
 1.32A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		4 ASP A 314
ASN A 248
ILE A 318
VAL A 289
 MAV  A 402 ( 4.7A)
None
None
None
 1.42A 4hytA-1hv6A:
undetectable		 4hytA-1hv6A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmr DIHYDROLIPOYL
SUCCINYLTRANSFERASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		4 PRO A   8
ASP A   9
ILE A   5
VAL A  19
 None
 1.31A 4hytA-1pmrA:
undetectable		 4hytA-1pmrA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 337
ASN A 313
ILE A 232
VAL A 281
 None
 1.34A 4hytA-1qpgA:
0.0		 4hytA-1qpgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A  91
ASN A 217
ILE A 219
VAL A  99
 None
 1.23A 4hytA-1r3nA:
0.0		 4hytA-1r3nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO E 346
ASP E 345
ILE E 340
VAL E 162
 None
None
None
SO4  E 474 (-4.1A)
 1.28A 4hytA-1skyE:
0.0		 4hytA-1skyE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PRO A 370
ASP A 369
ILE A 172
VAL A 169
 None
 1.43A 4hytA-1sy7A:
2.3		 4hytA-1sy7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzj FIBRILLIN-1

(Homo sapiens) 		PF00683
(TB)
PF07645
(EGF_CA) 		4 ASP A1537
ASN A1551
ILE A1553
VAL A1645
 None
 1.18A 4hytA-1uzjA:
undetectable		 4hytA-1uzjA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 PRO A 158
ASP A 157
ILE A 182
VAL A 220
 None
 1.29A 4hytA-1vm7A:
0.0		 4hytA-1vm7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		4 PRO A  99
ASP A 103
ILE A  62
VAL A 142
 None
 1.30A 4hytA-1wnhA:
0.0		 4hytA-1wnhA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 PRO A 259
ASP A 230
ILE A  62
VAL A 236
 None
 1.28A 4hytA-1xdpA:
0.0		 4hytA-1xdpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		4 PRO A 207
ASP A 205
ILE A 167
VAL A 174
 None
 1.38A 4hytA-1xfjA:
undetectable		 4hytA-1xfjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.20A 4hytA-1zcjA:
3.5		 4hytA-1zcjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 PRO A 170
ASP A 103
ILE A 175
VAL A 226
 None
 1.40A 4hytA-2bhmA:
undetectable		 4hytA-2bhmA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		4 PRO A  86
ASP A  85
ILE A 178
VAL A 263
 None
 1.15A 4hytA-2bjqA:
undetectable		 4hytA-2bjqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		4 PRO B  99
ASP B 103
ILE B  62
VAL B 142
 None
None
MPD  B 303 ( 4.8A)
None
 1.35A 4hytA-2bo9B:
undetectable		 4hytA-2bo9B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d28 TYPE II SECRETION
ATPASE XPSE

(Xanthomonas
campestris) 		PF05157
(T2SSE_N) 		4 PRO C 113
ASP C 112
ILE C  10
VAL C  49
 None
 1.35A 4hytA-2d28C:
undetectable		 4hytA-2d28C:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyy V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 PRO A 165
ASP A 163
ASN A 171
ILE A 182
 None
 1.42A 4hytA-2eyyA:
undetectable		 4hytA-2eyyA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 PRO A  64
ASP A  19
ILE A  66
VAL A 314
 None
 1.36A 4hytA-2gopA:
undetectable		 4hytA-2gopA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 110
ASP A 109
ILE A 146
VAL A 163
 None
None
None
MHO  A 162 ( 3.4A)
 1.45A 4hytA-2iqfA:
undetectable		 4hytA-2iqfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 246
 None
CA  A 316 (-2.2A)
None
None
 1.32A 4hytA-2masA:
5.0		 4hytA-2masA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 PRO A 292
ASP A 291
ILE A 260
VAL A 271
 None
 1.10A 4hytA-2osyA:
undetectable		 4hytA-2osyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D 339
ASP D 338
ILE D 333
VAL D 155
 None
 1.31A 4hytA-2qe7D:
undetectable		 4hytA-2qe7D:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B 200 (-3.6A)
None
GNP  B 200 (-3.9A)
 1.39A 4hytA-2qtvB:
2.8		 4hytA-2qtvB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5t NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.24A 4hytA-2v5tA:
undetectable		 4hytA-2v5tA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 PRO A 123
ASP A 122
ILE A 136
VAL A 321
 None
 1.08A 4hytA-2vwbA:
undetectable		 4hytA-2vwbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wim NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.25A 4hytA-2wimA:
undetectable		 4hytA-2wimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.23A 4hytA-2x58A:
1.1		 4hytA-2x58A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 PRO A 368
ASP A 367
ILE A 699
VAL A 671
 None
 1.35A 4hytA-2xsgA:
undetectable		 4hytA-2xsgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 PRO A 209
ASP A 290
ILE A 242
VAL A 280
 None
 1.22A 4hytA-2xy1A:
undetectable		 4hytA-2xy1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 PRO A 169
ASP A 170
ASN A 168
VAL A 414
 None
 1.39A 4hytA-2zwsA:
undetectable		 4hytA-2zwsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 PRO A 279
ASP A 180
ASN A 280
VAL A 285
 None
 1.42A 4hytA-3b9gA:
2.3		 4hytA-3b9gA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 PRO A 444
ASP A 443
ILE A 474
VAL A 502
 None
 1.02A 4hytA-3d3kA:
undetectable		 4hytA-3d3kA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PRO X 374
ASP X 375
ILE X  54
VAL X   5
 C8E  X 455 (-3.9A)
C8E  X 455 (-4.2A)
C8E  X 455 (-4.0A)
C8E  X 455 ( 4.8A)
 1.43A 4hytA-3dwoX:
undetectable		 4hytA-3dwoX:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 PRO A 365
ASP A 394
ILE A  53
VAL A  79
 None
 1.32A 4hytA-3e4eA:
undetectable		 4hytA-3e4eA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PRO A 429
ASP A 356
ILE A 407
VAL A 311
 None
 1.21A 4hytA-3fjoA:
undetectable		 4hytA-3fjoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 PRO A 119
ASP A 112
ILE A 143
VAL A 168
 None
 1.38A 4hytA-3fzgA:
2.9		 4hytA-3fzgA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		4 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 None
 1.45A 4hytA-3g4eA:
undetectable		 4hytA-3g4eA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  10
ILE A  33
VAL A 122
 None
CA  A 501 (-3.0A)
None
None
 1.34A 4hytA-3g5iA:
5.0		 4hytA-3g5iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 323
ASP A 322
ILE A 128
VAL A 292
 None
 1.05A 4hytA-3hpfA:
undetectable		 4hytA-3hpfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 PRO A 287
ASN A 299
ILE A  26
VAL A 111
 None
 1.39A 4hytA-3iu0A:
undetectable		 4hytA-3iu0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 PRO A 330
ASP A 297
ILE A 303
VAL A  80
 None
 1.19A 4hytA-3kjxA:
2.2		 4hytA-3kjxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASP A  46
ASN A  45
ILE A 127
VAL A 219
 None
 1.25A 4hytA-3o7qA:
undetectable		 4hytA-3o7qA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 PRO A 452
ASP A 379
ILE A 430
VAL A 334
 None
 1.32A 4hytA-3qfsA:
2.1		 4hytA-3qfsA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		4 PRO A  83
ASP A  82
ILE A   9
VAL A 206
 None
 1.31A 4hytA-3qvlA:
undetectable		 4hytA-3qvlA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 PRO A 169
ASN A 144
ILE A 236
VAL A 233
 None
 1.34A 4hytA-3rr6A:
undetectable		 4hytA-3rr6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 PRO A  70
ASN A  71
ILE A  64
VAL A 385
 None
 1.17A 4hytA-3t02A:
undetectable		 4hytA-3t02A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PRO A 154
ASN A 153
ILE A 172
VAL A 188
 None
 1.41A 4hytA-3vtfA:
4.2		 4hytA-3vtfA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 PRO A  72
ASP A 182
ILE A  64
VAL A 192
 None
 1.20A 4hytA-3wfzA:
undetectable		 4hytA-3wfzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus;
Thermus virus
P23-45) 		PF00562
(RNA_pol_Rpb2_6)
no annotation 		4 PRO B  17
ASP A 738
ILE A 745
VAL A 825
 None
 1.30A 4hytA-3woeB:
undetectable		 4hytA-3woeB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D 350
ASP D 349
ILE D 344
VAL D 161
 None
None
None
ADP  D1476 (-4.4A)
 1.14A 4hytA-4b2qD:
undetectable		 4hytA-4b2qD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B1190 (-3.6A)
None
GNP  B1190 (-3.9A)
 1.39A 4hytA-4bziB:
2.5		 4hytA-4bziB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 ASP A 154
ASN A 356
ILE A 352
VAL A 285
 None
 1.42A 4hytA-4c3yA:
undetectable		 4hytA-4c3yA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PRO A 272
ASP A 270
ILE A 287
VAL A 243
 None
 1.28A 4hytA-4dvjA:
2.7		 4hytA-4dvjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 ASO  A 304 (-4.4A)
None
None
None
 1.40A 4hytA-4gn8A:
undetectable		 4hytA-4gn8A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 PRO A 427
ASP A 426
ASN A 398
VAL A 408
 None
 1.24A 4hytA-4haqA:
undetectable		 4hytA-4haqA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 PRO A  82
ASP A  81
ILE A  48
VAL A 176
 None
 1.42A 4hytA-4i0nA:
undetectable		 4hytA-4i0nA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)

(Treponema
pallidum) 		PF02608
(Bmp) 		4 PRO A  83
ASP A 105
ILE A 164
VAL A 286
 RBF  A 401 ( 3.7A)
RBF  A 401 (-3.2A)
RBF  A 401 ( 4.7A)
None
 1.43A 4hytA-4iilA:
2.1		 4hytA-4iilA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A  85
ASP A  84
ILE A 148
VAL A 292
 None
None
NAI  A 401 (-4.2A)
None
 1.10A 4hytA-4ilkA:
3.9		 4hytA-4ilkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 PRO A  30
ASP A  29
ILE A  59
VAL A 145
 None
None
None
PGE  A 302 ( 4.7A)
 1.28A 4hytA-4jejA:
undetectable		 4hytA-4jejA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 PRO A 143
ASP A 142
ASN A  36
VAL A 151
 None
 1.28A 4hytA-4jr7A:
undetectable		 4hytA-4jr7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PRO A 152
ASP A 146
ILE A 666
VAL A 571
 None
 0.98A 4hytA-4lnvA:
undetectable		 4hytA-4lnvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 PRO A  29
ASN A  28
ILE A  26
VAL A 210
 None
 1.44A 4hytA-4lsbA:
undetectable		 4hytA-4lsbA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 ASP A 502
ASN A 530
ILE A 532
VAL A 600
 None
 1.42A 4hytA-4n3sA:
2.8		 4hytA-4n3sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 ASP B  24
ASN B  23
ILE B 194
VAL B 216
 None
 1.25A 4hytA-4o6dB:
undetectable		 4hytA-4o6dB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 ASP A 349
ASN A 350
ILE A  85
VAL A 322
 None
 1.27A 4hytA-4obsA:
undetectable		 4hytA-4obsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 PRO A 229
ASP A 234
ILE A 362
VAL A 377
 None
 0.98A 4hytA-4oc8A:
undetectable		 4hytA-4oc8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4l ATP SYNTHASE SUBUNIT
BETA 1

(Burkholderia
thailandensis) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO A 353
ASP A 352
ILE A 347
VAL A 170
 None
 1.28A 4hytA-4q4lA:
undetectable		 4hytA-4q4lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax CARD
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1

(Thermus
aquaticus;
Thermus
thermophilus) 		PF02559
(CarD_CdnL_TRCF)
PF04563
(RNA_pol_Rpb2_1) 		4 PRO A 369
ASP A 111
ILE A 108
VAL B  38
 None
 1.42A 4hytA-4xaxA:
undetectable		 4hytA-4xaxA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 PRO A 903
ASP A 902
ILE A1081
VAL A 881
 None
 1.15A 4hytA-4xqkA:
2.5		 4hytA-4xqkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 4 PRO A  62
ASP A  61
ILE A  93
VAL A  35
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.3A)
None
 1.37A 4hytA-5bw4A:
2.1		 4hytA-5bw4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 PRO A 110
ASP A 109
ILE A 131
VAL A 159
 None
 1.39A 4hytA-5d6nA:
undetectable		 4hytA-5d6nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		4 PRO A 298
ASP A 299
ILE A 229
VAL A 308
 PLP  A1001 (-4.3A)
PLP  A1001 (-3.2A)
None
None
 0.97A 4hytA-5d86A:
3.6		 4hytA-5d86A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 PRO A  43
ASN A  44
ILE A  91
VAL A  19
 None
 1.36A 4hytA-5firA:
3.2		 4hytA-5firA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A 381
ASN A 355
ILE A 352
VAL A 385
 None
 1.35A 4hytA-5fjiA:
4.9		 4hytA-5fjiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A1145
ASN A1144
ILE A1086
VAL A1136
 None
 0.99A 4hytA-5fkuA:
undetectable		 4hytA-5fkuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 ASP A 175
ASN A 177
ILE A 182
VAL A 129
 None
 1.25A 4hytA-5if3A:
4.0		 4hytA-5if3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		4 PRO A 123
ASP A 122
ILE A 136
VAL A 321
 None
 1.16A 4hytA-5jmvA:
undetectable		 4hytA-5jmvA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 PRO A  58
ASN A  48
ILE A  28
VAL A 267
 None
 1.38A 4hytA-5jowA:
undetectable		 4hytA-5jowA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PRO B 555
ASP B 594
ILE B 557
VAL B 565
 None
 1.41A 4hytA-5ldrB:
undetectable		 4hytA-5ldrB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwe C-C CHEMOKINE
RECEPTOR TYPE 9

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASP A  94
ASN A 313
ILE A 137
VAL A 262
 None
None
None
OLA  A 402 ( 4.0A)
 1.26A 4hytA-5lweA:
2.2		 4hytA-5lweA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 PRO D  62
ASP D  61
ILE D  40
VAL D  98
 None
 1.01A 4hytA-5n03D:
undetectable		 4hytA-5n03D:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 4 PRO A 117
ASP A 562
ILE A  78
VAL A 234
 None
 1.23A 4hytA-5nf2A:
undetectable		 4hytA-5nf2A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A  88
ASN A 301
ILE A 131
VAL A 251
 None
 1.25A 4hytA-5t1aA:
undetectable		 4hytA-5t1aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 PRO B 186
ASP B 185
ILE B 256
VAL B 147
 MGD  B 504 (-4.4A)
MGD  B 504 (-3.1A)
None
None
 1.25A 4hytA-5t5iB:
3.2		 4hytA-5t5iB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		4 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 ( 2.2A)
None
None
 1.26A 4hytA-5tsqA:
4.7		 4hytA-5tsqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 ASP A  76
ASN A 293
ILE A 119
VAL A 243
 None
 1.33A 4hytA-5uiwA:
undetectable		 4hytA-5uiwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 PRO A 222
ASP A 246
ILE A 262
VAL A 265
 None
 1.34A 4hytA-5umhA:
3.0		 4hytA-5umhA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 4 ASP A 333
ASN A 146
ILE A 132
VAL A 241
 None
 1.43A 4hytA-5v8cA:
undetectable		 4hytA-5v8cA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		4 ASP A 351
ASN A 347
ILE A 485
VAL A 388
 None
None
None
GB0  A1001 ( 4.7A)
 1.43A 4hytA-5v8kA:
undetectable		 4hytA-5v8kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4

(Homo sapiens) 		no annotation 4 PRO B 106
ASN B 153
ILE B 160
VAL B 133
 None
 1.30A 4hytA-5vgzB:
3.4		 4hytA-5vgzB:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 ASP C 335
ASN C 344
ILE C 286
VAL C 330
 None
 1.20A 4hytA-5x6xC:
undetectable		 4hytA-5x6xC:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 PRO A 382
ASP A 381
ILE A 378
VAL A 332
 None
EPE  A 504 (-3.8A)
None
None
 1.43A 4hytA-5xj1A:
2.7		 4hytA-5xj1A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 PRO A 768
ASP A 771
ASN A 777
VAL A 832
 None
 1.39A 4hytA-5xqoA:
undetectable		 4hytA-5xqoA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 4 PRO A 346
ASP A 376
ILE A 370
VAL A 430
 None
 1.41A 4hytA-5xt3A:
2.6		 4hytA-5xt3A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 PRO A 298
ASN A 276
ILE A 230
VAL A 250
 PLP  A 401 (-4.3A)
None
PLP  A 401 (-4.8A)
None
 1.33A 4hytA-5z5cA:
3.7		 4hytA-5z5cA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 PRO A 582
ASN A 583
ILE A 625
VAL A 621
 None
 1.40A 4hytA-6au1A:
undetectable		 4hytA-6au1A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 PRO A  48
ASP A  54
ILE A  95
VAL A  61
 None
 1.24A 4hytA-6c2hA:
2.3		 4hytA-6c2hA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 PRO A 219
ASP A 424
ASN A 423
VAL A 491
 None
 1.44A 4hytA-6cddA:
undetectable		 4hytA-6cddA:
6.74