SIMILAR PATTERNS OF AMINO ACIDS FOR 4HWK_C_SFYC804_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		5 LEU A  39
SER A 202
LEU A 201
PHE A 168
ALA A  73
 None
 1.26A 4hwkC-1abrA:
undetectable		 4hwkC-1abrA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		10 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
ALA A 210
 OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
 0.29A 4hwkC-1oaaA:
42.2		 4hwkC-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 LEU A 274
LEU A 157
PHE A 322
PRO A 162
ALA A 169
 None
 1.32A 4hwkC-1vgpA:
undetectable		 4hwkC-1vgpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3a SYNAPSE ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF03909
(BSD) 		5 LEU A  53
SER A  22
LEU A  21
TRP A  77
ALA A  49
 None
 1.41A 4hwkC-1x3aA:
undetectable		 4hwkC-1x3aA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4hwkC-2ad1A:
2.2		 4hwkC-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.09A 4hwkC-2e0wA:
undetectable		 4hwkC-2e0wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.02A 4hwkC-2e0xA:
0.0		 4hwkC-2e0xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 881
SER A 871
TYR A 884
ALA A 969
MET A 704
 None
 1.47A 4hwkC-2fgeA:
0.3		 4hwkC-2fgeA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 LEU A 220
LEU A  72
PRO A  77
GLN A 213
ALA A 166
 None
 1.12A 4hwkC-2nqoA:
undetectable		 4hwkC-2nqoA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 LEU A 121
LEU A 128
MET A 485
GLN A 486
ALA A 489
 None
 1.20A 4hwkC-2pyxA:
0.0		 4hwkC-2pyxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.16A 4hwkC-2rhzA:
undetectable		 4hwkC-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		5 LEU A 197
LEU A  35
TRP A 196
TYR A 193
ALA A 201
 None
 1.38A 4hwkC-2z6vA:
2.2		 4hwkC-2z6vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		5 LEU A  38
SER A 201
LEU A 200
PHE A 167
ALA A  72
 None
 1.46A 4hwkC-2zr1A:
undetectable		 4hwkC-2zr1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		5 LEU A 127
LEU A 145
PHE A 119
PRO A 147
ALA A 132
 None
 1.42A 4hwkC-3er6A:
undetectable		 4hwkC-3er6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 SER A 162
LEU A 163
TYR A 175
MET A 212
ALA A 216
 None
 0.86A 4hwkC-3gvcA:
25.8		 4hwkC-3gvcA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		5 LEU A 103
SER A 152
TYR A 165
MET A 202
ALA A 206
 None
ACT  A 255 (-2.6A)
ACT  A 255 ( 4.3A)
NAP  A 254 (-3.6A)
ACT  A 255 ( 4.0A)
 0.47A 4hwkC-3iahA:
27.1		 4hwkC-3iahA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4hwkC-3jckA:
undetectable		 4hwkC-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klu UNCHARACTERIZED
PROTEIN YQBN

(Bacillus
subtilis) 		PF08890
(Phage_TAC_5) 		5 LEU A 127
TRP A 126
TYR A 123
PRO A 109
ALA A  86
 None
 1.21A 4hwkC-3kluA:
undetectable		 4hwkC-3kluA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		5 LEU A  39
SER A 205
LEU A 204
PHE A 165
ALA A  71
 None
 1.39A 4hwkC-3mvgA:
undetectable		 4hwkC-3mvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus) 		PF08668
(HDOD) 		5 LEU A 165
SER A 131
LEU A 132
TYR A 127
ALA A  66
 None
 1.26A 4hwkC-3p3qA:
undetectable		 4hwkC-3p3qA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 146
SER A  80
LEU A  79
MET A 197
ALA A 201
 None
 1.19A 4hwkC-3q1oA:
undetectable		 4hwkC-3q1oA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 146
SER A  80
LEU A  79
PRO A  51
MET A 197
 None
 1.34A 4hwkC-3q1oA:
undetectable		 4hwkC-3q1oA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		no annotation 5 LEU A 442
SER A 467
TRP A 438
MET A 445
ALA A 441
 None
 1.43A 4hwkC-3vu0A:
undetectable		 4hwkC-3vu0A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 LEU A  70
LEU A  41
PHE A  27
PRO A 255
ALA A  22
 None
 1.48A 4hwkC-4c98A:
undetectable		 4hwkC-4c98A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 207
CYH A 114
PHE A 119
TRP A 214
TYR A 208
 None
 1.43A 4hwkC-4gtuA:
undetectable		 4hwkC-4gtuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		5 SER A 222
LEU A 223
PHE A 236
TYR A 237
ALA A 242
 None
 1.27A 4hwkC-4iqlA:
undetectable		 4hwkC-4iqlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3

(Homo sapiens) 		PF02820
(MBT) 		5 SER A 420
CYH A 416
PHE A 401
TYR A 414
ALA A 391
 None
 1.19A 4hwkC-4l59A:
undetectable		 4hwkC-4l59A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		5 LEU A 101
CYH A 168
PHE A 161
TRP A 164
MET A 202
 None
None
None
None
NAP  A 801 (-3.5A)
 1.43A 4hwkC-4z3kA:
45.5		 4hwkC-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		12 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
ALA A 206
MET A 215
 None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
 0.50A 4hwkC-4z3kA:
45.5		 4hwkC-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		5 LEU A  39
SER A 198
LEU A 197
PHE A 164
ALA A  71
 None
 1.25A 4hwkC-4z8sA:
undetectable		 4hwkC-4z8sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0v MATRIX PROTEIN VP40

(Marburg
marburgvirus) 		PF07447
(VP40) 		5 LEU A 174
PHE A 247
TYR A 274
GLN A 172
ALA A  60
 None
 1.15A 4hwkC-5b0vA:
undetectable		 4hwkC-5b0vA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmo HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Neisseria
meningitidis) 		PF01648
(ACPS) 		5 LEU A  49
LEU A  37
TYR A  48
GLN A  24
ALA A  27
 None
 1.37A 4hwkC-5cmoA:
undetectable		 4hwkC-5cmoA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 716
LEU A 691
PHE A 705
ALA A 711
MET A 663
 None
 1.32A 4hwkC-5d4wA:
undetectable		 4hwkC-5d4wA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 LEU A  45
SER A 215
LEU A 214
PHE A 181
ALA A  79
 None
 1.26A 4hwkC-5ddzA:
undetectable		 4hwkC-5ddzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A  51
CYH A  29
PRO A 147
MET A  56
ALA A  58
 None
 1.30A 4hwkC-5f7cA:
1.8		 4hwkC-5f7cA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 LEU A 126
SER A 135
LEU A 138
PHE A 102
ALA A  77
 None
 1.39A 4hwkC-5frsA:
undetectable		 4hwkC-5frsA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		5 LEU A 137
LEU A 495
TYR A 138
PRO A 497
ALA A 529
 None
 1.46A 4hwkC-5fx8A:
undetectable		 4hwkC-5fx8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 LEU A  14
SER A 603
LEU A 604
PRO A 599
ALA A 316
 None
 1.43A 4hwkC-5k3jA:
undetectable		 4hwkC-5k3jA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtg TRANSLOCATION AND
ASSEMBLY MODULE
SUBUNIT TAMB

(Escherichia
coli) 		no annotation 5 LEU A1100
LEU A1064
PRO A1094
GLN A1097
ALA A1125
 None
 1.47A 4hwkC-5vtgA:
undetectable		 4hwkC-5vtgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxv PEROXISOMAL MEMBRANE
PROTEIN PEX15

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 242
SER A 223
CYH A 216
TRP A 213
TYR A 212
 None
 1.31A 4hwkC-5vxvA:
undetectable		 4hwkC-5vxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU A 179
SER C1038
LEU C1037
GLN A 202
ALA A 199
 None
None
None
GOL  A 401 ( 3.3A)
None
 1.38A 4hwkC-6au8A:
undetectable		 4hwkC-6au8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU A 179
SER C1038
LEU C1037
TYR A 182
GLN A 202
 None
None
None
None
GOL  A 401 ( 3.3A)
 1.42A 4hwkC-6au8A:
undetectable		 4hwkC-6au8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 192
LEU A  60
PHE A 160
GLN A 199
ALA A 195
 None
 1.31A 4hwkC-6co1A:
undetectable		 4hwkC-6co1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 5 LEU A 240
LEU A 364
PRO A 310
ALA A 252
MET A 288
 None
 1.44A 4hwkC-6cpyA:
undetectable		 4hwkC-6cpyA:
undetectable