SIMILAR PATTERNS OF AMINO ACIDS FOR 4HOJ_A_ACTA303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 VAL A  99
ARG A 101
MET A 102
GLU A  58
 None
 1.26A 4hojA-1b4eA:
0.0		 4hojA-1b4eA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		4 VAL A 115
ARG A 118
MET A 119
GLU A 122
 None
 0.56A 4hojA-1booA:
undetectable		 4hojA-1booA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 VAL B  99
ARG B  68
GLU B  44
LEU B  40
 None
 1.43A 4hojA-1lpbB:
0.3		 4hojA-1lpbB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 VAL A 909
ARG A 910
GLU A 906
LEU A 991
 None
 1.40A 4hojA-1ofeA:
0.0		 4hojA-1ofeA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 VAL A  58
ARG A  60
MET A 533
GLU A 532
 None
 1.22A 4hojA-1t1uA:
undetectable		 4hojA-1t1uA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u00 CHAPERONE PROTEIN
HSCA

(Escherichia
coli) 		PF00012
(HSP70) 		4 VAL A 524
ARG A 527
MET A 528
GLU A 531
 None
 1.20A 4hojA-1u00A:
0.0		 4hojA-1u00A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL B 115
ARG B 116
MET B 117
GLU B 172
 None
 1.46A 4hojA-1umbB:
0.0		 4hojA-1umbB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		4 VAL A 113
MET A  16
GLU A  17
LEU A 268
 None
None
UNL  A 600 (-2.9A)
None
 1.28A 4hojA-1vkmA:
undetectable		 4hojA-1vkmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 VAL C 211
ARG C 210
MET C  34
GLU C  33
 None
 1.06A 4hojA-1w36C:
0.0		 4hojA-1w36C:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		4 VAL A 103
ARG A 104
GLU A 101
LEU A  54
 None
 1.49A 4hojA-1wwsA:
undetectable		 4hojA-1wwsA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 VAL A  33
ARG A   4
GLU A 218
LEU A 228
 None
 1.11A 4hojA-1x2gA:
undetectable		 4hojA-1x2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 479
ARG A 482
MET A 483
GLU A 629
 None
 1.17A 4hojA-1zcjA:
undetectable		 4hojA-1zcjA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zno HYPOTHETICAL UPF0244
PROTEIN VC0702

(Vibrio cholerae) 		PF01931
(NTPase_I-T) 		4 VAL A 119
ARG A 122
MET A 133
GLU A 135
 None
 1.06A 4hojA-1znoA:
undetectable		 4hojA-1znoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ARG B 242
MET B 247
GLU B 246
LEU B 329
 None
 1.33A 4hojA-2afhB:
undetectable		 4hojA-2afhB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 VAL A  26
ARG A  28
MET A  31
GLU A  30
 None
 0.94A 4hojA-2gjnA:
undetectable		 4hojA-2gjnA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyy POSSIBLE
ATP-DEPENDENT DNA
HELICASE
RECG-RELATED PROTEIN

(Nitrosomonas
europaea) 		PF04326
(AlbA_2) 		4 VAL A  36
MET A  33
GLU A  34
LEU A  89
 None
 1.28A 4hojA-2kyyA:
undetectable		 4hojA-2kyyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 305
MET A 307
GLU A 311
LEU A 189
 None
 1.40A 4hojA-2ldxA:
undetectable		 4hojA-2ldxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A  52
ARG A 327
GLU A 334
LEU A  44
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.2A)
None
FAD  A 401 (-4.5A)
 0.83A 4hojA-2mbrA:
undetectable		 4hojA-2mbrA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 VAL A 226
ARG A 163
MET A 164
LEU A 173
 None
 1.47A 4hojA-2obvA:
undetectable		 4hojA-2obvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 VAL X  10
ARG X   9
MET X  36
GLU X  37
 None
 1.43A 4hojA-2odtX:
undetectable		 4hojA-2odtX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 VAL A  66
ARG A  68
GLU A  44
LEU A  18
 None
 0.85A 4hojA-2p4zA:
undetectable		 4hojA-2p4zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmr PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH) 		4 VAL A 164
ARG A 167
MET A 151
GLU A 153
 None
 1.41A 4hojA-2rmrA:
undetectable		 4hojA-2rmrA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2van DNA POLYMERSE BETA

(Rattus
norvegicus) 		PF10391
(DNA_pol_lambd_f)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 VAL A 103
ARG A 102
GLU A 147
LEU A 122
 None
 1.37A 4hojA-2vanA:
undetectable		 4hojA-2vanA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 VAL A 375
ARG A 337
GLU A 324
LEU A  78
 None
 1.42A 4hojA-2wu0A:
undetectable		 4hojA-2wu0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 479
ARG A 482
MET A 483
GLU A 629
 None
 1.16A 4hojA-2x58A:
undetectable		 4hojA-2x58A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9q CYCLODIPEPTIDE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF16715
(CDPS) 		4 VAL A 116
ARG A 168
MET A 170
GLU A 172
 None
 1.32A 4hojA-2x9qA:
undetectable		 4hojA-2x9qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 VAL A 285
ARG A 286
GLU A  48
LEU A  52
 None
 1.45A 4hojA-2xuzA:
undetectable		 4hojA-2xuzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 VAL A  52
ARG A  51
MET A  55
GLU A 185
 None
 1.26A 4hojA-2yxlA:
undetectable		 4hojA-2yxlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 564
ARG A 565
MET A 566
GLU A 567
 None
 1.45A 4hojA-2z6hA:
undetectable		 4hojA-2z6hA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 VAL A 316
ARG A 317
MET A 329
GLU A 330
 None
 1.13A 4hojA-2zyjA:
undetectable		 4hojA-2zyjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 VAL P 235
ARG P 288
MET P 231
LEU P 208
 None
 1.42A 4hojA-3c5wP:
undetectable		 4hojA-3c5wP:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 VAL A 269
ARG A 268
GLU A 307
LEU A 311
 None
 1.31A 4hojA-3cdiA:
undetectable		 4hojA-3cdiA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 VAL A 160
ARG A 230
MET A 231
GLU A 233
 None
 1.45A 4hojA-3ee4A:
undetectable		 4hojA-3ee4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 VAL A 199
ARG A 197
GLU A 146
LEU A 213
 None
 1.39A 4hojA-3g79A:
undetectable		 4hojA-3g79A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 VAL A 368
MET A 372
GLU A 374
LEU A 385
 None
 0.75A 4hojA-3gsiA:
undetectable		 4hojA-3gsiA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 VAL A 157
ARG A 156
MET A 160
GLU A 231
 None
MET  A 296 (-3.2A)
None
None
 1.24A 4hojA-3gxaA:
undetectable		 4hojA-3gxaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		4 VAL A 216
ARG A 208
GLU A 145
LEU A 277
 None
 1.47A 4hojA-3hvmA:
undetectable		 4hojA-3hvmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		4 VAL A 283
ARG A 287
MET A 339
GLU A 344
 None
 1.43A 4hojA-3iacA:
undetectable		 4hojA-3iacA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 VAL A 157
ARG A 156
MET A 160
GLU A 231
 None
MET  A 600 (-3.2A)
None
None
 1.25A 4hojA-3ir1A:
undetectable		 4hojA-3ir1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S31,
MITOCHONDRIAL

(Bos taurus) 		no annotation 4 VAL h 345
MET h 342
GLU h 343
LEU h 329
 None
 1.33A 4hojA-3jd5h:
undetectable		 4hojA-3jd5h:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrq E3 UBIQUITIN-PROTEIN
LIGASE TRIM37

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		4 VAL A  12
ARG A  14
GLU A   7
LEU A  76
 None
 1.44A 4hojA-3lrqA:
undetectable		 4hojA-3lrqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 VAL A  74
ARG A  77
GLU A 349
LEU A  90
 None
 1.38A 4hojA-3m1gA:
14.9		 4hojA-3m1gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqi HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 VAL A 115
ARG A 263
GLU A 174
LEU A 236
 None
 1.25A 4hojA-3qqiA:
undetectable		 4hojA-3qqiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 VAL A 287
ARG A 286
MET A 291
GLU A 293
 None
 1.10A 4hojA-3v9aA:
undetectable		 4hojA-3v9aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		4 VAL A 182
ARG A 183
MET A 184
GLU A 195
 None
 1.39A 4hojA-3wz3A:
undetectable		 4hojA-3wz3A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 120
ARG A 119
MET A 118
GLU A 138
 PLP  A1350 ( 3.9A)
GOL  A1428 ( 4.3A)
None
None
 1.47A 4hojA-4bf5A:
undetectable		 4hojA-4bf5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 VAL A 298
ARG A 299
GLU A 345
LEU A 349
 None
 1.20A 4hojA-4c3yA:
undetectable		 4hojA-4c3yA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 VAL A 251
ARG A 254
MET A 255
GLU A  56
 VAL  A 251 ( 0.6A)
ARG  A 254 ( 0.6A)
MET  A 255 (-0.0A)
GLU  A  56 ( 0.6A)
 0.82A 4hojA-4c9gA:
undetectable		 4hojA-4c9gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		4 VAL A 525
ARG A 502
GLU A 342
LEU A 335
 None
 1.37A 4hojA-4eipA:
2.1		 4hojA-4eipA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 VAL A 797
MET A 801
GLU A 757
LEU A 777
 None
 1.10A 4hojA-4fgvA:
2.8		 4hojA-4fgvA:
12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hoj REGF PROTEIN

(Neisseria
gonorrhoeae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A  93
ARG A  96
MET A  97
GLU A 100
LEU A 132
 ACT  A 303 (-3.9A)
ACT  A 303 (-3.7A)
ACT  A 303 (-4.7A)
ACT  A 303 (-4.2A)
ACT  A 303 (-4.7A)
 0.01A 4hojA-4hojA:
38.3		 4hojA-4hojA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 VAL A  98
ARG A  99
MET A 152
GLU A 153
 None
 0.84A 4hojA-4id9A:
undetectable		 4hojA-4id9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		4 VAL A 139
ARG A 138
MET A  22
GLU A  23
 None
SO4  A 203 (-2.9A)
None
None
 1.38A 4hojA-4jcpA:
undetectable		 4hojA-4jcpA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 VAL A 190
ARG A 158
MET A 157
GLU A 159
 None
 1.44A 4hojA-4jgiA:
undetectable		 4hojA-4jgiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 VAL A 286
MET A 237
GLU A 279
LEU A 274
 None
 1.41A 4hojA-4mynA:
undetectable		 4hojA-4mynA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 VAL B 407
ARG B 410
MET B 411
GLU B 413
 CLA  B1220 (-4.1A)
CLA  B1227 (-3.9A)
CLA  B1227 (-3.9A)
CLA  B1227 (-3.9A)
 1.07A 4hojA-4rkuB:
undetectable		 4hojA-4rkuB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 VAL A 518
ARG A 383
GLU A 402
LEU A 493
 None
 1.35A 4hojA-4zdkA:
undetectable		 4hojA-4zdkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		4 VAL A  12
ARG A  13
GLU A  45
LEU A  55
 None
AGS  A1402 (-4.2A)
None
None
 1.32A 4hojA-5dacA:
undetectable		 4hojA-5dacA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 VAL A 417
MET A 413
GLU A 415
LEU A 437
 None
 1.20A 4hojA-5ddsA:
undetectable		 4hojA-5ddsA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Homo sapiens;
Homo sapiens) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		4 VAL H 143
ARG H 146
GLU G 982
LEU G1098
 None
 1.42A 4hojA-5furH:
undetectable		 4hojA-5furH:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR TRANSFERASE
TTUA
SULFUR CARRIER TTUB

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01171
(ATP_bind_3)
no annotation 		4 VAL E  35
ARG A 204
GLU E  33
LEU E  46
 EDO  E 101 (-4.8A)
None
None
None
 1.17A 4hojA-5ghaE:
undetectable		 4hojA-5ghaE:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 VAL A 464
ARG A 467
MET A 436
LEU A 428
 None
 1.27A 4hojA-5h8wA:
undetectable		 4hojA-5h8wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 4 VAL A 220
ARG A 221
GLU A 307
LEU A   7
 None
 1.43A 4hojA-5i1uA:
undetectable		 4hojA-5i1uA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		4 VAL A 628
MET A 623
GLU A 624
LEU A 373
 None
 1.38A 4hojA-5k5mA:
undetectable		 4hojA-5k5mA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 4 VAL A 138
ARG A 137
MET A 159
GLU A 160
 None
 1.46A 4hojA-5mh5A:
undetectable		 4hojA-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 273
ARG A 274
MET A 251
GLU A 252
 None
 1.22A 4hojA-5mx0A:
undetectable		 4hojA-5mx0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 VAL A 471
ARG A 474
MET A 475
GLU A 480
 None
 1.04A 4hojA-5td7A:
undetectable		 4hojA-5td7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 VAL A 289
ARG A 288
GLU A 239
LEU A 233
 None
 1.29A 4hojA-5tz8A:
undetectable		 4hojA-5tz8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 VAL C 289
ARG C 288
GLU C 239
LEU C 233
 None
 1.38A 4hojA-5tzkC:
undetectable		 4hojA-5tzkC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME

(Homo sapiens) 		PF06859
(Bin3)
PF13847
(Methyltransf_31) 		4 VAL A 561
ARG A 602
MET A 599
LEU A 450
 SAH  A 701 (-4.7A)
None
None
None
 1.37A 4hojA-5unaA:
undetectable		 4hojA-5unaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		4 VAL A 189
ARG A 144
MET A 193
GLU A 195
 None
GOL  A 304 (-3.7A)
None
GOL  A 304 (-2.2A)
 1.41A 4hojA-5v1mA:
undetectable		 4hojA-5v1mA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 VAL A 304
ARG A 307
MET A 308
GLU A 310
 None
 1.32A 4hojA-5xmjA:
undetectable		 4hojA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 4 ARG A 159
MET A 163
GLU A 162
LEU A 235
 None
 1.24A 4hojA-5yhjA:
undetectable		 4hojA-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 4 VAL A 179
ARG A 180
GLU A 177
LEU A 218
 None
 1.41A 4hojA-6b5vA:
undetectable		 4hojA-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 VAL A 141
ARG A 117
GLU A  35
LEU A  41
 None
 1.09A 4hojA-6d5iA:
undetectable		 4hojA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 VAL B  71
MET B  61
GLU B  62
LEU B 156
 EDO  B 501 (-4.8A)
None
None
None
 1.47A 4hojA-6g4qB:
undetectable		 4hojA-6g4qB:
undetectable